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1. 发明申请

US20080310582A1 X-Ray System for the Creation of Diagnostic X-Ray Images Using Contrast Media 有权
标题翻译：用于使用对比度媒体创建诊断X射线图像的X射线系统
公开(公告)号：US20080310582A1
公开(公告)日：2008-12-18
申请号：US12084259
申请日：2006-10-25
申请人： Thomas Flohr , Michael Grasruck , Hubertus Pietsch , Karl Stierstorfer , Christoph Suss , Hanns-Joachim Weinmann
发明人： Thomas Flohr , Michael Grasruck , Hubertus Pietsch , Karl Stierstorfer , Christoph Suss , Hanns-Joachim Weinmann
IPC分类号： A61B6/03
CPC分类号： A61K49/04 , A61B5/1075 , A61B6/032 , A61B6/06 , A61B6/4014 , A61B6/4035 , A61B6/4241 , A61B6/4266 , A61B6/4441 , A61B6/481 , A61B6/482 , A61B6/488 , A61B6/504 , A61B6/542 , A61B6/545 , A61B6/583
摘要： An x-ray system is disclosed including a selector for finding an optimum combination between the contrast medium and the energy spectrum of an x-radiation for a scan to optimize the noise-to-contrast ratio. A method for creating X-ray images is also provided. The x-ray images are created with the aid of contrast media by taking into account an optimal combination between the contrast medium and the energy spectrum of an X-radiation used for a scan. A method for the use of a lanthanide-containing complex to produce a contrast medium for optimizing the combination between the contrast medium and the radiation to obtain a maximum contrast-to-noise ratio in an X-ray image is also provided.
摘要翻译：公开了一种X射线系统，其包括用于找到造影剂与用于扫描的x辐射的能谱之间的最佳组合的选择器，以优化噪声对比度。还提供了一种用于创建X射线图像的方法。通过考虑造影介质和用于扫描的X射线的能谱之间的最佳组合，借助造影剂创建X射线图像。还提供了一种使用含镧系元素的络合物以产生用于优化造影剂和辐射之间的组合以在X射线图像中获得最大对比噪声比的造影剂的方法。

2. 发明申请

US20080213187A1 NOVEL CASCADE POLYMER COMPLEXES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开
标题翻译：新型聚合物复合物，其制备方法和包含它们的药物组合物
公开(公告)号：US20080213187A1
公开(公告)日：2008-09-04
申请号：US12015769
申请日：2008-01-17
申请人： Heribert SCHMITT-WILLICH , Heiko Schirmer , Bernd Misselwitz , Hanns-Joachim Weinmann , Peter Caravan
发明人： Heribert SCHMITT-WILLICH , Heiko Schirmer , Bernd Misselwitz , Hanns-Joachim Weinmann , Peter Caravan
IPC分类号： A61K49/06 , C07C69/76 , C07C39/04
CPC分类号： A61K49/085 , A61K49/124
摘要： The invention relates to novel cascade polymer complexes, to compositions comprising these compounds, to the use of the complexes in NMR diagnosis, and to processes for preparing these compounds and compositions. The complex-forming cascade polymer complexes according to the invention can be described by general formula I: R-L-A-{X—[Y-(Z-{W—Kw}z)y]x}a−1 (I) where R=is an HSA-binding unit, L=is a linker or a bond, A=is a nitrogen-containing cascade core of base multiplicity a, X and Y are independently of one another a direct linkage or a cascade reproduction unit of reproduction multiplicity x and y, respectively, Z and W=are independently of one another a direct linkage or a cascade reproduction unit of reproduction multiplicity z and w, respectively, K is the residue of a complexing agent, a=is numbers 2 to 12, and x, y, z and w are independently of one another the numbers 1 to 4, with the proviso that exactly one multiplicity of the base multiplicity a of the cascade core A represents exactly one point of linkage to L, and with the proviso that the cascade polymer complexes comprise in the complexing agent residue K in total at least 4 ions of an element of atomic number 20 to 29, 39, 42 to 44 or 57 to 83 and comprise where appropriate cations of inorganic and/or organic bases, amino acids or amino amides.
摘要翻译：本发明涉及新颖的级联聚合物复合物，包含这些化合物的组合物，在NMR诊断中使用复合物，以及制备这些化合物和组合物的方法。根据本发明的络合物形成级联聚合物复合物可以由通式I描述：<？in-line-formula description =“In-line Formulas”end =“lead”？> RLA- {X- [Y-（ a-1 （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R =是HSA结合单元，L =是接头或键，A = 包含碱基多重性a的级联核心，X和Y彼此独立地是再现倍数x和y的直接联动或级联再现单元，Z和W =彼此独立地是直接联动或级联再现单元分别是繁殖多重度z和w，K是络合剂的残基，a =数字2至12，x，y，z和w彼此独立地为数字1至4，条件是准确地级联核心A的碱基多重性a的一个多重性恰好代表连接点t的一个点 o L，条件是级联聚合物络合物在配位剂中含有总共至少4个原子序数为20至29,39,42至44或57至83的元素的残基K，并且包含适当的阳离子无机和/或有机碱，氨基酸或氨基酰胺。

3. 发明申请

US20070036729A1 Compositions containing magnetic iron oxide particles, and use of said compositions in imaging methods 审中-公开
标题翻译：含有磁性氧化铁颗粒的组合物，以及所述组合物在成像方法中的用途
公开(公告)号：US20070036729A1
公开(公告)日：2007-02-15
申请号：US11476934
申请日：2006-06-29
申请人： Andreas Briel , Bernhard Gleich , Juergen Weizenecker , Martin Rohrer , Hanns-Joachim Weinmann , Hubertus Pietsch , Rudiger LaWaczeck , Matthias Rothe , Jens Thomsen
发明人： Andreas Briel , Bernhard Gleich , Juergen Weizenecker , Martin Rohrer , Hanns-Joachim Weinmann , Hubertus Pietsch , Rudiger LaWaczeck , Matthias Rothe , Jens Thomsen
IPC分类号： A61K49/10
CPC分类号： A61B5/418 , A61B5/0515 , A61B5/411 , A61B5/415 , A61B5/416 , A61K49/1836 , A61K49/1863 , A61K49/1866 , A61K49/1875 , B82Y5/00
摘要： The present invention relates to complexes which contain magnetic iron oxide particles in a pharmaceutically acceptable shell, said particles having a diameter of 20 nm to 1 μm with an overall particle diameter/core diameter ratio of less than 6, and to the use of these complexes in magnetic particle imaging (MPI). Particular preference is given to the use of these compositions in examining the gastrointestinal tract, the vascular system of the heart and cranial components, in the diagnosis of arteriosclerosis, infarctions, and tumors and metastases, for example of the lymphatic system.
摘要翻译：本发明涉及在药学上可接受的壳中含有磁性氧化铁颗粒的复合物，所述颗粒的直径为20nm至1μm，总体颗粒直径/芯直径比小于6，并且使用这些配合物在磁粉成像（MPI）中。特别优选使用这些组合物来检查胃肠道，心脏和颅脑部分的血管系统，诊断动脉硬化，梗死以及肿瘤和转移灶，例如淋巴系统。

4. 发明申请

US20060120965A1 Trimeric, macrocyclically substituted aminoisophthalic acid-halo-benzene derivatives 审中-公开
标题翻译：三环，大环环取代的氨基间苯二甲酸 - 卤代苯衍生物
公开(公告)号：US20060120965A1
公开(公告)日：2006-06-08
申请号：US11274895
申请日：2005-11-16
申请人： Johannes Platzek , Heiko Schirmer , Hanns-Joachim Weinmann , Jose Martin , Juan Harto
发明人： Johannes Platzek , Heiko Schirmer , Hanns-Joachim Weinmann , Jose Martin , Juan Harto
IPC分类号： A61K49/10 , A61K49/04 , C07F5/00
CPC分类号： A61K49/0438 , A61K49/085 , A61K49/106 , C07D257/02
摘要： The metal complexes of general formula I in which Hal stands for bromine or iodine, and A1 and A2 have different meanings, are suitable as contrast media.
摘要翻译：其中Hal代表溴或碘的通式I的金属络合物和具有不同含义的A 1和A 2都适用作造影剂。

5. 发明授权

US06916461B2 Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis 失效
公开(公告)号：US06916461B2
公开(公告)日：2005-07-12
申请号：US10197421
申请日：2002-07-18
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
IPC分类号： C07D295/22 , A61K49/00 , A61K49/10 , A61P35/00 , A61P43/00 , B65D25/16 , B65D47/08 , B65D83/00 , C07C229/16 , C07C229/22 , C07C229/76 , C07C235/10 , C07C237/08 , C07C237/10 , C07C311/05 , C07C311/06 , C07D257/02 , C07D295/26 , C07F5/00 , C07F13/00 , A61B5/055 , A61K51/00
CPC分类号： C07D295/26 , A61K49/0002 , A61K49/0004 , B65D25/16 , B65D47/0847 , B65D83/0055 , C07C229/76 , C07C237/10 , C07D257/02
摘要： The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy.The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.

6. 发明授权

US06565830B1 DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production 失效
标题翻译： DTPA单酰胺，含这些化合物的药剂，它们的用途和制备方法
公开(公告)号：US06565830B1
公开(公告)日：2003-05-20
申请号：US09523310
申请日：2000-03-10
申请人： Heinz Gries , Erich Klieger , Bernd Radüchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jürgen Conrad
发明人： Heinz Gries , Erich Klieger , Bernd Radüchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jürgen Conrad
IPC分类号： A61B5055
CPC分类号： C07F5/003 , A61K49/06 , C07C237/04 , C07C237/12 , C07F15/025 , Y10S514/836
摘要： Compounds of formula I wherein Z1, Z2, X, R2 and R3 are as defined herein, are suitable as susceptibility reagents for use in susceptibility imaging.
摘要翻译：式Z1中Z 1，Z 2，X，R 2和R 3的化合物如本文所定义，适用于用于敏感性成像的易感性试剂。

7. 发明授权

US06180113B2 Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes 失效
标题翻译：含有含全氟烷基的金属络合物的药剂
公开(公告)号：US06180113B2
公开(公告)日：2001-01-30
申请号：US08801983
申请日：1997-02-19
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Rad{umlaut over (u)}chel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Rad{umlaut over (u)}chel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel
IPC分类号： A61K4900
CPC分类号： C07D295/26 , A61K31/28 , A61K31/555 , A61K33/24 , A61K45/06 , A61K49/06 , C07D257/02 , A61K2300/00
摘要： Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes are useful in tumor therapy and interventional radiology.
摘要翻译：含有全氟烷基的金属络合物的药剂可用于肿瘤治疗和介入放射学。

8. 发明授权

US06083479A Contrast media for infarction and necrosis imaging 失效
标题翻译：对照介质用于梗死和坏死成像
公开(公告)号：US06083479A
公开(公告)日：2000-07-04
申请号：US157959
申请日：1998-09-22
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Raduechel , Wolfgang Ebert , Hanns Joachim Weinmann
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Raduechel , Wolfgang Ebert , Hanns Joachim Weinmann
IPC分类号： A61K49/00 , A61K49/06 , A61K51/00 , A61K51/04 , C07B59/00 , C07D257/02 , A61B5/055 , A61K49/04
CPC分类号： A61K51/0478 , A61K49/103 , A61K49/106 , A61K51/0482 , C07B59/004 , C07D257/02 , Y10S514/836
摘要： The invention relates to new compounds that are suitable as contrast media especially for infarction and necrosis imaging, process for their production and pharmaceutical agents that contain these compounds.
摘要翻译：本发明涉及适用于特别用于梗塞和坏死成像的造影剂，其生产方法和含有这些化合物的药剂的新化合物。

9. 发明授权

US5874061A Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes 失效
标题翻译：级联聚合物复合物，其制备方法和含有所述复合物的药剂
公开(公告)号：US5874061A
公开(公告)日：1999-02-23
申请号：US777666
申请日：1996-12-20
申请人： Heribert Schmitt-Willich , Johannes Platzek , Bernd Raduchel , Hanns-Joachim Weinmann , Wolfgang Ebert , Bernd Misselwitz , Andreas Muhler , Thomas Frenzel
发明人： Heribert Schmitt-Willich , Johannes Platzek , Bernd Raduchel , Hanns-Joachim Weinmann , Wolfgang Ebert , Bernd Misselwitz , Andreas Muhler , Thomas Frenzel
IPC分类号： A61K49/04 , A61K49/08 , A61B5/055 , C07D225/00 , C07F5/00 , C08F283/00
CPC分类号： A61K49/124 , A61K49/04 , A61K51/065
摘要： Cascade polymer complexes that containa) complexing ligands of general formula IA--{X--�Y--(Z--(W--K.sub.w).sub.z).sub.y!.sub.x }.sub.a, (I) in whichA stands for a nitrogen-containing cascade nucleus of base multiplicity a,X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y,Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w,K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different, that 16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.64 holds true for the product of the multiplicities, and that at least one of cascade reproduction units X, Y, Z, W stands for a 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane reproduction unit,b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83,c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well asd) optionally acylated terminal amino groups are valuable compounds for diagnosis and therapy.
摘要翻译：含有a）通式IA- {X- [Y-（Z-（W-Kw）z）y] x} a，（I）的络合配体的级联聚合物络合物，其中A代表含氮级联核基本多重性a，X和Y彼此独立地代表再现多重性x或y，Z和W的直接键合或级联再现单元，彼此独立地代表再现倍数z的级联再现单位或w，K表示络合剂的基团，代表数字2至12，x，y，z和w彼此独立地代表数字1至4，条件是至少两个再现单位不同，多重性的乘积为16，并且级联再现单位X，Y，Z，W中的至少一个代表1,4,7,10-四氮杂环十二烷或1 ，4,8,11-四氮杂环十四烷再生单元，b）原子序数为20至29,39,42,44或57-83的元素的至少16个离子，c）任选的Inor阳离子甘氨酸和/或有机碱，氨基酸或氨基酸酰胺以及d）任选地酰化的末端氨基是用于诊断和治疗的有价值的化合物。

10. 发明授权

US5859214A DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production 失效
标题翻译： DTPA单酰胺，含这些化合物的药剂，它们的用途和制备方法
公开(公告)号：US5859214A
公开(公告)日：1999-01-12
申请号：US228524
申请日：1994-04-15
申请人： Heinz Gries , Erich Klieger , Bernd Raduchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jurgen Conrad
发明人： Heinz Gries , Erich Klieger , Bernd Raduchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jurgen Conrad
IPC分类号： A61K49/00 , A61K49/04 , A61K49/06 , C07C237/04 , C07C237/06 , C07C237/12 , C07C309/15 , C07C309/51 , C07C323/41 , C07C323/42 , C07D265/32 , C07F5/00 , C07F15/02 , C07F3/00 , A61B5/055 , A61K3/28
CPC分类号： C07F5/003 , A61K49/06 , C07C237/04 , C07C237/12 , C07F15/025 , Y10S514/836
摘要： Compounds of general formula I ##STR1## wherein Z.sup.1, Z.sup.2, X, R.sup.2 and R.sup.3 are as herein defined, are valuable pharmaceutical agents. In particular, the compounds are useful as contrast agents in NMR diagnosis.
摘要翻译：其中Z1，Z2，X，R2和R3如本文所定义的通式I的化合物（I）是有价值的药剂。特别地，该化合物可用作NMR诊断中的造影剂。

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