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1. 发明申请

US20070299030A1 MicroRNA biomarkers for human breast and lung cancer 有权
标题翻译：用于人乳腺癌和肺癌的微小RNA生物标志物
公开(公告)号：US20070299030A1
公开(公告)日：2007-12-27
申请号：US11730570
申请日：2007-04-02
申请人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak
发明人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak
IPC分类号： A61K48/00 , A61P43/00 , C12N15/11 , C12N5/06 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2320/12 , C12Q1/6886 , C12Q2600/112 , C12Q2600/178
摘要： The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
摘要翻译：本发明涉及用于人乳腺癌和肺癌诊断和分类的新型分子标志物。

2. 发明授权

US5843642A Methods for detection of acute promyelocytic leukemia (APL) 失效
标题翻译：检测急性早幼粒细胞白血病（APL）的方法
公开(公告)号：US5843642A
公开(公告)日：1998-12-01
申请号：US95728
申请日：1993-07-21
申请人： Ethan Dmitrovsky , Raymond P. Warrell, Jr. , Wilson H. Miller, Jr. , Stanley Frankel
发明人： Ethan Dmitrovsky , Raymond P. Warrell, Jr. , Wilson H. Miller, Jr. , Stanley Frankel
IPC分类号： A61K38/00 , A61K47/48 , C07K14/705 , C07K16/28 , C12Q1/68 , C12P19/34
CPC分类号： C07K16/2857 , A61K47/48561 , C07K14/705 , C12Q1/6886 , A61K38/00 , C12Q2600/106 , Y10S436/813
摘要： The present invention provides a method of diagnosing APL in a subject which comprises detecting in a sample from the subject either nucleic acid encoding an abnormal RAR-.alpha. receptor or an expressed protein encoded thereby. The present invention also provides methods of identifying a subject with APL who will or will not respond to treatment with a retinoid, as well as a subjects with APL who do not express a detectable t(15;17) translocation but will or will not respond to treatment with a retinoid. In addition, the present invention provides methods for monitoring the activity of APL and the process of treatment of APL. The present invention provides methods of identifying a subject with a neoplastic condition other than APL who will or will not respond to treatment with a retinoid as well as methods for monitoring the level of disease activity and progress and adequacy of treatment of a neoplastic condition. Lastly, the present invention provides a method for inhibiting the growth of a neoplastic cell.
摘要翻译：本发明提供了一种在受试者中诊断APL的方法，其包括在来自受试者的样品中检测编码异常RAR-α受体的核酸或由其编码的表达的蛋白质。本发明还提供了鉴定患有APL的受试者的方法，所述APL将会或不会对类视黄醇的治疗作出反应，以及APL的受试者不表达可检测的t（15; 17）易位，但将会或不会响应用类视黄醇治疗。此外，本发明提供了用于监测APL的活性和APL的治疗过程的方法。本发明提供了鉴定具有除APL之外的肿瘤状态的受试者的方法，所述肿瘤状况将会对或将不会对类视黄醇进行治疗作出反应，以及用于监测疾病活动水平和进展以及治疗肿瘤状况的充分性的方法。最后，本发明提供抑制肿瘤细胞生长的方法。

3. 发明授权

US09056135B2 MicroRNA biomarkers for human breast and lung cancer 有权
标题翻译：用于人乳腺癌和肺癌的微小RNA生物标志物
公开(公告)号：US09056135B2
公开(公告)日：2015-06-16
申请号：US13478408
申请日：2012-05-23
申请人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo F. Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
发明人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo F. Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
IPC分类号： C07H21/04 , A61K45/06 , C12N15/11 , C12N15/113 , C12Q1/68 , A61K31/7105
CPC分类号： A61K45/06 , A61K31/7105 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12Q1/6886 , C12Q2600/106 , C12Q2600/178
摘要： The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
摘要翻译：本发明涉及用于人乳腺癌和肺癌诊断和分类的新型分子标志物。

4. 发明申请

US20130005747A1 METHOD FOR SELECTING A CANCER THERAPY 审中-公开
标题翻译：选择癌症治疗方法
公开(公告)号：US20130005747A1
公开(公告)日：2013-01-03
申请号：US13333219
申请日：2011-12-21
申请人： Simon Richard GREEN , Judy H. CHIAO , Jeffery SETTLEMAN , Ethan DMITROVSKY , Fabrizio Vittorio GALIMBERTI
发明人： Simon Richard GREEN , Judy H. CHIAO , Jeffery SETTLEMAN , Ethan DMITROVSKY , Fabrizio Vittorio GALIMBERTI
IPC分类号： C12Q1/68 , A61P35/00 , A61K31/52
CPC分类号： C12Q1/6886 , A61K31/52 , C12Q2600/106 , C12Q2600/156
摘要： The present invention provides a method for determining whether or not a cancer subject is suitable for treatment with a purine-based roscovitine-like inhibitor, which method comprises the step of determining the ras status of the cancer, wherein a determination that the subject has mutant ras status is indicative that the subject is suitable for treatment with a purine-based roscovitine-like inhibitor.
摘要翻译：本发明提供了一种用于确定癌症受试者是否适合用嘌呤类roscovitine样抑制剂治疗的方法，该方法包括确定癌症的ras状态的步骤，其中所述受试者具有突变体 ras状态表明该受试者适合于用嘌呤类roscovitine样抑制剂治疗。

5. 发明申请

US20120041315A1 Fluorescence Lifetime Spectrometer (FLS) and Methods of Detecting Diseased Tissue 有权
标题翻译：荧光寿命光谱仪（FLS）和检测疾病组织的方法
公开(公告)号：US20120041315A1
公开(公告)日：2012-02-16
申请号：US13280557
申请日：2011-10-25
申请人： Mary-Ann Mycek , Ethan Dmitrovsky , Jonathan Pitts
发明人： Mary-Ann Mycek , Ethan Dmitrovsky , Jonathan Pitts
IPC分类号： A61B6/00
CPC分类号： G01N21/6408 , A61B5/0059 , G01N21/6458 , G01N21/6486 , G01N2021/6417
摘要： This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition times of less that one second. This invention is useful for studying human tissues and cells in vivo.
摘要翻译：本发明涉及用于在少于1秒的数据采集时间的同时收集所选频谱带的完整荧光发射光谱和瞬时衰减的方法和装置。本发明可用于研究体内人体组织和细胞。

6. 发明申请

US20090131357A1 Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG15 and/or UBP43 有权
标题翻译：通过调节UBE1L，ISG15和/或UBP43预防和治疗癌症的组合物和方法
公开(公告)号：US20090131357A1
公开(公告)日：2009-05-21
申请号：US12262337
申请日：2008-10-31
申请人： Ethan Dmitrovsky , Bret A. Hassel , Sutisak Kitareewan , Ian Pitha-Rowe
发明人： Ethan Dmitrovsky , Bret A. Hassel , Sutisak Kitareewan , Ian Pitha-Rowe
IPC分类号： A61K31/7105 , C12N5/06 , C07H21/02 , A61P35/00
CPC分类号： C07K16/40 , A61K31/7105 , C12N2799/027
摘要： Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
摘要翻译：提供了使用诱导UBE1L或泛素样蛋白质ISG15的组合物或抑制解淀粉酶UBP43降解致癌蛋白质并增强癌症（肿瘤）或癌前（前肿瘤）细胞凋亡的组合物和方法。还提供了通过施用这些组合物预防或治疗癌症的方法。

7. 发明申请

US20130296399A1 microRNA Biomarkers for Human Breast and Lung Cancer 有权
标题翻译：用于人乳腺癌和肺癌的微小RNA生物标志物
公开(公告)号：US20130296399A1
公开(公告)日：2013-11-07
申请号：US13478408
申请日：2012-05-23
申请人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo F. Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
发明人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo F. Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
IPC分类号： C12Q1/68 , A61K45/06 , A61K31/7105
CPC分类号： A61K45/06 , A61K31/7105 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12Q1/6886 , C12Q2600/106 , C12Q2600/178
摘要： The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
摘要翻译：本发明涉及用于诊断和分类人乳腺癌和肺癌的新型分子标志物。

8. 发明申请

US20060228425A1 Compositions and methods for destabilizing lysosomes to increase oncogenic or aberrant protein degradation 有权
标题翻译：用于使溶酶体不稳定以增加致癌或异常蛋白质降解的组合物和方法
公开(公告)号：US20060228425A1
公开(公告)日：2006-10-12
申请号：US10564070
申请日：2004-07-30
申请人： Sutisak Kitareewan , Roger Sloboda , Ethan Dmitrovsky
发明人： Sutisak Kitareewan , Roger Sloboda , Ethan Dmitrovsky
IPC分类号： C12Q1/37 , A61K31/4745 , A61K31/203 , A61K33/36
CPC分类号： A61K31/4706 , A61K31/203 , A61K31/4745 , A61K33/36 , G01N33/5011 , G01N33/5076 , G01N33/6896 , G01N2510/00 , G01N2800/2814 , A61K2300/00
摘要： The present invention relates to compositions and methods for destabilizing lysosomes to increase the degradation of oncogenic or aberrant proteins for the prevention and treatment of disease. Methods for identifying agents which destabilize lysosomes are also provided as are agents identified in accordance with the screening method.
摘要翻译：本发明涉及使溶酶体不稳定以增加致癌或异常蛋白质降解以预防和治疗疾病的组合物和方法。用于鉴定使溶酶体不稳定的试剂的方法也按照筛选方法鉴定的试剂提供。

9. 发明申请

US20050148502A1 Compositions and methods for preventing and treating cancer via modulating ube1l, isg15 and/or ubp43 审中-公开
标题翻译：通过调节ubl1，isg15和/或ubp43预防和治疗癌症的组合物和方法
公开(公告)号：US20050148502A1
公开(公告)日：2005-07-07
申请号：US10506226
申请日：2003-03-05
申请人： Ethan Dmitrovsky , Bret Hassel , Sutisak Kitareewan , Ian Pitha-Rowe
发明人： Ethan Dmitrovsky , Bret Hassel , Sutisak Kitareewan , Ian Pitha-Rowe
IPC分类号： C12N15/09 , A61K45/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N9/00 , C12Q1/02 , C12Q1/37 , C12Q1/68 , A61K38/48 , A61K38/17
CPC分类号： C12N9/93 , C07K16/40 , C12N2799/027
摘要： Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15 or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
摘要翻译：提供了使用诱导UBE1L或泛素样蛋白ISG15或抑制解缀酶UBP43降解致癌蛋白并增强癌症（肿瘤）或癌前（前肿瘤）细胞凋亡的组合物的组合物和方法。还提供了通过施用这些组合物预防或治疗癌症的方法。

10. 发明授权

US08207325B2 MicroRNA biomarkers for human breast and lung cancer 有权
标题翻译：用于人乳腺癌和肺癌的微小RNA生物标志物
公开(公告)号：US08207325B2
公开(公告)日：2012-06-26
申请号：US12436576
申请日：2009-05-06
申请人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
发明人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
IPC分类号： C07H21/04
CPC分类号： A61K45/06 , A61K31/7105 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12Q1/6886 , C12Q2600/106 , C12Q2600/178
摘要： The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
摘要翻译：本发明涉及用于人乳腺癌和肺癌诊断和分类的新型分子标志物。

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