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1. 发明申请

US20190352510A1 NIR LONG LIFETIME INDICATOR MOLECULE 审中-公开
公开(公告)号：US20190352510A1
公开(公告)日：2019-11-21
申请号：US16308675
申请日：2017-06-16
申请人： Arthur E. COLVIN, JR.
发明人： Arthur E. COLVIN, JR.
IPC分类号： C09B62/84 , A61K49/00 , G01N33/58 , G01N33/66 , C09B69/10
摘要： The invention relates to a porphyrin time domain indicator. The indicator may be used for detection of a particular analyte in vivo or in vitro. The indicator may be used for detection of glucose in vivo or in vitro.

2. 发明授权

US07939332B2 Detection of analytes in aqueous environments 有权
标题翻译：在水性环境中检测分析物
公开(公告)号：US07939332B2
公开(公告)日：2011-05-10
申请号：US11448903
申请日：2006-06-08
申请人： Arthur E. Colvin, Jr.
发明人： Arthur E. Colvin, Jr.
IPC分类号： G01N33/00 , C07D235/00
CPC分类号： G01N21/6428 , A61B5/14532 , A61B5/1459 , C07D257/02 , G01N31/22 , G01N33/542 , G01N33/66 , G01N33/84 , G01N2021/6432 , G01N2021/7786 , Y10T436/143333 , Y10T436/144444
摘要： The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.
摘要翻译：本发明涉及用于检测介质如液体中分析物的存在或浓度的指示剂分子以及用于实现这种检测的方法。更具体地，本发明涉及含有相对疏水的指示剂组分单体和亲水单体的共聚物大分子，使得大分子能够在水性环境中使用。

3. 发明申请

US20100298674A1 PROTECTIVE SHELL FOR AN IN VIVO SENSOR MADE FROM RESORBABLE POLYMER 审中-公开
标题翻译：用于可再生聚合物的血液传感器的保护壳
公开(公告)号：US20100298674A1
公开(公告)日：2010-11-25
申请号：US12764389
申请日：2010-04-21
申请人： Arthur E. Colvin, JR. , Jason D. Colvin
发明人： Arthur E. Colvin, JR. , Jason D. Colvin
IPC分类号： A61B5/145 , A61B5/1459
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/6861 , A61B2562/12
摘要： An implantable device with in vivo functionality, where the functionality of the device is negatively affected by the inflammation reaction generally associated with tissue injury, encapsulated by a protective coating that prevents damage to the device from any inflammation reactions. The protective coating is designed to persist for a set period of time, generally until after the inflammation reaction of the surrounding in vivo environment in response to the injury caused by the implantation procedure has concluded. The protective coating is further designed to “resorb” (i.e. to dissociate from the device, dissolve, and be absorbed into the surrounding environment) after a set period of time, allowing the device to perform its in vivo functionality unhindered without loss of performance.
摘要翻译：具有体内功能性的可植入装置，其中该装置的功能受到通常与组织损伤有关的炎症反应的不利影响，该保护性涂层包封，防止装置受到任何炎症反应的损害。保护涂层设计为持续一段时间，一般直到周围的体内环境的炎症反应响应于由植入程序引起的损伤已经结束。保护涂层进一步被设计成在一段时间之后“吸收”（即从器件解离，溶解并被吸收到周围环境中），允许器件不受阻碍地执行其体内功能而不损失性能。

4. 发明授权

US07755022B2 System and method for attenuating the effect of ambient light on an optical sensor 有权
标题翻译：用于衰减环境光对光学传感器的影响的系统和方法
公开(公告)号：US07755022B2
公开(公告)日：2010-07-13
申请号：US12180745
申请日：2008-07-28
申请人： Arthur E. Colvin, Jr. , Paul Samuel Zerwekh , Jeffrey C. Lesho , Robert W. Lynn , Carrie R. Lorenz , Casey J. O'Connor , Steven J. Walters
发明人： Arthur E. Colvin, Jr. , Paul Samuel Zerwekh , Jeffrey C. Lesho , Robert W. Lynn , Carrie R. Lorenz , Casey J. O'Connor , Steven J. Walters
IPC分类号： G01J1/16 , F21V9/16
CPC分类号： A61B5/14556 , A61B5/0031 , A61B5/14532 , A61B5/1459 , A61B5/681 , G01N21/6428 , G01N21/645 , G01N2201/1244 , H05K1/0306 , H05K1/165 , H05K3/403 , H05K2201/086 , H05K2201/09972 , H05K2201/10106
摘要： The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.
摘要翻译：本发明提供了用于衰减环境光对光学传感器的影响并用于量化和补偿环境光的系统和方法。

5. 发明授权

US07713745B2 Non-covalent immobilization of indicator molecules 有权
标题翻译：指示剂分子的非共价固定化
公开(公告)号：US07713745B2
公开(公告)日：2010-05-11
申请号：US10822670
申请日：2004-04-13
申请人： Arthur E. Colvin, Jr. , Carrie R. Lorenz
发明人： Arthur E. Colvin, Jr. , Carrie R. Lorenz
IPC分类号： G01N21/63 , G01N21/64
CPC分类号： G01N31/22 , A61B5/0071 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/1455 , A61B5/14735
摘要： The invention relates to immobilization methods, in particular for immobilizing indicator molecules on supports such as sensors and to sensors having those molecules immobilized to their surface. Non-covalent immobilization of macromolecular indicator molecules on those supports via mechanical interlacing with polymers at the surface of a support and via ionic bonding via charged moieties of indicator molecules and ionic groups on the surface of the support are disclosed.
摘要翻译：本发明涉及固定化方法，特别是用于将指示剂分子固定在诸如传感器的载体上，以及将具有固定在其表面上的那些分子的传感器。公开了通过在载体的表面与聚合物的机械交织，通过在载体表面上的指示剂分子和离子基团的带电部分经由离子键合，将大分子指示剂分子非共价固定在这些载体上。

6. 发明授权

US07405387B2 System and method for attenuating the effect of ambient light on an optical sensor 有权
标题翻译：用于衰减环境光对光学传感器的影响的系统和方法
公开(公告)号：US07405387B2
公开(公告)日：2008-07-29
申请号：US11646266
申请日：2006-12-28
申请人： Arthur E. Colvin, Jr. , Paul Samuel Zerwekh , Jeffrey C. Lesho , Robert William Lynn , Carrie R. Lorenz , Casey J. O'Connor , Steven J. Walters
发明人： Arthur E. Colvin, Jr. , Paul Samuel Zerwekh , Jeffrey C. Lesho , Robert William Lynn , Carrie R. Lorenz , Casey J. O'Connor , Steven J. Walters
IPC分类号： G01J1/16
CPC分类号： A61B5/14556 , A61B5/0031 , A61B5/14532 , A61B5/1459 , A61B5/681 , G01N21/6428 , G01N21/645 , G01N2201/1244 , H05K1/0306 , H05K1/165 , H05K3/403 , H05K2201/086 , H05K2201/09972 , H05K2201/10106
摘要： The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.
摘要翻译：本发明提供了用于衰减环境光对光学传感器的影响并用于量化和补偿环境光的系统和方法。

7. 发明授权

US06940590B2 High performance fluorescent optical sensor 有权
标题翻译：高性能荧光光学传感器
公开(公告)号：US06940590B2
公开(公告)日：2005-09-06
申请号：US10316188
申请日：2002-12-11
申请人： Arthur E. Colvin, Jr. , Steven J. Walters
发明人： Arthur E. Colvin, Jr. , Steven J. Walters
IPC分类号： G01N21/64 , G01N21/77 , G01J1/42 , G01N21/01
CPC分类号： G01N21/645 , G01N21/6428 , G01N21/7703 , G01N2201/0642
摘要： An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.
摘要翻译：用于确定分析物的存在或浓度的光学传感器装置包含设置在光源上的波导和安装在基板的表面上并由内部挡板隔开的光检测器，其中波导具有对应于远的由光源和光检测器之间的遮光挡板确定的光源的场发射点。分析物指示矩阵设置在波导的外表面上。传感器装置的几何形状仅利用指示矩阵的直接照明，并且直接收集指示矩阵照明，而不会被所述波导的任何明显的反射。由光源产生的不良光线噪声通过波导直接从器件中流出。

8. 发明授权

US06711423B2 Optical-based sensing devices 有权
标题翻译：光传感器
公开(公告)号：US06711423B2
公开(公告)日：2004-03-23
申请号：US09963798
申请日：2001-09-27
申请人： Arthur E. Colvin, Jr.
发明人： Arthur E. Colvin, Jr.
IPC分类号： A61B500
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6861 , A61B2560/0219 , A61B2562/12 , G01N21/552 , G01N21/6428 , G01N21/648 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , Y10S128/903
摘要： An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.
摘要翻译：一种光学传感器，用于使用指示器和参考通道来检测分析物的存在或量。该传感器具有一个传感器体，其中嵌有辐射源。源发射的辐射与靠近身体表面的指示剂膜指示剂分子相互作用。这些指示剂分子的至少一种光学特性随分析物浓度而变化。例如，荧光指示剂分子的荧光水平或光吸收指示剂分子吸收的光量可以作为分析物浓度的函数而变化。此外，源发射的辐射也与靠近身体表面的参考膜指示剂分子相互作用。由这些指示剂分子发射或反射的辐射（例如，光）进入并在内部反射在传感器主体中。传感器体内的感光元件产生指示通道和参考通道信号，以提供分析物浓度的准确指示。优选的实施方案是完全独立的并且其尺寸和形状用于人体内的体内。这样的实施例优选地包括电源，例如电源。电感器，其使用外部装置为辐射源供电，以及发射器，例如，电感器，用于向外部拾取装置传输表示分析物水平的信号。

9. 发明授权

US06330464B1 Optical-based sensing devices 有权
标题翻译：光传感器
公开(公告)号：US06330464B1
公开(公告)日：2001-12-11
申请号：US09383148
申请日：1999-08-26
申请人： Arthur E. Colvin, Jr. , Gregory A. Dale , Paul Samuel Zerwekh , Jeffery C. Lesho , Robert W. Lynn
发明人： Arthur E. Colvin, Jr. , Gregory A. Dale , Paul Samuel Zerwekh , Jeffery C. Lesho , Robert W. Lynn
IPC分类号： A61B500
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6861 , A61B2560/0219 , A61B2562/12 , G01N21/552 , G01N21/6428 , G01N21/648 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , Y10S128/903
摘要： An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.
摘要翻译：一种光学传感器，用于使用指示器和参考通道来检测分析物的存在或量。该传感器具有一个传感器体，其中嵌有辐射源。源发射的辐射与靠近身体表面的指示剂膜指示剂分子相互作用。这些指示剂分子的至少一种光学特性随分析物浓度而变化。例如，荧光指示剂分子的荧光水平或光吸收指示剂分子吸收的光量可以作为分析物浓度的函数而变化。此外，源发射的辐射也与靠近身体表面的参考膜指示剂分子相互作用。由这些指示剂分子发射或反射的辐射（例如，光）进入并在内部反射在传感器主体中。传感器体内的感光元件产生指示通道和参考通道信号，以提供分析物浓度的准确指示。优选的实施方案是完全独立的并且其尺寸和形状用于人体内的体内。这样的实施例优选地包括电源，例如电源。电感器，其使用外部装置为辐射源供电，以及发射器，例如，电感器，用于向外部拾取装置传输表示分析物水平的信号。

10. 外观设计

USD309498S Chromatography column closure or similar article 失效
公开(公告)号：USD309498S
公开(公告)日：1990-07-24
申请号：US87908
申请日：1987-08-20
申请人： Arthur E. Colvin, Jr.
设计人： Arthur E. Colvin, Jr.

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