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1. 发明授权

US06835175B1 Medical devices for contemporaneous decision support in metabolic control 失效
标题翻译：用于代谢控制同期决策支持的医疗设备
公开(公告)号：US06835175B1
公开(公告)日：2004-12-28
申请号：US10603133
申请日：2003-06-23
申请人： Aureliu M. Porumbescu
发明人： Aureliu M. Porumbescu
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/0002 , A61B5/14532 , G06F19/00 , G16H50/50
摘要： The invention addresses hardware and software products capable to make contemporaneous accurate predictions regarding how a person's biological system will respond to a serious of stimuli. The predictions can then be communicated in real time, enabling confirmation of good control status, need for corrective action, planning future actions, or even outside intervention in case of emergency. Also addressed by the invention is a family of diagnostic hardware based on intelligent optoelectronic sensors that incorporate one or more Wedge-and-Strip Position-Sensitive Photo-Detectors optimized for probabilistic real time evaluation of spectroscopy data from living subjects.
摘要翻译：本发明解决了能够对人的生物系统如何对严重刺激作出反应的同时准确预测的硬件和软件产品。然后可以实时传达预测，从而确认良好的控制状态，需要纠正措施，规划未来行动，甚至在紧急情况下甚至外部干预。本发明还提出了一种基于智能光电传感器的诊断硬件系列，该智能光电传感器包含一个或多个针对来自活体的光谱数据的概率实时评估优化的楔形和带状位置敏感光电探测器。

2. 发明授权

US06826419B2 Signal processing apparatus and method 失效
标题翻译：信号处理装置及方法
公开(公告)号：US06826419B2
公开(公告)日：2004-11-30
申请号：US10327234
申请日：2002-12-20
申请人： Mohamed Kheir Diab , Esmaiel Kiani-Azarbayjany
发明人： Mohamed Kheir Diab , Esmaiel Kiani-Azarbayjany
IPC分类号： A61B500
CPC分类号： G06K9/0051 , A61B5/14551 , A61B5/7214 , A61B5/7228 , H04B1/123
摘要： A signal processor which acquires a first signal, including a first desired signal portion and a first undesired signal portion, and a second signal, including a second desired signal portion and a second undesired signal portion, wherein the first and second desired signal portions are correlated. The signals may be acquired by propagating energy through a medium and measuring an attenuated signal after transmission or reflection. Alternatively, the signals may be acquired by measuring energy generated by the medium. A processor of the present invention generates a noise reference signal that is a combination of the undesired signal portions and is correlated to both the first and second undesired signal portions. The noise reference signal is then used to remove the undesired portion of each of the first and second measured signals. The processor of the present invention may be employed in physiological monitors wherein the known properties of energy attenuation through a medium are used to determine physiological characteristics of the medium. Many physiological conditions, such as the pulse of a patient or the concentration of a constituent in a medium, can be determined from the desired portion of the signal after undesired signal portions, such as those caused by erratic motion, are removed.
摘要翻译：一种信号处理器，其获取包括第一期望信号部分和第一不期望信号部分的第一信号，以及包括第二期望信号部分和第二非期望信号部分的第二信号，其中第一和第二期望信号部分相关。信号可以通过传播能量通过介质并在透射或反射之后测量衰减信号来获取。或者，可以通过测量由介质产生的能量来获取信号。本发明的处理器生成噪声参考信号，其是不需要的信号部分的组合，并且与第一和第二不期望信号部分相关。然后使用噪声参考信号来去除第一和第二测量信号中的每一个的不希望的部分。本发明的处理器可用于生理监视器，其中通过介质的能量衰减的已知特性用于确定介质的生理特性。可以从不期望的信号部分（例如由不规则运动引起的那些）去除信号的期望部分来确定许多生理条件，例如患者的脉搏或介质中成分的浓度。

3. 发明授权

US06819949B2 Method and apparatus for measuring blood oxygen saturation in a retinal vessel by separately detecting single pass optical signals 失效
标题翻译：通过单独检测单次光信号测量视网膜血管中血氧饱和度的方法和装置
公开(公告)号：US06819949B2
公开(公告)日：2004-11-16
申请号：US10134360
申请日：2002-04-29
申请人： Matthew H. Smith , Arthur Lompado , Kurt R. Denninghoff , Lloyd W. Hillman
发明人： Matthew H. Smith , Arthur Lompado , Kurt R. Denninghoff , Lloyd W. Hillman
IPC分类号： A61B500
CPC分类号： A61B5/14555 , A61B3/12
摘要： A method and apparatus are provided for accurately measuring the blood oxygen saturation with a retinal vessel. The apparatus includes an optical source for illuminating the retinal vessel with optical signals. The apparatus also includes a filter, such as an aperture, disposed within the path of the optical signals returning from the eye. The filter preferentially passes single pass optical signals that have diffused through the retinal layer and/or the choroidal layer of the eye while traversing the retinal vessel only once, while blocking or otherwise redirecting the other optical signals. The apparatus also includes a detector for separately detecting at least the single pass optical signals and, in some instances, the other optical signals as well. The apparatus can also include a processing element for determining the blood oxygen saturation in the retinal vessel based upon the optical signals that have been detected.
摘要翻译：提供了用视网膜血管精确测量血氧饱和度的方法和装置。该装置包括用于用光学信号照亮视网膜容器的光源。该装置还包括设置在从眼睛返回的光学信号的路径内的诸如孔的滤光器。滤波器优先通过已经通过视网膜层和/或眼睛的脉络膜扩散的单遍光信号，同时横穿视网膜容器只有一次，同时阻挡或以其它方式重定向其他光信号。该装置还包括检测器，用于分别检测至少单遍光信号，并且在一些情况下还检测其它光信号。该装置还可以包括用于基于已经检测到的光信号确定视网膜血管中的血氧饱和度的处理元件。

4. 发明授权

US06816741B2 Plethysmograph pulse recognition processor 有权
标题翻译：体积描记脉冲识别处理器
公开(公告)号：US06816741B2
公开(公告)日：2004-11-09
申请号：US10267446
申请日：2002-10-08
申请人： Mohamed K. Diab
发明人： Mohamed K. Diab
IPC分类号： A61B500
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/7264
摘要： An intelligent, rule-based processor provides recognition of individual pulses in a pulse oximeter-derived photo-plethysmograph waveform. Pulse recognition occurs in two stages. The first stage identifies candidate pulses in the plethysmograph waveform. The candidate pulse stage identifies points in the waveform representing peaks and valleys corresponding to an idealized triangular wave model of the waveform pulses. At this stage, waveform features that do not correspond to this model are removed, including the characteristic dicrotic notch. The second stage applies a plethysmograph model to the candidate pulses and decides which pulses satisfies this model. This is done by first calculating certain pulse features and then applying different checks to identify physiologically acceptable features. Various statistics can then be derived from the resulting pulse information, including the period and signal strength of each pulse and pulse density, which is the ratio of the analyzed waveform segment that has been classified as physiologically acceptable.
摘要翻译：智能的基于规则的处理器提供了脉冲血氧计衍生的光体积描记器波形中各个脉冲的识别。脉冲识别发生在两个阶段。第一阶段识别体积描记图波形中的候选脉冲。候选脉冲级识别波形中表示与波形脉冲的理想化三角波模型相对应的峰和谷的点。在这个阶段，消除了不对应于这个模型的波形特征，包括特征的重晶缺口。第二阶段对候选脉冲应用体积描记模型，并决定哪个脉冲满足该模型。这是通过首先计算某些脉冲特征，然后应用不同的检查来识别生理上可接受的特征。所得到的脉冲信息可以得到各种统计信息，包括每个脉冲的周期和信号强度以及脉冲密度，这是被分类为生理上可接受的分析波形段的比率。

5. 发明授权

US06814707B2 Blood collection safety device 失效
标题翻译：采血安全装置
公开(公告)号：US06814707B2
公开(公告)日：2004-11-09
申请号：US10175219
申请日：2002-06-19
申请人： Margie M. Collins , Cary C. Collins
发明人： Margie M. Collins , Cary C. Collins
IPC分类号： A61B500
CPC分类号： A61B5/154 , A61B5/15003 , A61B5/150389 , A61B5/150473 , A61B5/150572 , A61B5/150641 , A61B5/150732
摘要： A blood collection device includes a syringe assembly containing a slidable needle assembly within the cavity of a syringe body. The syringe body has a syringe top for receiving a seal assembly wherein the seal assembly is reversibly locked to the top of the syringe top. Within the insertable tube of the seal assembly is an occluding seal secured within the insertable cylinder with retaining rings. The occluding seal allows blood to flow from on end of a double pointed needle into a fully inserted collection tube. When the collection tube is removed the occluding seal keeps blood from flowing into the cavity of the insertable cylinder.
摘要翻译：采血装置包括注射器组件，该注射器组件在注射器主体的空腔内容纳可滑动的针头组件。注射器主体具有用于接收密封组件的注射器顶部，其中密封组件可逆地锁定到注射器顶部的顶部。在密封组件的可插入管内是封闭的密封件，固定在具有保持环的可插入圆筒内。闭塞密封允许血液从双尖针的一端流入完全插入的收集管。当收集管被移除时，封闭的密封件使得血液不会流入可插入气缸的空腔。

6. 发明授权

US06810277B2 Method, apparatus and system for removing motion artifacts from measurements of bodily parameters 失效
标题翻译：用于从身体参数测量中去除运动伪影的方法，装置和系统
公开(公告)号：US06810277B2
公开(公告)日：2004-10-26
申请号：US10213140
申请日：2002-08-06
申请人： Reuben W. Edgar, Jr. , August J. Allo, Jr. , Paul B. Gunneson , Jesus D. Martin , John R. DelFavero , Michael B. Jaffe
发明人： Reuben W. Edgar, Jr. , August J. Allo, Jr. , Paul B. Gunneson , Jesus D. Martin , John R. DelFavero , Michael B. Jaffe
IPC分类号： A61B500
CPC分类号： A61B5/14551 , A61B5/7207 , A61B5/7257 , A61B5/726
摘要： A method for removing motion artifacts from devices for sensing bodily parameters and apparatus and system for effecting same. The method includes analyzing segments of measured data representing bodily parameters and possibly noise from motion artifacts. Each segment of measured data may correspond to a single light signal transmitted and detected after transmission or reflection through bodily tissue. Each data segment is frequency analyzed to determine up to three candidate peaks for further analysis. Each of the up to three candidate frequencies may be filtered and various parameters associated with each of the up to three candidate frequencies are calculated. The best frequency, if one exists, is determined by arbitrating the candidate frequencies using the calculated parameters according to predefined criteria. If a best frequency is found, a pulse rate and SpO2 may be output. If a best frequency is not found, other, conventional techniques for calculating pulse rate and SpO2 may be used. The above method may be applied to red and infrared pulse oximetry signals prior to calculating pulse rate and/or pulsatile blood oxygen concentration. Apparatus and systems disclosed are configured to perform methods disclosed according to the invention.
摘要翻译：一种用于从用于感测身体参数的装置和用于实现其的设备和系统的装置中去除运动假象的方法。该方法包括分析表示身体参数和可能的运动伪影噪声的测量数据的段。测量数据的每一段可对应于通过身体组织透射或反射后传输和检测的单个光信号。对每个数据段进行频率分析，以确定最多三个候选峰进行进一步分析。可以对最多三个候选频率中的每一个进行滤波，并且计算与最多三个候选频率中的每一个相关联的各种参数。通过使用根据预定准则的计算参数来仲裁候选频率来确定最佳频率（如果存在）。如果发现最佳频率，则可以输出脉率和SpO2。如果没有发现最佳频率，则可以使用用于计算脉率和SpO2的其它常规技术。在计算脉搏率和/或脉动血氧浓度之前，上述方法可以应用于红色和红外脉搏血氧饱和度信号。公开的设备和系统被配置为执行根据本发明公开的方法。

7. 发明授权

US06808498B2 Placing a guide member into a heart chamber through a coronary vessel and delivering devices for placing the coronary vessel in communication with the heart chamber 失效
公开(公告)号：US06808498B2
公开(公告)日：2004-10-26
申请号：US09170793
申请日：1998-10-13
申请人： Gilbert S. Laroya , A. Adam Sharkawy , Mark J. Foley
发明人： Gilbert S. Laroya , A. Adam Sharkawy , Mark J. Foley
IPC分类号： A61B500
CPC分类号： A61F2/24 , A61B17/3415 , A61B2017/00247 , A61B2017/00252 , A61B2018/00392 , A61F2/2493 , A61F2/94 , A61F2002/30079 , A61F2210/009 , A61M25/01
摘要： A guide member positioned through a coronary vessel and the wall of the heart provides access to a heart chamber. A first end of the guide member is passed through the coronary vessel and the heart wall into the heart chamber, and then is passed back out of the heart chamber. The end of the guide member may then be used to deliver devices into the heart chamber to carry out various medical procedures. A conduit delivery system is coupled to the end of the guide member and is delivered into the heart chamber and then used to place a conduit in the heart wall to communicate the coronary vessel with the heart chamber.

8. 发明授权

US06804548B2 Irradiation system and its irradiation target movement monitoring method, and irradiation target position recognizing method 有权
标题翻译：照射系统及其照射目标运动监测方法和照射目标位置识别方法
公开(公告)号：US06804548B2
公开(公告)日：2004-10-12
申请号：US09964481
申请日：2001-09-28
申请人： Shuichi Takahashi , Katsunobu Muroi , Yoshikazu Nakajima
发明人： Shuichi Takahashi , Katsunobu Muroi , Yoshikazu Nakajima
IPC分类号： A61B500
CPC分类号： A61N5/1049 , A61N5/1067 , A61N5/107
摘要： A radiation system includes a measuring section of position and direction for computing relative position and direction between various components of the system; an irradiation condition correcting section for obtaining positions and directions of the irradiation target regions in the images using computation results obtained by the measuring section of position and direction and compared results obtained by comparing the irradiation target regions in the images taken by an irradiation target image acquisition section, and for correcting the irradiation conditions such that the obtained position and direction are reflected in the irradiation conditions; and a control section for controlling the radiation to the irradiation target region in response to the irradiation conditions obtained as a result of the correction by the irradiation condition correcting section. The irradiation system can solve a problem of a conventional system in that although the conventional system is effective for the radiation therapy to a head region, its irradiation accuracy is degraded in a trunk region such as abdominal organs where the effect of the body movement such as respiration is greater than in the head region, and hence the position and direction of the irradiation target is continuously changing.
摘要翻译：辐射系统包括用于计算系统的各个部件之间的相对位置和方向的位置和方向的测量部分; 照射条件校正部分，用于使用由测量部分获得的位置和方向的计算结果获得照片目标区域的位置和方向，并且通过比较通过照射目标图像获取拍摄的图像中的照射目标区域获得的比较结果并且用于校正照射条件，使得所获得的位置和方向在照射条件下反映; 以及控制部分，用于响应于作为由照射条件校正部分进行校正的结果而获得的照射条件，控制对照射目标区域的辐射。照射系统可以解决常规系统的问题，因为尽管常规系统对于头部区域的放射疗法是有效的，但是其在诸如腹部器官的躯干区域中的照射精度降低，其中身体运动的影响如呼吸大于头部区域，因此照射目标的位置和方向不断变化。

9. 发明授权

US06804543B2 Sensor for transcutaneous measurement of vascular access blood flow 失效
标题翻译：用于经皮测量血管通路血流量的传感器
公开(公告)号：US06804543B2
公开(公告)日：2004-10-12
申请号：US10099974
申请日：2002-03-19
申请人： David R. Miller , David A. Bell , Douglas L. Cox , Songbiao Zhang
发明人： David R. Miller , David A. Bell , Douglas L. Cox , Songbiao Zhang
IPC分类号： A61B500
CPC分类号： A61B5/14535 , A61B5/0261 , A61B5/0275 , A61B5/14532 , A61B5/14552 , A61B5/6843 , A61M1/3656 , A61M1/3663
摘要： An optical sensor includes a sensing pair of complementary emitter and detector elements for measuring the bulk absorptivity (&agr;) of an area parallel to and including a hemodialysis access site, and a normalizing pair of complementary emitter and detector elements for measuring the absorptivity (&agr;o) of the tissue itself perpendicular to the access site. The pairs of emitter and detector elements define two lines at right angles to each other, and one of the pairs lies to one side of the line defined by the other of the pairs, such that the two pairs of emitter and detector elements form a “T” shape. Indicator dilution techniques are used to measure vascular access flow rates during routine hemodialysis, using the sensor.
摘要翻译：光学传感器包括用于测量平行于并包括血液透析进入位置的区域的体积吸收率（α）的互补发射器和检测器元件的感测对，以及用于测量吸收率（αo）的归一化互补发射器和检测器元件对，的组织本身垂直于进入位置。发射器和检测器元件对定义了彼此成直角的两条线，并且其中一对位于由另一对对限定的线的一侧，使得两对发射极和检测器元件形成“ T“形。使用指示剂稀释技术在常规血液透析期间使用传感器来测量血管通路流速。

10. 发明授权

US06801799B2 Pulse oximeter and method of operation 有权
标题翻译：脉搏血氧仪及操作方法
公开(公告)号：US06801799B2
公开(公告)日：2004-10-05
申请号：US10360666
申请日：2003-02-06
申请人： Yitzhak Mendelson
发明人： Yitzhak Mendelson
IPC分类号： A61B500
CPC分类号： A61B5/14552 , A61B5/1455
摘要： A sensor for use in an optical measurement device and a method for non-invasive measurement of a blood parameter. The sensor includes sensor housing, a source of radiation coupled to the housing, and a detector assembly coupled to the housing. The source of radiation is adapted to emit radiation at predetermined frequencies. The detector assembly is adapted to detect reflected radiation at least one predetermined frequency and to generate respective signals. The signals are used to determine the parameter of the blood.
摘要翻译：用于光学测量装置的传感器和用于非侵入式测量血液参数的方法。传感器包括传感器外壳，耦合到壳体的辐射源，以及耦合到壳体的检测器组件。辐射源适于以预定频率发射辐射。检测器组件适于检测至少一个预定频率的反射辐射并产生相应的信号。这些信号用于确定血液的参数。

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