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1. 发明授权

US11634465B2 Analogues of VDAC1-derived peptides 有权
公开(公告)号：US11634465B2
公开(公告)日：2023-04-25
申请号：US17039042
申请日：2020-09-30
申请人： B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY , THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
发明人： Varda Shoshan-Barmatz
IPC分类号： C07K14/47 , C07K14/79 , A61P1/16 , A61P35/02 , A61P35/00 , A61K38/00
摘要： The present invention relates to peptides comprising analogues of VDAC1-derived peptides having improved pharmacokinetic characteristics compared to the native parent peptides, which are effective in impairing cell energy production, in inducing apoptosis and cell death, particularly of cancerous cells, in eliminating cancer stem cells and in reducing symptoms associated with fat accumulation in liver cells particularly with nonalcoholic fatty liver disease (NAFLD) and symptoms associated thereto.

2. 发明申请

US20220289677A1 DNA PRIMASE AND GYRASE INHIBITORS 有权
公开(公告)号：US20220289677A1
公开(公告)日：2022-09-15
申请号：US17750560
申请日：2022-05-23
申请人： B. G. Negev Technologies and Applications Ltd., At Ben-Gurion University
发明人： Barak AKABAYOV
IPC分类号： C07D209/42
摘要： Disclosed herein are compounds that are selective DNA primase and/or gyrase inhibitors. Further disclosed are pharmaceutical compositions comprising these compounds, and the uses of these compounds for treating disorders associated with microbial infections.

3. 发明申请

US20220160680A1 MICROORGANISM MIXTURES, MOLECULES DERIVED THEREFROM, AND METHODS OF USE THEREOF 有权
公开(公告)号：US20220160680A1
公开(公告)日：2022-05-26
申请号：US17534483
申请日：2021-11-24
申请人： B. G. Negev Technologies and Applications Ltd., at Ben-Gurion University
发明人： Raz JELINEK , Orit Malka , Elena Voronov
IPC分类号： A61K31/404 , A61K31/222 , A61K36/064 , A61P29/00
摘要： The present invention is directed to a composition comprising a Tryptophol derivative and a 4-Ethyl-Phenol derivative, and at least one acceptable carrier. Further provided are methods for reducing the formation of load of organic-based contaminant.

4. 发明授权

US11332510B2 Succinate-binding polypeptides and use thereof 有权
公开(公告)号：US11332510B2
公开(公告)日：2022-05-17
申请号：US16647945
申请日：2018-09-18
申请人： B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
发明人： Ehud Ohana
IPC分类号： C07K14/705 , A61K38/00 , A61P9/12 , A61P1/00 , C07K14/47
摘要： Polypeptides comprising an amino acid sequence of Slc26a6 or IRBIT comprising a mutation that increases NaDC-1 binding, stability of the polypeptide, stability of NaDC-1 complex or a combination thereof are provided. Polypeptides comprising an amino acid sequence of a mutant succinate receptor 1 (mutSUCNR1), comprising a mutation that increases succinate binding, stability of the polypeptide, stability of the mutSUCNR1-succinate complex or combinations thereof are also provided. Compositions comprising the polypeptides, nucleic acid molecules and vectors encoding the polypeptides, and methods of use of the polypeptides or compositions, specifically for treating succinate-associate diseases and conditions are also provided.

5. 发明申请

US20220016253A1 L-DOPA AND/OR DOPA DECARBOXYLSE INHIBITORS CONJUGATED TO SUGAR FOR THE TREATMENT OF DOPAMINE-RESPONSIVE DISORDERS 有权
公开(公告)号：US20220016253A1
公开(公告)日：2022-01-20
申请号：US17311338
申请日：2019-12-05
申请人： B. G. Negev Technologies and Applications Ltd., at Ben-Gurion University
发明人： Eliahu HELDMAN , Moshe KUSHNIR , Eleonora SHAUBI
IPC分类号： A61K47/54 , C07C235/34 , C07C243/28 , C07C243/34 , C07C231/12
摘要： The present invention provides conjugates comprising a sugar such as mannitol and one or more L-DOPA and/or DOPA decarboxylse inhibitors including, inter alia, L-DOPA, carbidopa, benserazide, or a combination thereof, wherein the sugar is conjugated to the carboxyl group of the L-DOPA and/or DOPA decarboxylse inhibitor/ s) via a hydroxyl group of the sugar. The present invention further provides related pharmaceutical compositions and methods of producing the conjugates, as well as methods of use for treating medical disorders responsive to dopamininergic stimulation such as movement disorders including, inter alia, Parkinson's Disease.

6. 发明申请

US20210364355A1 RECOVERY OF HYPERSPECTRAL DATA FROM IMAGE 有权
公开(公告)号：US20210364355A1
公开(公告)日：2021-11-25
申请号：US17397328
申请日：2021-08-09
申请人： B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
发明人： Ohad BEN-SHAHAR , Boaz ARAD
IPC分类号： G01J3/28 , G06T7/90
摘要： A method for approximating spectral data, the method comprising using at least one hardware processor for: providing a digital image comprising data in a first set of spectral bands; providing a dictionary comprising (a) signatures in a second set of spectral bands and (b) values in said first set of spectral bands, wherein said values correspond to the signatures, and wherein said first and second sets of spectral bands are different; and approximating, based on the dictionary, data in said second set of spectral bands of said digital image

7. 发明授权

US10770969B2 Digital average current-mode control voltage regulator and a method for tuning compensation coefficients thereof 有权
公开(公告)号：US10770969B2
公开(公告)日：2020-09-08
申请号：US16337283
申请日：2017-09-25
申请人： B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
发明人： Mor Mordechai Peretz
IPC分类号： H02M3/157 , G05F1/575 , H02M1/00
摘要： A digital controller for controlling an average-current-mode voltage regulator with an output connected to a load. The controller comprises a digital voltage-sampling window Analog-to-Digital Converter (ADC), based on Delay-Lines (DLs) and configured to obtain a sample of a voltage error signal being the difference between the reference voltage and the output voltage, and to convert the voltage error signal from analog to digital representation; a digital current-sampling window ADC, based on DLs and configured to obtain a sample of the output current and to convert the current output from analog to digital representation; a digital compensator for voltage regulation, receiving as input the digital voltage error signal, configured to generate a current reference signal based thereupon; a digital compensator for current regulation, receiving as input the current error signal and the current reference signal, configured to generate a duty-ratio command signal based thereupon; and a digital hybrid High Resolution (HR) Digital Pulse Width Modulator (HR-DPWM) receiving as input the duty-ratio command signal and generating a pulse-width-modulated signal that is fed to the gates of the converter's transistors, to thereby control the current and voltage supplied to the load.

8. 发明授权

US10654930B2 Composition and method for treating amyotrophic lateral sclerosis 有权
公开(公告)号：US10654930B2
公开(公告)日：2020-05-19
申请号：US16079391
申请日：2017-02-26
申请人： B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
发明人： Rachel Lichtenstein
IPC分类号： A61P25/28 , C07K16/28 , C07K16/00 , C07K14/705 , A61K39/00
摘要： The present invention provides a composition and method for treating, delaying the onset, delaying progression of, reducing the incidence of or reducing the severity of amyotrophic lateral sclerosis, in a subject. The composition in some embodiments of the invention is an immunoglobulin derived Fc fragment which binds and partially antagonizes the action of CD16.

9. 发明申请

US20200083808A1 PLUG-AND-PLAY ELECTRONIC CAPACITOR FOR VOLTAGE REGULATOR MODULES APPLICATIONS 审中-公开
公开(公告)号：US20200083808A1
公开(公告)日：2020-03-12
申请号：US16075939
申请日：2017-02-09
申请人： B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
发明人： Mor Mordechai PERETZ , Alon CERVERA , Or KIRSHENBOIM
IPC分类号： H02M3/158
摘要： A plug-and-play Transient Suppression Unit (TSU) for Voltage Regulator Modules (VRMs), which comprises a bi-directional current source connected via a high voltage port and a low voltage port of the TSU in parallel to a voltage output of the VRM, adapted to immediately sink or source current supplied to a load; a detection circuit for detecting mismatches between the voltage output of the VRM to a reference steady-state voltage, which comprises a first comparator for detecting a match between the voltage output of the VRM to the reference steady-state voltage; a second comparator for detecting a mismatch between the voltage output of the VRM to a predefined threshold higher than the reference steady-state voltage; a third comparator for detecting a mismatch between the voltage output of the VRM to a predefined threshold lower than the reference steady-state voltage value; a transient response accelerator, connected via a third port of the TSU to the output compensation port of the VRM error amplifier, and adapted to control duty-ratio saturation of the VRM. A loading transient is detected by the third comparator, upon which the VRM's duty ratio is saturated to a maximal value by the transient response accelerator and current is sourced from the current source to the output, until the first comparator detects that the voltage output of the VRM matches the expected steady-state voltage. An unloading transient is detected by the second comparator, upon which the VRM's duty ratio is saturated to a minimal value by the transient response accelerator and current is sunk from the output into the current source, until the first comparator detects that the voltage output of the VRM matches the expected steady-state voltage.

10. 发明授权

US10561706B2 Isolated polypeptide and compositions comprising same 有权
公开(公告)号：US10561706B2
公开(公告)日：2020-02-18
申请号：US16067080
申请日：2016-12-28
申请人： B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
发明人： Stanislav Engel
IPC分类号： C07K14/435 , A61K38/17 , A61K39/00 , A61P25/02 , C07K4/12 , C07K7/04 , C07K16/40
摘要： The present invention provides a composition and method for treating, delaying the onset, delaying progression of, reducing the incidence of or reducing the severity of amyotrophic lateral sclerosis in a subject. The composition a peptide derived from SOD1 which can be used to inhibit formation of SOD1 amyloid-like aggregates or for production of anti-SOD1 antibodies.

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