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1. 发明申请

US20220289756A1 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF PROTEIN KINASES 有权
公开(公告)号：US20220289756A1
公开(公告)日：2022-09-15
申请号：US17692153
申请日：2022-03-10
申请人： WAI KIT PANG , HEEJIN KIM
发明人： WAI KIT PANG , HEEJIN KIM
IPC分类号： C07D487/04 , C07D277/40 , C07D413/12 , C07D471/04 , C07D417/12 , C07D233/88
摘要： The invention provides small molecule heteroaromatic compounds that are ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency towards resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor resistant diseases, such as imatinib resistant chronic myelogenous leukemia.

2. 发明授权

US09550728B2 Thermo-responsive draw solute for forward osmosis and method for water desalination and purification using the same 有权
标题翻译：用于正向渗透的热敏吸引溶质和使用其的水脱盐和纯化方法
公开(公告)号：US09550728B2
公开(公告)日：2017-01-24
申请号：US14235192
申请日：2012-07-27
申请人： Yan Lee , Minwoo Noh , Yeongbong Mok , Heejin Kim , Seonju Lee , Daichi Nakayama
发明人： Yan Lee , Minwoo Noh , Yeongbong Mok , Heejin Kim , Seonju Lee , Daichi Nakayama
IPC分类号： B01D11/00 , C02F1/44 , B01D61/00 , B01D61/24 , C07C233/05 , C07C233/36 , C07C309/14 , C02F103/08
CPC分类号： C07C233/05 , B01D61/002 , B01D61/005 , C02F1/445 , C02F2103/08 , C02F2303/18 , C07C233/36 , C07C309/14 , Y02A20/131 , Y02W10/37
摘要： The present invention relates to a thermo-responsive draw solute that can be applied to water desalination and purification based on forward osmosis. The thermo-responsive draw solute has a molar mass of 50 to 3000 g/mol and undergoes a phase transition at a temperature of 0° C. to 70° C. The thermo-responsive draw solute creates optimum conditions for the desalination of seawater and the purification of contaminated water based on forward osmosis. The present invention also relates to a method for water desalination and purification using the thermo-responsive draw solute. The method consumes little energy for water desalination or purification, is simple to apply to water desalination or purification, and enables separation of the draw solute in a very easy manner.
摘要翻译：本发明涉及可应用于基于正向渗透的水脱盐和净化的热响应性拉伸溶质。热响应拉伸溶质的摩尔质量为50-3000g / mol，并在0℃至70℃的温度下进行相变。热响应拉伸溶质为海水淡化提供了最佳条件，基于正向渗透的污染水净化。本发明还涉及使用热敏吸引溶质的水脱盐和净化方法。该方法消耗少量用于水脱盐或净化的能量，易于应用于海水淡化或净化，并且能够以非常容易的方式分离吸附溶质。

3. 发明申请

US20080242865A1 PROCESSES FOR THE PREPARATION OF HYDROXYLAMINES 失效
标题翻译：制备羟甲基胺的方法
公开(公告)号：US20080242865A1
公开(公告)日：2008-10-02
申请号：US12135299
申请日：2008-06-09
申请人： Datong Tang , Yao-Ling Qiu , Heejin Kim , Yat Sun Or , Zhe Wang
发明人： Datong Tang , Yao-Ling Qiu , Heejin Kim , Yat Sun Or , Zhe Wang
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):
摘要翻译：本发明一般涉及合成O-（6-吡唑-1-基 - 吡啶-3-基甲基） - 羟胺的新方法，其是合成桥联红霉素衍生物之一及其各自药学上的必需试剂 PCT申请WO 03/097659 A1中的可接受的盐。特别地，本发明涉及制备式（Ia）化合物的方法和中间体：

4. 发明申请

US20080027012A1 BRIDGED CARBAMATE MACROLIDES 审中-公开
公开(公告)号：US20080027012A1
公开(公告)日：2008-01-31
申请号：US11781985
申请日：2007-07-24
申请人： Heejin Kim , Ly Tam Phan , Yat Or
发明人： Heejin Kim , Ly Tam Phan , Yat Or
IPC分类号： A61K31/7048 , A61P31/00 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formulae (I) and (II) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了具有抗菌性质的式（I）和（II）化合物或其药学上可接受的盐，酯或前药。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

5. 发明申请

US20060247440A1 Processes for the preparation of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine 有权
标题翻译：用于制备O-（6-吡唑-1-基 - 吡啶-3-基甲基） - 羟胺的方法
公开(公告)号：US20060247440A1
公开(公告)日：2006-11-02
申请号：US11205764
申请日：2005-08-17
申请人： Datong Tang , Yao-Ling Qiu , Heejin Kim , Yat Or , Zhe Wang
发明人： Datong Tang , Yao-Ling Qiu , Heejin Kim , Yat Or , Zhe Wang
IPC分类号： C07D403/04 , C07D401/00
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):
摘要翻译：本发明一般涉及合成O-（6-吡唑-1-基 - 吡啶-3-基甲基） - 羟胺的新方法，其是合成桥联红霉素衍生物之一及其各自药学上的必需试剂 PCT申请WO 03/097659 A1中的可接受的盐。特别地，本发明涉及制备式（Ia）化合物的方法和中间体：

6. 发明授权

US08964010B2 Display device and method of outputting audio signal 有权
标题翻译：显示装置和输出音频信号的方法
公开(公告)号：US08964010B2
公开(公告)日：2015-02-24
申请号：US13096678
申请日：2011-04-28
申请人： Heejin Kim , Sungkoo Lee
发明人： Heejin Kim , Sungkoo Lee
IPC分类号： H04N13/04 , H04R5/00 , H04N5/60 , G06T7/00 , H04N21/439 , H04N21/44 , H04N21/81 , H04S7/00
CPC分类号： H04N5/60 , G06T7/593 , G06T7/97 , G06T2207/10021 , H04N21/439 , H04N21/44008 , H04N21/816 , H04S7/305 , H04S2400/07 , H04S2420/01
摘要： A display device receives first data for an object to be displayed at a first point in time and second data for the object to be displayed at a second point in time, the second point in time being after the first point in time. A controller determines a difference between the first and second data and controls output of an audio signal based on the difference. The difference is indicative of a change in perceived depth by a viewer.
摘要翻译：显示装置在第一时间点接收要显示的对象的第一数据和在第二时间点显示的对象的第二数据，第二时间点在第一时间点之后。控制器确定第一和第二数据之间的差异，并且基于该差异来控制音频信号的输出。差异表示观众感知深度的变化。

7. 发明申请

US20140158621A1 THERMO-RESPONSIVE DRAW SOLUTE FOR FORWARD OSMOSIS AND METHOD FOR WATER DESALINATION AND PURIFICATION USING THE SAME 有权
标题翻译：用于前向麻醉的热反应性溶液和使用其的水脱盐和纯化方法
公开(公告)号：US20140158621A1
公开(公告)日：2014-06-12
申请号：US14235192
申请日：2012-07-27
申请人： Yan Lee , Minwoo Noh , Yeongbong Mok , Heejin Kim , Seonju Lee , Daichi Nakayama
发明人： Yan Lee , Minwoo Noh , Yeongbong Mok , Heejin Kim , Seonju Lee , Daichi Nakayama
IPC分类号： C07C233/05 , C07C233/36 , C07C309/14 , C02F1/44
CPC分类号： C07C233/05 , B01D61/002 , B01D61/005 , C02F1/445 , C02F2103/08 , C02F2303/18 , C07C233/36 , C07C309/14 , Y02A20/131 , Y02W10/37
摘要： The present invention relates to a thermo-responsive draw solute that can be applied to water desalination and purification based on forward osmosis. The thermo-responsive draw solute has a molar mass of 50 to 3000 g/mol and undergoes a phase transition at a temperature of 0° C. to 70° C. The thermo-responsive draw solute creates optimum conditions for the desalination of seawater and the purification of contaminated water based on forward osmosis. The present invention also relates to a method for water desalination and purification using the thermo-responsive draw solute. The method consumes little energy for water desalination or purification, is simple to apply to water desalination or purification, and enables separation of the draw solute in a very easy manner.
摘要翻译：本发明涉及可应用于基于正向渗透的水脱盐和净化的热响应性拉伸溶质。热响应拉伸溶质的摩尔质量为50-3000g / mol，并在0℃至70℃的温度下进行相变。热敏吸引溶质为海水淡化提供了最佳条件，基于正向渗透的污染水净化。本发明还涉及使用热敏吸引溶质的水脱盐和净化方法。该方法消耗少量用于水脱盐或净化的能量，易于应用于海水淡化或净化，并且能够以非常容易的方式分离吸附溶质。

8. 发明授权

US08582282B2 Display apparatus 有权
标题翻译：显示装置
公开(公告)号：US08582282B2
公开(公告)日：2013-11-12
申请号：US13031985
申请日：2011-02-22
申请人： Heejin Kim , Sangdon Park
发明人： Heejin Kim , Sangdon Park
IPC分类号： G06F1/16
CPC分类号： H04N5/65 , H04N5/645
摘要： Disclosed with are a display apparatus. The apparatus includes a display module; a front panel disposed on a front of the display module; a first supporting member including a plurality of surfaces formed in directions perpendicular to each other, a first surface of the plurality of surfaces being fixed to the front panel and a second surface being fixed to the display module; and a bezel formed on an outer edge region of the display apparatus to surround a edge of the front panel.
摘要翻译：公开了一种显示装置。该装置包括显示模块; 布置在所述显示模块的前面的前面板; 第一支撑构件，其包括在彼此垂直的方向上形成的多个表面，所述多个表面中的第一表面固定到所述前面板，并且第二表面固定到所述显示模块; 以及形成在所述显示装置的外缘区域上以围绕所述前面板的边缘的边框。

9. 发明申请

US20070244160A1 6-11 Bicyclic Ketolide Derivatives 审中-公开
标题翻译： 6-11双环酮内酯衍生物
公开(公告)号：US20070244160A1
公开(公告)日：2007-10-18
申请号：US11758225
申请日：2007-06-05
申请人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
IPC分类号： A61K31/44 , A61P31/04
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

10. 发明申请

US20050159370A1 6-11 Bicyclic ketolide derivatives 有权
公开(公告)号：US20050159370A1
公开(公告)日：2005-07-21
申请号：US11042720
申请日：2005-01-25
申请人： Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
发明人： Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
IPC分类号： A61K31/7052 , A61K45/06 , C07H17/08
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

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