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1. 发明授权

US07892255B2 Tissue connector apparatus and methods 有权
标题翻译：组织连接器装置和方法
公开(公告)号：US07892255B2
公开(公告)日：2011-02-22
申请号：US10653027
申请日：2003-08-28
申请人： Laurent Schaller , Barry Gardiner , Art Hill , John Nguyen , Liem Ho , Isidro Matias Gandionco
发明人： Laurent Schaller , Barry Gardiner , Art Hill , John Nguyen , Liem Ho , Isidro Matias Gandionco
IPC分类号： A61B17/04 , A61B17/08
CPC分类号： A61B17/064 , A61B17/0469 , A61B17/06 , A61B17/0644 , A61B17/11 , A61B2017/06009 , A61B2017/06057 , A61B2017/1107 , A61B2017/1135
摘要： Tissue connector assemblies having at least two piercing members, each releaseably coupled to a surgical fastener such as a surgical clip. A flexible member such as a suture may be used to couple one or both piercing members to respective ends of the fastener.
摘要翻译：组织连接器组件具有至少两个穿刺构件，每个穿孔构件可释放地联接到诸如手术夹子的手术紧固件。可以使用诸如缝合线的柔性构件将一个或两个刺穿构件联接到紧固件的相应端部。

2. 发明授权

US06607541B1 Tissue connector apparatus and methods 失效
公开(公告)号：US06607541B1
公开(公告)日：2003-08-19
申请号：US09089884
申请日：1998-06-03
申请人： Barry Gardiner , Laurent Schaller , Isidro Matias Gandionco , John Nguyen
发明人： Barry Gardiner , Laurent Schaller , Isidro Matias Gandionco , John Nguyen
IPC分类号： A61B1708
CPC分类号： A61B17/06 , A61B17/064 , A61B17/0644 , A61B17/11 , A61B2017/06009 , A61B2017/06057
摘要： A tissue connector assembly having a flexible member and a surgical clip releasably coupled to the flexible member. A needle may be secured to one end portion of the flexible member with the surgical clip coupled to the other end portion of the flexible member. A locking device may be used to couple the flexible member to the surgical clip. A method for connecting tissues is also disclosed. The method includes drawing tissue portions together with a clip assembly and securing the tissue portions together with the clip assembly.

3. 发明授权

US06613059B2 Tissue connector apparatus and methods 有权
公开(公告)号：US06613059B2
公开(公告)日：2003-09-02
申请号：US09260623
申请日：1999-03-01
申请人： Laurent Schaller , Barry Gardiner , Art Hill , John Nguyen , Liem Ho , Isidro Matias Gandionco
发明人： Laurent Schaller , Barry Gardiner , Art Hill , John Nguyen , Liem Ho , Isidro Matias Gandionco
IPC分类号： A61B1704
CPC分类号： A61B17/064 , A61B17/0469 , A61B17/06 , A61B17/0644 , A61B17/11 , A61B2017/06009 , A61B2017/06057 , A61B2017/1107 , A61B2017/1135
摘要： Tissue connector assemblies having at least two piercing members, each releaseably coupled to a surgical fastener such as a surgical clip. A flexible member such as a suture may be used to couple one or both piercing members to respective ends of the fastener.

4. 发明授权

US06514265B2 Tissue connector apparatus with cable release 有权
标题翻译：具有电缆释放的组织连接器设备
公开(公告)号：US06514265B2
公开(公告)日：2003-02-04
申请号：US09259705
申请日：1999-03-01
申请人： Liem Ho , Isidro Matias Gandionco , Nga T. Doan
发明人： Liem Ho , Isidro Matias Gandionco , Nga T. Doan
IPC分类号： A61B1708
CPC分类号： A61B17/083 , A61B17/06 , A61B17/06004 , A61B2017/00867 , A61B2017/06057 , A61B2017/06076 , A61B2017/1135 , A61F2002/30093 , A61F2210/0019
摘要： A tissue connector assembly comprising a clip movable between an open configuration and a closed configuration and a mechanical restraining device including a plurality of strands releasably attachable to the clip for restraining the clip in its open configuration. A needle may be releasably attached to the clip. A flexible member may also interconnect the clip and the needle.
摘要翻译：一种组织连接器组件，其包括可在打开构型和闭合构型之间移动的夹子，以及机械约束装置，其包括可释放地附接到夹子的多个股线，用于将夹子限制在其打开构型。针可以可释放地附接到夹子。柔性构件还可以使夹子和针相互连接。

5. 发明申请

US20110028996A1 Tissue Connector Apparatus and Methods 失效
标题翻译：组织连接器装置和方法
公开(公告)号：US20110028996A1
公开(公告)日：2011-02-03
申请号：US12849861
申请日：2010-08-04
申请人： Laurent Schaller , Barry Gardiner , Art Hill , John Nguyen , Liem Ho , Isidro Matias Gandionco
发明人： Laurent Schaller , Barry Gardiner , Art Hill , John Nguyen , Liem Ho , Isidro Matias Gandionco
IPC分类号： A61B17/04
CPC分类号： A61B17/064 , A61B17/0469 , A61B17/06 , A61B17/0644 , A61B17/11 , A61B2017/06009 , A61B2017/06057 , A61B2017/1107 , A61B2017/1135
摘要： Tissue connector assemblies having at least two piercing members, each releaseably coupled to a surgical fastener such as a surgical clip. A flexible member such as a suture may be used to couple one or both piercing members to respective ends of the fastener.
摘要翻译：组织连接器组件具有至少两个穿刺构件，每个穿孔构件可释放地联接到诸如手术夹子的手术紧固件。可以使用诸如缝合线的柔性构件将一个或两个刺穿构件联接到紧固件的相应端部。

6. 发明授权

US07763040B2 Tissue connector apparatus and methods 有权
标题翻译：组织连接器装置和方法
公开(公告)号：US07763040B2
公开(公告)日：2010-07-27
申请号：US10364064
申请日：2003-02-10
申请人： Laurent Schaller , Charles T. Maroney , Phillip Drews , Isidro Matias Gandionco , John Nguyen
发明人： Laurent Schaller , Charles T. Maroney , Phillip Drews , Isidro Matias Gandionco , John Nguyen
IPC分类号： A61B17/08 , A61B17/04
CPC分类号： A61B17/083 , A61B17/06 , A61B17/06004 , A61B2017/00867 , A61B2017/06057 , A61B2017/06076 , A61B2017/1135 , A61F2002/30093 , A61F2210/0019
摘要： A tissue connector assembly comprising a clip movable between an open configuration and a closed configuration and a mechanical restraining device attached to the clip for restraining the clip in its open configuration. A needle may be releasably attached to the clip. A method for connecting tissues is also disclosed. The method includes inserting a clip through tissue with the clip being biased in an open position by a restraining device secured to the clip, and removing the restraining device from the clip.
摘要翻译：一种组织连接器组件，包括可在打开构型和闭合构型之间移动的夹子以及附接到夹子的机械约束装置，用于将夹子限制在其打开构型。针可以可释放地附接到夹子。还公开了连接组织的方法。该方法包括通过组件插入夹子，夹子被固定在夹子上的约束装置偏置在打开位置，并且从夹子上移除限制装置。

7. 发明授权

US07547313B2 Tissue connector apparatus and methods 有权
标题翻译：组织连接器装置和方法
公开(公告)号：US07547313B2
公开(公告)日：2009-06-16
申请号：US10439973
申请日：2003-05-16
申请人： Barry Gardiner , Laurent Schaller , Isidro Matias Gandionco , John Nguyen
发明人： Barry Gardiner , Laurent Schaller , Isidro Matias Gandionco , John Nguyen
IPC分类号： A61B17/08
CPC分类号： A61B17/06 , A61B17/064 , A61B17/0644 , A61B17/11 , A61B2017/06009 , A61B2017/06057
摘要： A tissue connector assembly having a flexible member and a surgical clip releasably coupled to the flexible member. A needle may be secured to one end portion of the flexible member with the surgical clip coupled to the other end portion of the flexible member. A locking device may be used to couple the flexible member to the surgical clip. A method for connecting tissues is also disclosed. The method includes drawing tissue portions together with a clip assembly and securing the tissue portions together with the clip assembly.
摘要翻译：一种组织连接器组件，其具有可释放地联接到柔性构件的柔性构件和外科夹具。针可以被固定到柔性构件的一个端部，而手术夹固定在柔性构件的另一端部上。可以使用锁定装置将柔性构件联接到手术夹。还公开了连接组织的方法。该方法包括将组织部分与夹子组件一起绘图，并将组织部分与夹子组件一起固定。

8. 发明授权

US06960221B2 Tissue connector apparatus with cable release 失效
标题翻译：具有电缆释放的组织连接器设备
公开(公告)号：US06960221B2
公开(公告)日：2005-11-01
申请号：US10188013
申请日：2002-07-01
申请人： Liem Ho , Isidro Matias Gandionco , Nga T. Doan
发明人： Liem Ho , Isidro Matias Gandionco , Nga T. Doan
IPC分类号： A61B17/00 , A61B17/06 , A61B17/08 , A61B17/11 , A61F2/00
CPC分类号： A61B17/083 , A61B17/06 , A61B17/06004 , A61B2017/00867 , A61B2017/06057 , A61B2017/06076 , A61B2017/1135 , A61F2002/30093 , A61F2210/0019
摘要： A tissue connector assembly comprising a clip movable between an open configuration and a closed configuration and a mechanical restraining device including a plurality of strands releasably attachable to the clip for restraining the clip in its open configuration. A needle may be releasably attached to the clip. A flexible member may also interconnect the clip and the needle.
摘要翻译：一种组织连接器组件，其包括可在打开构型和闭合构型之间移动的夹子，以及机械约束装置，其包括可释放地附接到夹子的多个股线，用于将夹子限制在其打开构型。针可以可释放地附接到夹子。柔性构件还可以使夹子和针相互连接。

9. 发明授权

US6125294A Method and apparatus for measuring corneal incisions 失效
标题翻译：用于测量角膜切口的方法和装置
公开(公告)号：US6125294A
公开(公告)日：2000-09-26
申请号：US907112
申请日：1997-08-06
申请人： John Anthony Scholl , Thomas A. Silvestrini , Isidro Matias Gandionco , William P. Kuhn , Phillip C. Baker
发明人： John Anthony Scholl , Thomas A. Silvestrini , Isidro Matias Gandionco , William P. Kuhn , Phillip C. Baker
IPC分类号： A61B3/10 , A61B8/10 , A61B19/00 , A61F9/007 , A61F9/013 , A61B5/00
CPC分类号： A61F9/0133 , A61B8/10 , A61B90/06 , A61B2090/062 , A61F9/013
摘要： A method and apparatus for performing a surgical procedure on a patient is described. An incision is made into tissue of the patient to create a tissue pocket. The tissue has an anterior surface. Preferably, the tissue is corneal tissue of an eye. A reflective element is inserted into the pocket. An energy source generates a radiant energy signal, which is directed toward the reflective element. Reflected energy is received from the reflective element. A detector determines the depth of the reflective element below the anterior surface based upon the energy reflected by the reflective element. The speed of transmission of the radiant energy in the reflective element is different (preferably slower) than the speed of transmission of the radiant energy in the tissue. The reflective element may be in the form of a tool on which is disposed a biocompatible polymer layer, the layer comprising trapped air spaces, or a tool having an open space for containing trapped air. The radiant energy may take the form of ultrasound generated by an ultrasonic probe, or light generated by a confocal microscope. The confocal microscope may employ longitudinal chromatic aberration to measure the depth of the reflective element. When employing a confocal microscope, the depth of the reflective element is a function of the reflected energy from the anterior surface and the reflected energy from the reflective element.
摘要翻译：描述了一种用于对患者进行外科手术的方法和装置。将切口制成患者的组织以产生组织袋。组织具有前表面。优选地，组织是眼睛的角膜组织。将反射元件插入口袋中。能量源产生朝向反射元件的辐射能信号。从反射元件接收反射能量。检测器基于由反射元件反射的能量确定反射元件在前表面下方的深度。反射元件中的辐射能的传输速度与组织中的辐射能的传递速度不同（优选地较慢）。反射元件可以是工具的形式，其上设置有生物相容性聚合物层，该层包括被捕获的空气空间，或具有用于容纳被捕获的空气的开放空间的工具。辐射能可以采用由超声波探头产生的超声或由共聚焦显微镜产生的光的形式。共焦显微镜可以采用纵向色差来测量反射元件的深度。当使用共焦显微镜时，反射元件的深度是来自前表面的反射能量和来自反射元件的反射能量的函数。

10. 发明授权

US06641593B1 Tissue connector apparatus and methods 失效
标题翻译：组织连接器装置和方法
公开(公告)号：US06641593B1
公开(公告)日：2003-11-04
申请号：US09090305
申请日：1998-06-03
申请人： Laurent Schaller , Charles T. Maroney , Phillip Drews , Isidro Matias Gandionco , John Nguyen
发明人： Laurent Schaller , Charles T. Maroney , Phillip Drews , Isidro Matias Gandionco , John Nguyen
IPC分类号： A61B1708
CPC分类号： A61B17/083 , A61B17/06 , A61B17/06004 , A61B2017/00867 , A61B2017/06057 , A61B2017/06076 , A61B2017/1135 , A61F2002/30093 , A61F2210/0019
摘要： A tissue connector assembly comprising a clip movable between an open configuration and a closed configuration and a mechanical restraining device attached to the clip for restraining the clip in its open configuration. A needle may be releasably attached to the clip. A method for connecting tissues is also disclosed. The method includes inserting a clip through tissue with the clip being biased in an open position by a restraining device secured to the clip, and removing the restraining device from the clip.
摘要翻译：一种组织连接器组件，包括可在打开构型和闭合构型之间移动的夹子以及附接到夹子的机械约束装置，用于将夹子限制在其打开构型。针可以可释放地附接到夹子。还公开了连接组织的方法。该方法包括通过组件插入夹子，夹子被固定在夹子上的约束装置偏置在打开位置，并且从夹子上移除限制装置。

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