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1. 发明授权

US08871955B2 Process for the purification of pharmaceutically acceptable salts 有权
标题翻译：纯化药学上可接受的盐的方法
公开(公告)号：US08871955B2
公开(公告)日：2014-10-28
申请号：US13810959
申请日：2011-07-12
申请人： Hans Petersen , Martin Markvard Knudsen
发明人： Hans Petersen , Martin Markvard Knudsen
IPC分类号： C07D307/87
CPC分类号： C07D307/87
摘要： The present invention is concerned with a process in connection with the purification of a pharmaceutically acceptable salt of escitalopram or citalopram.
摘要翻译：本发明涉及与依他普仑或西酞普兰的药学上可接受的盐的纯化相关的方法。

2. 发明授权

US08067640B2 Method for the separation of intermediates which may be used for the preparation of escitalopram 失效
标题翻译：用于分离可用于制备依他普仑的中间体的方法
公开(公告)号：US08067640B2
公开(公告)日：2011-11-29
申请号：US12781026
申请日：2010-05-17
申请人： Naoki Taoka , Takahisa Kato , Shogo Yamamoto , Takashi Yoshida , Toshihiro Takeda , Yasuyoshi Ueda , Hans Petersen , Robert Dancer , Haleh Ahmadian , Lars O. Lyngso
发明人： Naoki Taoka , Takahisa Kato , Shogo Yamamoto , Takashi Yoshida , Toshihiro Takeda , Yasuyoshi Ueda , Hans Petersen , Robert Dancer , Haleh Ahmadian , Lars O. Lyngso
IPC分类号： C07C57/00
CPC分类号： C07B57/00 , C07B2200/07 , C07C253/30 , C07C253/34 , C07C255/34 , C07C255/59 , C07D307/87 , C12P7/22 , C12P13/001 , C12P13/002 , C12P13/008 , C12P13/02 , C12P41/007
摘要： The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation.
摘要翻译：本发明涉及一种制备具有式（II）的二醇中间体和/或具有式（Ⅳ）的酰化二醇的相反对映异构体的新方法，其可用于制备涉及选择性酶酰化或脱酰基化的依他普仑。

3. 发明申请

US20110065937A1 METHOD FOR THE SEPARATION OF INTERMEDIATES WHICH MAY BE USED FOR THE PREPARATION OF ESCITALOPRAM 失效
标题翻译：用于分离可用于制备ESCITALOPRAM的中间体的方法
公开(公告)号：US20110065937A1
公开(公告)日：2011-03-17
申请号：US12781026
申请日：2010-05-17
申请人： Naoki Taoka , Takahisa Kato , Shogo Yamamoto , Takashi Yoshida , Toshihiro Takeda , Yasuyoshi Ueda , Hans Petersen , Robert Dancer , Haleh Ahmadian , Lars O. Lyngso
发明人： Naoki Taoka , Takahisa Kato , Shogo Yamamoto , Takashi Yoshida , Toshihiro Takeda , Yasuyoshi Ueda , Hans Petersen , Robert Dancer , Haleh Ahmadian , Lars O. Lyngso
IPC分类号： C07D307/87
CPC分类号： C07B57/00 , C07B2200/07 , C07C253/30 , C07C253/34 , C07C255/34 , C07C255/59 , C07D307/87 , C12P7/22 , C12P13/001 , C12P13/002 , C12P13/008 , C12P13/02 , C12P41/007
摘要： The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation.
摘要翻译：本发明涉及一种制备具有式（II）的二醇中间体和/或具有式（Ⅳ）的酰化二醇的相反对映异构体的新方法，其可用于制备涉及选择性酶酰化或脱酰基化的依他普仑。

4. 发明授权

US07723533B2 Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base 有权
标题翻译：依他普仑和包含依他普仑碱的分散片的结晶基
公开(公告)号：US07723533B2
公开(公告)日：2010-05-25
申请号：US12046999
申请日：2008-03-12
申请人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
发明人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
IPC分类号： C07D307/87
CPC分类号： C07D307/81
摘要： The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.
摘要翻译：本发明涉及众所周知的抗抑郁药物依他普仑S-1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃腈的结晶碱，其制剂的所述碱的方法，使用碱，通过所述方法获得的盐以及含有这些盐的制剂来制备依他普仑的纯化盐如草酸盐的方法，以及制备纯化的依他普仑游离碱或其盐的方法使用氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂，例如草酸盐。最后，本发明涉及硬度至少为22N，口服崩解时间小于120秒的可分散片剂，其包含吸附在水溶性填料上的活性药物成分，其中活性药物成分的熔点为 40-100℃的范围，以及制造这种可分散片剂的方法。

5. 发明申请

US20090247772A1 Method for the Preparation of Escitalopram 审中-公开
标题翻译：艾司西酞普兰的制备方法
公开(公告)号：US20090247772A1
公开(公告)日：2009-10-01
申请号：US12085063
申请日：2006-11-14
申请人： Antonio Paulon , Ottorino De Lucchi , Andrea Castellin , Fabrizio Fabris , Federico Sbrogio , Emanuele Ceron , Hans Petersen , Robert Dancer
发明人： Antonio Paulon , Ottorino De Lucchi , Andrea Castellin , Fabrizio Fabris , Federico Sbrogio , Emanuele Ceron , Hans Petersen , Robert Dancer
IPC分类号： C07D307/93 , C07D307/87
CPC分类号： C07D307/87 , C07D407/04
摘要： The invention relates to intermediates and the use thereof in a method for the preparation of escitalopram:
摘要翻译：本发明涉及中间体及其在制备依他普仑方法中的用途：

6. 发明申请

US20080161388A1 CRYSTALLINE BASE OF ESCITALOPRAM AND ORODISPERSIBLE TABLETS COMPRISING ESCITALOPRAM BASE 有权
标题翻译：包括ESCITALOPRAM基板的晶圆和可折叠片
公开(公告)号：US20080161388A1
公开(公告)日：2008-07-03
申请号：US12046984
申请日：2008-03-12
申请人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
发明人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
IPC分类号： A61K31/343 , C07D307/87
CPC分类号： C07D307/81
摘要： The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.
摘要翻译：本发明涉及众所周知的抗抑郁药物依他普仑S-1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃腈的结晶碱，其制剂的所述碱的方法，使用碱，通过所述方法获得的盐以及含有这些盐的制剂来制备依他普仑的纯化盐如草酸盐的方法，以及制备纯化的依他普仑游离碱或其盐的方法使用氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂，例如草酸盐。最后，本发明涉及硬度至少为22N，口服崩解时间小于120秒的可分散片剂，其包含吸附在水溶性填料上的活性药物成分，其中活性药物成分的熔点为 40-100℃的范围，以及制造这种可分散片剂的方法。

7. 发明申请

US20070134119A1 Hydraulic machine 有权
标题翻译：液压机
公开(公告)号：US20070134119A1
公开(公告)日：2007-06-14
申请号：US11635948
申请日：2006-12-08
申请人： Joergen Pedersen , Hans Petersen , Claus Johansen
发明人： Joergen Pedersen , Hans Petersen , Claus Johansen
IPC分类号： F01C1/02 , F01C1/10 , F01C1/063 , F03C2/00
CPC分类号： F04C2/084 , F04C2/10
摘要： A hydraulic machine has a gear wheel (2) with outwardly extending teeth and a gear ring (4) with inwardly extending teeth formed by rollers each of which is supported in a pocket (8) in the gear ring, and pressurized spaces are formed between the gear wheel and the inwardly extending teeth. To keep the wear of the machine small each pocket (8) has at least two different radii (R1, R2, Rn) whereby a radius (R2, Rn) at a smaller displacement from the edge (12) of the pocket is larger than a radius (R1) at a larger displacement from the same edge (12) of the pocket (8).
摘要翻译：液压机具有带齿向外延伸的齿轮（2）和齿轮环（4），齿轮环（4）具有由辊形成的向内延伸的齿，每个齿被支撑在齿圈中的凹槽（8）中，加压空间形成在齿轮和向内延伸的齿。为了保持机器的磨损，每个凹口（8）具有至少两个不同的半径（R 1，R 2，Rn），由此距离口袋的边缘（12）更小的位移处的半径（R 2，Rn）大于从口袋（8）的同一边缘（12）移位较大的半径（R 1）。

8. 发明申请

US20070129561A1 Method for the separation of intermediates which may be used for the preparation of escitalopram 审中-公开
标题翻译：用于分离可用于制备依他普仑的中间体的方法
公开(公告)号：US20070129561A1
公开(公告)日：2007-06-07
申请号：US10524937
申请日：2003-08-12
申请人： Naoki Taoka , Takahisa Kato , Shogo Yamamoto , Takashi Yoshida , Toshihiro Takeda , Yasuyoshi Ueda , Hans Petersen , Robert Dancer , Haleh Ahmadian , Lars Lyngso
发明人： Naoki Taoka , Takahisa Kato , Shogo Yamamoto , Takashi Yoshida , Toshihiro Takeda , Yasuyoshi Ueda , Hans Petersen , Robert Dancer , Haleh Ahmadian , Lars Lyngso
IPC分类号： C07C323/20 , C07C271/40 , C12P13/00 , C12P7/22
CPC分类号： C07B57/00 , C07B2200/07 , C07C253/30 , C07C253/34 , C07C255/34 , C07C255/59 , C07D307/87 , C12P7/22 , C12P13/001 , C12P13/002 , C12P13/008 , C12P13/02 , C12P41/007
摘要： The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation.
摘要翻译：本发明涉及一种制备具有式（II）的二醇中间体和/或具有式（Ⅳ）的酰化二醇的相反对映异构体的新方法，其可用于制备涉及选择性酶酰化或脱酰基化的依他普仑。

9. 发明申请

US20060247451A1 CRYSTALLINE BASE OF CITALOPRAM 审中-公开
公开(公告)号：US20060247451A1
公开(公告)日：2006-11-02
申请号：US11425321
申请日：2006-06-20
申请人： Hans Petersen , Klaus Bogeso , Per Holm
发明人： Hans Petersen , Klaus Bogeso , Per Holm
IPC分类号： C07D307/02
CPC分类号： C07D307/87
摘要： The present invention relates to the crystalline base of the well known antidepressant drug citalopram, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of citalopram, such as the hydrobromide, using the base, the salts obtained by said process and formulations containing such salts.

10. 发明申请

US20060247076A1 Goal detector for detection of an object passing a goal plane 有权
标题翻译：用于检测通过目标平面的物体的目标检测器
公开(公告)号：US20060247076A1
公开(公告)日：2006-11-02
申请号：US10547115
申请日：2004-03-01
申请人： Hans Petersen
发明人： Hans Petersen
IPC分类号： A63B63/00
CPC分类号： A63B24/0021 , A63B43/00 , A63B63/00 , A63B63/004 , A63B71/0605 , A63B2024/0037 , A63B2071/0611 , A63B2102/24 , A63B2220/83 , A63B2220/89 , A63B2225/50 , A63B2243/0025
摘要： A system is disclosed for detection of whether a movable object, such as a sports object, e.g. a football or an ice hockey puck, has passed a flat plane in space, such as a goal plane defined e.g. as a vertical plane extending from a goal line or a horizontal plane defined by the upper rim of the basketball basket The system comprises a plurality of pairs of antennas arranged along the periphery of the flat target plane, the two antennas of each of said pairs being arranged with a mutual displacement in the direction perpendicularly to the flat target plane, radio wave emitter means arranged in the movable object and/or each antenna, and means for receiving the radio waves from the radio wave emitter means and provide an output accordingly arranged in each antenna and/or in the movable object, the system further comprising processing means to receive and process said output together with a predetermined set of conditions and providing a resulting output if the set of conditions are fulfilled so as to determine whether the movable object passes the flat target plane.
摘要翻译：公开了一种用于检测诸如运动物体之类的可移动物体的系统。一个足球或一个冰球冰球已经在太空中经过一个平面飞机，比如一个定位的目标飞机。作为从由篮球篮的上边缘限定的球门线或水平面延伸的垂直平面。该系统包括沿着平面目标平面的周边布置的多对天线，每个所述对的两个天线是在与平面目标平面垂直的方向上相互位移布置，布置在可移动物体和/或每个天线中的无线电波发射器装置和用于从无线电波发射装置接收无线电波的装置，并提供相应地布置在每个天线和/或可移动物体中，所述系统还包括处理装置，用于接收并处理所述输出以及预定的一组条件，并且如果满足条件集合以提供结果输出，以便确定可移动物体是否通过平面目标飞机。

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