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1. 发明授权

US08601521B2 Method and apparatus for managing media content from an optical drive 有权
标题翻译：用于从光盘驱动器管理媒体内容的方法和装置
公开(公告)号：US08601521B2
公开(公告)日：2013-12-03
申请号：US12024482
申请日：2008-02-01
申请人： Scott White , James Cansler , Bradley Thompson
发明人： Scott White , James Cansler , Bradley Thompson
IPC分类号： H04N7/173
CPC分类号： H04N7/17336 , H04N21/2225 , H04N21/42646 , H04N21/43615 , H04N21/4402 , H04N21/6125
摘要： A system that incorporates teachings of the present disclosure may include, for example, a communication device having a controller to read media content from an optical storage medium inserted into an optical drive of the communication device, obtain one or more preferences of a set top box for presentation of the media content, adjust the media content from a current format into a target format based at least in part on the one or more preferences, and transmit the media content in the target format to the set top box. Other embodiments are disclosed.
摘要翻译：包含本公开的教导的系统可以包括例如具有控制器的通信设备，该控制器从插入到通信设备的光驱中的光存储介质读取媒体内容，获得机顶盒的一个或多个偏好为了呈现媒体内容，至少部分地基于一个或多个偏好将媒体内容从当前格式调整为目标格式，并将目标格式的媒体内容发送到机顶盒。公开了其他实施例。

2. 发明申请

US20080038822A1 Virus clearance of neoplastic cells from mixed cellular compositions 审中-公开
标题翻译：来自混合细胞组合物的肿瘤细胞的病毒清除
公开(公告)号：US20080038822A1
公开(公告)日：2008-02-14
申请号：US11807921
申请日：2007-05-30
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： C12N5/00
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N15/86 , C12N2500/70 , C12N2720/12232 , C12N2720/12243
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
摘要翻译：本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。

3. 发明申请

US20080031851A1 Sensitization of chemotherapeutic agent resistant neoplastic cells with a virus 有权
标题翻译：具有病毒的抗化学药物抗肿瘤细胞的致敏作用
公开(公告)号：US20080031851A1
公开(公告)日：2008-02-07
申请号：US11809293
申请日：2007-05-31
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K35/76 , A61K38/21 , A61P35/00 , C12N5/00
CPC分类号： A61K33/24 , A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus and chemotherapeutic agents, and a method for preventing a neoplasm from developing drug resistance to chemotherapeutic agents. The virus is preferably a reovirus.
摘要翻译：本发明涉及通过使用病毒增加肿瘤细胞对化学治疗剂的敏感性的方法，使用病毒和化学治疗剂治疗增殖性病症的方法以及预防肿瘤对化疗药物的耐药性的方法。病毒优选为呼肠孤病毒。

4. 发明申请

US20070071723A1 In Vivo Enhancement of Immune System Recognition of Neoplasms Following Treatment with an Oncolytic Virus or Gene Therapy Vector 审中-公开
标题翻译：用溶瘤病毒或基因治疗载体处理后体内免疫系统识别的体内增强
公开(公告)号：US20070071723A1
公开(公告)日：2007-03-29
申请号：US11468676
申请日：2006-08-30
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K48/00 , A61K35/76
CPC分类号： A61K45/06 , A61K31/00 , A61K31/7084 , A61K35/765 , A61K2039/55561 , C12N2720/12032 , A61K2300/00
摘要： This invention provides novel methods of treating or alleviating neoplasms and enhancing the efficacy of oncolytic viruses by administering an oncolytic virus to a mammal suffering from a neoplasm and subsequently administering an immunostimulant. The invention also provides methods of increasing immunorecognition of neoplastic cells.
摘要翻译：本发明提供了通过向患有肿瘤的哺乳动物施用溶瘤病毒并随后施用免疫刺激剂来治疗或减轻肿瘤并增强溶瘤病毒的功效的新方法。本发明还提供增加肿瘤细胞免疫认知的方法。

5. 发明申请

US20060121007A1 Combined regulation of neural cell production 失效
公开(公告)号：US20060121007A1
公开(公告)日：2006-06-08
申请号：US11343419
申请日：2006-01-30
申请人： Bradley Thompson , Samuel Weiss , Tetsuro Shingo
发明人： Bradley Thompson , Samuel Weiss , Tetsuro Shingo
IPC分类号： C12N5/08 , A61K35/30
CPC分类号： C12N5/0623 , A61K35/12 , A61K38/2257 , A61K38/27 , A61K38/30 , A61K2300/00
摘要： This invention relates to a method of selectively producing neural cells, including neurons or glial cells, in vitro or in vivo. Also provided are methods of treating or ameliorating neurodegenerative disease or medical conditions by producing neural cells. Thus, a combination of factors is used to achieve two steps: increasing the number of neural stem cells and instructing the neural stem cells to selectively become neurons or glial cells.

6. 发明申请

US20050214266A1 Combination of transplantation and oncolytic virus treatment 审中-公开
标题翻译：组合移植和溶瘤病毒治疗
公开(公告)号：US20050214266A1
公开(公告)日：2005-09-29
申请号：US11079008
申请日：2005-03-10
申请人： Donald Morris , Bradley Thompson , Matthew Coffey
发明人： Donald Morris , Bradley Thompson , Matthew Coffey
IPC分类号： A61K35/14 , A61K35/15 , A61K35/23 , A61K35/28 , A61K35/34 , A61K35/36 , A61K35/39 , A61K35/407 , A61K35/42 , A61K35/44 , A61K35/76 , A61K35/765 , A61K39/00 , A61K45/06 , A61K48/00 , C12N15/86
CPC分类号： A61K35/15 , A61K35/28 , A61K35/765 , A61K39/00 , A61K45/06 , C12N2720/12032
摘要： Oncolytic viruses can be used to purge cellular compositions to remove undesired neoplastic cells before the cellular compositions are used for transplantation. The present invention relates to the use of a virus to pre-treat a subject prior to delivery into the subject a transplant that has been purged with the same virus. This pre-treatment serves to elicit an immune response in the subject against the virus, thereby protecting the subject from infections by the virus after receiving the transplant, which likely contains infectious viruses.
摘要翻译：在将细胞组合物用于移植之前，溶瘤病毒可用于清除细胞组合物以除去不想要的肿瘤细胞。本发明涉及病毒在将相同病毒清除的移植物递送到受试者之前预处理对象的用途。该预处理用于在受试者中引起针对病毒的免疫应答，从而在接受可能含有感染性病毒的移植物之后保护受试者免受病毒感染。

7. 发明申请

US20050095692A1 Method of extracting virus from cell culture 有权
标题翻译：从细胞培养中提取病毒的方法
公开(公告)号：US20050095692A1
公开(公告)日：2005-05-05
申请号：US10916378
申请日：2004-08-10
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K35/76 , A61P35/00 , A61P35/02 , C12N7/02 , C12R1/93
CPC分类号： C12N7/00 , A61K35/765 , C12N2720/12232 , C12N2720/12251
摘要： The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a convenient temperature such as 25° C. or 37° C. to produce high virus titers. Both ionic and non-ionic detergents can be used in the present invention.
摘要翻译：本发明涉及从细胞培养物中提取病毒，特别是呼肠弧病毒的方法。感染性病毒可以用诸如25℃或37℃的方便温度的洗涤剂从培养物中提取，以产生高病毒效价。离子和非离子洗涤剂都可用于本发明。

8. 发明申请

US20080075729A1 Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 失效
标题翻译：用于预防呼肠孤病毒识别用于治疗细胞增殖性疾病的方法
公开(公告)号：US20080075729A1
公开(公告)日：2008-03-27
申请号：US11809195
申请日：2007-05-30
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K39/395 , A61K35/76 , A61P43/00
CPC分类号： A61K35/765 , A61K38/13 , C07K16/081 , C07K16/10 , C07K16/4216 , C12N9/1205 , C12N2720/12232 , Y10S435/948 , Y10S435/975 , A61K2300/00
摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The mammal may be selected from dogs, cats, sheep, goats, cattle, horses, pigs, mice, humans and non-human primates. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. In particular, the methods provide for reovirus treatment of immunosuppressed or immuno-deficient mammals to treat the proliferative disorders. Immunosuppression, immunoinhibition or otherwise inducing an immunodeficient state in a mammal renders the reovirus more effective. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells. Immune systems may be compromised by one or more of the following: an HIV infection; as a side effect of chemotherapy or radiation therapy; by selective removal of B and/or T cell populations; by removal of antibodies (anti-antireovirus antibodies or all antibodies), and the like.
摘要翻译：本发明涉及在哺乳动物中治疗细胞增殖性疾病，特别是ras介导的细胞增殖性疾病中预防呼肠孤病毒识别的方法。哺乳动物可以选自狗，猫，绵羊，山羊，牛，马，猪，小鼠，人和非人灵长类动物。该方法包括抑制或以其他方式抑制哺乳动物的免疫系统，并且同时或随后在导致增殖细胞的实质性裂解的条件下向增殖细胞施用有效量的一种或多种呼吸道病毒。特别地，该方法提供了呼肠孤病毒治疗免疫抑制或免疫缺陷型哺乳动物以治疗增殖性疾病。在哺乳动物中的免疫抑制，免疫抑制或其他诱导免疫缺陷状态使呼肠孤病毒更有效。所述方法可以包括选择性去除可能干扰病毒的全身递送的免疫组分; 预防宿主免疫系统的呼肠孤病毒识别; 并在用呼肠孤病毒治疗后从免疫抑制或免疫不称职的宿主中除去病毒。或者，呼肠孤病毒可以在导致增殖细胞的实质性裂解的条件下给予具有减少的免疫应答系统的哺乳动物。免疫系统可能受到以下一种或多种感染：HIV感染; 作为化疗或放射治疗的副作用; 通过选择性去除B和/或T细胞群体; 通过除去抗体（抗 - 抗病毒抗体或全部抗体）等。

9. 发明申请

US20080031886A1 Viruses for the treatment of cellular proliferative disorders 有权
公开(公告)号：US20080031886A1
公开(公告)日：2008-02-07
申请号：US11807920
申请日：2007-05-30
申请人： Matthew Coffey , Bradley Thompson
发明人： Matthew Coffey , Bradley Thompson
IPC分类号： A61K39/42 , A61K39/395 , A61K48/00
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.

10. 发明申请

US20050071185A1 Regulatory compliance evaluation system and method 审中-公开
标题翻译：监管合规评估体系及方法
公开(公告)号：US20050071185A1
公开(公告)日：2005-03-31
申请号：US10913843
申请日：2004-08-06
申请人： Bradley Thompson
发明人： Bradley Thompson
IPC分类号： G06Q10/00 , G06F17/60
CPC分类号： G06Q10/10 , G06Q30/018
摘要： The present invention involves a system and method for producing a quantitative and precise assessment of overall compliance with the laws and regulations administered by a regulatory organization by using data obtained from and produced by that agency. This system and method for assessing regulatory compliance comprises several steps. One step involves obtaining audit information relating to the business entity. Another step involves interviewing personnel of the business entity and recording interview information, either personal or written interviews. Also, regulatory information is obtained relating to inspection of the business entity by the corresponding agency. Regulatory quality data is also obtained from the company, the corresponding agency, and other companies within the industry. Finally, the audit, interview, inspection, and regulatory quality information is combined and scored to create a compliance index related to the efficiency of the regulatory compliance of the business entity and then identifying any more general risk factors for that company. A machine-readable program storage device stores encoded instructions for normalizing a company's compliance assessment and calculating, evaluating, analyzing and conducting subanalysis on a company's and the industry's relative degree of compliance.
摘要翻译：本发明涉及一种系统和方法，用于通过使用从该机构获得并产生的数据，对监管机构管理的法律和法规的整体遵守情况进行定量和精确的评估。用于评估合规性的这种系统和方法包括几个步骤。一步涉及获取有关业务实体的审计信息。另一个步骤是访问业务实体的人员，并记录面试信息，无论是个人还是书面访谈。此外，有关相关机构检查业务实体的监管信息。监管质量数据也从公司，相应机构和行业内的其他公司获取。最后，将审计，面试，检查和监管质量信息相结合，制定与业务实体的合规效率相关的合规指标，然后确定该公司的任何更一般的风险因素。机器可读程序存储装置存储用于对公司的合规性评估进行标准化的编码指令，以及对公司和行业相对合规程度的计算，评估，分析和执行子分析。

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