专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20190218944A1 MECHANICAL SYSTEM FOR GENERATING MECHANICAL ENERGY FROM LIQUID NITROGEN, AND CORRESPONDING METHOD 审中-公开
公开(公告)号：US20190218944A1
公开(公告)日：2019-07-18
申请号：US16332208
申请日：2017-08-30
申请人： Eric DUPONT
发明人： Eric DUPONT
IPC分类号： F01K25/10 , F01K13/00 , F17C7/04
CPC分类号： F01K25/10 , F01K13/00 , F17C7/04 , F17C9/04 , F17C2221/014 , F17C2223/0153 , F17C2227/0157 , F17C2227/0306 , F17C2265/038 , F17C2270/0168
摘要： The invention relates to a system for generating mechanical energy, comprising at least: a compressor; an expander; a heat exchanger; said system having a motor operative mode in which said system additionally comprises: means for the intake of pressurised liquid nitrogen in a liquid nitrogen intake inlet of said exchanger, means for the intake of air or gaseous nitrogen in an air or gaseous nitrogen intake inlet of said exchanger, means for discharging vaporised nitrogen at a vaporised nitrogen outlet of said exchanger, and means for discharging air or cooled nitrogen at another outlet of said exchanger for air or cooled gaseous nitrogen; means for the intake of said vaporised nitrogen into the interior of said expander in order to expand same; means for the intake of the air or cooled gaseous nitrogen into said compressor so as to produce compressed air or gaseous nitrogen therein.

2. 发明授权

US06855338B2 Anti-tumor therapies comprising a combination of a cartilage extract and an anti-neoplastic agent providing high efficacy and low toxic side effects 失效
标题翻译：抗肿瘤治疗包括软骨提取物和抗肿瘤剂的组合，提供高效力和低毒副作用
公开(公告)号：US06855338B2
公开(公告)日：2005-02-15
申请号：US10087041
申请日：2002-02-28
申请人： Eric Dupont
发明人： Eric Dupont
IPC分类号： A61K45/00 , A61K35/32 , A61K35/60 , A61K45/06 , A61P39/00 , A61P43/00 , A61K35/34
CPC分类号： A61K45/06 , A61K35/60 , A61K2300/00
摘要： This invention described a novel use for cartilage extract, namely a shark cartilage extract, in a combined anti-tumor therapy. The cartilage extract is used in combination with anti-neoplastics. The combined therapy provides for a higher anti-tumor efficacy with no concomitant increase, even better with a decrease, of toxic side effects.
摘要翻译：本发明描述了组合抗肿瘤治疗中软骨提取物，即鲨鱼软骨提取物的新用途。软骨提取物与抗肿瘤剂组合使用。联合治疗提供更高的抗肿瘤功效，无伴随增加，甚至更好地减少毒副作用。

3. 发明授权

US6025334A Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof 失效
标题翻译：具有抗溶解，抗炎，抗血管生成和抗肿瘤活性的鲨鱼软骨提取物; 制造方法，使用方法及其组合物
公开(公告)号：US6025334A
公开(公告)日：2000-02-15
申请号：US550003
申请日：1995-10-30
申请人： Eric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus
发明人： Eric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus
IPC分类号： A61K38/00 , A23J1/00 , A61K20060101 , A61K8/96 , A61K8/98 , A61K9/19 , A61K33/06 , A61K33/14 , A61K33/26 , A61K33/30 , A61K35/32 , A61K35/60 , A61P1/04 , A61P9/00 , A61P9/10 , A61P17/00 , A61P17/06 , A61P17/10 , A61P17/14 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/06 , B01D15/08 , B01D61/14 , C07K1/00
CPC分类号： A61K8/987 , A61K35/60 , A61Q17/00 , A61Q19/00 , A61Q19/08 , A61K2800/75 , Y10S514/828 , Y10S514/855 , Y10S514/859 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, direct anti-tumor proliferating, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a homogenate of cartilage in an aqueous solution, this homogenate being centrifuged and further fractionated to obtain a total extract having molecules of a molecular weight comprised between 0 to 500 KDa. The composition of the liquid extract has then been investigated by different ways. Further fractionation of this extract led to the preliminary characterization of some of its active components. Due to the multiplicity of biological activities of the total liquid extract, it can be used for treating numerous diseases or conditions such as those having components selected from the group consisting of tumor proliferation, angiogenesis, inflammation and collagenolysis. This extract has no offensive effect on normal body functions. Therefore, this shark cartilage extract has a very promising therapeutic value. The process for the obtention of cartilage extracts is simple and efficient. The unexpectedly valuable products obtained by this process are therefore an indication of a new and non-obvious process.
摘要翻译：本发明涉及软骨提取物及其制造方法。已经通过改进的方法获得具有抗血管生成，直接抗肿瘤增殖，抗炎和抗胶原活化的鲨鱼软骨提取物。该方法包括以下步骤：在水溶液中获得软骨匀浆，将该匀浆离心分离并进一步分级，得到分子量为0-500KDa的分子的总提取物。然后通过不同的方式研究了液体提取物的组成。该提取物的进一步分级导致其一些活性组分的初步表征。由于总液体提取物的生物活性的多样性，其可用于治疗多种疾病或病症，例如具有选自肿瘤增殖，血管发生，炎症和胶原溶解的组分的疾病或病症。该提取物对正常身体功能无异味。因此，这种鲨鱼软骨提取物具有非常有希望的治疗价值。获取软骨提取物的过程简单有效。因此，通过这一过程获得的意想不到的有价值的产品是新的和非显而易见的过程的指示。

4. 发明授权

US5618925A Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof 失效
标题翻译：鲨鱼软骨提取物具有抗血管生成活性和对肿瘤消退的作用; 制作方法
公开(公告)号：US5618925A
公开(公告)日：1997-04-08
申请号：US384555
申请日：1995-02-03
申请人： Eric Dupont , Paul Brazeau , Christi Juneau
发明人： Eric Dupont , Paul Brazeau , Christi Juneau
IPC分类号： A61K38/00 , A23J1/00 , A61K20060101 , A61K33/06 , A61K33/14 , A61K33/26 , A61K33/30 , A61K35/32 , A61K35/60 , A61P17/00 , A61P17/06 , A61P17/10 , A61P35/00 , C07K1/00
CPC分类号： A61K35/60 , Y10S514/828 , Y10S514/855 , Y10S514/859 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： The present invention relates to shark cartilage extracts and to a method of producing the same, these extracts having anti-angiogenic properties (reduction of the area of blood vessels observed in vivo on experimentally induced tumors), tumor regressive activity in vivo as well as demonstrating a direct inhibitory effect on tumor cell lines. This process does not involve any denaturing solvent or product and does not involve the use of any enzymes. It consists of obtaining a blend of whole cartilage in an aqueous solution of neutral pH, preferably pure water, this blend being centrifuged and the pellet and supernatant kept for further processing. The pellet is lyophylized and tested for anti-tumor and anti-angiogenic activities in vivo and in vitro, with or without supernatant. The supernatant has been shown to have anti-angiogenic and tumor regressive activities in vivo. The composition of the supernatant has then been investigated by different ways. Fractionation of this supernatant led to the characterization of some of its active components. The fractions were tested for their direct in vitro activity on cancer cell lines. Therefore, it is assumed that the non-fractionated supernatant has such an in vitro activity. Lyophilization substantially destroys the activity of these liquid fractions while no such abolition is observed in the solid extract.
摘要翻译：本发明涉及鲨鱼软骨提取物及其制备方法，这些提取物具有抗血管生成特性（减少实验诱导的肿瘤体内观察到的血管面积），体内的肿瘤回归活性以及展示对肿瘤细胞系的直接抑制作用。该方法不涉及任何变性溶剂或产物，并且不涉及使用任何酶。它包括在中性pH水溶液（优选纯水）中获得整个软骨的混合物，将该混合物离心，并将沉淀和上清液保持进一步处理。将沉淀物冻干，并在体内和体外测试具有或不含上清液的抗肿瘤和抗血管生成活性。已经显示上清液在体内具有抗血管生成和肿瘤回归活性。然后通过不同的方式研究上清液的组成。分离这种上清液导致其一些活性组分的表征。测试这些级分在癌细胞系上的直接体外活性。因此，假定非分级上清液具有这样的体外活性。冻干基本上破坏了这些液体部分的活性，而在固体提取物中没有观察到这样的消除。

5. 发明授权

US11187114B2 Mechanical system for generating mechanical energy from liquid nitrogen, and corresponding method 有权
公开(公告)号：US11187114B2
公开(公告)日：2021-11-30
申请号：US16332208
申请日：2017-08-30
申请人： Eric Dupont
发明人： Eric Dupont
IPC分类号： F01K25/10 , F17C9/04 , F01K13/00 , F17C7/04
摘要： The invention relates to a system for generating mechanical energy, comprising at least: a compressor; an expander; a heat exchanger; said system having a motor operative mode in which said system additionally comprises: means for the intake of pressurised liquid nitrogen in a liquid nitrogen intake inlet of said exchanger, means for the intake of air or gaseous nitrogen in an air or gaseous nitrogen intake inlet of said exchanger, means for discharging vaporised nitrogen at a vaporised nitrogen outlet of said exchanger, and means for discharging air or cooled nitrogen at another outlet of said exchanger for air or cooled gaseous nitrogen; means for the intake of said vaporised nitrogen into the interior of said expander in order to expand same; means for the intake of the air or cooled gaseous nitrogen into said compressor so as to produce compressed air or gaseous nitrogen therein.

6. 发明授权

US11027839B2 Tactical rapid access small unmanned aerial system 有权
公开(公告)号：US11027839B2
公开(公告)日：2021-06-08
申请号：US16138978
申请日：2018-09-22
申请人： Eric Dupont Becnel
发明人： Eric Dupont Becnel
IPC分类号： B64C39/02 , F41C27/00
摘要： The invention specifies key small Unmanned Aerial System (sUAS) features which include the tactical mounting of the sUAS to a firearm for rapid access in tactical situations. The invention claims both the fixturing of a sUAS to a firearm and technologies and methodologies to allow for deployment of the sUAS utilizing a single hand of the operator.

7. 发明申请

US20110158922A1 Skin Care Compositions and Method of Use Thereof 审中-公开
标题翻译：皮肤护理组合物及其使用方法
公开(公告)号：US20110158922A1
公开(公告)日：2011-06-30
申请号：US12904263
申请日：2010-10-14
申请人： Eric DUPONT , Marc SAMSON , Alyson GALDERISI
发明人： Eric DUPONT , Marc SAMSON , Alyson GALDERISI
IPC分类号： A61K8/37 , A61K36/185 , A61P17/10 , A61P17/00 , A61Q19/06 , A61Q19/00 , A61Q19/08 , A61P29/00 , A61P17/08 , A61Q19/02 , A61P17/18 , A61P39/04 , A61P9/00 , A61P35/00
CPC分类号： A61Q19/08 , A61K8/73 , A61K8/8147 , A61K8/8158 , A61K8/8182 , A61Q19/00
摘要： A topical composition comprising at least 10 isolated active agents which each have at least one activity selected from the group consisting of anti-oxidant activity, anti-matrix metalloproteinase (MPP) activity, anti-elastase activity, anti-inflammation activity, anti-irritation activity, microcirculation support activity, collagen synthesis activity, energy production activity, oxygenation activity, DNA protection and repair activity, cell anchorage support activity, dermal-epidermal cohesion support activity, cellular renewal activity, synthesis and/or protection of glycosaminoglycans activity, prevention and/or repair and/or elimination of damaged proteins activity, protection of skin immune function activity, hydration activity, modulation of skin pigmentation activity, and anti-cellulite activity, the composition possessing at least five of the foregoing activitie. Methods of use thereof.
摘要翻译：一种局部组合物，其包含至少10种分离的活性剂，其各自具有选自抗氧化活性，抗基质金属蛋白酶（MPP）活性，抗弹性蛋白酶活性，抗炎活性，抗刺激性的至少一种活性活性，微循环支持活性，胶原合成活性，能量产生活性，氧合活性，DNA保护和修复活性，细胞锚定支持活性，真皮表皮粘附支持活性，细胞更新活性，糖胺聚糖活性的合成和/或保护，预防和 /或修复和/或消除损伤的蛋白质活性，保护皮肤免疫功能活性，水合活性，调节皮肤色素沉着活性和抗脂肪团活性，所述组合物具有至少五种上述活性。使用方法。

8. 发明申请

US20070095007A1 Prefabricated structure made of reinforced concrete with an integrated removable handling system 失效
标题翻译：预制结构由钢筋混凝土制成，具有集成的可移动处理系统
公开(公告)号：US20070095007A1
公开(公告)日：2007-05-03
申请号：US11389160
申请日：2006-03-27
申请人： Maurice Lecuyer , Eric Dupont , Raymond Leblanc , Mario Robichaud , Jean-Francois Lupien , Robert Tallard
发明人： Maurice Lecuyer , Eric Dupont , Raymond Leblanc , Mario Robichaud , Jean-Francois Lupien , Robert Tallard
IPC分类号： E04B1/00
CPC分类号： E04G21/142 , B28B23/005 , B66C1/62
摘要： A method for manufacturing, transporting and installing on a building site a prefabricated structure made of reinforced concrete for the replacement of a structure such as a manhole, access chamber, access vault, junction box or other, which is buried in the ground and is part of an underground network such as a sewer, aqueduct, gas, electrical distribution, telecommunications, cable television and the like. In this method, concrete is poured in factory against the external surfaces of an integrated removable handling system, which is used as top part of a mold for manufacturing the prefabricated structure. The handling system is fixed to the prefabricated structure in a removable manner. The handling system remains in place during the subsequent steps of unmoulding, transporting and installing the prefabricated structure to the building site. Finally, once the installation is completed, the handling system is removed from the structure.
摘要翻译：一种在建筑工地上制造，运输和安装由钢筋混凝土制成的预制结构的方法，用于更换埋在地下的诸如人孔，进入室，通道拱顶，接线盒等结构，并且是部分诸如下水道，输水管，气体，配电，电信，有线电视等的地下网络。在这种方法中，混凝土在工业中相对于集成的可移除处理系统的外表面浇注，该系统用作制造预制结构的模具的顶部。处理系统以可移动的方式固定在预制结构上。在拆除模具，运输和安装预制结构到建筑工地的后续步骤中，处理系统保持原样。最后，安装完成后，将搬运系统从结构中取出。

9. 发明授权

US6028118A Methods of using extracts of shark cartilage 失效
标题翻译：使用鲨鱼软骨提取物的方法
公开(公告)号：US6028118A
公开(公告)日：2000-02-22
申请号：US693535
申请日：1996-08-08
申请人： Eric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus
发明人： Eric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus
IPC分类号： A61K8/98 , A61K35/60 , A61Q17/00 , A61Q19/00 , A61Q19/08 , A61K35/12
CPC分类号： A61K35/60 , A61K8/987 , A61Q17/00 , A61Q19/00 , A61Q19/08 , Y10S514/828 , Y10S514/859
摘要： The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumoral, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a homogenate of cartilage in an aqueous solution, this homogenate being separated in a solid fraction (SOLID EXTRACT) and a liquid fraction which was further fractionated to obtain a LIQUID EXTRACT having molecules of a molecular weight comprised between 0 to 500 kDa. The composition of the liquid extract has then been investigated by different ways. Further fractionation of this extract led to the preliminary characterization of some of its active components. Due to the multiplicity of biological activities of the total liquid extract, it can be used for treating numerous diseases or conditions such as those having components selected from the group consisting of tumor proliferation, angiogenesis, inflammation and collagenolysis. Several cosmetic applications based on the capacity of the liquid extract to improve skin barrier function are also under the scope of this invention. These extracts have no offensive effect on normal body functions. Therefore, these shark cartilage extracts have a very promising therapeutic value. The process for the obtention of cartilage extracts is simple and efficient. The unexpectedly valuable products obtained by this process are therefore an indication of a new and non-obvious process.
摘要翻译：本发明涉及软骨提取物及其制造方法。已经通过改进的方法获得具有抗血管生成，抗肿瘤，抗炎和抗胶原活化的鲨鱼软骨提取物。该方法包括以下步骤：在水溶液中获得软骨匀浆，将该匀浆在固体级分（SOLID EXTRACT）和液体级分中分离，将其进一步分级分离，得到分子量为0 至500kDa。然后通过不同的方式研究了液体提取物的组成。该提取物的进一步分级导致其一些活性组分的初步表征。由于总液体提取物的生物活性的多样性，其可用于治疗多种疾病或病症，例如具有选自肿瘤增殖，血管发生，炎症和胶原溶解的组分的疾病或病症。基于液体提取物提高皮肤屏障功能的能力的几种化妆品应用也在本发明的范围内。这些提取物对正常身体功能无异味。因此，这些鲨鱼软骨提取物具有非常有希望的治疗价值。获取软骨提取物的过程简单有效。因此，通过这一过程获得的意想不到的有价值的产品是新的和非显而易见的过程的指示。

10. 发明授权

US07467910B2 Prefabricated structure made of reinforced concrete with an integrated removable handling system 失效
标题翻译：预制结构由钢筋混凝土制成，具有集成的可移动处理系统
公开(公告)号：US07467910B2
公开(公告)日：2008-12-23
申请号：US11389160
申请日：2006-03-27
申请人： Maurice Lecuyer , Eric Dupont , Raymond Leblanc , Mario Robichaud , Jean-Françcois Lupien , Robert Tallard
发明人： Maurice Lecuyer , Eric Dupont , Raymond Leblanc , Mario Robichaud , Jean-Françcois Lupien , Robert Tallard
IPC分类号： E01C5/08
CPC分类号： E04G21/142 , B28B23/005 , B66C1/62
摘要： A method for manufacturing, transporting and installing on a building site a prefabricated structure made of reinforced concrete for the replacement of a structure such as a manhole, access chamber, access vault, junction box or other, which is buried in the ground and is part of an underground network such as a sewer, aqueduct, gas, electrical distribution, telecommunications, cable television and the like. In this method, concrete is poured in factory against the external surfaces of an integrated removable handling system, which is used as top part of a mold for manufacturing the prefabricated structure. The handling system is fixed to the prefabricated structure in a removable manner. The handling system remains in place during the subsequent steps of unmoulding, transporting and installing the prefabricated structure to the building site. Finally, once the installation is completed, the handling system is removed from the structure.
摘要翻译：一种在建筑工地上制造，运输和安装由钢筋混凝土制成的预制结构的方法，用于更换埋在地下的诸如人孔，进入室，通道拱顶，接线盒等结构，并且是部分诸如下水道，输水管，气体，配电，电信，有线电视等的地下网络。在这种方法中，混凝土在工业中相对于集成的可移除处理系统的外表面浇注，该系统用作制造预制结构的模具的顶部。处理系统以可移动的方式固定在预制结构上。在拆除模具，运输和安装预制结构到建筑工地的后续步骤中，处理系统保持原样。最后，安装完成后，将搬运系统从结构中取出。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式