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1. 发明授权

US10532190B2 Coated medical device 有权
公开(公告)号：US10532190B2
公开(公告)日：2020-01-14
申请号：US12892177
申请日：2010-09-28
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61M31/00 , A61M25/10 , A61F2/82 , A61L27/54 , A61L31/16 , A61L29/16 , A61F2/844 , A61F2/958 , A61L29/08 , A61L29/18 , A61L31/14 , A61F2/86
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

2. 发明授权

US09398902B2 Vessel closure device 有权
标题翻译：容器关闭装置
公开(公告)号：US09398902B2
公开(公告)日：2016-07-26
申请号：US13497708
申请日：2010-09-20
申请人： Ram H. Paul, Jr. , Brian L. Bates , Cleon Stanley
发明人： Ram H. Paul, Jr. , Brian L. Bates , Cleon Stanley
IPC分类号： A61B17/128 , A61B17/122 , A61B17/00 , A61B17/29 , A61B17/14 , A61B17/30
CPC分类号： A61B17/0057 , A61B17/29 , A61B2017/0034 , A61B2017/00473 , A61B2017/00575 , A61B2017/2905 , A61B2017/2931 , A61B2017/303
摘要： A device and system for closure of an opening formed in a body vessel includes a bioabsorbable grasping member and locking member. The grasping member includes grasping lingers that are radially collapsible to the closed positions by movement of the locking member over the fingers. A distal portion of the fingers is configured to grasp an outer wall portion of the body vessel surrounding the opening when the fingers are in the open position. Movement of the locking member can cause the fingers to at least substantially close the vessel opening. Structural features on the fingers and/or locking member can inhibit proximal or distal movement of the locking member when in a locking position. A detachable arm can be coupled to the grasping member to facilitate placement of the grasping member. A sheath can fit over the detachable arm and be configured to move the locking member over the fingers.
摘要翻译：用于封闭形成在体容器中的开口的装置和系统包括生物可吸收的抓持构件和锁定构件。抓持构件包括通过锁定构件通过手指的移动而径向可折叠到关闭位置的抓握件。手指的远端部分构造成当手指处于打开位置时抓住围绕开口的身体血管的外壁部分。锁定构件的运动可导致手指至少基本上关闭容器开口。手指和/或锁定构件上的结构特征可以在锁定位置时阻止锁定构件的近端或远端运动。可拆卸臂可以联接到抓握构件以便于抓握构件的放置。护套可以装配在可拆卸臂上方并且被配置成使锁定构件移动超过手指。

3. 发明授权

US08974522B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US08974522B2
公开(公告)日：2015-03-10
申请号：US13072332
申请日：2011-03-25
申请人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
发明人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
IPC分类号： A61F2/82 , A61M25/10 , A61L27/54 , A61L29/16 , A61L31/16
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

4. 发明授权

US08469943B2 Coated implantable medical device 失效
公开(公告)号：US08469943B2
公开(公告)日：2013-06-25
申请号：US12902788
申请日：2010-10-12
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号： A61M25/00
CPC分类号： A61L33/022 , A61F2/0077 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/82 , A61F2/91 , A61F2210/0076 , A61F2250/0067 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

5. 发明授权

US08029560B2 Enhanced remodelable materials for occluding bodily vessels 有权
标题翻译：用于闭塞身体血管的增强的可重塑材料
公开(公告)号：US08029560B2
公开(公告)日：2011-10-04
申请号：US12209483
申请日：2008-09-12
申请人： Brian L. Bates , Ram H. Paul , Jacob A. Flagle
发明人： Brian L. Bates , Ram H. Paul , Jacob A. Flagle
IPC分类号： A61F2/06
CPC分类号： A61B17/12022 , A61B17/00008 , A61B17/12109 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61L27/3633 , A61L27/3645 , A61L27/50 , A61L27/54 , A61L31/005 , A61L31/04 , A61L31/14 , A61L31/16 , A61L2300/412 , A61L2430/36
摘要： Described are methods, devices, and systems for occluding or ablating vascular vessels. Noninvasive procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous valve insufficiency. Further described is the cooperative use of an angiogenic remodelable material with one or more sclerosing agents to cause closure of a targeted bodily vessel.
摘要翻译：描述了用于闭塞或消融血管的方法，装置和系统。非侵入性手术可用于闭塞和闭塞大隐静脉，例如在静脉瓣膜功能不全引起的静脉曲张治疗中。进一步描述的是具有一种或多种硬化剂的血管生成可重塑材料与靶器官血管闭合的协同使用。

6. 发明授权

US07901453B2 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US07901453B2
公开(公告)日：2011-03-08
申请号：US11932113
申请日：2007-10-31
申请人： Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma , Brian L. Bates , Thomas A. Osborne
发明人： Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma , Brian L. Bates , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61K51/1282 , A61F2/24 , A61F2/82 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppressive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食管，气管，结肠，胆管或尿道中的结构12，以及至少一个位于结构的至少一个表面上的免疫抑制剂层18 任选地，装置10可以包括位于免疫抑制剂的层18上的至少一个多孔的，优选的聚合物层20，并且可以替代地或另外包括至少一个涂覆层16，该涂层16位于结构12的一个表面上，至少一层18的免疫抑制剂依次放置在涂层16的至少一部分上。多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。结构12是优选构造为冠状动脉支架。多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

7. 发明授权

US07897167B2 Implantable graft to close a fistula 有权
标题翻译：植入式移植物闭合瘘管
公开(公告)号：US07897167B2
公开(公告)日：2011-03-01
申请号：US11472642
申请日：2006-06-21
申请人： David N. Armstrong , Brian L. Bates , Mark W. Bleyer , F. Joseph Obermiller , Umesh H. Patel
发明人： David N. Armstrong , Brian L. Bates , Mark W. Bleyer , F. Joseph Obermiller , Umesh H. Patel
IPC分类号： A61F2/02
CPC分类号： A61B17/0057 , A61B17/0401 , A61B17/06 , A61B17/06166 , A61B17/3468 , A61B50/30 , A61B2017/00004 , A61B2017/00628 , A61B2017/00641 , A61B2017/00646 , A61B2017/00654 , A61B2017/00659 , A61B2017/00898 , A61B2017/0404 , A61B2017/0464 , A61B2017/0496 , A61B2017/22038 , A61L27/227 , A61L27/24 , A61L27/3616 , A61L27/3629 , A61L27/3633 , A61L27/58 , A61M27/00
摘要： An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.
摘要翻译：提供了一种植入式移植物，其可以插入瘘道以封闭瘘的主要开口。为了防止移植物的意外移位或将移植物从患者的瘘管挤出，移植物可以设置有从移植物的主体的至少一端侧向延伸的帽，其中帽可以与移植物的主体，可附接到移植物的身体的至少一端，和/或沿着移植物的主体移动。移植物还可以具有从移植物的身体的一端延伸的尾部，以帮助将移植物放置在瘘管道中。移植物可以是由诸如异种移植材料的单一材料制成的整体单元，或者可以包括由相同或不同材料制成的不同部件。还提供了关闭瘘管的方法。

8. 发明授权

US07896914B2 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US07896914B2
公开(公告)日：2011-03-01
申请号：US11931694
申请日：2007-10-31
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/24 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

9. 发明申请

US20110015725A1 COATED MEDICAL DEVICE 审中-公开
标题翻译：涂层医疗器械
公开(公告)号：US20110015725A1
公开(公告)日：2011-01-20
申请号：US12892177
申请日：2010-09-28
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61F2/82
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

10. 发明授权

US07846202B2 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US07846202B2
公开(公告)日：2010-12-07
申请号：US11965385
申请日：2007-12-27
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma
IPC分类号： A61F2/06
CPC分类号： A61F2/885 , A61F2/0077 , A61F2250/0068
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 以及至少一层生物活性材料层18，其被定位在涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以位于生物活性材料层18上，其中多孔层包括聚合物，并且通过其提供生物活性材料的受控释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

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