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1. 发明申请

US20120225477A1 VIRAL AND VIRAL ASSOCIATED MIRNAS AND USES THEREOF 有权
标题翻译：病毒和病毒相关的MIRNAS及其用途
公开(公告)号：US20120225477A1
公开(公告)日：2012-09-06
申请号：US12850091
申请日：2010-08-04
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
IPC分类号： C12N15/63 , C07H21/04 , C07H21/02
CPC分类号： C12Q1/701 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/141 , C12N2320/10 , C12N2320/30 , C12N2330/10 , C12N2710/16222 , C12Q2600/136
摘要： Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections.
摘要翻译：本文描述的是与病毒感染相关的新型多核苷酸。多核苷酸是miRNA和miRNA前体。公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。本文还描述了可用于鉴定病毒感染调节剂的方法。

2. 发明授权

US07842800B2 Bioinformatically detectable group of novel regulatory bacterial and bacterial associated oligonucleotides and uses thereof 有权
标题翻译：生物信息学可检测的新型调节性细菌和细菌相关寡核苷酸及其用途
公开(公告)号：US07842800B2
公开(公告)日：2010-11-30
申请号：US10708951
申请日：2004-04-02
申请人： Itzhak Bentwich
发明人： Itzhak Bentwich
IPC分类号： C07H21/04
CPC分类号： C12Q1/689 , C12Q2600/158 , C12Q2600/178 , G06F19/22
摘要： The present invention relates to a first group of novel bacterial and human associated oligonucleotides, here identified as Genomic Address Messenger or GAM oligonucleotide, and a second group of novel operon-like bacterial and human polynucleotides, here identified as Genomic Record or GR polynucleotide. GAM oligonucleotides selectively inhibit translation of known ‘target’ genes, many of which are known to be involved in various bacterial diseases. Nucleic acid molecules are provided respectively encoding 6444 GAM precursors oligonucleotides, and 726 GR polynucleotides, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM oligonucleotides and GR polynucleotides and specific functions and utilities thereof, for detecting expression of GAM oligonucleotides and GR polynucleotides, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.
摘要翻译：本发明涉及第一组新的细菌和人类相关的寡核苷酸，这里被鉴定为Genomic Address Messenger或GAM寡核苷酸，以及第二组新的操纵子样的细菌和人多核苷酸，这里被鉴定为Genomic Record或GR多核苷酸。 GAM寡核苷酸选择性地抑制已知的“靶”基因的翻译，其中许多已知涉及各种细菌性疾病。提供分别编码6444GAM前体寡核苷酸和726个GR多核苷酸的核酸分子，以及包含核酸分子的载体和探针，以及用于检测GAM寡核苷酸和GR多核苷酸的方法和系统及其特定功能和用途，用于检测表达的GAM寡核苷酸和GR多核苷酸，并且用于选择性增强和选择性抑制其各自的靶基因的翻译。

3. 发明授权

US07795419B2 Viral and viral associated miRNAs and uses thereof 有权
标题翻译：病毒和病毒相关的miRNA及其用途
公开(公告)号：US07795419B2
公开(公告)日：2010-09-14
申请号：US11511035
申请日：2006-08-28
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
IPC分类号： C07H21/04
CPC分类号： C12Q1/701 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/141 , C12N2320/10 , C12N2320/30 , C12N2330/10 , C12N2710/16222 , C12Q2600/136
摘要： Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections.
摘要翻译：本文描述的是与病毒感染相关的新型多核苷酸。多核苷酸是miRNA和miRNA前体。公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。本文还描述了可用于鉴定病毒感染调节剂的方法。

4. 发明申请

US20080188428A1 BIOINFORMATICALLY DETECTABLE GROUP OF NOVEL HIV REGULATORY GENES AND USES THEREOF 审中-公开
标题翻译：生物检测艾滋病毒检测基因及其用途组
公开(公告)号：US20080188428A1
公开(公告)日：2008-08-07
申请号：US10605838
申请日：2003-10-30
申请人： Itzhak Bentwich
发明人： Itzhak Bentwich
IPC分类号： A61K31/7105 , C07H21/04 , C12N15/66 , A61P31/00 , C12Q1/70
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/11 , C12N2330/10 , C12N2740/16022 , Y02A90/26
摘要： The present invention relates to a group of novel viral RNA regulatory genes, here identified as “viral genomic address messenger genes” or “VGAM genes”, and as “viral genomic record” or “VGR genes”. VGAM genes selectively inhibit translation of known host target genes, and are believed to represent a novel pervasive viral attack mechanism. VGR genes encode an operon-like cluster of VGAM genes. VGAM and viral VGR genes may therefore be useful in diagnosing, preventing and treating viral disease. Several nucleic acid molecules are provided respectively encoding several VGAM genes, as are vectors and probes, both comprising the nucleic acid molecules, and methods and systems for detecting VGAM genes, and for counteracting their activity.
摘要翻译：本发明涉及一组新型病毒RNA调节基因，这些基因被鉴定为“病毒基因组地址信使基因”或“VGAM基因”，以及“病毒基因组记录”或“VGR基因”。 VGAM基因选择性地抑制已知宿主靶基因的翻译，并且被认为代表了一种新的普遍的病毒攻击机制。 VGR基因编码VGAM基因的操纵子样簇。因此，VGAM和病毒VGR基因可用于诊断，预防和治疗病毒性疾病。提供了分别编码若干VGAM基因的核酸分子，以及包含核酸分子的载体和探针以及用于检测VGAM基因的方法和系统以及抵消其活性。

5. 发明申请

US20070259350A1 Liver cancer-related nucleic acids 有权
标题翻译：肝癌相关核酸
公开(公告)号：US20070259350A1
公开(公告)日：2007-11-08
申请号：US11418875
申请日：2006-05-04
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/02 , C12M3/00
CPC分类号： C12Q1/6886 , C07K14/4748 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： Described herein are novel polynucleotides associated with liver cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of liver cancer. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described herein are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.
摘要翻译：本文描述的是与肝癌相关的新型多核苷酸。多核苷酸是miRNA，miRNA前体和相关核酸。描述了可用于肝癌诊断，预后和治疗的方法和组合物。本文还描述了可用于鉴定疾病相关多核苷酸的调节剂的方法。本文还描述了用于靶向核酸的线性扩增和标记的方法和组合物。扩增的靶向分子可用于杂交技术，如Luminex和Microarray分析。

6. 发明授权

US07217807B2 Bioinformatically detectable group of novel HIV regulatory genes and uses thereof 有权
标题翻译：生物信息学可检测的新型HIV调节基因及其用途
公开(公告)号：US07217807B2
公开(公告)日：2007-05-15
申请号：US10604944
申请日：2003-08-28
申请人： Itzhak Bentwich
发明人： Itzhak Bentwich
IPC分类号： C07H21/00 , C12Q1/68 , C12N7/00 , G06F19/00
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/11 , C12N2330/10 , C12N2740/16022 , Y02A90/26
摘要： The present invention relates to a group of novel viral RNA regulatory genes, here identified as “viral genomic address messenger genes” or “VGAM genes”, and as “genomic record” or “GR” genes. VGAM genes selectively inhibit translation of known host target genes, and are believed to represent a novel pervasive viral attack mechanism. GR genes encode an operon-like cluster of VGAM genes. VGAM and viral GR genes may therefore be useful in diagnosing, preventing and treating viral disease. Several nucleic acid molecules are provided respectively encoding several VGAM genes, as are vectors and probes, both comprising the nucleic acid molecules, and methods and systems for detecting VGAM genes, and for counteracting their activity.
摘要翻译：本发明涉及一组新的病毒RNA调节基因，这些基因被鉴定为“病毒基因组地址信使基因”或“VGAM基因”，以及“基因组记录”或“GR”基因。 VGAM基因选择性地抑制已知宿主靶基因的翻译，并且被认为代表了一种新的普遍的病毒攻击机制。 GR基因编码VGAM基因的操纵子样簇。因此，VGAM和病毒GR基因可用于诊断，预防和治疗病毒性疾病。提供了分别编码若干VGAM基因的核酸分子，以及包含核酸分子的载体和探针以及用于检测VGAM基因的方法和系统以及抵消其活性。

7. 发明申请

US20070042381A1 BIOINFORMATICALLY DETECTABLE GROUP OF NOVEL REGULATORY VIRAL AND VIRAL ASSOCIATED OLIGONUCLEOTIDES AND USES THEREOF 有权
标题翻译：生物检测组织的新型法规和病毒相关的寡核苷酸及其用途
公开(公告)号：US20070042381A1
公开(公告)日：2007-02-22
申请号：US10709739
申请日：2004-05-26
申请人： Itzhak Bentwich , Amir Avniel
发明人： Itzhak Bentwich , Amir Avniel
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/11 , C12N2330/10 , C12N2740/16022 , Y02A90/26
摘要： The present invention relates to a first group of novel viral and human associated oligonucleotides, here identified as “Genomic Address Messenger” or “GAM” oligonucleotide, and a second group of novel operon-like viral and human polynucleotides, here identified as “Genomic Record” or “GR” polynucleotide. GAM oligonucleotides selectively inhibit translation of known “target” genes, many of which are known to be involved in various viral diseases. Nucleic acid molecules are provided respectively encoding 1,655 viral and 105,537 human GAM precursor oligonucleotides, and 190 viral and 14,813 human GR polynucleotides, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM oligonucleotides and GR polynucleotides and specific functions and utilities thereof, for detecting expression of GAM oligonucleotides and GR polynucleotides, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.
摘要翻译：本发明涉及第一组新的病毒和人类相关寡核苷酸，这里被鉴定为“基因组地址信使”或“GAM”寡核苷酸，以及第二组新的操纵子样病毒和人多核苷酸，这里被鉴定为“基因组记录 “或”GR“多核苷酸。 GAM寡核苷酸选择性地抑制已知的“靶”基因的翻译，其中许多已知涉及各种病毒性疾病。提供分别编码1,655个病毒和105,537个人GAM前体寡核苷酸的核酸分子，以及190个病毒和14,813个人GR多核苷酸，以及包含核酸分子的载体和探针，以及用于检测GAM寡核苷酸和GR多核苷酸的方法和系统以及特异性功能和用途，用于检测GAM寡核苷酸和GR多核苷酸的表达，并用于选择性增强和选择性抑制其各自靶基因的翻译。

8. 发明授权

US08455633B2 Viral and viral associated mirnas and uses thereof 有权
标题翻译：病毒和病毒相关mirnas及其用途
公开(公告)号：US08455633B2
公开(公告)日：2013-06-04
申请号：US12850091
申请日：2010-08-04
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00
CPC分类号： C12Q1/701 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/141 , C12N2320/10 , C12N2320/30 , C12N2330/10 , C12N2710/16222 , C12Q2600/136
摘要： Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections.
摘要翻译：本文描述的是与病毒感染相关的新型多核苷酸。多核苷酸是miRNA和miRNA前体。公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。本文还描述了可用于鉴定病毒感染调节剂的方法。

9. 发明授权

US08236939B2 Micrornas and uses thereof 有权
标题翻译： Micrornas及其用途
公开(公告)号：US08236939B2
公开(公告)日：2012-08-07
申请号：US12800556
申请日：2010-02-08
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , C12N5/00 , A01N43/04 , A61K31/70
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2330/10 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
摘要翻译：本文描述的是与前列腺和肺癌相关的多核苷酸。多核苷酸是miRNA和miRNA前体。公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。本文还描述了可用于鉴定前列腺和肺癌调节剂的方法。

10. 发明授权

US07790867B2 Vaccinia virus-related nucleic acids and microRNA 有权
标题翻译：牛痘病毒相关核酸和微小RNA
公开(公告)号：US07790867B2
公开(公告)日：2010-09-07
申请号：US10604943
申请日：2003-08-28
申请人： Itzhak Bentwich
发明人： Itzhak Bentwich
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , C12N5/00 , A01N43/04 , A61K31/70
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/11 , C12N2330/10 , C12N2740/16022 , Y02A90/26
摘要： The present invention relates to a group of viral RNA regulatory genes, here identified as “viral genomic address messenger genes” or “VGAM genes”, and as “genomic record” or “GR” genes. VGAM genes selectively inhibit translation of known host target genes, and are believed to represent a pervasive viral attack mechanism. GR genes encode an operon-like cluster of VGAM genes. VGAM and viral GR genes may therefore be useful in diagnosing, preventing and treating viral disease. Several nucleic acid molecules are provided respectively encoding several VGAM genes, as are vectors and probes, both comprising the nucleic acid molecules, and methods and systems for detecting VGAM genes, and for counteracting their activity.
摘要翻译：本发明涉及一组病毒RNA调节基因，这里被鉴定为“病毒基因组地址信使基因”或“VGAM基因”，以及“基因组记录”或“GR”基因。 VGAM基因选择性地抑制已知宿主靶基因的翻译，并且被认为代表普遍的病毒攻击机制。 GR基因编码VGAM基因的操纵子样簇。因此，VGAM和病毒GR基因可用于诊断，预防和治疗病毒性疾病。提供了分别编码若干VGAM基因的核酸分子，以及包含核酸分子的载体和探针以及用于检测VGAM基因的方法和系统以及抵消其活性。

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