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1. 发明授权

US09499838B2 Human artificial chromosome containing human antibody λ light chain gene and non-human animal containing the human artificial chromosome capable of genetic transmission 有权
标题翻译：含有人抗体λ轻链基因的人类人造染色体和含有能够遗传传播的人类人造染色体的非人动物
公开(公告)号：US09499838B2
公开(公告)日：2016-11-22
申请号：US12140009
申请日：2008-06-16
申请人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
发明人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
IPC分类号： A01K67/027 , C12P21/00 , C12N15/85 , C07K16/00 , C07K16/24 , C12N15/87 , C12N15/90 , A61K48/00 , A61K39/00
CPC分类号： A01K67/0278 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/052 , A01K2217/054 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A01K2267/0381 , A61K48/00 , A61K2039/505 , C07K16/00 , C07K16/243 , C07K2317/21 , C12N15/8509 , C12N15/87 , C12N15/90 , C12N2800/30
摘要： The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
摘要翻译：本发明涉及一种以高效率遗传传播到下一代的人类人造染色体及其使用方法。更具体地，本发明涉及：人类人造染色体，其中含有源自人染色体22的抗体λ轻链基因的约3.5Mb至约1Mb区域与染色体片段结合，该染色体片段可通过生殖系的非人类动物，所述染色体片段衍生自另一个人染色体; 携带人类人造染色体的非人类动物及其后代; 一种生产非人动物的方法; 使用非人动物或其后代生产人抗体的方法; 和携带人类人造染色体的人抗体生产小鼠。

2. 发明授权

US09363411B2 Data certification system, server device, client device, publishing server, and data certification method 有权
标题翻译：数据认证系统，服务器设备，客户端设备，发布服务器和数据认证方法
公开(公告)号：US09363411B2
公开(公告)日：2016-06-07
申请号：US14240521
申请日：2012-04-27
申请人： Shinichi Murao , Masakazu Uehata , Hitoshi Yoshida , Toshio Takahashi
发明人： Shinichi Murao , Masakazu Uehata , Hitoshi Yoshida , Toshio Takahashi
IPC分类号： H04L9/32 , H04N1/32 , G06T1/00
CPC分类号： H04N1/32336 , G06T1/0021 , G06T2201/0062 , G06T2201/0064 , G06T2201/0065 , H04L9/321 , H04L9/3239 , H04L9/3297 , H04N1/32352
摘要： A data certification system includes a proof information generation unit that generates certification information for certifying non-falsification of raw data, and generates proof information including the certification information and time information representing the time of the generation of the certification information. A server transmission unit transmits the proof information which is received by a client reception unit. A time information acquisition unit acquires the time information representing the time of the generation of the certification information from the proof information. A report generation unit generates report data in which the time information and publishing destination information representing a publishing destination are included in the raw data. A transfer unit transfers the raw data, the proof information, and the report data to a publishing server which releases the report data. An output unit outputs the report data.
摘要翻译：数据认证系统包括证明信息生成单元，其生成用于认证原始数据的非伪造的认证信息，并且生成包括认证信息的证明信息和表示认证信息生成的时间的时间信息。服务器发送单元发送由客户接收单元接收的证明信息。时间信息获取单元从证明信息获取表示认证信息生成时间的时间信息。报告生成单元生成报告数据，其中表示发布目的地的时间信息和发布目的地信息被包括在原始数据中。转移单元将原始数据，证明信息和报告数据传送到发布报告数据的发布服务器。输出单元输出报告数据。

3. 发明授权

US09290569B2 Anti FGF23 antibody and a pharmaceutical composition comprising the same 有权
标题翻译：抗FGF23抗体和包含其的药物组合物
公开(公告)号：US09290569B2
公开(公告)日：2016-03-22
申请号：US13019557
申请日：2011-02-02
申请人： Yuji Yamazaki , Itaru Urakawa , Hitoshi Yoshida , Yukiko Aono , Takeyoshi Yamashita , Takashi Shimada , Hisashi Hasegawa
发明人： Yuji Yamazaki , Itaru Urakawa , Hitoshi Yoshida , Yukiko Aono , Takeyoshi Yamashita , Takashi Shimada , Hisashi Hasegawa
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/244 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).
摘要翻译：提供针对FGF23的抗体和通过使用抗体抑制FGF23的作用可以预防或治疗的药物组合物，例如预防或治疗剂。由杂交瘤C10（登录号FERM BP-10772）产生的针对人FGF23的抗体或其功能片段。

4. 发明申请

US20130045617A1 CONTACT AND METHOD FOR MANUFACTURING METAL COMPONENT 有权
标题翻译：用于制造金属部件的接触和方法
公开(公告)号：US20130045617A1
公开(公告)日：2013-02-21
申请号：US13266936
申请日：2011-03-24
申请人： Hitoshi Yoshida , Hidekazu Yoshioka , Takaaki Suzumura , Jiro Koyama
发明人： Hitoshi Yoshida , Hidekazu Yoshioka , Takaaki Suzumura , Jiro Koyama
IPC分类号： H01R13/62 , H01R13/40 , C25D1/00 , H01R13/02
CPC分类号： H01R12/88 , H01R12/778
摘要： A method for manufacturing a metal component includes the steps of forming a resist film on a surface of an electrode plate, making the resist film exposed to light by use of a photomask having a mask pattern, in at least part of a rim of which a fine concavity and convexity are drawn, developing the resist film, to form an opening for molding in the resist film, and epositing an electroforming material by electroforming inside the opening for molding, to mold the material.
摘要翻译：一种制造金属部件的方法包括以下步骤：在电极板的表面上形成抗蚀剂膜，通过使用具有掩模图案的光掩模使抗蚀剂膜暴露于光，其边缘的至少一部分为制成微小的凹凸，显影抗蚀剂膜，形成抗蚀剂膜中的成型用开口，通过在成形用开口内电铸而形成电铸材料，使其成型。

5. 发明申请

US20120238118A1 CONNECTOR 有权
标题翻译：连接器
公开(公告)号：US20120238118A1
公开(公告)日：2012-09-20
申请号：US13258223
申请日：2011-03-24
申请人： Hitoshi Yoshida , Hidekazu Yoshioka , Takaaki Suzumura , Yoshinobu Yamazaki , Takanobu Nagata
发明人： Hitoshi Yoshida , Hidekazu Yoshioka , Takaaki Suzumura , Yoshinobu Yamazaki , Takanobu Nagata
IPC分类号： H01R13/40 , C25D1/00 , H01R13/62
CPC分类号： H01R12/57 , C25D1/003 , H01R12/79 , H01R12/88
摘要： A connecting terminal for a connector has a fixed portion configured to be connected to an electrode portion provided in a member for mounting the connector, and a contact configured to electrically come in contact with a contact portion of a connected portion to be connected to the connector. At least one concave portion is provided along a whole outer peripheral surface of the connector terminal.
摘要翻译：用于连接器的连接端子具有固定部分，该固定部分被配置为连接到设置在用于安装连接器的部件中的电极部分，以及触点，被配置为与要连接到连接器的连接部分的接触部分接触。沿着连接器端子的整个外周面设置至少一个凹部。

6. 发明授权

US08049919B2 Image processing apparatus 有权
标题翻译：图像处理装置
公开(公告)号：US08049919B2
公开(公告)日：2011-11-01
申请号：US12289229
申请日：2008-10-23
申请人： Hitoshi Yoshida
发明人： Hitoshi Yoshida
IPC分类号： G06F3/12
CPC分类号： H04N1/00891 , G03G15/5004 , G03G15/5079 , H04N1/00222 , H04N2201/001 , H04N2201/0072 , H04N2201/3205 , H04N2201/3207
摘要： An image processing apparatus is connected to a specific network for processing an image according to image information input to the image processing apparatus. The image processing apparatus includes an apparatus information storage unit for storing apparatus information of other apparatus connected to the network; an inquiry unit for inquiring an operational state of the other apparatus according to the apparatus information stored in the apparatus information storage unit; a determining unit for determining the operational state of the other apparatus according to an inquiry result of the inquiry unit; and a switching control unit for switching an operational state of the image processing apparatus between an active state and a power save state according to a number of apparatus that the determining unit determines as being in the active state.
摘要翻译：图像处理装置连接到特定网络，用于根据输入到图像处理装置的图像信息处理图像。图像处理装置包括：设备信息存储单元，用于存储连接到网络的其他设备的设备信息; 查询单元，用于根据存储在设备信息存储单元中的设备信息查询其他设备的操作状态; 确定单元，用于根据查询单元的查询结果确定其他设备的操作状态; 以及切换控制单元，用于根据确定单元确定为处于活动状态的设备的数量，在活动状态和省电状态之间切换图像处理设备的操作状态。

7. 发明申请

US20110051192A1 Printing system and printer with setting switch 有权
标题翻译：打印系统和带打印机的打印机
公开(公告)号：US20110051192A1
公开(公告)日：2011-03-03
申请号：US12926180
申请日：2010-10-29
申请人： Hitoshi Yoshida
发明人： Hitoshi Yoshida
IPC分类号： G06F15/00
CPC分类号： G06F3/1285 , G06F3/1203 , G06F3/121 , G06F3/1226 , G06F3/1229 , G06F3/1236
摘要： A host device is connected to at least one printer through a network. Before printing, the host device broadcasts a query on the network, selects a printer that replies to the query, and sends printer setting information to the printer. The printer includes a setting switch that can be set to different states to accept or reject the printer setting information. A printer replies to the query only if its setting switch is set to the state that accepts the printer setting information. The setting switch avoids the generation of unnecessary replies and thereby simplifies the selection of the printer, as well as protecting the printer from unwanted alteration of its settings.
摘要翻译：主机设备通过网络连接至至少一台打印机。在打印之前，主机设备在网络上广播查询，选择回复查询的打印机，并向打印机发送打印机设置信息。打印机包括一个设置开关，可以设置为不同的状态来接受或拒绝打印机设置信息。只有打印机的设置开关设置为接受打印机设置信息的状态，打印机才会回复查询。设置开关避免了不必要的回复的产生，从而简化了打印机的选择，以及保护打印机免受其设置的不必要的改变。

8. 发明授权

US07801051B2 Network system, node device and management server 失效
标题翻译：网络系统，节点设备和管理服务器
公开(公告)号：US07801051B2
公开(公告)日：2010-09-21
申请号：US11964210
申请日：2007-12-26
申请人： Takuro Mori , Kazuma Yumoto , Hitoshi Yoshida
发明人： Takuro Mori , Kazuma Yumoto , Hitoshi Yoshida
IPC分类号： H04J3/14 , G06F11/00
CPC分类号： H04L47/10 , H04L47/11 , H04L47/283
摘要： Erroneous detection of a failure in spite of the absence of failure on the route on account of a communication delay is to be prevented. A node device detects a failure on the route to a remote node device is detected by a failure to receive a packet from the remote node device after the elapse of a determined detection time. The node device sets “remote system transmission interval×detection multiplier” to be a first detecting time on the basis of a packet transmission interval determined by negotiation with the remote node device. It also sets the sum of “remote system actual transmission interval ×detection multiplier” and “tolerable delay time” to be a second detecting time. The first detecting time and the second detecting time are compared, and what is longer is determined as the detecting time to be applied to actual operation.
摘要翻译：考虑到由于通信延迟而导致路由不存在故障，故障的错误检测是可以防止的。在经过确定的检测时间之后，通过从远程节点设备接收到分组的故障来检测节点设备检测到到远程节点设备的路由的故障。节点设备基于通过与远程节点设备协商确定的分组传输间隔将“远程系统传输间隔×检测乘数”设置为第一检测时间。它还将“远程系统实际发送间隔×检测乘数”和“可容忍延迟时间”的和设置为第二检测时间。比较第一检测时间和第二检测时间，将更长的时间确定为要应用于实际操作的检测时间。

9. 发明申请

US20100196359A1 Human Monoclonal Antibody Human CD134 (Ox40) and Methods of Making and Using Same 有权
标题翻译：人单克隆抗体人CD134（Ox40）及其制备和使用方法
公开(公告)号：US20100196359A1
公开(公告)日：2010-08-05
申请号：US12087436
申请日：2006-11-27
申请人： Shinichiro Kato , Rachel Soloff , Hitoshi Yoshida , Michael Croft
发明人： Shinichiro Kato , Rachel Soloff , Hitoshi Yoshida , Michael Croft
IPC分类号： A61K39/395 , C07K16/00 , A61P3/10 , A61P1/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C12N2799/026
摘要： The invention provides antibodies that specifically bind to OX40 (CD134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention antibodies that specifically bind to OX40 include mammalian (human, primate, etc.), humanized and chimeric anti-OX40 antibodies. Invention antibodies and antibody subsequences (fragments) that specifically bind to OX40 include purified and isolated antibodies, as well as pharmaceutical formulations thereof, are useful in various methods including treatment, screening and detection methods.
摘要翻译：本发明提供特异性结合OX40（CD134），称为OX40抗体，抗OX40或抗OX40抗体的抗体。特异性结合OX40的本发明抗体包括哺乳动物（人，灵长类动物等），人源化和嵌合抗OX40抗体。特异性结合OX40的本发明抗体和抗体子序列（片段）包括纯化和分离的抗体及其药物制剂，可用于各种方法，包括治疗，筛选和检测方法。

10. 发明申请

US20090253902A1 Isolation of a rearranged human immunoglobulin gene from a chimeric mouse and recombinant production of the encoded immunoglobulin 有权
标题翻译：从嵌合小鼠中分离重排的人免疫球蛋白基因并重组产生编码的免疫球蛋白
公开(公告)号：US20090253902A1
公开(公告)日：2009-10-08
申请号：US11797904
申请日：2007-05-08
申请人： Kazuma Tomizuka , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida
发明人： Kazuma Tomizuka , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida
IPC分类号： C07H21/04
CPC分类号： A01K67/0275 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C07K16/00 , C07K16/18 , C07K2317/21 , C12N15/8509 , C12N15/90 , C12N2517/02 , C12N2800/30
摘要： The specification relates to a method for producing a chimeric non-human animal, which comprises preparing a microcell containing a foreign chromosome(s) or a fragment(s) thereof and transferring the foreign chromosome(s) or fragment(s) thereof into a pluripotent cell by fusion with the microcell; a chimeric non-human animal which can be produced by the above method and its progeny; tissues and cells derived therefrom; and a method for using the same. Further, a pluripotent cell containing a foreign chromosome(s) or a fragment(s) thereof, a method for producing the same, and a method for using the same are also provided. Moreover, a pluripotent cell in which at least two endogenous genes are disrupted, and a method for producing the same by homologous recombination are provided.
摘要翻译：本说明书涉及嵌合非人动物的制造方法，其包括制备含有外来染色体或其片段的微细胞，并将其外来的染色体或片段转移到多细胞与微细胞融合; 可以通过上述方法及其后代产生的嵌合非人动物; 从其衍生的组织和细胞; 及其使用方法。此外，还提供了含有外来染色体或其片段的多能细胞，其制备方法及其使用方法。此外，提供其中至少两个内源基因被破坏的多能细胞，以及通过同源重组产生其的方法。

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