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1. 发明申请

US20220304616A1 CONTINGENT CARDIO-PROTECTION FOR EPILEPSY PATIENTS 有权
公开(公告)号：US20220304616A1
公开(公告)日：2022-09-29
申请号：US17831753
申请日：2022-06-03
申请人： IVAN Osorio
发明人： IVAN Osorio
IPC分类号： A61B5/00 , A61B5/0245 , A61B5/024 , A61N1/36 , A61B5/35 , A61B5/316 , A61B5/349 , A61B5/352 , A61B5/364
摘要： Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

2. 发明申请

US20220296155A1 RESPONSIVENESS TESTING OF A PATIENT HAVING BRAIN STATE CHANGES 有权
公开(公告)号：US20220296155A1
公开(公告)日：2022-09-22
申请号：US17832602
申请日：2022-06-04
申请人： IVAN OSORIO
发明人： IVAN OSORIO
IPC分类号： A61B5/369 , A61B5/16 , A61B5/00 , G16H50/30 , G16H40/63
摘要： A method of determining a responsiveness of a patient having brain state changes, comprising receiving an indication of a triggering event; administering to the patient, in response to the indication, a test of responsiveness; determining, based upon a result of the test, at least one responsiveness parameter selected from the group consisting of (i) a time of occurrence of a change in the patient's responsiveness, (ii) a duration of a change in the patient's responsiveness; (iii) a magnitude of a change in the patient's responsiveness, (iv) a time interval from the indication of event occurrence to a change in the patient's responsiveness, (v) a type of change in the patient's responsiveness, (vi) an estimation of a seizure severity; (vii) a classification of a seizure into clinical or subclinical; (viii) a classification of a clinical seizure into simple partial, complex partial, or generalized; (ix) an assessment of efficacy of a therapy for the patient's medical condition; (x) an assessment of the state of the disease and formulation of a prognosis for the patient; (xi) an estimation of a risk of injury or death for the patient; and (xii) two or more thereof. A medical device system capable of implementing the method.

3. 发明申请

US20210138246A1 SYSTEM AND METHOD FOR SEIZURE DETECTION AND AUTOMATED THALAMIC STIMULATION 有权
公开(公告)号：US20210138246A1
公开(公告)日：2021-05-13
申请号：US17150908
申请日：2021-01-15
申请人： Ivan Osorio
发明人： Ivan Osorio , Richard Wennberg
IPC分类号： A61N1/36 , A61N1/05
摘要： A thalamic medical device system and method enables automated detection of epileptic seizures and optionally providing contingent thalamic stimulation triggered by automated seizure detection. The method includes detecting electrical signals in a frequency band of 8-42 Hz from an anterior thalamic nucleus or a centro-median thalamic nucleus in a first hemisphere and/or a second hemisphere of a brain with one or more electrode assemblies surgically implanted at least partially within an anterior thalamic nuclei or a centro-median thalamic nuclei, and outside of a subthalamic nuclei of the patient. The method also includes transmitting the detected electrical signals to a medical device, analyzing them using a seizure detection algorithm, and delivering electrical stimulation to the anterior thalamic nuclei or centro-median thalamic nuclei in the first hemisphere and/or the second hemisphere via the electrode assemblies in response to a seizure detected by the medical device.

4. 发明申请

US20200337652A1 DETECTING, ASSESSING AND MANAGING A RISK OF DEATH IN EPILEPSY 审中-公开
公开(公告)号：US20200337652A1
公开(公告)日：2020-10-29
申请号：US16928198
申请日：2020-07-14
申请人： IVAN OSORIO
发明人： IVAN OSORIO
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/08 , A61B5/021 , A61B5/0245 , A61B5/11 , A61N1/39 , A61N1/36 , A61N1/365 , A61B5/0452 , A61B5/16 , G16H50/30 , A61F7/00 , A61M5/172
摘要： A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A computer readable program storage device is also provided. Also provided is a method for receiving body data, determining a cardiac, an arousal, a responsiveness, or a kinetic index, determining an increased or increasing risk of death over a first time window relating to a patient with epilepsy and issuing a warning and logging relevant information.

5. 发明申请

US20200147387A1 METHOD, SYSTEM AND APPARATUS FOR AUTOMATED TERMINATION OF A THERAPY FOR AN EPILEPTIC EVENT UPON A DETERMINATION OF EFFECTS OF A THERAPY 审中-公开
公开(公告)号：US20200147387A1
公开(公告)日：2020-05-14
申请号：US16743142
申请日：2020-01-15
申请人： IVAN OSORIO
发明人： IVAN OSORIO
IPC分类号： A61N1/36 , A61N5/06 , A61N2/00 , A61F7/12 , A61B5/00
摘要： A method comprising detecting an epileptic event in a patient; applying an electrical therapy to a first target area in at least one of a brain region or a cranial nerve of said patient in response to said detecting; receiving a body signal responsive to the electrical therapy, wherein said body signal is selected from an autonomic signal, a neurologic signal, a metabolic signal, an endocrine signal, or a tissue stress marker signal; determining whether said body signal indicates that said electrical therapy has an efficacious effect; and terminating the application of said electrical therapy if the response indicates that the electrical therapy has an efficacious effect. An apparatus capable of performing the method. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform the method.

6. 发明申请

US20190328262A1 QUANTITATIVE MULTIVARIATE ANALYSIS OF SEIZURES 审中-公开
公开(公告)号：US20190328262A1
公开(公告)日：2019-10-31
申请号：US16419327
申请日：2019-05-22
申请人： Ivan OSORIO
发明人： Ivan OSORIO
IPC分类号： A61B5/0476 , G16H50/20 , A61N1/36 , A61B5/00
摘要： Methods, including a method, comprising selecting a plurality of dependent variables relating to each of a plurality of seizures in a patient; selecting a plurality of independent variables, wherein each independent variable comprises a therapy parameter, a therapy delivery parameter, a temporal factor, an environmental factor, or a patient factor; quantifying at least one relationship between each of at least two dependent variables and each of at least two independent variables; and performing an action in response to said quantifying, selected from reporting said at least one relationship, assessing an efficacy of a therapy, assessing an adverse effect of said therapy, providing a therapy modification recommendation, or adjusting said therapy. A medical device system capable of implementing a method. A non-transitory computer readable program storage medium containing instructions that, when executed by a computer, perform a method.

7. 发明授权

US10307324B2 Selective recruitment and activation of fiber types in nerves for the control of undesirable brain state changes 有权
公开(公告)号：US10307324B2
公开(公告)日：2019-06-04
申请号：US15429705
申请日：2017-02-10
申请人： Ivan Osorio
发明人： Ivan Osorio
IPC分类号： A61N1/05 , A61N1/36 , A61B17/12 , A61F7/12 , A61H9/00 , A61H39/08
摘要： We disclose methods and medical device systems for selectively recruiting a nerve fiber type within a cranial nerve, a peripheral nerve or a spinal root. Such a method may comprise applying a first pressure, a heating, and/or a cooling to a second location of the nerve, the pressure, heating, or cooling sufficient to substantially block at least one of activation or conduction in at least one fiber population through the second location of the nerve for a blocking time period; and applying an electrical signal to a first location during the blocking time period.

8. 发明授权

US10232114B2 Automatic treatment of pain 有权
公开(公告)号：US10232114B2
公开(公告)日：2019-03-19
申请号：US15164697
申请日：2016-05-25
申请人： Ivan Osorio
发明人： Ivan Osorio
IPC分类号： A61M5/172 , G06F19/00 , A61M5/142 , A61B3/11 , A61B5/0205 , A61B5/11 , A61B5/16 , A61B5/00 , A61N1/02 , A61N1/08 , A61N1/36 , A61N5/06 , G16H10/60 , G16H50/30 , A61M5/14 , A61B5/021 , A61B5/024 , A61B5/053 , A61B5/087 , A61B5/1455 , A61N5/067
摘要： Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.

9. 发明授权

US10226220B2 Detecting, assessing and managing a risk of death in epilepsy 有权
公开(公告)号：US10226220B2
公开(公告)日：2019-03-12
申请号：US15796887
申请日：2017-10-30
申请人： Ivan Osorio
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61N1/365 , A61B5/0205 , A61B5/08 , A61B5/021 , A61B5/0245 , A61B5/11 , A61N1/39 , A61N1/36 , A61B5/0452 , A61B5/16 , A61F7/00 , A61M5/172 , G16H50/30 , G06F19/00 , A61N1/372
摘要： A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A computer readable program storage device is also provided. Also provided is a method for receiving body data, determining a cardiac, an arousal, a responsiveness, or a kinetic index, determining an increased or increasing risk of death over a first time window relating to a patient with epilepsy and issuing a warning and logging relevant information.

10. 发明申请

US20180078150A1 SEIZURE DETECTION METHODS, APPARATUS, AND SYSTEMS USING AN AUTOREGRESSION ALGORITHM 审中-公开
公开(公告)号：US20180078150A1
公开(公告)日：2018-03-22
申请号：US15729168
申请日：2017-10-10
申请人： Ivan Osorio , Alexey Lyubushin , Didier Sornette
发明人： Ivan Osorio , Alexey Lyubushin , Didier Sornette
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/048 , A61B5/04 , A61B5/0476 , A61B5/024 , A61B5/11 , A61B5/08
CPC分类号： A61B5/02055 , A61B5/0205 , A61B5/024 , A61B5/04001 , A61B5/0476 , A61B5/048 , A61B5/0816 , A61B5/0833 , A61B5/1118 , A61B5/14542 , A61B5/16 , A61B5/165 , A61B5/4094 , A61B5/4836 , A61B5/726 , A61B5/746
摘要： A method, comprising receiving a time series of patient body signal, determining first and second sliding time windows for the time series; applying an autoregression algorithm, comprising: applying an autoregression analysis to each of the first and second windows, yielding autoregression coefficients and a residual variance for each window; estimating a parameter vector for each window based on the autoregression coefficients and residual variances; and determining a difference between the parameter vectors; and determining seizure onset and seizure termination based on the difference between the parameter vectors. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

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