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1. 发明申请

US20120184832A1 MANUAL AND AUTOMATIC PROBE CALIBRATION 失效
标题翻译：手动和自动探头校准
公开(公告)号：US20120184832A1
公开(公告)日：2012-07-19
申请号：US13430451
申请日：2012-03-26
申请人： Mohamed Kheir Diab , Esmaiel Kiani-Azarbayjany , Charles Robert Ragsdale , James M. Lepper, JR.
发明人： Mohamed Kheir Diab , Esmaiel Kiani-Azarbayjany , Charles Robert Ragsdale , James M. Lepper, JR.
IPC分类号： A61B5/1455
CPC分类号： A61B5/1495 , A61B5/0205 , A61B5/02427 , A61B5/14552 , A61B5/6826 , A61B5/6838 , A61B2562/08 , G01J3/02 , G01J3/0254 , G01J3/027 , G01J3/0275 , G01J3/0291 , G01J3/10 , G01J2003/2866 , G01N21/255 , G01N21/274 , G01N21/31 , G01N21/3151 , G01N21/39 , G01N2021/3144 , G01N2201/0627
摘要： Embodiments of the present disclosure include an optical probe capable of communicating identification information to a patient monitor in addition to signals indicative of intensities of light after attenuation by body tissue. The identification information may indicate operating wavelengths of light sources, indicate a type of probe, such as, for example, that the probe is an adult probe, a pediatric probe, a neonatal probe, a disposable probe, a reusable probe, or the like. The information could also be utilized for security purposes, such as, for example, to ensure that the probe is configured properly for the oximeter, to indicate that the probe is from an authorized supplier, or the like.
摘要翻译：本公开的实施例还包括能够向身体组织衰减之后除了表示光强度的信号之外，向患者监视器传送识别信息的光学探针。识别信息可以指示光源的操作波长，指示探针的类型，例如探针是成人探针，儿科探针，新生儿探针，一次性探针，可重复使用的探针等。该信息也可以用于安全目的，例如，以确保探针被适当地配置用于血氧计，以指示探针来自授权供应商等。

2. 发明授权

US6011986A Manual and automatic probe calibration 失效
公开(公告)号：US6011986A
公开(公告)日：2000-01-04
申请号：US16924
申请日：1998-02-02
申请人： Mohamed Kheir Diab , Esmaiel Kiani-Azarbayjany , Charles Robert Ragsdale , James M. Lepper, Jr.
发明人： Mohamed Kheir Diab , Esmaiel Kiani-Azarbayjany , Charles Robert Ragsdale , James M. Lepper, Jr.
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01J3/10 , G01J3/28 , G01N21/01 , G01N21/25 , G01N21/27 , G01N21/39 , G01N21/64 , G05F3/08 , H05B37/02
CPC分类号： A61B5/1495 , A61B5/0205 , A61B5/14552 , A61B5/6826 , A61B5/6838 , G01J3/02 , G01J3/0254 , G01J3/027 , G01J3/0275 , G01J3/0291 , G01J3/10 , G01N21/255 , G01N21/274 , G01N21/31 , G01N21/3151 , G01N21/39 , A61B2562/08 , A61B5/02427 , G01J2003/2866 , G01N2021/3144 , G01N2201/0627
摘要： The method and apparatus of the present invention provides a system wherein light-emitting diodes (LEDs) can be tuned within a given range by selecting their operating drive current in order to obtain a precise wavelength. The present invention further provides a manner in which to calibrate and utilize an LED probe, such that the shift in wavelength for a known change in drive current is a known quantity. In general, the principle of wavelength shift for current drive changes for LEDs is utilized in order to allow better calibration and added flexibility in the use of LED sensors, particularly in applications when the precise wavelength is needed in order to obtain accurate measurements. The present invention also provides a system in which it is not necessary to know precise wavelengths of LEDs where precise wavelengths were needed in the past. Finally, the present invention provides a method and apparatus for determining the operating wavelength of a light emitting element such as a light emitting diode.

3. 发明授权

US5758644A Manual and automatic probe calibration 失效
公开(公告)号：US5758644A
公开(公告)日：1998-06-02
申请号：US478493
申请日：1995-06-07
申请人： Mohamed Kheir Diab , Massi E. Kiani , Charles Robert Ragsdale , James M. Lepper, Jr.
发明人： Mohamed Kheir Diab , Massi E. Kiani , Charles Robert Ragsdale , James M. Lepper, Jr.
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01J3/10 , G01J3/28 , G01N21/01 , G01N21/25 , G01N21/27 , G01N21/39 , G01N21/64 , G05F3/08 , H05B37/02
CPC分类号： A61B5/1495 , A61B5/0205 , A61B5/14552 , A61B5/6826 , A61B5/6838 , G01J3/02 , G01J3/0254 , G01J3/027 , G01J3/0275 , G01J3/0291 , G01J3/10 , G01N21/255 , G01N21/274 , G01N21/31 , G01N21/3151 , G01N21/39 , A61B2562/08 , A61B5/02427 , G01J2003/2866 , G01N2021/3144 , G01N2201/0627
摘要： The method and apparatus of the present invention provides a system wherein light-emitting diodes (LEDs) can be tuned within a given range by selecting their operating drive current in order to obtain a precise wavelength. The present invention further provides a manner in which to calibrate and utilize an LED probe, such that the shift in wavelength for a known change in drive current is a known quantity. In general, the principle of wavelength shift for current drive changes for LEDs is utilized in order to allow better calibration and added flexibility in the use of LED sensors, particularly in applications when the precise wavelength is needed in order to obtain accurate measurements. The present invention also provides a system in which it is not necessary to know precise wavelengths of LEDs where precise wavelengths were needed in the past. Finally, the present invention provides a method and apparatus for determining the operating wavelength of a light emitting element such as a light emitting diode.

4. 发明授权

US08781543B2 Manual and automatic probe calibration 失效
标题翻译：手动和自动探头校准
公开(公告)号：US08781543B2
公开(公告)日：2014-07-15
申请号：US13430451
申请日：2012-03-26
申请人： Mohamed Kheir Diab , Massi E. Kiani , Charles Robert Ragsdale , James M. Lepper, Jr.
发明人： Mohamed Kheir Diab , Massi E. Kiani , Charles Robert Ragsdale , James M. Lepper, Jr.
IPC分类号： A61B5/1455
CPC分类号： A61B5/1495 , A61B5/0205 , A61B5/02427 , A61B5/14552 , A61B5/6826 , A61B5/6838 , A61B2562/08 , G01J3/02 , G01J3/0254 , G01J3/027 , G01J3/0275 , G01J3/0291 , G01J3/10 , G01J2003/2866 , G01N21/255 , G01N21/274 , G01N21/31 , G01N21/3151 , G01N21/39 , G01N2021/3144 , G01N2201/0627
摘要： Embodiments of the present disclosure include an optical probe capable of communicating identification information to a patient monitor in addition to signals indicative of intensities of light after attenuation by body tissue. The identification information may indicate operating wavelengths of light sources, indicate a type of probe, such as, for example, that the probe is an adult probe, a pediatric probe, a neonatal probe, a disposable probe, a reusable probe, or the like. The information could also be utilized for security purposes, such as, for example, to ensure that the probe is configured properly for the oximeter, to indicate that the probe is from an authorized supplier, or the like.
摘要翻译：本公开的实施例还包括能够向身体组织衰减之后除了表示光强度的信号之外，向患者监视器传送识别信息的光学探针。识别信息可以指示光源的操作波长，指示探针的类型，例如探针是成人探针，儿科探针，新生儿探针，一次性探针，可重复使用的探针等。该信息也可以用于安全目的，例如，以确保探针被适当地配置用于血氧计，以指示探针来自授权供应商等。

5. 发明授权

US07526328B2 Manual and automatic probe calibration 失效
标题翻译：手动和自动探头校准
公开(公告)号：US07526328B2
公开(公告)日：2009-04-28
申请号：US11640077
申请日：2006-12-15
申请人： Mohamed Kheir Diab , Massi E. Kiani , Charles Robert Ragsdale , James M. Lepper, Jr.
发明人： Mohamed Kheir Diab , Massi E. Kiani , Charles Robert Ragsdale , James M. Lepper, Jr.
IPC分类号： A61B5/1455
CPC分类号： A61B5/1495 , A61B5/0205 , A61B5/02427 , A61B5/14552 , A61B5/6826 , A61B5/6838 , A61B2562/08 , G01J3/02 , G01J3/0254 , G01J3/027 , G01J3/0275 , G01J3/0291 , G01J3/10 , G01J2003/2866 , G01N21/255 , G01N21/274 , G01N21/31 , G01N21/3151 , G01N21/39 , G01N2021/3144 , G01N2201/0627
摘要： Embodiments of the present disclosure include an optical probe capable of communicating identification information to a patient monitor in addition to signals indicative of intensities of light after attenuation by body tissue. The identification information may indicate operating wavelengths of light sources, indicate a type of probe, such as, for example, that the probe is an adult probe, a pediatric probe, a neonatal probe, a disposable probe, a reusable probe, or the like. The information could also be utilized for security purposes, such as, for example, to ensure that the probe is configured properly for the oximeter, to indicate that the probe is from an authorized supplier, or the like. In one preferred embodiment, coding resistors could be provided across the light sources to allow additional information about the probe to be coded without added leads. However, any device could be used without it being used in parallel.
摘要翻译：本公开的实施例还包括能够向身体组织衰减之后除了表示光强度的信号之外，向患者监视器传送识别信息的光学探针。识别信息可以指示光源的操作波长，指示探针的类型，例如探针是成人探针，儿科探针，新生儿探针，一次性探针，可重复使用的探针等。该信息也可以用于安全目的，例如，以确保探针被适当地配置用于血氧计，以指示探针来自授权供应商等。在一个优选实施例中，编码电阻器可以跨越光源提供，以允许关于探针的附加信息被编码而没有添加引线。但是，任何设备都可以在没有并行使用的情况下使用。

6. 发明授权

US06278522B1 Optical filter for spectroscopic measurement and method of producing the optical filter 有权
标题翻译：用于光谱测量的光学滤波器及其制造方法
公开(公告)号：US06278522B1
公开(公告)日：2001-08-21
申请号：US09318721
申请日：1999-05-26
申请人： James M. Lepper, Jr. , Mohamed Kheir Diab
发明人： James M. Lepper, Jr. , Mohamed Kheir Diab
IPC分类号： G01N2125
CPC分类号： G01N21/314 , G01J3/26 , G02B5/285
摘要： An optical filter used in applications involving spectroscopic measurements is fabricated by depositing layers of optical coatings onto a substrate. The layers are deposited so as to have a substantially constant thickness in a first direction along the surface of the substrate, and a gradually increasing thickness along a direction perpendicular to the first direction. The structure of the optical filter allows for large scale production of the filter so that costs in producing the filter are greatly reduced. The filter may be used in a variety of applications including, but not limited to chemical analysis, blood glucose monitoring, and the like.
摘要翻译：用于涉及光谱测量的应用中的光学滤波器通过将光学涂层层沉积到衬底上来制造。这些层被沉积成沿着基板的表面沿着第一方向具有基本恒定的厚度，并且沿垂直于第一方向的方向逐渐增加厚度。滤光器的结构允许大规模生产过滤器，从而大大降低了生产过滤器的成本。过滤器可以用于各种应用，包括但不限于化学分析，血糖监测等。

7. 发明授权

US5638818A Low noise optical probe 失效
标题翻译：低噪声光探头
公开(公告)号：US5638818A
公开(公告)日：1997-06-17
申请号：US333132
申请日：1994-11-01
申请人： Mohamed Kheir Diab , Esmaiel Kiani-Azarbayjany , James M. Lepper, Jr.
发明人： Mohamed Kheir Diab , Esmaiel Kiani-Azarbayjany , James M. Lepper, Jr.
IPC分类号： A61B5/022 , A61B5/00 , A61B5/024 , A61B5/0245 , A61B5/145 , A61B5/1455 , G01N21/17 , G01N21/59 , H05K1/18
CPC分类号： A61B5/14552 , A61B5/02427 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B2562/08 , A61B2562/12 , H05K1/189
摘要： An optical probe for measurements, which is particularly suited to reduce noise in measurements taken on an easily compressible material, such as a finger, a toe, a forehead, an earlobe, or a lip. The probe includes a base having an aperture which leads to a chamber. The base is placed adjacent a portion of the material, the chamber being placed directly adjacent any easily compressible portion of the material. A photodetector is located within the chamber and does not contact the material. A light emitting diode (LED) is affixed to the material, opposite the photodetector and above the chamber. The material which is supported by the aperture and therefore rests above or has intruded into the chamber is inhibited from compression since nothing comes in contact with this portion of the material, even when the material moves. Thus, light from the LED is directed through a stabilized portion of the material, i.e., the optical path length through which light travels is stabilized, even during motion of the material. This reduces noise in the signal measured by the photodetector. A scattering medium is interposed between the LED and the material, between the material and the photodetector, or between the LED and the material as well as between the material and the photodetector. The scattering medium is used to improve the signal-to-noise ratio of the received optical signal.
摘要翻译：用于测量的光学探针，其特别适用于减少在容易压缩的材料（例如手指，脚趾，额头，耳垂或唇部）上进行的测量中的噪声。探针包括具有通向腔室的孔的底座。基部放置在材料的一部分附近，该腔被直接放置在材料的任何容易压缩的部分附近。光电检测器位于室内并且不接触材料。发光二极管（LED）固定在材料上，与光电检测器相对并且在室上方。被孔支撑并且因此搁置在腔室中或已经入侵到腔室中的材料被抑制，因为即使当材料移动时也不会与材料的这一部分接触。因此，即使在材料的运动期间，来自LED的光被引导通过材料的稳定部分，即光行进的光路长度被稳定。这降低了由光电检测器测量的信号中的噪声。散射介质介于LED和材料之间，材料和光电检测器之间，或介于LED和材料之间以及材料与光电检测器之间。散射介质用于提高接收到的光信号的信噪比。

8. 再颁专利

USRE44875E1 Active pulse blood constituent monitoring 失效
标题翻译：有源脉搏血液成分监测
公开(公告)号：USRE44875E1
公开(公告)日：2014-04-29
申请号：US13047740
申请日：2011-03-14
申请人： Massi Joe E. Kiani , Mohamed Kheir Diab , James M. Lepper, Jr.
发明人： Massi Joe E. Kiani , Mohamed Kheir Diab , James M. Lepper, Jr.
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/14532 , A61B5/1455 , A61B5/6826 , A61B5/6838 , A61B2560/0462
摘要： A blood constituent monitoring method for inducing an active pulse in the blood volume of a patient. The induction of an active pulse results in a cyclic, and periodic change in the flow of blood through a fleshy medium under test. By actively inducing a change of the blood volume, modulation of the volume of blood can be obtained to provide a greater signal to noise ratio. This allows for the detection of constituents in blood at concentration levels below those previously detectable in a non-invasive system. Radiation which passes through the fleshy medium is detected by a detector which generates a signal indicative of the intensity of the detected radiation. Signal processing is performed on the electrical signal to isolate those optical characteristics of the electrical signal due to the optical characteristics of the blood.
摘要翻译：一种用于在患者的血液体积中诱导活性脉冲的血液成分监测方法。活性脉冲的诱导导致血液通过待测肉质培养基的循环和周期性变化。通过积极地引起血液量的变化，可以获得血液体积的调节以提供更大的信噪比。这允许以非侵入性系统中先前可检测的浓度水平检测血液中的成分。通过肉质培养基的辐射由产生指示检测到的辐射强度的信号的检测器检测。对电信号执行信号处理，以隔离由于血液的光学特性引起的电信号的这些光学特性。

9. 发明授权

US6110522A Blood glucose monitoring system 失效
标题翻译：血糖监测系统
公开(公告)号：US6110522A
公开(公告)日：2000-08-29
申请号：US61174
申请日：1998-04-16
申请人： James M. Lepper, Jr. , Mohamed Kheir Diab
发明人： James M. Lepper, Jr. , Mohamed Kheir Diab
IPC分类号： G01N21/35 , A61B5/00 , A61B5/145 , A61B5/1455 , G01N21/31 , G02B7/00 , B05D3/00 , B05D5/06
CPC分类号： A61B5/1455 , A61B5/14532 , G01N21/31 , G02B26/008
摘要： A blood glucose monitoring system includes a broadband light source and a specially fabricated optical filter for modulating optical radiation to be transmitted through a fleshy medium. Optical radiation which passes through the fleshy medium is detected by an optical detector which generates an electrical signal indicative of the intensity of the detected light. Digital signal processing is performed on the electrical signal to extract those optical characteristics of the electrical signal due to the optical characteristics of the filter and constituents of the fleshy May 1, 1995 medium other than blood glucose concentration. The monitoring system employs a unique "double-log" transformation to minimize errors due to indeterminate path length variations of the optical radiation through the fleshy medium. The monitoring system further employs specialized signal processing to avoid inaccuracies due to the previously unidentified solvent effect which arises when glucose is dissolved into water.
摘要翻译：血糖监测系统包括宽带光源和用于调制通过肉质培养基传播的光辐射的特制光滤波器。通过肉质介质的光辐射由光学检测器检测，该检测器产生指示检测到的光的强度的电信号。对电信号执行数字信号处理，以提取滤光器的光学特性和除了血糖浓度以外的肉质的1995年5月1日的培养基的成分的电信号的这些光学特性。监测系统采用独特的“双对数”变换，以通过肉肉培养基对光学辐射的不确定的路径长度变化来最小化误差。监测系统还采用专门的信号处理，以避免由于当葡萄糖溶解在水中时出现的先前未识别的溶剂效应引起的不准确。

10. 发明授权

US5860919A Active pulse blood constituent monitoring method 失效
标题翻译：有源脉搏血成分监测方法
公开(公告)号：US5860919A
公开(公告)日：1999-01-19
申请号：US843863
申请日：1997-04-17
申请人： Esmaiel Kiani-Azarbayjany , Mohamed Kheir Diab , James M. Lepper, Jr.
发明人： Esmaiel Kiani-Azarbayjany , Mohamed Kheir Diab , James M. Lepper, Jr.
IPC分类号： G01N21/35 , A61B5/00 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/14552 , A61B5/14532 , A61B5/1455 , A61B5/6826 , A61B5/6838 , A61B2560/0462 , G01N2021/1723
摘要： A monitoring method is disclosed which provides for inducing an active pulse in a blood volume of a patient. The induction of an active pulse results in a cyclic, and periodic change in the flow of blood through a fleshy medium under test. By actively inducing a change of the blood volume, modulation of the volume of blood can be obtained to provide a greater signal to noise ratio. This allows for the detection of constituents in blood at concentration levels below those previously detectable in a non-invasive system. Radiation which passes through the fleshy medium is detected by a detector which generates a signal indicative of the intensity of the detected radiation. Signal processing is performed on the electrical signal to isolate those optical characteristics of the electrical signal due to the optical characteristics of the blood.
摘要翻译：公开了一种监测方法，其提供在患者的血液体积中诱导活动脉冲。活性脉冲的诱导导致血液通过待测肉质培养基的循环和周期性变化。通过积极地引起血液量的变化，可以获得血液体积的调节以提供更大的信噪比。这允许以非侵入性系统中先前可检测的浓度水平检测血液中的成分。通过肉质培养基的辐射由产生指示检测到的辐射强度的信号的检测器检测。对电信号执行信号处理，以隔离由于血液的光学特性引起的电信号的这些光学特性。

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