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1. 发明授权

US08883861B2 Iminic monomers and polymers thereof 有权
标题翻译：亚胺单体及其聚合物
公开(公告)号：US08883861B2
公开(公告)日：2014-11-11
申请号：US13287008
申请日：2011-11-01
申请人： Joachim B. Kohn , Durgadas Bolikal
发明人： Joachim B. Kohn , Durgadas Bolikal
IPC分类号： A61K31/08 , A61L27/14 , C08G64/12 , C08G64/42 , C08G69/48 , C08G64/24 , A61L31/16 , A61L31/04 , A61L27/54 , C07D241/18 , A61K47/34 , A61K9/00
CPC分类号： C08G64/12 , A61K9/0024 , A61K47/34 , A61L27/14 , A61L27/54 , A61L31/04 , A61L31/16 , C07D241/18 , C08G64/24 , C08G64/42 , C08G69/48
摘要： Disclosed are biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an imine group, wherein the inclusion of said imine group is effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without an imine group.
摘要翻译：公开了包含多个含有亚胺基团的单体重复单元的生物相容性生物可吸收聚合物，其中与不含亚胺基团的相同聚合物相比，所述亚胺基团的包含可有效降低熔体粘度，溶液粘度或两者。

2. 发明授权

US08551511B2 Phase-separated biocompatible polymer compositions for medical uses 有权
标题翻译：用于医疗用途的相分离的生物相容性聚合物组合物
公开(公告)号：US08551511B2
公开(公告)日：2013-10-08
申请号：US12577203
申请日：2009-10-11
申请人： Don K. Brandom , Durgadas Bolikal , Lioubov Kabalnova , James E. McGrath , Joachim Kohn
发明人： Don K. Brandom , Durgadas Bolikal , Lioubov Kabalnova , James E. McGrath , Joachim Kohn
IPC分类号： A61F13/00
CPC分类号： C08G64/42 , A61L31/148 , C08G63/08 , C08G63/672 , C08G63/6822 , C08G63/6856 , C08G63/912 , C08G64/0241 , C08G64/12 , C08G65/3326 , C08G65/33313 , C08G65/337 , C08G2261/126 , C08L67/02 , C08L69/00 , C08L2203/02 , C08L2205/05 , C08L2666/02
摘要： A variety of phase-separated biocompatible polymer compositions are described. In preferred embodiments the polymers are bioresorbable and/or biodegradable, and have desirable mechanical properties, such as fracture and/or fatigue toughness, that have previously not been a primary design criteria for such polymers. The polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices.
摘要翻译：描述了各种相分离的生物相容性聚合物组合物。在优选的实施方案中，聚合物是生物可再吸收的和/或可生物降解的，并且具有以前不是这种聚合物的主要设计标准的期望的机械性能，例如断裂和/或疲劳韧性。聚合物组合物可用于各种医疗应用中，例如在医疗装置的制造中。

3. 发明授权

US08252887B2 Biocompatible polymers for medical devices 有权
标题翻译：用于医疗器械的生物相容性聚合物
公开(公告)号：US08252887B2
公开(公告)日：2012-08-28
申请号：US12577205
申请日：2009-10-11
申请人： Durgadas Bolikal , Don K. Brandom , Lioubov Kabalnova , Ernest G. Baluca , Joachim Kohn
发明人： Durgadas Bolikal , Don K. Brandom , Lioubov Kabalnova , Ernest G. Baluca , Joachim Kohn
IPC分类号： C08G63/02 , C08G63/06
CPC分类号： C08G64/42 , A61L31/148 , C08G63/08 , C08G63/672 , C08G63/6822 , C08G63/6856 , C08G63/912 , C08G64/0241 , C08G64/12 , C08G65/3326 , C08G65/33313 , C08G65/337 , C08G2261/126 , C08L67/02 , C08L69/00 , C08L2203/02 , C08L2205/05 , C08L2666/02
摘要： The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorbable polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radioopacity and are useful for medical device applications and controlled release therapeutic formulations.
摘要翻译：本发明涉及新类型的单体化合物，其可以被聚合以形成新的可生物降解和生物可再吸收的聚合物和共聚物。这些聚合物和共聚物虽然不限于此，但可适用于放射性能力，并且可用于医疗器械应用和控制释放治疗剂型。

4. 发明申请

US20120108677A1 IMINIC MONOMERS AND POLYMERS THEREOF 有权
标题翻译： IMINIC单体及其聚合物
公开(公告)号：US20120108677A1
公开(公告)日：2012-05-03
申请号：US13287008
申请日：2011-11-01
申请人： Joachim B. Kohn , Durgadas Bolikal
发明人： Joachim B. Kohn , Durgadas Bolikal
IPC分类号： A61K47/34 , C08G64/42 , C07D241/02 , A61L31/06 , C07D241/08 , C08G64/16 , C08G64/24
CPC分类号： C08G64/12 , A61K9/0024 , A61K47/34 , A61L27/14 , A61L27/54 , A61L31/04 , A61L31/16 , C07D241/18 , C08G64/24 , C08G64/42 , C08G69/48
摘要： Disclosed are biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an imine group, wherein the inclusion of said imine group is effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without an imine group.
摘要翻译：公开了包含多个含有亚胺基团的单体重复单元的生物相容性生物可吸收聚合物，其中与不含亚胺基团的相同聚合物相比，所述亚胺基团的包含可有效降低熔体粘度，溶液粘度或两者。

5. 发明申请

US20060182752A1 Tri-block polymers for nanosphere-based drug or gene delivery 审中-公开
标题翻译：用于基于纳米球的药物或基因递送的三嵌段聚合物
公开(公告)号：US20060182752A1
公开(公告)日：2006-08-17
申请号：US10514215
申请日：2003-05-15
申请人： Joachim Kohn , Corinne Vebert-Nardin , Durgadas Bolikal , Agnieszka Seyda
发明人： Joachim Kohn , Corinne Vebert-Nardin , Durgadas Bolikal , Agnieszka Seyda
IPC分类号： A61K48/00 , A61K39/00 , C12N15/87 , A61K9/50 , C08L77/00 , A61K9/16
CPC分类号： A61K48/0041 , A61K9/5146 , A61K47/32 , A61K47/34 , C08G63/19 , C08G63/52 , C08G63/64 , C08G63/672 , C08G63/6856 , C08G2261/126 , C12N15/87
摘要： Biocompatible non-toxic polyarylate triblock copolymers having an A-B-A structure wherein each A is a water-soluble, hydrophilic polymer end block and the B middle block is an polyarylate oligomer. The polymers spontaneously self-assemble to form low CAC nanospheres having utility as transfection agents for gene delivery.
摘要翻译：具有A-B-A结构的生物相容性无毒多芳基化合物三嵌段共聚物，其中每个A是水溶性亲水性聚合物端嵌段，B中间嵌段是聚芳基化合物低聚物。聚合物自发地自组装形成低CAC纳米球，其具有用作基因递送的转染剂。

6. 发明授权

US4941940A Pre-swelling and etching of plastics for plating 失效
标题翻译：用于电镀的塑料的预膨胀和蚀刻
公开(公告)号：US4941940A
公开(公告)日：1990-07-17
申请号：US268154
申请日：1988-11-07
申请人： Gordhanbhai N. Patel , Durgadas Bolikal , Richard A. Bellemare
发明人： Gordhanbhai N. Patel , Durgadas Bolikal , Richard A. Bellemare
IPC分类号： C23C18/22 , H05K3/18 , H05K3/38
CPC分类号： C23C18/22 , H05K3/181 , H05K3/381
摘要： Formulations are provided for pre-swelling and etching of functionalized polymers, such as polycarbonate in one, two and three steps. The etched surface can then be plated with electroless nickel or copper with satisfactory adhesion of the plated metals. Swelling agents make polymer molecules on and near the surface of the polymer easily accessible to a degradation agent. A degradation agent degradates the polymer molecules. If required, a solubilizing agent increases the miscibility of the degradation agent and the swelling agent. A wetting agent increases the effectiveness of the etching agent.In the one-step process, polymer parts are dipped in a solution containing at least one swelling agent and at least one degradation agent. In the two-step process, polymer parts are first treated with a solution of a swelling agent followed by etching with a solution of degradation agent. In the three-step process, polymer parts are first micro-roughened with a solution of a swelling agent, then etched with a solution of mineral acids followed by dipping in a caustic bath to make the surface wettable.
摘要翻译：提供了用于在一步，二步和三步骤中预功能化聚合物（例如聚碳酸酯）的预膨胀和蚀刻的制剂。然后，蚀刻的表面可以镀有化学镀镍或铜，并且电镀金属具有令人满意的粘合性。溶胀剂使聚合物表面上和附近的聚合物分子容易被降解剂所接近。降解剂使聚合物分子降解。如果需要，增溶剂增加了降解剂和溶胀剂的混溶性。润湿剂增加了蚀刻剂的有效性。在一步法中，将聚合物部分浸入含有至少一种溶胀剂和至少一种降解剂的溶液中。在两步法中，首先用溶胀剂溶液处理聚合物部分，随后用降解剂溶液进行蚀刻。在三步法中，聚合物部分首先用溶胀剂进行微粗化，然后用无机酸溶液蚀刻，随后浸入苛性碱浴中以使表面可润湿。

7. 发明授权

US09080015B2 Biocompatible polymers for medical devices 有权
标题翻译：用于医疗器械的生物相容性聚合物
公开(公告)号：US09080015B2
公开(公告)日：2015-07-14
申请号：US13387799
申请日：2010-07-31
申请人： Joachim B. Kohn , Durgadas Bolikal , Ramiro Rojas
发明人： Joachim B. Kohn , Durgadas Bolikal , Ramiro Rojas
IPC分类号： A61K47/34 , C08G67/00 , C08G69/44 , C08G69/48 , C08G79/02 , A61K47/48
CPC分类号： C08G79/02 , A61K47/59 , A61K47/60 , C08G79/025
摘要： The present invention relates to new classes of biocompatible polymers comprising at least one repeating unit derived from a compound of Formula (I) as defined in the claims and specification. These polymers may be biodegradable and bioresorble, and, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations. Therefore, methods for preparing these polymers and medical devices prepared therefrom are also encompassed by this disclosure.
摘要翻译：本发明涉及包含至少一种衍生自权利要求书和说明书中定义的式（I）化合物的重复单元的新型生物相容性聚合物。这些聚合物可以是可生物降解的和生物可再生的，并且虽然不限于此，但可适用于无线电透明性，并且可用于医疗器械应用和控制释放治疗制剂。因此，制备这些聚合物的方法和由其制备的医疗装置也包括在本公开中。

8. 发明申请

US20120302719A1 BIORESORBABLE POLYMERS SYNTHESIZED FROM MONOMER ANALOGS OF NATURAL METABOLITES 有权
标题翻译：从天然代谢物的单体模拟合成的生物可降解聚合物
公开(公告)号：US20120302719A1
公开(公告)日：2012-11-29
申请号：US13482667
申请日：2012-05-29
申请人： Joachim B. Kohn , Durgadas Bolikal
发明人： Joachim B. Kohn , Durgadas Bolikal
IPC分类号： C08G69/44 , C07C209/16 , C07C229/28
CPC分类号： A61L27/58 , A61L27/18 , C08G64/12 , C08L77/00
摘要： New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profiles
摘要翻译：新的生物可吸收聚合物由天然代谢物的单体类似物合成。特别地，聚合物由氨基酸的类似物聚合，从而为由其制备的聚合物贡献有利的合成，加工和材料性质，包括特别有利的降解曲线

9. 发明申请

US20120226013A1 BIOCOMPATIBLE POLYMERS FOR MEDIAL DEVICES 有权
标题翻译：生物成分聚合物用于医疗器械
公开(公告)号：US20120226013A1
公开(公告)日：2012-09-06
申请号：US13501255
申请日：2010-10-11
申请人： Joachim B. Kohn , Durgadas Bolikal
发明人： Joachim B. Kohn , Durgadas Bolikal
IPC分类号： C08G69/44 , C07C231/08
CPC分类号： C08G69/44 , A61L24/046 , A61L27/18 , A61L31/06 , C08G69/08
摘要： The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.
摘要翻译：本发明涉及新类型的单体化合物，其可以被聚合以形成新的可生物降解和生物再生聚合物和共聚物。这些聚合物和共聚物虽然不限于此，但可适用于无线电透明性，并且可用于医疗器械应用和控制释放治疗制剂。

10. 发明申请

US20120189713A1 MONOMERS AND PHASE-SEPARATED BIOCOMPATIBLE POLYMER COMPOSITIONS PREPARED THEREFROM FOR MEDICAL USES 有权
标题翻译：用于医疗用途制备的单体和相分离生物成分聚合物组合物
公开(公告)号：US20120189713A1
公开(公告)日：2012-07-26
申请号：US13387908
申请日：2010-07-31
申请人： Joachim B. Kohn , Durgadas Bolikal , Ramiro Rojas
发明人： Joachim B. Kohn , Durgadas Bolikal , Ramiro Rojas
IPC分类号： A61K47/34 , C08G79/04 , C08F30/02 , C08L77/12 , C07C229/36 , A61P35/00 , A61P29/00 , A61P17/02 , A61K31/337 , A61K31/704 , A61K33/24 , A61K31/616 , A61K31/573 , A61K31/192 , C08G69/44
CPC分类号： C08G79/02 , A61K47/59 , A61K47/60 , C08G79/025
摘要： The invention relates to novel monomers of Formula (I) useful for preparation of phase-separated biocompatible polymers or polymer compositions. These polymers or polymer compositions may be bioresorbable and/or biodegradable and have desirable mechanical properties, such as fracture and/or fatigue toughness, which have not been a primary design criteria for such polymers previously. The polymers or polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices. Therefore, methods for preparing these polymers or polymer compositions and medical devices are also encompassed by this disclosure.
摘要翻译：本发明涉及可用于制备相分离的生物相容性聚合物或聚合物组合物的式（I）的新型单体。这些聚合物或聚合物组合物可以是生物可再吸收的和/或可生物降解的并且具有期望的机械性能，例如断裂和/或疲劳韧性，其先前尚未成为这种聚合物的主要设计标准。聚合物或聚合物组合物可用于各种医疗应用，例如在医疗装置的制造中。因此，本公开也包括制备这些聚合物或聚合物组合物和医疗装置的方法。

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