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1. 发明申请

US20150218601A1 MICROBIOLOGICAL PRODUCTION OF 3-HYDROXYISOBUTYRIC ACID 审中-公开
标题翻译： 3-羟基丁酸的微生物生产
公开(公告)号：US20150218601A1
公开(公告)日：2015-08-06
申请号：US14624713
申请日：2015-02-18
申请人： Achim MARX , Markus Poetter , Stefan Buchholz , Alexander May , Hermann Siegert , Georg Fuchs , Birgit Alber , Lothar Eggeling
发明人： Achim MARX , Markus Poetter , Stefan Buchholz , Alexander May , Hermann Siegert , Georg Fuchs , Birgit Alber , Lothar Eggeling
IPC分类号： C12P7/42 , C12N9/88 , C08F120/10 , C12N9/10 , C08F120/06 , C12N9/16 , C12N9/02
CPC分类号： C12P7/42 , C08F120/06 , C08F120/10 , C12N9/0008 , C12N9/001 , C12N9/1096 , C12N9/16 , C12N9/88 , C12P7/40 , C12P7/52 , C12P7/625 , C12Y102/04004 , C12Y103/99012 , C12Y206/01042 , C12Y301/02004 , C12Y402/01017
摘要： The present invention relates to a cell which has been modified in comparison with its wild type in such a way that it is capable of forming more, by comparison with its wild, 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid via methylmalonate-semialdehyde or 3-hydroxybutyryl-coenzyme A as precursors. The invention also relates to a method of generating a genetically modified cell, to the genetically modified cell obtainable by these methods, to a method of producing 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid, to a method of producing methacrylic acid or methacrylic esters, and to a method of producing polymethacrylic acid or polymethacrylic esters. The present invention furthermore relates to an isolated DNA, to a vector, to the use of this vector for transforming a cell, to a transformed cell, and to a polypeptide.
摘要翻译：本发明涉及与其野生型相比已被修饰的细胞，使得其能够通过与其野生型3-羟基异丁酸或基于3-羟基异丁酸的聚羟基链烷酸通过甲基丙二酸酯 - 半醛或3-羟基丁酰辅酶A作为前体。本发明还涉及生产基于3-羟基异丁酸的3-羟基异丁酸或聚羟基链烷酸酯的生产方法，该方法可以通过这些方法产生遗传修饰的细胞，生产甲基丙烯酸或其制备方法甲基丙烯酸酯，以及生产聚甲基丙烯酸或聚甲基丙烯酸酯的方法。本发明还涉及分离的DNA，载体，使用该载体转化细胞，转化细胞和多肽。

2. 发明申请

US20110306784A1 METHOD FOR PRODUCING A CARBOXYLIC ACID AMIDE FROM A CARBONYL COMPOUND AND HYDROCYANIC ACID 有权
标题翻译：从碳化合物和羟基酸生产羧酸酰胺的方法
公开(公告)号：US20110306784A1
公开(公告)日：2011-12-15
申请号：US13131462
申请日：2009-10-29
申请人： Alexander May , Martin Koestner , Joerg Becker , Joerg Schallenberg , Hermann Siegert , Bernd Vogel
发明人： Alexander May , Martin Koestner , Joerg Becker , Joerg Schallenberg , Hermann Siegert , Bernd Vogel
IPC分类号： C07C67/20 , C07C231/24
CPC分类号： C07C231/06 , C07C231/065 , C07C231/14 , C07C253/00 , C07C233/09 , C07C255/16
摘要： The invention relates to a method for producing a carboxylic acid amide from a carbonyl compound and hydrocyanic acid, comprising the steps of A) reacting a carbonyl compound with hydrocyanic acid to produce a hydroxycarboxylic acid nitrile, B) hydrolysis of the hydroxycarboxylic acid nitrile obtained in step A) in the presence of a catalyst comprising manganese dioxide, wherein a molar excess of carbonyl compound is used in relation to the hydrocyanic acid to react the carbonyl compound with hydrocyanic acid according to step A), and the reaction mixture obtained in step A) is not purified by distillation before the hydrolysis according to step B) is carried out. The invention furthermore relates to a method for producing alkyl(meth)acrylates from polymers, moulding compounds and moulded bodies, wherein a method for producing a carboxylic acid amide from a carbonyl compound and hydrocyanic acid is carried out in accordance with the method described above.
摘要翻译：本发明涉及一种由羰基化合物和氢氰酸制备羧酸酰胺的方法，包括以下步骤：a）使羰基化合物与氢氰酸反应生成羟基羧酸腈，B）水解得到的羟基羧酸腈步骤A）在包含二氧化锰的催化剂存在下，其中相对于氢氰酸使用摩尔过量的羰基化合物以使羰基化合物与氢氰酸根据步骤A）反应，并将步骤A中获得的反应混合物）在根据步骤B）进行水解之前未经蒸馏纯化。本发明还涉及从聚合物，成型化合物和成型体制备（甲基）丙烯酸烷基酯的方法，其中根据上述方法由羰基化合物和氢氰酸制备羧酸酰胺的方法。

3. 发明授权

US07928251B2 Process for preparing tetramethyl glycolide 有权
标题翻译：制备四甲基乙交酯的方法
公开(公告)号：US07928251B2
公开(公告)日：2011-04-19
申请号：US12443784
申请日：2007-08-30
申请人： Bernd Vogel , Alexander May , Hermann Siegert
发明人： Bernd Vogel , Alexander May , Hermann Siegert
IPC分类号： C07D319/12
CPC分类号： C07D319/12
摘要： The present invention relates to a process for preparing tetramethylglycolide by heating a composition which comprises at least 50% by weight of 2-hydroxy-isobutyric acid and/or tetramethylglycolide to a temperature of at least 100° C.
摘要翻译：本发明涉及一种通过将包含至少50重量％的2-羟基 - 异丁酸和/或四甲基乙二醇酸的组合物加热至至少100℃的温度来制备四甲基乙交酯的方法。

4. 发明申请

US20100029979A1 PROCESS FOR PREPARING (METH)ACRYLIC ACID 失效
标题翻译：制备（甲基）丙烯酸的方法
公开(公告)号：US20100029979A1
公开(公告)日：2010-02-04
申请号：US12442415
申请日：2007-08-30
申请人： Bernd Vogel , Alexander May , Hermann Siegert
发明人： Bernd Vogel , Alexander May , Hermann Siegert
IPC分类号： C07C51/09 , C07C67/00
CPC分类号： C07C51/377 , C07C57/04
摘要： The present invention relates to a process for preparing (meth)acrylic acid, characterized in that a cyclic ester is converted to (meth)acrylic acid in the presence of a catalyst. The (meth)acrylic acid prepared can in particular be converted to (meth)acrylates.
摘要翻译：本发明涉及一种制备（甲基）丙烯酸的方法，其特征在于在催化剂存在下将环酯转化为（甲基）丙烯酸。所制备的（甲基）丙烯酸特别可以转化为（甲基）丙烯酸酯。

5. 发明申请

US20100010276A1 PROCESS FOR PREPARING TETRAMETHYL GLYCOLIDE 有权
标题翻译：制备四甲基甘氨酸的方法
公开(公告)号：US20100010276A1
公开(公告)日：2010-01-14
申请号：US12443784
申请日：2007-08-30
申请人： Bernd Vogel , Alexander May , Hermann Siegert
发明人： Bernd Vogel , Alexander May , Hermann Siegert
IPC分类号： C07C29/60
CPC分类号： C07D319/12
摘要： The present invention relates to a process for preparing tetramethylglycolide by heating a composition which comprises at least 50% by weight of 2-hydroxy-isobutyric acid and/or tetramethylglycolide to a temperature of at least 100° C.
摘要翻译：本发明涉及一种通过将包含至少50重量％的2-羟基 - 异丁酸和/或四甲基乙二醇酸的组合物加热至至少100℃的温度来制备四甲基乙交酯的方法。

6. 发明申请

US20080269431A1 Apparatus and Method for Continuously Carried Out Equilibrium Reactions 审中-公开
标题翻译：用于连续进行平衡反应的装置和方法
公开(公告)号：US20080269431A1
公开(公告)日：2008-10-30
申请号：US11995206
申请日：2006-08-16
申请人： Dirk Sarcinelli , Hermann Siegert
发明人： Dirk Sarcinelli , Hermann Siegert
IPC分类号： C08F2/01 , C08G69/02 , C08G63/02
CPC分类号： B01J4/002 , B01J19/006 , B01J2219/00083 , B01J2219/00777 , C07C67/03 , Y02P20/582 , C07C69/54
摘要： The invention relates to an apparatus and a process for carrying out equilibrium reactions continuously.
摘要翻译：本发明涉及连续进行平衡反应的装置和方法。

7. 发明授权

US09234218B2 Process for preparing methacrylic acid or methacrylic esters 有权
标题翻译：制备甲基丙烯酸或甲基丙烯酸酯的方法
公开(公告)号：US09234218B2
公开(公告)日：2016-01-12
申请号：US12602593
申请日：2008-05-30
申请人： Achim Marx , Markus Poetter , Stefan Buchholz , Alexander May , Hermann Siegert , Birgit Alber , Georg Fuchs , Lothar Eggeling
发明人： Achim Marx , Markus Poetter , Stefan Buchholz , Alexander May , Hermann Siegert , Birgit Alber , Georg Fuchs , Lothar Eggeling
IPC分类号： C12P7/42 , C12P7/52 , C12N9/02 , C12P7/40 , C12P7/62 , C08F120/06 , C08F120/10 , C12N9/10 , C12N9/16 , C12N9/88
CPC分类号： C12P7/42 , C08F120/06 , C08F120/10 , C12N9/0008 , C12N9/001 , C12N9/1096 , C12N9/16 , C12N9/88 , C12P7/40 , C12P7/52 , C12P7/625 , C12Y102/04004 , C12Y103/99012 , C12Y206/01042 , C12Y301/02004 , C12Y402/01017
摘要： The present invention relates to a process for the preparation of methacrylic acid or methacrylic esters, comprising the process steps of IA) preparation of 3-hydroxyisobutyric acid by a process comprising the process step of bringing a cell which has been genetically modified in comparison with its wild type in such a way that it is capable of forming more 3-hydroxyisobutyric acid, or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid in comparison with its wild type, into contact with a nutrient medium comprising, as carbon source, carbohydrates, glycerol, carbon dioxide, methanol, L-valine or L-glutamate under conditions under which 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid are formed from the carbon source, if appropriate, isolation of the 3-hydroxyisobutyric acid from the nutrient medium and also, if appropriate, neutralization of the 3-hydroxyisobutyric acid, IB) dehydration of the 3-hydroxyisobutyric acid with formation of methacrylic acid and also, where appropriate, esterification methacrylic acid. The invention also relates to a process for the preparation of polymethacrylic acid or polymethacrylic esters.
摘要翻译：本发明涉及一种制备甲基丙烯酸或甲基丙烯酸酯的方法，其包括以下工艺步骤：IA）通过包括以下步骤的方法制备3-羟基异丁酸，所述方法包括将经遗传修饰的细胞与其野生型，使得其能够形成更多的3-羟基异丁酸或与其野生型相比基于3-羟基异丁酸的聚羟基链烷酸酯与营养培养基接触，所述营养培养基包含作为碳源的碳水化合物，甘油，碳二氧化物，甲醇，L-缬氨酸或L-谷氨酸盐，其中3-羟基异丁酸或基于3-羟基异丁酸的聚羟基链烷酸酯由碳源形成的条件下，如果合适，则从营养培养基中分离出3-羟基异丁酸，如果适当，中和3-羟基异丁酸，IB）3-羟基异丁酸脱水形成甲基丙烯酸酸，并且在适当的情况下酯化甲基丙烯酸。本发明还涉及一种制备聚甲基丙烯酸或聚甲基丙烯酸酯的方法。

8. 发明授权

US08791296B2 Process for preparing methacrylic acid 有权
标题翻译：制备甲基丙烯酸的方法
公开(公告)号：US08791296B2
公开(公告)日：2014-07-29
申请号：US14113228
申请日：2012-04-24
申请人： Dirk Broell , Hermann Siegert , Horst Hiltner , Thomas Krauss
发明人： Dirk Broell , Hermann Siegert , Horst Hiltner , Thomas Krauss
IPC分类号： C07C51/44
CPC分类号： C07C51/09 , C07C67/20 , Y02P20/582 , C07C57/04 , C07C69/54
摘要： The present invention relates to a process for preparing methacrylic acid based on the hydrolysis of methacrylic esters.
摘要翻译：本发明涉及一种基于甲基丙烯酸酯水解制备甲基丙烯酸的方法。

9. 发明授权

US08207371B2 Process for preparing (meth)acrylic acid 失效
标题翻译：制备（甲基）丙烯酸的方法
公开(公告)号：US08207371B2
公开(公告)日：2012-06-26
申请号：US12442415
申请日：2007-08-30
申请人： Bernd Vogel , Alexander May , Hermann Siegert
发明人： Bernd Vogel , Alexander May , Hermann Siegert
IPC分类号： C07C67/30 , C07C35/00
CPC分类号： C07C51/377 , C07C57/04
摘要： The present invention relates to a process for preparing (meth)acrylic acid, characterized in that a cyclic ester is converted to (meth)acrylic acid in the presence of a catalyst. The (meth)acrylic acid prepared can in particular be converted to (meth)acrylates.
摘要翻译：本发明涉及一种制备（甲基）丙烯酸的方法，其特征在于在催化剂存在下将环酯转化为（甲基）丙烯酸。所制备的（甲基）丙烯酸特别可以转化为（甲基）丙烯酸酯。

10. 发明授权

US08084640B2 Method for the continuous production of unsaturated carboxylic acid anhydrides 有权
标题翻译：连续生产不饱和羧酸酐的方法
公开(公告)号：US08084640B2
公开(公告)日：2011-12-27
申请号：US12299217
申请日：2007-03-14
申请人： Dirk Broell , Hermann Siegert
发明人： Dirk Broell , Hermann Siegert
IPC分类号： C07C65/00
CPC分类号： C07C51/56 , C07C51/567 , Y02P20/582 , C07C57/04
摘要： Process for continuously preparing unsaturated carboxylic anhydrides of the general formula I R—C(O)—O—C(O)—R (I) in which R is an unsaturated organic radical having 2 to 12 carbon atoms by transanhydridization of an aliphatic carboxylic anhydride with a carboxylic acid of the general formula II R—COOH (II) in which R is as defined above in a rectification column having an upper, middle and lower region, characterized in that f) an inert boiling oil is initially charged in the bottom of the column, g) the reactants are fed into a reaction region in stoichiometric ratios, h) the carboxylic acid formed as the by-product is withdrawn at the top of the column, i) the unconverted reactants are recycled into the reaction region and j) the product of the formula I is obtained via a side draw, preferably between the middle and lower column region.
摘要翻译：用于连续制备通式IR-C（O）-O-C（O）-R（I）的不饱和羧酸酐的方法，其中R是具有2至12个碳原子的不饱和有机基团，通过脂族羧酸酐的反式氢化与具有上，中，下区域的精馏塔中的R如上定义的通式II R-COOH（II）的羧酸反应，其特征在于f）惰性沸腾油最初装入底部，g）将反应物以化学计量比进料到反应区域中，h）作为副产物形成的羧酸在塔的顶部排出，i）将未转化的反应物再循环到反应区域中， j）式I的产物通过侧拉取得，优选在中间和下部区域之间。

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