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1. 发明申请

US20160015417A1 REAL TIME THREE-DIMENSIONAL HEAT-INDUCED ECHO-STRAIN IMAGING FOR MONITORING HIGH-INTENSITY ACOUSTIC ABLATION PRODUCED BY CONFORMAL INTERSTITIAL AND EXTERNAL DIRECTIONAL ULTRASOUND THERAPY APPLICATORS 有权
标题翻译：实时三维热诱导的ECHO-STR成像监测由连续的间接和外部方向超声治疗应用者产生的高强度消融
公开(公告)号：US20160015417A1
公开(公告)日：2016-01-21
申请号：US14745116
申请日：2015-06-19
申请人： Everette C. Burdette , Emad M. Boctor
发明人： Everette C. Burdette , Emad M. Boctor
IPC分类号： A61B17/32
CPC分类号： A61B17/320068 , A61B8/00 , A61B8/085 , A61B8/485 , A61B2017/00084 , A61B2017/00106 , A61B2090/378 , A61N7/02 , A61N7/022 , A61N2007/0078 , A61N2007/025
摘要： A system for thermal treatment or ablation of tissue includes an ultrasonic thermal ablation probe, an ultrasonic three-dimensional imaging probe that captures an image from radio frequency image data obtained before the radio frequency image data is processed, a control system for multi-axis control of the imaging probe's position, and an ultrasonic feedback mechanism that measures ultrasound echo strain to estimate heat-induced structural changes of an area surrounding the ultrasonic thermal ablation probe, from the image. The ultrasonic thermal ablation probe is either an interstitial ablator inserted into tissue, a natural cavity or a vessel to emit high intensity ultrasound energy to deposit thermal dose, or an external applicator that emits a directional high intensity ultrasound energy to deposit thermal dose via surface contact with tissue. The control system adjusts power levels of the ultrasonic thermal ablation probe based on the estimated heat-induced structural changes.
摘要翻译：一种用于热处理或消融组织的系统包括超声波热消融探针，从处理射频图像数据之前获得的射频图像数据捕获图像的超声三维成像探针，用于多轴控制的控制系统以及超声波反馈机构，其测量超声回波应变以估计来自图像的超声波热消融探针周围区域的热诱导的结构变化。超声波热消融探针是插入到组织中的间质消融器，自然腔或发射高强度超声能量以沉积热剂量的容器，或者外部施加器，其发射定向高强度超声能量以通过表面接触沉积热剂量与组织。控制系统基于估计的热诱导结构变化来调节超声波热消融探针的功率水平。

2. 发明申请

US20110317810A1 METHODS AND SYSTEMS FOR LOCATING OBJECTS EMBEDDED IN A BODY 有权
标题翻译：用于定位嵌入体内的物体的方法和系统
公开(公告)号：US20110317810A1
公开(公告)日：2011-12-29
申请号：US13171034
申请日：2011-06-28
申请人： Junghoon Lee , Jerry L. Prince , Christian Labat , Everette C. Burdette
发明人： Junghoon Lee , Jerry L. Prince , Christian Labat , Everette C. Burdette
IPC分类号： G01N23/04 , G06K9/00
CPC分类号： A61B8/12 , A61B6/00 , A61B6/12 , A61B6/4417 , A61B6/4441 , A61B6/5247 , A61B8/0841 , A61N5/1001 , G06T7/55 , G06T2207/10121 , G06T2207/20088 , G06T2207/30081
摘要： A method of processing image data from an imaging system for locating a plurality N of objects embedded in a body includes receiving data for a first two-dimensional image of a region of interest of the body containing the plurality N of objects, the first two-dimensional image being obtained from a first imaging setting of the imaging system relative to the region of interest; receiving data for a second two-dimensional image of a region of interest of the body containing the plurality N of objects, the second two-dimensional image being obtained from a second imaging setting of the imaging system relative to the region of interest; and receiving data for a third two-dimensional image of a region of interest of the body containing the plurality N of objects, the third two-dimensional image being obtained from a third imaging setting of said imaging system relative to said region of interest.
摘要翻译：一种处理来自成像系统的图像数据的方法，用于定位嵌入在人体内的多个物体N包括接收包含多个物体的身体的感兴趣区域的第一二维图像的数据，从成像系统的第一成像设置获得相对于感兴趣区域的三维图像; 接收包含所述多个物体的所述主体的感兴趣区域的第二二维图像的数据，所述第二二维图像是从所述成像系统相对于所述感兴趣区域的第二成像设置获得的; 以及接收包含所述多个物体的所述身体的感兴趣区域的第三二维图像的数据，所述第三二维图像是从所述成像系统相对于所述感兴趣区域的第三成像设置获得的。

3. 发明授权

US08047990B2 Collagen density and structural change measurement and mapping in tissue 有权
标题翻译：胶原密度和组织结构变化测量和绘图
公开(公告)号：US08047990B2
公开(公告)日：2011-11-01
申请号：US11656315
申请日：2007-01-19
申请人： Everette C. Burdette , Scott P. Huntley
发明人： Everette C. Burdette , Scott P. Huntley
IPC分类号： A61B8/00
CPC分类号： G01S7/52071 , A61B8/08 , G06T7/0012 , G06T2207/10132 , G06T2207/30024
摘要： A method and system for two and three dimensional mapping of tissue density and/or structural changes from image data and/or spatial reflected or transmitted signal maps, and correlating the maps to changes in collagen density. The method and system includes the steps of: receiving an image or spatial maps of acoustic-derived RF signal data from tissue comprised of multiple pixels, segregating the image into groups of pixels, each group of pixels having characteristics within a defined class, establishing a baseline set of classes corresponding to initial conditions of the imaged/mapped tissue, measuring a differential in the set of classes for a group of pixels, the differential corresponding to a change in pixel values for the group of pixels, correlating said measured differential to a density change for the tissue corresponding to the group of pixels, and overlaying an indication of collagen density over the tissue image or mapped signal responses correlated with thermal dose indicating a change in collagen density for the tissue.
摘要翻译：一种用于从图像数据和/或空间反射或发射信号图中组织密度和/或结构变化的二维和三维映射的方法和系统，并且将该图与胶原密度变化相关联。所述方法和系统包括以下步骤：从由多个像素组成的组织接收声学导出的RF信号数据的图像或空间图，将图像分离成像素组，每组像素具有在限定类别内的特征，建立对应于成像/映射组织的初始条件的类的基准集合，测量一组像素的类的集合中的差分，所述差异对应于所述像素组的像素值的变化，将所述测量的差分与对应于该组像素的组织的密度变化，并且覆盖组织图像上的胶原密度的指示或与表示组织的胶原密度变化的热剂量相关的映射信号响应。

4. 发明授权

US07201715B2 Real time brachytherapy spatial registration and visualization system 有权
标题翻译：实时近距离放射治疗空间注册和可视化系统
公开(公告)号：US07201715B2
公开(公告)日：2007-04-10
申请号：US10329281
申请日：2002-12-23
申请人： Everette C. Burdette , Bruce M. Komandina
发明人： Everette C. Burdette , Bruce M. Komandina
IPC分类号： A61N5/00
CPC分类号： A61N5/00 , A61B5/055 , A61B8/12 , A61B8/42 , A61B8/4209 , A61B8/5238 , A61B18/22 , A61B34/10 , A61B34/20 , A61B90/36 , A61B2017/00274 , A61B2017/3411 , A61B2018/00547 , A61B2034/256 , A61B2090/365 , A61B2090/378 , A61B2090/3782 , A61M37/0069 , A61N5/1001 , A61N5/1002 , A61N5/1007 , A61N5/1027 , A61N5/103 , A61N5/1048 , A61N5/1049 , A61N2005/1011 , A61N2005/1012
摘要： A method and system for monitoring loading of radiation into an insertion device for use in a radiation therapy treatment to determine whether the treatment will be in agreement with a radiation therapy plan. In a preferred embodiment, optical sensors and radiation sensors are used to monitor loading of radioactive seeds and spacers into a needle as part of a prostate brachytherapy treatment.
摘要翻译：一种用于监测辐射加载到用于放射治疗治疗中的插入装置中的方法和系统，以确定治疗是否与放射治疗计划一致。在优选实施例中，光学传感器和辐射传感器用于监测作为前列腺近距离放射治疗治疗的一部分的放射性种子和间隔物到针中的负载。

5. 发明授权

US07171255B2 Virtual reality 3D visualization for surgical procedures 有权
标题翻译：虚拟现实3D可视化外科手术
公开(公告)号：US07171255B2
公开(公告)日：2007-01-30
申请号：US09897326
申请日：2001-07-02
申请人： Edward J. Holupka , Everette C. Burdette , Irving D. Kaplan
发明人： Edward J. Holupka , Everette C. Burdette , Irving D. Kaplan
IPC分类号： A61B5/05
CPC分类号： A61N5/1027 , A61B5/055 , A61B8/08 , A61B8/12 , A61B8/42 , A61B8/4209 , A61B8/4218 , A61B8/5238 , A61B18/22 , A61B34/10 , A61B34/20 , A61B90/36 , A61B2017/00274 , A61B2017/3411 , A61B2018/00547 , A61B2034/256 , A61B2090/365 , A61B2090/378 , A61B2090/3782 , A61M37/0069 , A61N5/1001 , A61N5/1007 , A61N5/103 , A61N5/1048 , A61N5/1049 , A61N2005/1011 , A61N2005/1012
摘要： A method and apparatus for three-dimensional imaging and treatment of a patient's body. The method and apparatus utilize a system for developing a therapy plan for treatment of an organ of the patient, a device for generating ultrasound image data from a treatment region and a device for providing a translucent volume image of a portion of a patient's body and a separate translucent image of the patient organ and a three dimensional viewing device to superimpose a translucent article image to enable viewing of the article image simultaneously with the patient organ and a portion of the patient's body.
摘要翻译：一种用于三维成像和治疗患者身体的方法和装置。该方法和装置利用系统来开发用于治疗患者器官的治疗计划，用于从治疗区域产生超声图像数据的装置和用于提供患者身体的一部分的半透明体积图像的装置，以及单独的患者器官的半透明图像和三维观察装置以叠加半透明的物品图像以使得能够与患者器官和患者身体的一部分同时观看物品图像。

6. 发明授权

US5810007A Ultrasound localization and image fusion for the treatment of prostate cancer 失效
标题翻译：超声定位和图像融合治疗前列腺癌
公开(公告)号：US5810007A
公开(公告)日：1998-09-22
申请号：US507199
申请日：1995-07-26
申请人： Edward J. Holupka , Irving D. Kaplan , Everette C. Burdette
发明人： Edward J. Holupka , Irving D. Kaplan , Everette C. Burdette
IPC分类号： A61B8/08 , A61B8/12 , A61B19/00 , A61N5/10 , A61B8/00
CPC分类号： A61N5/103 , A61B8/08 , A61B8/12 , A61B8/4218 , A61B8/5238 , A61B2090/365 , A61B2090/378 , A61B34/20 , A61N2005/1058
摘要： A method and apparatus for localizing and treating a patient's prostate by radiation therapy. The system includes an ultrasound probe for generating an ultrasound image of the prostate with the probe having at least two fiducial end points as landmarks. In addition, the system includes a CT apparatus to generate X-ray simulator images of the anatomical region near the prostate and further includes a computer executing computer software to transform the ultrasound image to the simulator image enabling accurate localization of the prostate relative to proximate anatomical features enabling accurate radiation therapy to be carried out on the prostate.
摘要翻译：一种通过放射治疗定位和治疗患者前列腺的方法和装置。该系统包括用于产生前列腺超声波图像的超声波探头，探头具有至少两个基准端点作为界标。另外，该系统还包括一个CT装置，用于产生前列腺附近的解剖区域的X射线模拟器图像，还包括执行计算机软件的计算机软件，以将超声图像转换成模拟器图像，从而使前列腺相对于近端解剖学具有能够在前列腺上进行精确放射治疗的特征。

7. 发明授权

US5549638A Ultrasound device for use in a thermotherapy apparatus 失效
公开(公告)号：US5549638A
公开(公告)日：1996-08-27
申请号：US245301
申请日：1994-05-17
申请人： Everette C. Burdette
发明人： Everette C. Burdette
IPC分类号： A61N7/02 , A61N1/00
CPC分类号： A61N7/02
摘要： A thermotherapy device for use in treating cancer. The thermotherapy device includes a radio frequency power source for energizing transducers to output ultrasound waves to heat a patient treatment site. The transducers are arranged in a cylindrical shape to treat the patient and a variable number of ultrasound transducers can provide a customized therapy treatment.

8. 发明授权

US10183183B2 Acoustic applicators for controlled thermal modification of tissue 有权
公开(公告)号：US10183183B2
公开(公告)日：2019-01-22
申请号：US11744773
申请日：2007-05-04
申请人： Everette C. Burdette
发明人： Everette C. Burdette
IPC分类号： A61N7/02 , A61B17/00 , A61N7/00
摘要： An apparatus and method for modifying collagen containing dermal tissue. The apparatus includes a source of ultrasound energy comprised of a plurality of curvilinear ultrasound transducers shaped to direct ultrasound energy to selected skin depths. The transducers have variable curvature, drive frequency, power level and geometries to effect precise control of collagen modification.

9. 发明授权

US08025688B2 Apparatus for thermal therapy of prostate gland with ultrasound energy 有权
标题翻译：用超声波治疗前列腺的装置
公开(公告)号：US08025688B2
公开(公告)日：2011-09-27
申请号：US10397070
申请日：2003-03-24
申请人： Chris J. Diederich , Everette C. Burdette
发明人： Chris J. Diederich , Everette C. Burdette
IPC分类号： A61F7/00
CPC分类号： A61B18/1815 , A61B18/18 , A61B18/24 , A61B90/04 , A61B2017/00092 , A61B2017/00106 , A61B2017/00274 , A61B2017/22051 , A61B2017/22065 , A61B2018/00017 , A61B2018/00547 , A61B2090/0472 , A61B2090/0481 , A61B2090/049 , A61B2090/378 , A61B2090/3925 , A61F7/12 , A61F2007/0095 , A61N5/04 , A61N7/02 , A61N7/022
摘要： An apparatus for applying thermal energy to a prostate gland, comprising a support tube having a longitudinal passageway, a power lead channeled through the longitudinal central passageway and an ultrasound crystal disposed around at least part of the support tube. The ultrasound crystal is coupled to the power lead which provides the power to energize the ultrasound crystal and generate ultrasound energy providing thermal therapy to the prostate gland. The ultrasound crystal further includes inactivated portions for reducing ultrasound energy directed to the rectal wall of the patient. A sealant is disposed in contact with the ultrasound crystal allowing vibration necessary for efficient ultrasound energy radiation for the thermal therapy of the prostate gland.
摘要翻译：一种用于向前列腺施加热能的装置，包括具有纵向通道的支撑管，通过所述纵向中心通道引导的动力引导件和围绕所述支撑管的至少一部分设置的超声波晶体。超声波晶体耦合到电源引线，其提供激励超声晶体的功率，并产生向前列腺提供热治疗的超声能量。超声波晶体还包括用于减少被引导到患者直肠壁的超声能量的失活部分。将密封剂设置成与超声波晶体接触，允许用于前列腺热疗的有效超声能量辐射所需的振动。

10. 发明授权

US07438685B2 Apparatus and method for registration, guidance and targeting of external beam radiation therapy 有权
标题翻译：外部束放射治疗的注册，指导和靶向的装置和方法
公开(公告)号：US07438685B2
公开(公告)日：2008-10-21
申请号：US10286368
申请日：2002-11-01
申请人： Everette C. Burdette , Dana L. Deardorff
发明人： Everette C. Burdette , Dana L. Deardorff
IPC分类号： A61B8/00
CPC分类号： A61B8/463 , A61B6/00 , A61B6/03 , A61B6/5247 , A61B8/08 , A61B8/12 , A61B8/4245 , A61B8/4263 , A61B8/5238 , A61B34/10 , A61B34/20 , A61B2017/00274 , A61B2017/3413 , A61B2018/00547 , A61B2034/2055 , A61B2090/101 , A61B2090/365 , A61B2090/367 , A61B2090/374 , A61B2090/376 , A61B2090/378 , A61B2090/3983 , A61N5/103 , A61N2005/1058
摘要： An improved system and method for optimizing the planning, registration, targeting, and delivery of conformal, external beam radiation therapy of prostate cancer and other soft-tissue diseases. Real-time ultrasound imaging during planning and treatment is used forlocalization of soft tissue treatment targets and fused with radiographic or CT data for conformal treatment optimization. The fusion technique provides accurate localization of the prostate volume in real time. For treatment of prostate cancer, visualization of the prostate gland is achieved using transrectal ultrasonography and the fusion of that image in the precise location of the prostate within the pelvic region, accurately determining the location of the prostate target by transformation of the ultrasound image data on both the ultrasound and X-ray/CT images. The radiation field may be optimized to significantly reduce the volume of irradiated normal tissue, minimizing the exposure of the surrounding healthy tissues and increasing dosage delivered to the prostate treatment target.
摘要翻译：一种改进的系统和方法，用于优化前列腺癌和其他软组织疾病的适形外部束放射治疗的规划，注册，靶向和传递。计划和治疗期间的实时超声成像用于软组织治疗靶标的局部化，并与放射照相或CT数据融合以进行保形治疗优化。融合技术可以实时准确定位前列腺体积。对于前列腺癌的治疗，使用经直肠超声检查和该图像在骨盆区域内前列腺的精确位置的融合来实现前列腺的可视化，通过将超声图像数据转换成精确地确定前列腺目标的位置超声和X射线/ CT图像。可以优化辐射场以显着减少照射的正常组织的体积，使周围健康组织的暴露最小化，并增加递送至前列腺治疗靶标的剂量。

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