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1. 发明授权

US08524241B2 Fusion proteins comprising a fragment of Vibrio cholerae exotoxin A 有权
标题翻译：包含霍乱弧菌外毒素A片段的融合蛋白
公开(公告)号：US08524241B2
公开(公告)日：2013-09-03
申请号：US12669712
申请日：2008-07-18
申请人： Brian Seed , Jia Liu Wolfe , Chia-Lun Tsai
发明人： Brian Seed , Jia Liu Wolfe , Chia-Lun Tsai
IPC分类号： C07K19/00 , C07K14/28 , C12P21/00 , C12N15/31 , C07H21/04
CPC分类号： C07K14/28
摘要： The invention features recombinant exotoxins from Vibrio cholerae are for the therapeutic treatment of a variety of human diseases, particularly diseases characterized by an abundance or excess of undesired cells.
摘要翻译：本发明特征在于来自霍乱弧菌的重组外毒素用于治疗各种人类疾病，特别是以不希望的细胞丰度或过量为特征的疾病。

2. 发明授权

US08106021B2 Benzylbenzene derivatives and methods of use 有权
标题翻译：苄苯衍生物和使用方法
公开(公告)号：US08106021B2
公开(公告)日：2012-01-31
申请号：US12917367
申请日：2010-11-01
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

3. 发明申请

US20110195952A1 TREATING PSYCHOLOGICAL CONDITIONS USING MUSCARINIC RECEPTOR M1 ANTAGONISTS 有权
标题翻译：使用MUSCARINIC RECEPTOR M1 ANTAGONISTS治疗心理状况
公开(公告)号：US20110195952A1
公开(公告)日：2011-08-11
申请号：US13004837
申请日：2011-01-11
申请人： Brian Seed , Jordan Mechanic
发明人： Brian Seed , Jordan Mechanic
IPC分类号： A61K31/55 , A61K31/5513 , A61P3/04 , A61P25/24
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/15 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/4525 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K2300/00
摘要： Provided are methods of treating psychological diseases and conditions by administration of a preferential muscarinic acetylcholine receptor M1 antagonist, optionally with at least one antidepressant other than a selective muscarinic acetylcholine receptor M1 antagonist. The invention also provides for pharmaceutical compositions and kits for administration of at least one selective muscarinic acetylcholine receptor M1 antagonist in combination with at least one antidepressant other than a selective muscarinic acetylcholine receptor M1 antagonist.
摘要翻译：提供了通过施用优先毒蕈碱性乙酰胆碱受体M1拮抗剂，任选地与选择性毒蕈碱性乙酰胆碱受体M1拮抗剂以外的至少一种抗抑郁药来治疗心理疾病和病症的方法。本发明还提供用于至少一种选择性毒蕈碱性乙酰胆碱受体M1拮抗剂与除选择性毒蕈碱性乙酰胆碱受体M1拮抗剂之外的至少一种抗抑郁药组合的药物组合物和试剂盒。

4. 发明申请

US20110077212A1 THERAPEUTIC USES OF SGLT2 INHIBITORS 审中-公开
标题翻译： SGLT2抑制剂的治疗用途
公开(公告)号：US20110077212A1
公开(公告)日：2011-03-31
申请号：US12888326
申请日：2010-09-22
申请人： Brian Seed , Jordan Mechanic
发明人： Brian Seed , Jordan Mechanic
IPC分类号： A61K31/70 , A61P7/10 , A61P3/10
CPC分类号： A61K31/00 , A61K31/70 , A61K45/06 , A61K2300/00
摘要： Provided are methods of using one or more SGLT2 inhibitors, independently or in combination, for treating edema or reducing fluid retention. The invention also provides methods of using one or more SGLT2 inhibitors for the preparation of a medicament for treating edema or fluid retention. Methods are also provided for treating diabetes with an amount of one or more SGLT2 inhibitors and one or more PPAR-gamma agonists.
摘要翻译：提供了独立地或组合地使用一种或多种SGLT2抑制剂来治疗水肿或减少流体保留的方法。本发明还提供使用一种或多种SGLT2抑制剂制备用于治疗水肿或液体保留的药物的方法。还提供了用一种或多种SGLT2抑制剂和一种或多种PPAR-γ激动剂治疗糖尿病的方法。

5. 发明申请

US20110021507A1 INHIBITING ANTIPSYCHOTIC-INDUCED WEIGHT GAIN 审中-公开
标题翻译：抑制抗生素诱导的体重增加
公开(公告)号：US20110021507A1
公开(公告)日：2011-01-27
申请号：US12835395
申请日：2010-07-13
申请人： Brian Seed , Jordan Mechanic
发明人： Brian Seed , Jordan Mechanic
IPC分类号： A61K31/551 , A61P25/18 , A61P3/04
CPC分类号： A61K31/551 , A61K31/5513 , A61K2300/00
摘要： The present invention provides methods, compositions and kits for preventing, inhibiting, reducing and reversing weight gain induced by antipsychotic medications, for example olanzapine and clozapine, by co-administration of an M1R-selective antagonist, for example, telenzepine.
摘要翻译：本发明提供了通过共同施用M1R选择性拮抗剂例如替硝西泮来预防，抑制，减少和逆转由抗精神病药物诱导的体重增加的方法，组合物和试剂盒，例如奥氮平和氯氮平。

6. 发明授权

US07838499B2 Benzylbenzene derivatives and methods of use 有权
标题翻译：苄苯衍生物和使用方法
公开(公告)号：US07838499B2
公开(公告)日：2010-11-23
申请号：US12197095
申请日：2008-08-22
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
IPC分类号： A01N43/04 , A61K31/70 , C07H1/00 , C07H5/02
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

7. 发明申请

US20100256070A1 RECOMBINANT VIBRIO CHOLERAE EXOTOXINS 有权
标题翻译：重组VIBRIO CHOLERAE EXOTOXINS
公开(公告)号：US20100256070A1
公开(公告)日：2010-10-07
申请号：US12669712
申请日：2008-07-18
申请人： Brian Seed , Jia Liu Wolfe , Chia-Lun Tsai
发明人： Brian Seed , Jia Liu Wolfe , Chia-Lun Tsai
IPC分类号： A61K38/16 , C07K14/28 , C07K19/00 , C12N15/63
CPC分类号： C07K14/28
摘要： The invention features recombinant exotoxins from Vibrio cholerae are for the therapeutic treatment of a variety of human diseases, particularly diseases characterized by an abundance or excess of undesired cells.
摘要翻译：本发明特征在于来自霍乱弧菌的重组外毒素用于治疗各种人类疾病，特别是以不希望的细胞丰度或过量为特征的疾病。

8. 发明授权

US07803778B2 Glucose transport inhibitors and methods of use 有权
标题翻译：葡萄糖转运抑制剂和使用方法
公开(公告)号：US07803778B2
公开(公告)日：2010-09-28
申请号：US11752226
申请日：2007-05-22
申请人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael J. Hadd
发明人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael J. Hadd
IPC分类号： A01N43/04 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07D311/96 , C07D407/12 , C07H7/04 , C07H19/00
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

9. 发明授权

US07399847B1 Nucleic acids encoding artificial P-selectin ligands 失效
标题翻译：编码人工P-选择素配体的核酸
公开(公告)号：US07399847B1
公开(公告)日：2008-07-15
申请号：US08756018
申请日：1996-11-25
申请人： Brian Seed , Tara Pouyani
发明人： Brian Seed , Tara Pouyani
IPC分类号： C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C07K14/705
摘要： Disclosed herein are organic molecules to which are covalently bonded a sialyl-Lex determinant and a sulfated determinant, at least one of these determinants being positioned at a non-naturally occurring site on the molecule. Also disclosed are particular P-selectin ligands and P-selectin ligand-antibody fusions. These molecules, ligands, and fusion proteins find use in methods of reducing or protecting against inflammation and extravasation-dependent adverse reactions, such as organ damage and clotting (for example, associated with adult respiratory distress syndrome or ischemic myocardial injury).
摘要翻译：本文公开的是共价键合唾液酸基 - 决定子和硫酸化决定簇的有机分子，这些决定簇中的至少一个位于分子上的非天然存在位点。还公开了特定的P-选择素配体和P-选择素配体 - 抗体融合物。这些分子，配体和融合蛋白可用于减少或保护免受炎症和外渗依赖性不良反应（如器官损伤和凝血）（例如与成人呼吸窘迫综合征或缺血性心肌损伤相关）的方法。

10. 发明申请

US20070293480A1 TREATING PSYCHOLOGICAL CONDITIONS USING MUSCARINIC RECEPTOR M1 ANTAGONISTS 有权
标题翻译：使用MUSCARINIC RECEPTOR M1 ANTAGONISTS治疗心理状况
公开(公告)号：US20070293480A1
公开(公告)日：2007-12-20
申请号：US11763145
申请日：2007-06-14
申请人： Brian Seed , Jordan Mechanic
发明人： Brian Seed , Jordan Mechanic
IPC分类号： A61K31/5513 , A61K31/551 , A61K31/343 , A61K31/137
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/15 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/4525 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K2300/00
摘要： Provided are methods of treating psychological diseases and conditions by administration of a preferential muscarinic acetylcholine receptor M1 antagonist, optionally with at least one antidepressant other than a selective muscarinic acetylcholine receptor M1 antagonist. The invention also provides for pharmaceutical compositions and kits for administration of at least one selective muscarinic acetylcholine receptor M1 antagonist in combination with at least one antidepressant other than a selective muscarinic acetylcholine receptor M1 antagonist.
摘要翻译：提供了通过施用优先的毒蕈碱性乙酰胆碱受体M 1拮抗剂来治疗心理疾病和病症的方法，任选与至少一种除选择性毒蕈碱性乙酰胆碱受体M 1 N 2以外的抗抑郁药拮抗剂。本发明还提供用于将至少一种选择性毒蕈碱性乙酰胆碱受体M 1拮抗剂与选自毒蕈碱乙酰胆碱受体M 1以外的至少一种抗抑郁药组合的药物组合物和试剂盒， SUB>拮抗剂。

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