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1. 发明授权

US09561126B2 Catheter with attached flexible side sheath 有权
标题翻译：导管附有柔性侧护套
公开(公告)号：US09561126B2
公开(公告)日：2017-02-07
申请号：US13534720
申请日：2012-06-27
申请人： Gil M. Vardi , Charles J. Davidson , Eric Williams
发明人： Gil M. Vardi , Charles J. Davidson , Eric Williams
IPC分类号： A61F2/954 , A61F2/958 , A61F2/856
CPC分类号： A61F2/954 , A61F2/856 , A61F2/958 , A61F2250/006 , A61F2250/0097 , Y10S623/903
摘要： A method of positioning a main stent at a vessel bifurcation includes positioning a main guidewire in the main vessel; and advancing a stent delivery system to a position proximate the bifurcation. The stent delivery system includes a catheter with a flexible side sheath attached thereto and a main stent positioned over the catheter. The flexible side sheath is positioned to pass through the side opening in the main stent. The method also includes advancing a branch guidewire through the flexible side sheath and into the branch vessel; and subsequently, advancing the catheter over the main guidewire while advancing the flexible side sheath over the branch guidewire while viewing relative movement of a marker positioned on the flexible side sheath with respect to at least one marker positioned on the catheter.
摘要翻译：将主支架定位在血管分叉处的方法包括将主导丝定位在主血管中; 并将支架输送系统推进到靠近分叉的位置。支架输送系统包括其上附着柔性侧鞘的导管和位于导管上的主支架。柔性侧护套被定位成穿过主支架中的侧开口。该方法还包括使分支导丝穿过柔性侧鞘并进入分支容器; 并且随后，当相对于位于导管上的至少一个标记物观察位于柔性侧护套上的标记物的相对运动时，将导管推进主导丝上，同时使柔性侧鞘超过分支导丝。

2. 发明申请

US20120108943A1 SYSTEMS AND METHODS FOR MINIMALLY-INVASIVE OPTICAL-ACOUSTIC IMAGING 有权
标题翻译：用于最小入射光学声像成像的系统和方法
公开(公告)号：US20120108943A1
公开(公告)日：2012-05-03
申请号：US13285551
申请日：2011-10-31
申请人： Kenneth N. Bates , Gil M. Vardi
发明人： Kenneth N. Bates , Gil M. Vardi
IPC分类号： A61B6/00 , G01V1/145 , G02F1/335
CPC分类号： A61B5/0095 , A61B1/00117 , A61B1/00165 , A61B5/0097 , A61B5/02007 , A61B5/6851 , A61B5/6876 , A61B5/742 , A61B8/0833 , A61B8/12 , G01H9/004 , G01N29/24 , G02B6/10
摘要： An imaging guidewire can include optical fibers communicating light along the guidewire. At or near its distal end, one or more blazed or other fiber Bragg gratings (FBGs) directs light to a photoacoustic transducer material that provides ultrasonic imaging energy. Returned ultrasound is sensed by an FBG sensor. A responsive signal is optically communicated to the proximal end of the guidewire, and processed to develop a 2D or 3D image. The guidewire outer diameter is small enough such that an intravascular catheter can be passed over the guidewire. Techniques for improving ultrasound reception include using a high compliance material, resonating the ultrasound sensing transducer, using an attenuation-reducing coating and/or thickness, and/or using optical wavelength discrimination. Techniques for improving the ultrasound generating transducer include using a blazed FBG, designing the photoacoustic material thickness to enhance optical absorption. Techniques for distinguishing plaque or vulnerable plaque may enhance the displayed image.
摘要翻译：成像导丝可以包括沿导丝传送光的光纤。在其远端处或附近，一个或多个闪耀或其它光纤布拉格光栅（FBG）将光引导到提供超声成像能量的光声换能器材料。返回的超声波由FBG传感器感测。响应信号被光学地传递到导丝的近端，并被处理以形成2D或3D图像。导丝外径足够小，使得血管内导管可以穿过导丝。用于改善超声波接收的技术包括使用高柔顺性材料，使用衰减减小涂层和/或厚度谐振超声波感测传感器和/或使用光波长鉴别。用于改进超声波产生换能器的技术包括使用闪耀的FBG，设计光声材料厚度以增强光学吸收。用于区分斑块或易损斑块的技术可以增强显示的图像。

3. 发明授权

US07892279B2 Extendible stent apparatus 有权
标题翻译：可扩展支架装置
公开(公告)号：US07892279B2
公开(公告)日：2011-02-22
申请号：US12472189
申请日：2009-05-26
申请人： Charles J. Davidson , Eric Williams , Gil M. Vardi , Stuart Lin
发明人： Charles J. Davidson , Eric Williams , Gil M. Vardi , Stuart Lin
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/064 , A61F2/07 , A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/067 , A61F2002/821 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2250/006 , A61F2250/0098
摘要： The present invention concerns novel stent apparatuses for use in treating lesions at or near the bifurcation point in bifurcated cardiac, coronary, renal, peripheral vascular, gastrointestinal, pulmonary, urinary and neurovascular vessels and brain vessels. More particularly, the invention concerns a stent apparatus with at least one side opening which may further comprise an extendable stent portion laterally extending from the side opening and at least partly in registry with the wall of the side opening. Devices constructed in accordance with the invention include, singularly or in combination, a main expandable stent comprising at least one substantially circular side opening located between its proximal and distal end openings, which side opening may further comprise an expandable portion extending radially outward from the edges of the side opening; and a branch stent comprising proximal and distal end openings and which may further comprise a contacting portion at its proximal end, and which may optionally be constructed to form either a perpendicular branch or a non-perpendicular branch when inserted through a side opening of the main stent. The stents of the invention are marked with, or at least partially constructed of, a material which is imagable during intraluminal catheterization techniques, most preferably but not limited to ultrasound and x-ray.
摘要翻译：本发明涉及用于治疗分叉的心脏，冠状动脉，肾脏，外周血管，胃肠，肺，尿和神经血管血管和脑血管中的分叉点处或附近的病变的新型支架装置。更具体地说，本发明涉及具有至少一个侧面开口的支架装置，所述至少一个侧面开口还可以包括从所述侧面开口横向延伸并且至少部分地与所述侧面开口的壁对齐的可延伸支架部分。根据本发明构造的装置包括单独地或组合地包括主扩展支架，其包括位于其近端和远端开口之间的至少一个基本上圆形的侧开口，该侧开口还可包括从边缘径向向外延伸的可扩张部分的侧面开口; 以及分支支架，其包括近端和远端开口，并且其可以在其近端处进一步包括接触部分，并且其可以可选地被构造成当插入通过主体的侧开口插入时垂直分支或非垂直分支支架。本发明的支架标记有或至少部分地由在腔内导管插入术技术中可成像的材料标记，或者至少部分地构成，最优选但不限于超声和X射线。

4. 发明授权

US07815675B2 Stent with protruding branch portion for bifurcated vessels 失效
标题翻译：支架具有突出的分支部分用于分叉血管
公开(公告)号：US07815675B2
公开(公告)日：2010-10-19
申请号：US12045537
申请日：2008-03-10
申请人： Charles J. Davidson , Gil M. Vardi , Eric Williams , Amnon Yadin , Yossi Morik , Eitan Konstantino , Tanhum Feld
发明人： Charles J. Davidson , Gil M. Vardi , Eric Williams , Amnon Yadin , Yossi Morik , Eitan Konstantino , Tanhum Feld
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/07 , A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/067 , A61F2002/821 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2250/0018 , A61F2250/0039 , A61M25/1002 , A61M2025/1045
摘要： A stent for use in a bifurcated body lumen having a main branch and a side branch. The stent comprises a radially expandable generally tubular stent body having proximal and distal opposing ends with a body wall having a surface extending therebetween. The surface has a geometrical configuration defining a first pattern, and the first pattern has first pattern struts and connectors arranged in a predetermined configuration. The stent also comprises a branch portion comprised of a second pattern, wherein the branch portion is outwardly expandable from the stent body.
摘要翻译：一种用于分支体腔的支架，具有主支和侧分支。所述支架包括径向可扩张的大体上管状的支架体，所述支架主体具有近端和远端相对端部，所述主体壁具有在其间延伸的表面。表面具有限定第一图案的几何构造，并且第一图案具有以预定构造布置的第一图案支柱和连接器。支架还包括由第二图案组成的分支部分，其中分支部分从支架主体向外可扩张。

5. 发明申请

US20090240321A1 Extendible Stent Apparatus 有权
标题翻译：可扩展支架装置
公开(公告)号：US20090240321A1
公开(公告)日：2009-09-24
申请号：US12472189
申请日：2009-05-26
申请人： Charles J. Davidson , Eric Williams , Gil M. Vardi , Stuart Lin
发明人： Charles J. Davidson , Eric Williams , Gil M. Vardi , Stuart Lin
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/064 , A61F2/07 , A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/067 , A61F2002/821 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2250/006 , A61F2250/0098
摘要： The present invention concerns novel stent apparatuses for use in treating lesions at or near the bifurcation point in bifurcated cardiac, coronary, renal, peripheral vascular, gastrointestinal, pulmonary, urinary and neurovascular vessels and brain vessels. More particularly, the invention concerns a stent apparatus with at least one side opening which may further comprise an extendable stent portion laterally extending from the side opening and at least partly in registry with the wall of the side opening. Devices constructed in accordance with the invention include, singularly or in combination, a main expandable stent comprising at least one substantially circular side opening located between its proximal and distal end openings, which side opening may further comprise an expandable portion extending radially outward from the edges of the side opening; and a branch stent comprising proximal and distal end openings and which may further comprise a contacting portion at its proximal end, and which may optionally be constructed to form either a perpendicular branch or a non-perpendicular branch when inserted through a side opening of the main stent. The stents of the invention are marked with, or at least partially constructed of, a material which is imageable during intraluminal catheterization techniques, most preferably but not limited to ultrasound and x-ray.
摘要翻译：本发明涉及用于治疗分叉的心脏，冠状动脉，肾脏，外周血管，胃肠，肺，尿和神经血管血管和脑血管中的分叉点处或附近的病变的新型支架装置。更具体地说，本发明涉及具有至少一个侧面开口的支架装置，所述至少一个侧面开口还可以包括从所述侧面开口横向延伸并且至少部分地与所述侧面开口的壁对齐的可延伸支架部分。根据本发明构造的装置包括单独地或组合地包括主扩展支架，其包括位于其近端和远端开口之间的至少一个基本上圆形的侧开口，该侧开口还可包括从边缘径向向外延伸的可扩张部分的侧面开口; 以及分支支架，其包括近端和远端开口，并且其可以在其近端处进一步包括接触部分，并且其可以可选地被构造成当插入通过主体的侧开口插入时垂直分支或非垂直分支支架。本发明的支架由管腔内导管插入技术中可成像的材料标记或至少部分地构成，最优选但不限于超声和x射线。

6. 发明申请

US20090076592A1 Stent with Protruding Branch Portion for Bifurcated Vessels 失效
公开(公告)号：US20090076592A1
公开(公告)日：2009-03-19
申请号：US12045537
申请日：2008-03-10
申请人： Charles J. Davidson , Gil M. Vardi , Eric Williams , Amnon Yadin , Yossi Morik , Eitan Konstantino , Tanhum Feld
发明人： Charles J. Davidson , Gil M. Vardi , Eric Williams , Amnon Yadin , Yossi Morik , Eitan Konstantino , Tanhum Feld
IPC分类号： A61F2/86
CPC分类号： A61F2/82 , A61F2/07 , A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/067 , A61F2002/821 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2250/0018 , A61F2250/0039 , A61M25/1002 , A61M2025/1045
摘要： The present invention is directed to a stent for use in a bifurcated body lumen having a main branch and a side branch. The stent comprises a radially expandable generally tubular stent body having proximal and distal opposing ends with a body wall having a surface extending therebetween. The surface has a geometrical configuration defining a first pattern, and the first pattern has first pattern struts and connectors arranged in a predetermined configuration. The stent also comprises a branch portion comprised of a second pattern, wherein the branch portion is at least partially detachable from the stent body.

7. 发明授权

US07118593B2 Extendible stent apparatus 有权
公开(公告)号：US07118593B2
公开(公告)日：2006-10-10
申请号：US10683165
申请日：2003-10-14
申请人： Charles J. Davidson , Eric Williams , Gil M. Vardi , Stuart Lin
发明人： Charles J. Davidson , Eric Williams , Gil M. Vardi , Stuart Lin
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/064 , A61F2/07 , A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/067 , A61F2002/821 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2250/006 , A61F2250/0098
摘要： The present invention concerns novel stent apparatuses for use in treating lesions at or near the bifurcation point in bifurcated cardiac, coronary, renal, peripheral vascular, gastrointestinal, pulmonary, urinary and neurovascular vessels and brain vessels. More particularly, the invention concerns a stent apparatus with at least one side opening which may further comprise an extendable stent portion laterally extending from the side opening and at least partly in registry with the wall of the side opening. Devices constructed in accordance with the invention include, singularly or in combination, a main expandable stent comprising at least one substantially circular side opening located between its proximal and distal end openings, which side opening may further comprise an expandable portion extending radially outward from the edges of the side opening; and a branch stent comprising proximal and distal end openings and which may further comprise a contacting portion at its proximal end, and which may optionally be constructed to form either a perpendicular branch or a non-perpendicular branch when inserted through a side opening of the main stent. The stents of the invention are marked with, or at least partially constructed of, a material which is imageable during intraluminal catheterization techniques, most preferably but not limited to ultrasound and x-ray.

8. 发明授权

US06689156B1 Stent range transducers and methods of use 失效
标题翻译：支架范围传感器和使用方法
公开(公告)号：US06689156B1
公开(公告)日：2004-02-10
申请号：US09669060
申请日：2000-09-22
申请人： Charles J. Davidson , Gil M. Vardi , Eric Williams , Stephen Kao , Niyazi U. Behyan
发明人： Charles J. Davidson , Gil M. Vardi , Eric Williams , Stephen Kao , Niyazi U. Behyan
IPC分类号： A61F206
CPC分类号： A61B8/12 , A61B8/445 , A61F2/82 , A61F2/856 , A61F2/954 , A61F2002/821 , A61F2250/0002 , A61F2250/0018 , A61F2250/0039
摘要： A system and method for delivering and positioning a stent within a bifurcated body lumen includes a stent delivery system including a catheter, expansion device, a stent with a side hole disposed on the expansion device, and an ultrasound transducer disposed between the expansion device and the stent. The ultrasound transducer is configured for transmitting and receiving signals and for imaging of a body lumen so as to locate an ostium of a branch vessel and facilitate alignment of the stent side hole with the ostium.
摘要翻译：用于在分叉体腔内输送和定位支架的系统和方法包括：支架输送系统，包括导管，膨胀装置，具有设置在扩张装置上的侧孔的支架，以及设置在膨胀装置和膨胀装置之间的超声换能器支架。超声波换能器被配置为用于发送和接收信号并用于体腔成像，以便定位分支血管的口，并且便于支架侧孔与口的对准。

9. 发明授权

US06659957B1 Optical-acoustic imaging device 有权
标题翻译：光声成像装置
公开(公告)号：US06659957B1
公开(公告)日：2003-12-09
申请号：US09623248
申请日：2002-06-11
申请人： Gil M. Vardi , Victor Spivak
发明人： Gil M. Vardi , Victor Spivak
IPC分类号： A61B814
CPC分类号： A61B8/12 , A61B5/0095 , A61B5/0097 , A61B8/56 , A61B2017/22042 , A61B2090/3614 , G01H9/004
摘要： The present invention is a guide wire imaging device for vascular or non-vascular imaging utilizing optic acoustical methods, which device has a profile of less than 1 mm in diameter. The ultrasound imaging device of the invention comprises a single mode optical fiber with at least one Bragg grating (8), and a piezoelectric or piezo-ceramic jacket (31), which device may achieve omnidirectional (360°) imaging. The imaging guide wire of the invention can function as the guide wire for vascular interventions, can enable real time imaging during balloon inflation, and stent deployment, thus will provide clinical information that is not available when catheter based imaging systems are used. The device of the invention may enable shortened total procedure times, including the fluoroscopy time, will also reduce radiation exposure to the patient, and the operator.
摘要翻译：本发明是利用光学声学方法进行血管或非血管成像的导丝成像装置，该装置具有直径小于1mm的轮廓。本发明的超声成像装置包括具有至少一个布拉格光栅（8）的单模光纤和压电或压电陶瓷护套（31），该装置可以实现全向（360°）成像。本发明的成像引导线可以用作血管干预的导丝，可以在球囊充气和支架展开期间实现实时成像，从而提供当使用基于导管的成像系统时不可用的临床信息。本发明的装置可以实现缩短的总程序时间，包括透视时间，还可减少对患者和操作者的辐射。

10. 发明授权

US06599316B2 Extendible stent apparatus 有权
公开(公告)号：US06599316B2
公开(公告)日：2003-07-29
申请号：US09750372
申请日：2000-12-27
申请人： Gil M. Vardi , Charles J. Davidson
发明人： Gil M. Vardi , Charles J. Davidson
IPC分类号： A61F206
CPC分类号： A61F2/856 , A61F2/064 , A61F2/07 , A61F2/82 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/067 , A61F2002/821 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2230/005 , A61F2250/006 , A61F2250/0098
摘要： The present invention concerns novel stent apparatuses for use in treating lesions at or near the bifurcation point in bifurcated cardiac, coronary, renal, peripheral vascular, gastrointestinal, pulmonary, urinary and neurovascular vessels and brain vessels. More particularly, the invention concerns a stent apparatus with at least one side opening which may further comprise an extendable stent portion laterally extending from the side opening and at least partly in registry with the wall of the side opening. Devices constructed in accordance with the invention include, singularly or in combination, a main expandable stent comprising at least one substantially circular side opening located between its proximal and distal end openings, which side opening may further comprise an expandable portion extending radially outward from the edges of the side opening; and a branch stent comprising proximal and distal end openings and which may further comprise a contacting portion at its proximal end, and which may optionally be constructed to form either a perpendicular branch or a non-perpendicular branch when inserted through a side opening of the main stent. The stents of the invention are marked with, or at least partially constructed of, a material which is imageable during intraluminal catheterization techniques, most preferably but not limited to ultrasound and x-ray.

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