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1. 发明公开

US20230165809A1 INTRAVENOUS FORMULATIONS OF COENZYME Q10 (CoQ10) AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20230165809A1
公开(公告)日：2023-06-01
申请号：US17836950
申请日：2022-06-09
申请人： Berg LLC
发明人： Niven Rajin Narain , John Patrick McCook
IPC分类号： A61K31/122 , A61K47/34 , A61K47/24 , A61K9/00 , A61K9/10
CPC分类号： A61K31/122 , A61K9/10 , A61K9/0019 , A61K47/24 , A61K47/34
摘要： Disclosed herein are formulations suitable for parenteral administration of certain hydrophobic active agents such as Coenzyme Q10. Methods of preparing the same and methods of treatment of oncological disorders using the same are also provided herein. The formulations comprise an aqueous solution; a hydrophobic active agent dispersed to form a colloidal nano-dispersion of particles; and at least one of a dispersion stabilizing agent and an opsonization reducer wherein the colloidal nano-dispersion of the active agent is dispersed into nano-dispersion particles having a mean size of less than 200-nm. Methods of preparing the parenteral formulations comprise dispersing the hydrophobic active agent by high pressure homogenization by (1) adding hydrophobic active agent to a 65° C. bath of water and mixing to form a hydrophobic active agent/water mixture; (2) adding a dispersion stabilizing agent to the hydrophobic active agent/water mixture and mix at 65° C. to form a hydrophobic active agent/water/stabilizer mixture; (3) adding an opsonization reducer to form a hydrophobic active agent/water/stabilizer/reducer mixture; (4) pre-heating a Microfluidizer to 65° C.; and (5) processing by mixing the hydrophobic active agent/water/stabilizer/reducer mixture in the Microfluidizer at 65° C. such that a hydrophobic active agent colloidal nano-dispersion having a mean particle size less than 200-nm is formed. Provided herein are also methods of treating oncological disorders by administering formulations described herein to a subject such that treatment or prevention of the oncological disorder occurs.

2. 发明申请

US20220202741A1 METHODS OF TREATMENT OF TEMOZOLOMIDE-RESISTANT GLIOMA USING COENZYME Q10 有权
公开(公告)号：US20220202741A1
公开(公告)日：2022-06-30
申请号：US17572092
申请日：2022-01-10
申请人： Berg LLC
发明人： Niven Rajin Narain , Rangaprasad Sarangarajan , Vivek K. Vishnudas , Anne R. Diers , Stephane Gesta
IPC分类号： A61K31/122 , A61K9/00 , A61K31/495 , A61K39/395 , A61K45/06 , C07K16/22
摘要： The invention provides methods and compositions for treatment of a subject with a glioma that has failed treatment with temozolomide (TMZ) comprising administration of a composition comprising a Coenzyme Q10 compound to the subject. The invention also provides a method of treating a cancer that exhibits increased Complex II activity in a subject comprising administration of a composition comprising a Coenzyme Q10 compound to the subject.

3. 发明申请

US20220137070A1 METHODS AND SYSTEMS FOR IDENTIFYING MODULATORS OF PERVASIVE DEVELOPMENTAL DISORDERS 有权
公开(公告)号：US20220137070A1
公开(公告)日：2022-05-05
申请号：US17346152
申请日：2021-06-11
申请人： Berg LLC
发明人： Niven Rajin Narain , Paula Patricia Narain
IPC分类号： G01N33/68 , C12Q1/6883 , A61K38/17 , A61K38/44 , A61K38/45 , A61K38/46 , A61K38/48 , C07K16/18
摘要： Methods for treatment and diagnosis of pervasive developmental disorders in humans are described.

4. 发明申请

US20220096399A1 METHODS OF TREATMENT OF SOLID TUMORS USING COENZYME Q10 有权
公开(公告)号：US20220096399A1
公开(公告)日：2022-03-31
申请号：US17321699
申请日：2021-05-17
申请人： Berg LLC
发明人： Niven Rajin Narain , John Patrick McCook , Paul Song , Ines Macias-Perez
IPC分类号： A61K31/122 , A61K9/00 , A61K47/24 , A61K47/22 , A61K9/12 , A61K9/08 , A61K47/44 , A61K45/06 , A61K9/10 , A61K9/14
摘要： The invention provides methods and compositions for treatment of a subject with a solid tumor comprising administration of Coenzyme Q10 (CoQ10), particularly when the subject has failed at least one prior chemotherapeutic regimen.

5. 发明申请

US20210346291A1 INHALABLE PHARMACEUTICAL COMPOSITIONS 有权
公开(公告)号：US20210346291A1
公开(公告)日：2021-11-11
申请号：US17118229
申请日：2020-12-10
申请人： Berg LLC
发明人： Niven Rajin Narain , John Patrick McCook
IPC分类号： A61K9/12 , A61K9/00 , A61K9/127 , A61K31/122 , G01N15/02
摘要： Inhalable pharmaceutical compositions can include an aqueous dispersion of particles including a hydrophobic bioactive agent (e.g., CoQ10) suitable for continuous aerosolization. Due to their chemical composition and methods of manufacture, the pharmaceutical compositions exhibit distinctive physicochemical properties that provide advantageous aerosol transmission and output.

6. 发明授权

US11091447B2 UBE2K modulators and methods for their use 有权
公开(公告)号：US11091447B2
公开(公告)日：2021-08-17
申请号：US17139188
申请日：2020-12-31
申请人： Berg LLC
发明人： Vivek K. Vishnudas , Dinesh U. Chimmanamada , Santosh A. Khedkar
IPC分类号： C07D249/08 , C07D405/12
摘要： Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating conditions associated with modulation of UBE2K.

7. 发明授权

US10933032B2 Methods for the treatment of cancer using coenzyme Q10 combination therapies 有权
公开(公告)号：US10933032B2
公开(公告)日：2021-03-02
申请号：US14248313
申请日：2014-04-08
申请人： Berg LLC
发明人： Niven Rajin Narain , Rangaprasad Sarangarajan
IPC分类号： A61K31/122 , A61K45/06 , A61K31/7068 , A61K31/704 , A61K33/24 , C07K16/32 , A61K31/513 , A61K39/395 , A61K31/4745
摘要： Presented herein are methods for the treatment of oncological disorders by the co-administration of CoQ10 formulations and chemotherapeutic agents and/or surgery. The CoQ10 formulations may be at least one of intravenous, topical, or by inhalation. The chemotherapeutic agents may be at least one of antimetabolites or anthracyclines. Co-administration of the CoQ10 formulations may be prior to, concurrent or substantially concurrent with, intermittent with or subsequent to the administration of the chemotherapy.

8. 发明申请

US20210002725A1 METHODS FOR THE DIAGNOSIS OF METABOLIC DISORDERS USING EPIMETABOLIC SHIFTERS, MULTIDIMENSIONAL INTRACELLULAR MOLECULES, OR ENVIRONMENTAL INFLUENCES 有权
公开(公告)号：US20210002725A1
公开(公告)日：2021-01-07
申请号：US16805557
申请日：2020-02-28
申请人： Berg LLC
发明人： Niven Rajin Narain , John Patrick McCook , Rangaprasad Sarangarajan
IPC分类号： C12Q1/6886 , A61K31/00 , A61K31/122 , G01N33/574 , C12Q1/6883 , G01N33/573
摘要： Methods and formulations for diagnosing metabolic disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described.

9. 发明申请

US20200018758A1 METHODS FOR DIFFERENTIATING BENIGN PROSTATIC HYPERPLASIA FROM PROSTATE CANCER 审中-公开
公开(公告)号：US20200018758A1
公开(公告)日：2020-01-16
申请号：US16509808
申请日：2019-07-12
申请人： Berg LLC
发明人： Michael Andrew Kiebish , Poornima Tekumalla , Niven Rajin Narain , Rangaprasad Sarangarajan
IPC分类号： G01N33/574 , C12Q1/6886
摘要： Methods for differentiating between benign prostatic hyperplasia (BPH) and prostate cancer, in a subject, are provided, such methods including the detection of levels of one or more biomarker diagnostic of BPH. The invention also provides a kit for the diagnosis of BPH, without the need for a biopsy.

10. 发明申请

US20190304566A1 INTERROGATORY CELL-BASED ASSAYS FOR IDENTIFYING DRUG-INDUCED TOXICITY MARKERS 审中-公开
公开(公告)号：US20190304566A1
公开(公告)日：2019-10-03
申请号：US16180446
申请日：2018-11-05
申请人： Berg LLC
发明人： Niven Rajin Narain , Rangaprasad Sarangarajan , Vivek K. Vishnudas
IPC分类号： G16B5/00 , C12Q1/6883 , G16B20/00 , C12Q1/6837
摘要： Described herein is a discovery Platform Technology for analyzing a drug-induced toxicity condition, such as cardiotoxicity via model building.

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