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1. 发明授权

US06426185B1 Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation 失效
标题翻译：通过将供体植物的核酸序列转化成反义方向的不同宿主植物来在植物中编辑功能基因谱的方法
公开(公告)号：US06426185B1
公开(公告)日：2002-07-30
申请号：US09359301
申请日：1999-07-21
申请人： Monto H. Kumagai , Guy R. della-Cioppa , Robert L. Erwin , David R. McGee
发明人： Monto H. Kumagai , Guy R. della-Cioppa , Robert L. Erwin , David R. McGee
IPC分类号： C12Q168
CPC分类号： C12Q1/68 , A01H1/04 , A01H5/12 , C07K14/415 , C12N15/1034 , C12N15/8203 , C12N15/8216 , C12N15/8242 , C12N15/8243 , C12N15/825 , C12N15/8257 , C12N15/8261 , Y02A40/146 , Y10S977/804
摘要： The present invention provides a method of compiling a plant functional gene profile, a method of changing the phenotype or biochemistry of a plant, a method of determining a change in phenotype or biochemistry of a plant, and a method of determining the presence of a trait in plant. The methods comprise expressing transiently a nucleic acid sequence of a plant into a host plant to affect phenotypic or biochemical changes in the host plant. A viral vector functional genomic screen has been developed to identify nucleotide sequences in transfected plants by systemically knocking out endogenous gene expression in an antisense mechanism. Once the presence of a trait in a plant is identified by phenotypic or biochemical changes in the host plant, the nucleic acid insert in the cDNA clone or in the vector that results in the changes is then sequenced. The present invention exemplifies that genes encoding GTP binding proteins in one plant can silence endogenous gene expression in a different plant.
摘要翻译：本发明提供一种编辑植物功能基因谱的方法，改变植物的表型或生物化学的方法，确定植物的表型或生物化学变化的方法以及确定性状存在的方法在植物中。所述方法包括将植物的核酸序列瞬时表达到宿主植物中以影响宿主植物的表型或生物化学变化。已经开发了病毒载体功能基因组筛选，以通过在反义机制中系统敲除内源基因表达来鉴定转染植物中的核苷酸序列。一旦通过宿主植物中的表型或生物化学变化鉴定植物中性状的存在，则对cDNA克隆中的核酸插入物或导致变化的载体进行测序。本发明举例说明在一种植物中编码GTP结合蛋白的基因可以使不同植物中的内源基因表达沉默。

2. 发明授权

US5703051A Therapeutic uses of melanin 失效
标题翻译：黑色素的治疗用途
公开(公告)号：US5703051A
公开(公告)日：1997-12-30
申请号：US988739
申请日：1992-12-10
申请人： David L Berliner , Robert L. Erwin , David R. McGee
发明人： David L Berliner , Robert L. Erwin , David R. McGee
IPC分类号： A61K31/53 , A61K9/12 , A61K31/40 , A61K31/41 , A61K31/69 , A61K31/70 , A61K31/711 , A61K31/787 , A61K31/795 , A61K33/20 , A61K38/00 , A61K38/22 , A61K38/43 , A61K38/44 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61K51/00 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P43/00 , C12N9/02 , C12P17/00 , C12P17/18 , C12R1/465 , A61K47/06 , A61K47/46
CPC分类号： C12P17/00 , A61K31/40 , A61K31/69 , A61K33/22 , A61K38/185 , A61K38/22 , A61K47/48415 , A61K47/4843 , A61K48/00 , C12N9/0059 , C12N9/0071 , C12Y110/03001 , C12Y114/18001 , A61K38/00
摘要： The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the administration of an active substance which causes an increased concentration of melanin in the tissue. Such active substances include melanin, melanin variants, melanin analogs, melanin derivatives, tyrosinase, tyrosinase gene, melanin-concentrating hormone and combinations thereof. Examples of such diseases include Parkinson's disease, Alzheimer's disease, retinitis pigmentosa, schizophrenia and dementia. The invention is also useful in assisting in the repair of neurons in a mammal having neuron damage by administering an effective amount of an active substance which causes an increased concentration of melanin in the neuron to aid in nerve repair. The invention is further useful in protecting a mammal from a toxin-induced disease or from the adverse effects of a toxin by administering an effective amount of the active substance described above.
摘要翻译：本发明涉及通过施用导致组织中黑色素浓度增加的活性物质而失去黑色素的组织的退行性疾病的治疗，其通过神经系统的组织共享共同的胚胎学基础。这些活性物质包括黑色素，黑色素变体，黑色素类似物，黑色素衍生物，酪氨酸酶，酪氨酸酶基因，黑色素浓缩激素及其组合。这些疾病的实例包括帕金森病，阿尔茨海默病，色素性视网膜炎，精神分裂症和痴呆。本发明还可用于通过施用有效量的活性物质来辅助具有神经元损伤的哺乳动物的神经元的修复，所述活性物质引起神经元中黑色素浓度增加以帮助神经修复。本发明还可用于通过施用有效量的上述活性物质来保护哺乳动物免受毒素诱发的疾病或毒素的不利影响。

3. 发明申请

US20120054601A1 METHODS AND SYSTEMS FOR AUTOMATED CREATION, RECOGNITION AND DISPLAY OF ICONS 审中-公开
标题翻译：自动创建，识别和显示图标的方法和系统
公开(公告)号：US20120054601A1
公开(公告)日：2012-03-01
申请号：US13149057
申请日：2011-05-31
申请人： Philip R. Cohen , R. Matthews Wesson , Michael Robin , David R. McGee
发明人： Philip R. Cohen , R. Matthews Wesson , Michael Robin , David R. McGee
IPC分类号： G06F17/00 , G06F17/30
CPC分类号： G06F3/04817 , G06F9/451
摘要： Methods, techniques, and systems for icon automated generation and placement are provided. Some embodiments provide an icon generation and placement system configured to ingest one or more icon templates, wherein the icon templates comprise an icon symbol, an icon label, and an icon dimensionality; populate source data for the one or more icon templates, wherein the source data is accessible by at least one of a speech recognition subsystem, handwriting recognition subsystem, and sketch recognition subsystem; generate an icon attribute table for the one or more icon templates; store the ingested one or more icon templates in an icon database; and place an icon, from the icon database into a selected location within a digital document in response to one or more multimodal inputs.
摘要翻译：提供了图标自动生成和放置的方法，技术和系统。一些实施例提供了被配置为摄取一个或多个图标模板的图标生成和放置系统，其中图标模板包括图标符号，图标标签和图标维度; 填充所述一个或多个图标模板的源数据，其中所述源数据可由语音识别子系统，手写识别子系统和草图识别子系统中的至少一个访问; 为一个或多个图标模板生成图标属性表; 将摄取的一个或多个图标模板存储在图标数据库中; 并且响应于一个或多个多模式输入，将图标数据库中的图标放置在数字文档内的选定位置。

4. 发明授权

US5210076A Methods of treating Parkinson's disease using melanin 失效
标题翻译：使用黑色素治疗帕金森病的方法
公开(公告)号：US5210076A
公开(公告)日：1993-05-11
申请号：US609311
申请日：1990-11-05
申请人： David L. Berliner , Robert L. Erwin , David R. McGee
发明人： David L. Berliner , Robert L. Erwin , David R. McGee
IPC分类号： A61K31/53 , A61K9/12 , A61K31/40 , A61K31/41 , A61K31/69 , A61K31/70 , A61K31/711 , A61K31/787 , A61K31/795 , A61K33/20 , A61K38/00 , A61K38/22 , A61K38/43 , A61K38/44 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61K51/00 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P43/00 , C12N9/02 , C12P17/00 , C12P17/18 , C12R1/465
CPC分类号： C12P17/00 , A61K31/40 , A61K31/69 , A61K33/22 , A61K38/185 , A61K38/22 , A61K47/48415 , A61K47/4843 , A61K48/00 , C12N9/0059 , C12N9/0071 , C12Y110/03001 , C12Y114/18001 , A61K38/00
摘要： The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the administration of an active substance which causes an increased concentration of melanin in the tissue. Such active substances include melanin, melanin variants, melanin analogs, melanin derivatives, tyrosinase, tyrosinase gene, melanin-concentrating hormone and combinations thereof. Examples. of such diseases include Parkinson's disease, Alzheimer's disease, retinitis pigmentosa, schizophrenia and dementia. The invention is also useful in assisting in the repair of neurons in a mammal having neuron damage by administering an effective amount of an active substance which causes an increased concentration of melanin in the neuron to aid in nerve repair. The invention is further useful in protecting a mammal from a toxin-induced disease or from the adverse effects of a toxin by administering an effective amount of the active substance described above.
摘要翻译：本发明涉及通过施用导致组织中黑色素浓度增加的活性物质而失去黑色素的组织的退行性疾病的治疗，其通过神经系统的组织共享共同的胚胎学基础。这些活性物质包括黑色素，黑色素变体，黑色素类似物，黑色素衍生物，酪氨酸酶，酪氨酸酶基因，黑色素浓缩激素及其组合。例子。的疾病包括帕金森病，阿尔茨海默病，色素性视网膜炎，精神分裂症和痴呆。本发明还可用于通过施用有效量的活性物质来辅助具有神经元损伤的哺乳动物的神经元的修复，所述活性物质引起神经元中黑色素浓度增加以帮助神经修复。本发明还可用于通过施用有效量的上述活性物质来保护哺乳动物免受毒素诱发的疾病或毒素的不利影响。

5. 发明授权

US06674426B1 Augmenting and not replacing paper based work practice via multi-modal interaction 失效
标题翻译：通过多式互动增强并不取代纸质的工作实践
公开(公告)号：US06674426B1
公开(公告)日：2004-01-06
申请号：US09802156
申请日：2001-03-08
申请人： David R. McGee , Philip R. Cohen , Lizhong Wu
发明人： David R. McGee , Philip R. Cohen , Lizhong Wu
IPC分类号： G09G500
CPC分类号： G06F3/0418 , G06F3/038 , G06F3/04883
摘要： A method and system designed to augment, rather than replace, the work habits of its users. These work habits include practices such as drawing on Post-it™ notes using a symbolic language. The system observes and understands the language used on the Post-it notes and the system assigns meaning simultaneously to objects in both the physical and virtual worlds. Since the data is preserved in physical form, the physical documents serve as a back-up in the case of electronic system failure. With the present invention users can rollout a primary paper document such as a map, register it, and place secondary physical documents on the map. The secondary physical documents can be moved from one place to another on the primary document. Once an object is augmented, users can modify the meaning represented by it, ask questions about that representation, view it in virtual reality, or give directions to it, all with speech and gestures.
摘要翻译：一种旨在增加而不是取代其用户的工作习惯的方法和系统。这些工作习惯包括使用符号语言绘制Post-it（TM）笔记的做法。该系统观察并理解了Post-it注释上使用的语言，并且系统将物理和虚拟世界中的对象同时分配给对象。由于数据以物理形式保存，因此在电子系统故障的情况下，物理文件将作为备份。利用本发明，用户可以将诸如地图的主要纸质文档，注册它，并将二次物理文档放置在地图上。辅助物理文件可以在主文档上从一个地方移动到另一个地方。一旦增加了一个对象，用户可以修改它所代表的意义，提出关于该表示的问题，在虚拟现实中查看它，或者通过语音和手势来指导它。

6. 发明授权

US5817631A Therapeutic uses of melanin 失效
公开(公告)号：US5817631A
公开(公告)日：1998-10-06
申请号：US471071
申请日：1995-06-06
申请人： David L. Berliner , Robert L. Erwin , David R. McGee
发明人： David L. Berliner , Robert L. Erwin , David R. McGee
IPC分类号： A61K31/53 , A61K9/12 , A61K31/40 , A61K31/41 , A61K31/69 , A61K31/70 , A61K31/711 , A61K31/787 , A61K31/795 , A61K33/20 , A61K38/00 , A61K38/22 , A61K38/43 , A61K38/44 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61K51/00 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P43/00 , C12N9/02 , C12P17/00 , C12P17/18 , C12R1/465 , A61K47/06 , A61K47/46
CPC分类号： C12P17/00 , A61K31/40 , A61K31/69 , A61K33/22 , A61K38/185 , A61K38/22 , A61K47/48415 , A61K47/4843 , A61K48/00 , C12N9/0059 , C12N9/0071 , C12Y110/03001 , C12Y114/18001 , A61K38/00
摘要： The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the administration of an active substance which causes an increased concentration of melanin in the tissue. Such active substances include melanin, melanin variants, melanin analogs, melanin derivatives, tyrosinase, tyrosinase gene, melanin-concentrating hormone and combinations thereof. Examples of such diseases include Parkinson's disease, Alzheimer's disease, retinitis pigmentosa, schizophrenia and dementia. The invention is also useful in assisting in the repair of neurons in a mammal having neuron damage by administering an effective amount of an active substance which causes an increased concentration of melanin in the neuron to aid in nerve repair. The invention is further useful in protecting a mammal from a toxin-induced disease or from the adverse effects of a toxin by administering an effective amount of the active substance described above.

7. 发明授权

US5776968A Therapeutic uses of melanin 失效
标题翻译：黑色素的治疗用途
公开(公告)号：US5776968A
公开(公告)日：1998-07-07
申请号：US488419
申请日：1995-06-07
申请人： David L. Berliner , Robert L. Erwin , David R. McGee
发明人： David L. Berliner , Robert L. Erwin , David R. McGee
IPC分类号： A61K31/53 , A61K9/12 , A61K31/40 , A61K31/41 , A61K31/69 , A61K31/70 , A61K31/711 , A61K31/787 , A61K31/795 , A61K33/20 , A61K38/00 , A61K38/22 , A61K38/43 , A61K38/44 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61K51/00 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P43/00 , C12N9/02 , C12P17/00 , C12P17/18 , C12R1/465 , A61K31/38
CPC分类号： C12P17/00 , A61K31/40 , A61K31/69 , A61K33/22 , A61K38/185 , A61K38/22 , A61K47/48415 , A61K47/4843 , A61K48/00 , C12N9/0059 , C12N9/0071 , C12Y110/03001 , C12Y114/18001 , A61K38/00
摘要： The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the administration of an active substance which causes an increased concentration of melanin in the tissue. Such active substances include melanin, melanin variants, melanin analogs, melanin derivatives, tyrosinase, tyrosinase gene, melanin-concentrating hormone and combinations thereof. Examples of such diseases include Parkinson's disease, Alzheimer's disease, retinitis pigmentosa, schizophrenia and dementia. The invention is also useful in assisting in the repair of neurons in a mammal having neuron damage by administering an effective amount of an active substance which causes an increased concentration of melanin in the neuron to aid in nerve repair. The invention is further useful in protecting a mammal from a toxin-induced disease or from the adverse effects of a toxin by administering an effective amount of the active substance described above.
摘要翻译：本发明涉及通过施用导致组织中黑色素浓度增加的活性物质而失去黑色素的组织的退行性疾病的治疗，其通过神经系统的组织共享共同的胚胎学基础。这些活性物质包括黑色素，黑色素变体，黑色素类似物，黑色素衍生物，酪氨酸酶，酪氨酸酶基因，黑色素浓缩激素及其组合。这些疾病的实例包括帕金森病，阿尔茨海默病，色素性视网膜炎，精神分裂症和痴呆。本发明还可用于通过施用有效量的活性物质来辅助具有神经元损伤的哺乳动物的神经元的修复，所述活性物质引起神经元中黑色素浓度增加以帮助神经修复。本发明还可用于通过施用有效量的上述活性物质来保护哺乳动物免受毒素诱发的疾病或毒素的不利影响。

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