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1. 发明申请

US20140275479A1 SPECIFIC BINDING AGENTS OF HUMAN ANGIOPOEITIN-2 审中-公开
标题翻译：人类神经母细胞瘤-2特异性结合剂
公开(公告)号：US20140275479A1
公开(公告)日：2014-09-18
申请号：US14290531
申请日：2014-05-29
申请人： Jonathan Daniel OLINER , Hosung MIN
发明人： Jonathan Daniel OLINER , Hosung MIN
IPC分类号： C07K14/00 , A61K47/48
CPC分类号： C07K14/001 , A61K47/68 , C07K7/06 , C07K7/08 , C07K14/00 , C07K16/22 , C07K2317/73 , C07K2317/92 , C07K2319/30 , C07K2319/32
摘要： Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.
摘要翻译：公开了结合Ang-2的肽。还公开了包含肽的肽类，制备这些肽和肽类的方法，以及使用这些肽和肽抗体的治疗方法。

2. 发明申请

US20110158994A1 POLYPEPTIDES SPECIFICALLY BINDING TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 AND METHODS THEREFOR 有权
标题翻译：多肽与血管内皮生长因子受体2的特异性结合及其方法
公开(公告)号：US20110158994A1
公开(公告)日：2011-06-30
申请号：US12973468
申请日：2010-12-20
申请人： A-yeon CHO , Min-kyung KIM , Brian Hosung MIN , Jong-sang RYU
发明人： A-yeon CHO , Min-kyung KIM , Brian Hosung MIN , Jong-sang RYU
IPC分类号： A61K39/395 , C07K7/06 , C07K19/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/06 , A61P35/00
CPC分类号： C07K14/475 , C07K2319/30
摘要： A polypeptide inhibiting binding between vascular endothelial growth factor receptor-2 and a vascular endothelial growth factor, a fusion protein including the same, and a method of preparing the fusion protein are disclosed.
摘要翻译：公开了抑制血管内皮生长因子受体-2与血管内皮生长因子之间的结合的多肽，包含其的融合蛋白和制备融合蛋白的方法。

3. 发明授权

US07790674B2 Methods of treatment using specific binding agents of human angiopoietin-2 有权
公开(公告)号：US07790674B2
公开(公告)日：2010-09-07
申请号：US11499892
申请日：2006-08-04
申请人： Jonathan Daniel Oliner , Hosung Min
发明人： Jonathan Daniel Oliner , Hosung Min
IPC分类号： A61K38/10 , A61K38/16
CPC分类号： A61K38/16 , A61K38/08 , A61K38/10 , A61K39/3955 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/515 , C07K16/22 , C07K2317/52 , C07K2319/30 , A61K2300/00
摘要： Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.

4. 发明授权

US07737111B2 Peptides and related molecules that bind to TALL-1 有权
标题翻译：结合TALL-1的肽和相关分子
公开(公告)号：US07737111B2
公开(公告)日：2010-06-15
申请号：US11272521
申请日：2005-11-10
申请人： Hosung Min , Hailing Hsu , Fei Xiong
发明人： Hosung Min , Hailing Hsu , Fei Xiong
IPC分类号： A61K38/10
CPC分类号： C07K7/08 , A61K38/00 , A61K38/10 , C07K1/047 , C07K14/001 , C07K14/4702 , C07K14/7151 , C07K16/241 , C07K2319/30 , C07K2319/74 , C12N15/1037 , C40B40/02
摘要： The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae (SEQ. ID. NO:100) a1a2a3CDa6La8a9a10Ca12a13a14, (SEQ. ID. NO:104) b1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18 (SEQ. ID. NO:105) c1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18 (SEQ. ID. NO:106) d1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18 (SEQ. ID. NO:107) e1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18 (SEQ. ID NO:109) f1f2f3Kf5Df7Lf9f10Qf12f13f14 wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X1)a—V1—(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.
摘要翻译：本发明涉及调节TALL-1活性的治疗剂。根据本发明，TALL-1的调节剂可以包含氨基酸序列Dz2Lz4，其中z2是氨基酸残基，z4是苏氨酰基或异亮氨酰基。示例性分子包括下式的一个序列（SEQ。ID NO：100）a1a2a3CDa6La8a9a10Ca12a13a14，（SEQ ID NO：104）b1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18（SEQ ID。NO：105）c1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18（SEQ ID。NO：106）d1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18（ SEQ ID NO：107）e1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18（SEQ ID NO：109）f1f2f3Kf5Df7Lf9f10Qf12f13f14其中取代基如说明书中所定义。本发明还包括式（X1）a-V1-（X2）b的物质的组合物，其中V1是共价连接到一种或多种上述TALL-1调节组合物的载体。载体和TALL-1调节组合物可以通过TALL-1调节部分的N末端或C末端连接。优选的载体是Fc结构域，优选的Fc结构域是IgG Fc结构域。

5. 发明授权

US07666839B2 Methods of treatment using specific binding agents of human angiopoietin-2 有权
公开(公告)号：US07666839B2
公开(公告)日：2010-02-23
申请号：US11499891
申请日：2006-08-04
申请人： Jonathan Daniel Oliner , Hosung Min
发明人： Jonathan Daniel Oliner , Hosung Min
IPC分类号： A61K38/10
CPC分类号： A61K38/16 , A61K38/08 , A61K38/10 , A61K39/3955 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/515 , C07K16/22 , C07K2317/52 , C07K2319/30 , A61K2300/00
摘要： Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.

6. 发明申请

US20090011497A1 Peptides and related compounds having thrombopoietic activity 审中-公开
标题翻译：具有血小板生成活性的肽和相关化合物
公开(公告)号：US20090011497A1
公开(公告)日：2009-01-08
申请号：US12070643
申请日：2008-02-19
申请人： Hosung Min , Karen C. Sitney , Cynthia Hartley
发明人： Hosung Min , Karen C. Sitney , Cynthia Hartley
IPC分类号： C12N5/06 , C12N15/11 , C07K14/00 , C07K16/18 , C12N15/00 , C12N1/20
CPC分类号： C07K14/524 , A61K38/00
摘要： The present invention relates generally to novel peptides and related compounds that have thrombopoietic activity. The compounds of the invention may be used to increase production of platelets or platelet precursors (e.g. megakaryocytes) in a mammal.
摘要翻译：本发明一般涉及具有血小板生成活性的新型肽和相关化合物。本发明的化合物可用于增加哺乳动物血小板或血小板前体（例如巨核细胞）的产生。

7. 发明申请

US20080070840A1 Thrombopoietic compounds 有权
标题翻译：血栓形成
公开(公告)号：US20080070840A1
公开(公告)日：2008-03-20
申请号：US11820463
申请日：2007-06-18
申请人： Hosung Min , Kenneth Walker , Colin Gegg , Francesco Galimi , Jeonghoon Sun , Mei-Mei Tsai
发明人： Hosung Min , Kenneth Walker , Colin Gegg , Francesco Galimi , Jeonghoon Sun , Mei-Mei Tsai
IPC分类号： A61K38/17 , A61P7/02 , C07H21/04 , C07K14/47 , C12N1/19 , C12N1/21 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K14/524 , A61K38/17 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/30
摘要： The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
摘要翻译：本发明涉及具有血小板生成活性的化合物，特别是肽或多肽的领域。本发明的肽和多肽可用于增加哺乳动物中的血小板或血小板前体（例如巨核细胞）。

8. 发明申请

US20060135431A1 Peptides and related molecules that bind to TALL-1 有权
公开(公告)号：US20060135431A1
公开(公告)日：2006-06-22
申请号：US11272521
申请日：2005-11-10
申请人： Hosung Min , Hailing Hsu , Fei Xiong
发明人： Hosung Min , Hailing Hsu , Fei Xiong
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K7/08 , A61K38/00 , A61K38/10 , C07K1/047 , C07K14/001 , C07K14/4702 , C07K14/7151 , C07K16/241 , C07K2319/30 , C07K2319/74 , C12N15/1037 , C40B40/02
摘要： The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae (SEQ. ID. NO:100) a1a2a3CDa6La8a9a10Ca12a13a14, (SEQ. ID. NO:104) b1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18 (SEQ. ID. NO:105) c1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18 (SEQ. ID. NO:106) d1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18 (SEQ. ID. NO:107) e1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18 (SEQ. ID NO:109) f1f2f3Kf5Df7Lf9f10Qf12f13f14 wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X1)a-V1-(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.

9. 发明授权

US08388976B2 Polypeptide specifically binding to vascular endothelial growth factor, fusion protein including polypeptide, and methods therefor 有权
标题翻译：多肽特异性结合血管内皮生长因子，融合蛋白包括多肽，及其方法
公开(公告)号：US08388976B2
公开(公告)日：2013-03-05
申请号：US13588715
申请日：2012-08-17
申请人： A-yeon Cho , Min-kyung Kim , Brian Hosung Min , Jong-sang Ryu
发明人： A-yeon Cho , Min-kyung Kim , Brian Hosung Min , Jong-sang Ryu
IPC分类号： A61K39/00 , A61K39/38 , A61K39/395 , A61K45/00 , A61K47/00 , A61B5/055
CPC分类号： C07K14/71 , C07K7/06 , C07K14/475
摘要： A polypeptide inhibiting binding between a vascular endothelial growth factor and a vascular endothelial growth factor receptor, a fusion protein including the same, and a method of preparing the fusion protein are disclosed.
摘要翻译：公开了抑制血管内皮生长因子与血管内皮生长因子受体之间的结合的多肽，包含其的融合蛋白以及制备融合蛋白的方法。

10. 发明授权

US08268322B2 Polypeptide specifically binding to vascular endothelial growth factor, fusion protein including polypeptide, and methods therefor 有权
标题翻译：多肽特异性结合血管内皮生长因子，融合蛋白包括多肽，及其方法
公开(公告)号：US08268322B2
公开(公告)日：2012-09-18
申请号：US12973488
申请日：2010-12-20
申请人： A-yeon Cho , Min-kyung Kim , Brian Hosung Min , Jong-sang Ryu
发明人： A-yeon Cho , Min-kyung Kim , Brian Hosung Min , Jong-sang Ryu
IPC分类号： A61K39/00 , A61K39/38 , A61K39/385 , A61K45/00 , A61K47/00 , A61B5/055
CPC分类号： C07K14/71 , C07K7/06 , C07K14/475
摘要： A polypeptide inhibiting binding between a vascular endothelial growth factor and a vascular endothelial growth factor receptor, a fusion protein including the same, and a method of preparing the fusion protein are disclosed.
摘要翻译：公开了抑制血管内皮生长因子与血管内皮生长因子受体之间的结合的多肽，包含其的融合蛋白以及制备融合蛋白的方法。

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