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1. 发明申请

US20220392065A1 SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING 有权
公开(公告)号：US20220392065A1
公开(公告)日：2022-12-08
申请号：US17820439
申请日：2022-08-17
申请人： CLEERLY, INC.
发明人： James K. Min , James P. Earls , Hugo Miguel Rodrigues Marques , Shant Malkasian , Ben Hootnick
IPC分类号： G06T7/00 , A61B8/14 , A61B6/00 , A61B6/03 , A61B5/00 , A61B8/12 , G06K9/62 , A61B5/055 , A61K49/04
摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

2. 发明申请

US20220375072A1 SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING 有权
公开(公告)号：US20220375072A1
公开(公告)日：2022-11-24
申请号：US17657877
申请日：2022-04-04
申请人： CLEERLY, INC.
发明人： James K. MIN , James P. EARLS , Hugo Miguel RODRIGUES MARQUES
IPC分类号： G06T7/00 , A61B5/055 , A61B6/03 , A61B8/14 , A61B8/12 , A61B5/00 , A61B6/00 , G06K9/62 , A61K49/04
摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

3. 发明授权

US11317883B2 Systems and methods of characterizing high risk plaques 有权
公开(公告)号：US11317883B2
公开(公告)日：2022-05-03
申请号：US17461587
申请日：2021-08-30
申请人： Cleerly, Inc.
发明人： James K. Min
IPC分类号： A61B6/00 , A61B6/03 , G06T7/00
摘要： A method for characterization of coronary plaque tissue data and perivascular tissue data using image data gathered from a computed tomography (CT) scan along a blood vessel, the image information including radiodensity values of coronary plaque and perivascular tissue located adjacent to the coronary plaque, the method comprising quantifying radiodensity in regions of coronary plaque, quantifying, radiodensity in at least one region of corresponding perivascular tissue adjacent to the coronary plaque, determining gradients of the quantified radiodensity values within the coronary plaque and the quantified radiodensity values within the corresponding perivascular tissue, and determining a ratio of the quantified radiodensity values within the coronary plaque and the corresponding perivascular tissue; and characterizing the coronary plaque by analyzing a gradient of the quantified radiodensity values in the coronary plaque and the corresponding perivascular, and/or the ratio of the coronary plaque radiodensity values and the radiodensity values of the corresponding perivascular tissue.

4. 发明申请

US20210366116A1 SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING 有权
公开(公告)号：US20210366116A1
公开(公告)日：2021-11-25
申请号：US17394260
申请日：2021-08-04
申请人： CLEERLY, INC.
发明人： JAMES K. MIN , JAMES P. EARLS , HUGO MIGUEL RODRIGUES MARQUES
IPC分类号： G06T7/00 , A61B5/00 , A61B6/00 , A61B6/03 , G06K9/62 , A61K49/04 , A61B8/14 , A61B8/12 , A61B5/055
摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

5. 发明申请

US20210366115A1 SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING 有权
公开(公告)号：US20210366115A1
公开(公告)日：2021-11-25
申请号：US17394222
申请日：2021-08-04
申请人： CLEERLY, INC.
发明人： James K. Min , James P. Earls , Hugo Miguel Rodrigues Marques
IPC分类号： G06T7/00 , A61B5/055 , A61B6/03 , A61B8/14 , A61B8/12 , A61B5/00 , A61B6/00 , G06K9/62 , A61K49/04
摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

6. 发明申请

US20210343010A1 SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING 有权
公开(公告)号：US20210343010A1
公开(公告)日：2021-11-04
申请号：US17367549
申请日：2021-07-05
申请人： CLEERLY, INC.
发明人： JAMES K. MIN , JAMES P. EARLS , HUGO MIGUEL RODRIGUES MARQUES , Ben Hootnick
IPC分类号： G06T7/00 , A61B6/03 , A61B6/00 , A61B5/055 , A61B5/00 , A61K49/04 , G06K9/62 , A61B8/12 , A61B8/14
摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

7. 发明申请

US20210334961A1 SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING 有权
公开(公告)号：US20210334961A1
公开(公告)日：2021-10-28
申请号：US17305326
申请日：2021-07-05
申请人： CLEERLY, INC.
发明人： JAMES K. MIN , JAMES P. EARLS , HUGO MIGUEL RODRIGUES MARQUES , Ben Hootnick
IPC分类号： G06T7/00 , A61B5/00 , A61B6/00 , G06K9/62 , A61B6/03 , A61B8/12 , A61K49/04 , A61B5/055 , A61B8/14
摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

8. 发明授权

US11132796B2 Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking 有权
公开(公告)号：US11132796B2
公开(公告)日：2021-09-28
申请号：US17214593
申请日：2021-03-26
申请人： CLEERLY, INC.
发明人： James K. Min , James P. Earls , Hugo Miguel Rodrigues Marques
IPC分类号： G06K9/00 , G06T7/00 , A61B8/14 , A61B6/00 , A61B6/03 , A61B5/00 , A61B8/12 , G06K9/62 , A61B5/055 , A61K49/04
摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

9. 发明申请

US20210186448A1 SYSTEMS AND METHODS FOR CHARACTERIZING HIGH RISK PLAQUES 有权
公开(公告)号：US20210186448A1
公开(公告)日：2021-06-24
申请号：US17033136
申请日：2020-09-25
申请人： Cleerly, Inc.
发明人： James K. Min
IPC分类号： A61B6/00 , A61B6/03 , G06T7/00
摘要： A method for characterization of coronary plaque tissue data and perivascular tissue data using image data gathered from a computed tomography (CT) scan along a blood vessel, the image information including radiodensity values of coronary plaque and perivascular tissue located adjacent to the coronary plaque, the method comprising quantifying radiodensity in regions of coronary plaque, quantifying, radiodensity in at least one region of corresponding perivascular tissue adjacent to the coronary plaque, determining gradients of the quantified radiodensity values within the coronary plaque and the quantified radiodensity values within the corresponding perivascular tissue, and determining a ratio of the quantified radiodensity values within the coronary plaque and the corresponding perivascular tissue; and characterizing the coronary plaque by analyzing a gradient of the quantified radiodensity values in the coronary plaque and the corresponding perivascular, and/or the ratio of the coronary plaque radiodensity values and the radiodensity values of the corresponding perivascular tissue.

10. 发明申请

US20230138144A1 SYSTEMS, METHODS, AND DEVICES FOR MEDICAL IMAGE ANALYSIS, DIAGNOSIS, RISK STRATIFICATION, DECISION MAKING AND/OR DISEASE TRACKING 有权
公开(公告)号：US20230138144A1
公开(公告)日：2023-05-04
申请号：US18149017
申请日：2022-12-30
申请人： CLEERLY, INC.
发明人： James K. Min , James P. Earls , Hugo Miguel Rodrigues Marques , Shant Malkasian , Ben Hootnick
IPC分类号： G06T7/00 , A61B8/14 , A61B6/00 , A61B6/03 , A61B5/00 , A61B8/12 , A61B5/055 , A61K49/04 , G06F18/10
摘要： The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

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