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1. 发明授权

US10857200B2 Methods and compositions for the treatment of radiation-related disorders 有权
公开(公告)号：US10857200B2
公开(公告)日：2020-12-08
申请号：US16197408
申请日：2018-11-21
申请人： Cleveland BioLabs, Inc.
发明人： Vadim Krivokrysenko , Elena Feinstein
IPC分类号： A61K35/74 , A61N5/00 , A61P39/00 , C07K14/195 , C07K14/255 , A61K38/16 , A61K45/06 , A61K35/68 , A61K9/00 , C07K14/705
摘要： This invention relates, in part, to methods and compositions that are useful for the treatment and/or prevention of various disorders, including radiation-related disorders, such as acute radiation syndrome.

2. 发明申请

US20190275128A1 USE OF TOLL-LIKE RECEPTOR AGONIST FOR TREATING CANCER 审中-公开
公开(公告)号：US20190275128A1
公开(公告)日：2019-09-12
申请号：US16279457
申请日：2019-02-19
申请人： Cleveland BioLabs, Inc.
发明人： Anatoli GLEIBERMAN , Lyudmila BURDELYA , Andrei GUDKOV
IPC分类号： A61K39/00 , A61K38/16 , C07K14/255 , A61K39/395 , C07K16/28 , C07K14/195
摘要： The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.

3. 发明申请

US20180251498A1 FLAGELLIN COMPOSITIONS AND USES 审中-公开
公开(公告)号：US20180251498A1
公开(公告)日：2018-09-06
申请号：US15329870
申请日：2015-07-29
申请人： Cleveland BioLabs, Inc.
发明人： Vadim METT
IPC分类号： C07K14/195 , A61K38/16 , A61K45/06
CPC分类号： C07K14/195 , A61K38/164 , A61K39/0013 , A61K39/02 , A61K39/39 , A61K45/06 , A61K2039/55505 , A61K2039/55516 , A61K2039/55583 , A61K2039/55594 , A61K2039/57 , A61K2039/575 , C07K2319/00 , C07K2319/21 , Y02A50/388 , Y02A50/39 , Y02A50/466 , Y02A50/484
摘要： The present invention relates to compositions comprising improved flagellin derived constructs and methods of using the same in the treatment of various diseases.

4. 发明授权

US10034926B2 Use of toll-like receptor agonist for treating cancer 有权
公开(公告)号：US10034926B2
公开(公告)日：2018-07-31
申请号：US15631427
申请日：2017-06-23
申请人： Cleveland BioLabs, Inc.
发明人： Anatoli Gleiberman , Lyudmila Burdelya , Andrei Gudkov
IPC分类号： C07K14/195 , C07K14/255 , A61K38/16 , A61K39/02 , A61K39/112 , A61K39/00 , C07K16/28 , A61K39/395 , C07K14/705
摘要： The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.

5. 发明申请

US20170266278A1 FLAGELLIN-BASED AGENTS AND USES INCLUDING EFFECTIVE VACCINATION 审中-公开
公开(公告)号：US20170266278A1
公开(公告)日：2017-09-21
申请号：US15500133
申请日：2015-07-30
申请人： Cleveland BioLabs, Inc.
发明人： Andrei V. GUDKOV , Vadim METT , Vadim KRIVOKRYSENKO
IPC分类号： A61K39/39 , A61K39/02 , A61K39/00
CPC分类号： C07K14/195 , A61K38/164 , A61K39/0013 , A61K39/02 , A61K39/39 , A61K45/06 , A61K2039/55505 , A61K2039/55516 , A61K2039/55583 , A61K2039/55594 , A61K2039/57 , A61K2039/575 , C07K2319/00 , C07K2319/21 , Y02A50/388 , Y02A50/39 , Y02A50/466 , Y02A50/484
摘要： The present invention relates to, in part, compositions comprising improved flagellin derived constructs and methods of using for vaccination, including adjuvants comprising flagellin-based agents.

6. 发明申请

US20210169972A1 USE OF TOLL-LIKE RECEPTOR AGONIST FOR TREATING CANCER 有权
公开(公告)号：US20210169972A1
公开(公告)日：2021-06-10
申请号：US16934556
申请日：2020-07-21
申请人： Cleveland BioLabs, Inc.
发明人： Anatoli GLEIBERMAN , Lyudmila BURDELYA , Andrei GUDKOV
IPC分类号： A61K38/16 , C07K14/255 , A61K39/395 , C07K14/195 , C07K16/28 , A61K39/00 , A61K39/02 , C07K14/705 , A61K39/112
摘要： The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.

7. 发明申请

US20150328284A1 COMPOSITIONS AND METHODS COMPRISING TOLL LIKE RECEPTOR (TLR) STIMULATING AGENTS FOR PROPHYLAXIS AND THERAPY FOR DAMAGE TO DERMAL EPITHELIUM 审中-公开
标题翻译：包含类似感受器（TLR）刺激剂的组合物和方法用于预防和治疗对上皮损伤的治疗
公开(公告)号：US20150328284A1
公开(公告)日：2015-11-19
申请号：US14389862
申请日：2013-04-02
申请人： Cleveland BioLabs, Inc
发明人： Andrei GUDKOV , Lyudmila BURDELYA
IPC分类号： A61K38/16 , A61K9/70
CPC分类号： A61K38/164 , A61K9/70
摘要： Provided are compositions and methods for prophylaxis and/or therapy of dermal damage. The compositions and methods involve Toll like receptor (TLR) agonists that can inhibit the formation or accelerate healing of dermal damage, and/or inhibit inflammation at near the location of the dermal damage. The TLR agonists can be TLR2 and/or TLR5 agonists. The compositions and methods are suitable for prophylaxis and/or therapy of dermal damage caused by radiation, or non-radiation thermal injury such as burns caused by contact with heated surfaces or heated objects, light, and for disruptions in integument resulting in cuts, such as incisions, or punctures. The compositions can be used topically, subcutaneously or systemically. Articles of manufacture coated or impregnated with TLR agonist(s) are also provided.
摘要翻译：提供用于预防和/或治疗皮肤损伤的组合物和方法。组合物和方法包括Toll样受体（TLR）激动剂，其可以抑制皮肤损伤的形成或加速愈合，和/或抑制皮肤损伤位置附近的炎症。 TLR激动剂可以是TLR2和/或TLR5激动剂。组合物和方法适合于预防和/或治疗由放射引起的皮肤损伤或非辐射热损伤，例如由与接触加热表面或被加热物体引起的灼伤，光，以及导致切割的皮肤中断，例如作为切口或穿刺。组合物可以局部，皮下或全身使用。还提供了涂覆或浸渍TLR激动剂的制品。

8. 发明申请

US20140045747A1 METHODS FOR INCREASING AND MOBILIZING HEMATOPOIETIC STEM CELLS 审中-公开
标题翻译：增加和动员HEMATOPOIETIC干细胞的方法
公开(公告)号：US20140045747A1
公开(公告)日：2014-02-13
申请号：US13933954
申请日：2013-07-02
申请人： Cleveland Biolabs, Inc.
发明人： Alexander Shakhov , Evguenia Strom
IPC分类号： C07K7/06 , A61K38/08 , A61K38/07 , C07K5/10 , A61K38/19
CPC分类号： A61K38/08 , A61K31/395 , A61K35/28 , A61K35/545 , A61K38/07 , A61K38/164 , A61K38/1841 , A61K38/193 , A61K47/542 , A61K47/543 , A61K2035/124 , C07K5/10 , C07K7/06 , A61K2300/00
摘要： A method is provided for increasing the number of hematopoietic stem cells in the bone marrow, increasing the mobilization of these cells to migrate from the bone marrow to the bloodstream and elsewhere, and increasing the number of differentiating hematopoietic stem cells in the bloodstream.
摘要翻译：提供了一种增加骨髓造血干细胞数量的方法，增加这些细胞从骨髓迁移到血流和其他地方的动员，并增加血流中分化的造血干细胞的数量。

9. 发明授权

US11628201B2 Use of toll-like receptor agonist for treating cancer 有权
公开(公告)号：US11628201B2
公开(公告)日：2023-04-18
申请号：US16934556
申请日：2020-07-21
申请人： Cleveland BioLabs, Inc.
发明人： Anatoli Gleiberman , Lyudmila Burdelya , Andrei Gudkov
IPC分类号： C07K14/195 , C07K14/255 , A61K38/16 , A61K39/02 , A61K39/112 , A61K39/395 , C07K16/28 , A61K39/00 , C07K14/705
摘要： The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.

10. 发明申请

US20210275627A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF RADIATION-RELATED DISORDERS 有权
公开(公告)号：US20210275627A1
公开(公告)日：2021-09-09
申请号：US17090237
申请日：2020-11-05
申请人： Cleveland BioLabs, Inc.
发明人： Vadim KRIVOKRYSENKO , Elena FEINSTEIN
IPC分类号： A61K38/16 , A61K45/06 , A61K35/68 , A61K9/00
摘要： This invention relates, in part, to methods and compositions that are useful for the treatment and/or prevention of various disorders, including radiation-related disorders, such as acute radiation syndrome.

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