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    • 1. 发明申请
    • Treating mouth sores caused by dental braces with blobs of hydrophilic gums
    • 治疗口腔溃疡由牙套和亲水性牙龈斑点引起
    • US20070098648A1
    • 2007-05-03
    • US11640147
    • 2006-12-14
    • Jeffrey Haley
    • Jeffrey Haley
    • A61K36/48A61K31/58A61K9/68
    • A61K31/58A61K9/006A61K36/484A61K2300/00
    • A method for treating mouth sores caused by abrasion of orthodontic braces by placing oral patch or blob on the brace or sore to speed healing and relieve pain. The oral patch or blob is placed either on the portion of the brace that comes into contact with the sore or onto the sore directly. If certain medications are applied to a mouth sore using an oral patch or blob that restricts local flow of saliva and delivers the medication for at least 30 minutes and the patch or blobs are used for at least two or more hours per day, the method reduces the healing time for mouth sores from typical 10-14 days to 1-5 days. The method can be used with various antimicrobials, glucocorticoids or anthihistamines incorporated into the patch or blob that reduce inflammation or speed the healing of mouth sores caused by braces.
    • 一种通过将口腔贴片或斑点放置在支架或疮上来治疗由正畸括号磨损引起的口疮的方法,以加速愈合和缓解疼痛。 将口腔贴片或斑块放置在与疼痛接触或直接暴露于酸痛的支架部分上。 如果使用限制唾液局部流动并将药物输送至少30分钟的口腔补片或斑块将某些药物施用于口腔炎,并且每天使用斑块或斑块至少两个或更多小时,则该方法减少 口疮从典型的10-14天到1-5天的愈合时间。 该方法可与各种抗微生物剂,糖皮质激素或结合到斑块或斑块中的硫代组胺一起使用,可减少炎症或加速由大括号引起的口腔溃疡愈合。
    • 5. 发明申请
    • Combating sinus, throat, and blood infections with xylitol delivered in the mouth
    • 与口腔中输送的木糖醇抵抗窦,咽喉和血液感染
    • US20070293587A1
    • 2007-12-20
    • US11895441
    • 2007-08-24
    • Jeffrey Haley
    • Jeffrey Haley
    • A61K31/45A61P11/02A61P11/04A61P19/02A61P9/00
    • A61K31/45
    • A method of suppressing bacteria that cause infections of the throat, sinuses, heart and arteries, and joints (arthritis) by delivering xylitol in a human mouth. The method is effective with troches of pure xylitol or with xylitol chewing gum or liquid, provided sufficient quantities of xylitol are delivered. Streptococcus mutans and Staphylococcus aureus in the blood are important contributors to plaque in arteries and on heart valves and bacterial arthritis. For people whose blood is not already infected with significant levels of these bacteria, every day use of xylitol sufficient to suppress these bacteria in the oral cavity will reduce their risk of subsequent cardiovascular disease, arthritis, and sinus infections. Strep throat is a common throat infection caused by Streptococcus pyogenes. Frequent bathing with xylitol, such as from time release in the mouth, will speed recovery from strep throat.
    • 通过在人口中输送木糖醇来抑制引起喉咙,鼻窦,心脏和动脉以及关节(关节炎)感染的细菌的方法。 该方法对于纯木糖醇或木糖醇口香糖或液体的混合物是有效的,只要提供足够量的木糖醇即可。 血液中的变形链球菌和金黄色葡萄球菌是动脉和心脏瓣膜和细菌性关节炎中斑块的重要贡献者。 对于血液尚未感染这些细菌的人群,每天使用足以抑制口腔细菌的木糖醇会降低其后续心血管疾病,关节炎和鼻窦感染的风险。 链球菌性咽喉炎是由化脓性链球菌引起的常见咽喉感染。 频繁沐浴木糖醇,例如从口中释放出来,将加速从链球菌唾液中恢复。
    • 7. 发明申请
    • Water soluble anesthetic in an oral patch of hydrophilic gums
    • 水溶性麻醉剂在亲水性牙龈的口腔贴剂中
    • US20070042027A1
    • 2007-02-22
    • US11492416
    • 2006-07-24
    • Jeffrey Haley
    • Jeffrey Haley
    • A61F13/02
    • A61K9/006
    • An oral patch for treating toothaches and oral lesions, including mouth ulcers (canker sores/aphthous ulcers) with water soluble topical anesthetics such as dyclonine hydrochloride. In one embodiment, the patch is made by depositing blobs of wet mixture including anesthetic, muco-adhesive hydrocolloids such as collagen, and bingers onto flat sheets. The blobs on the sheets are then dried with air convection, causing the blobs to shrink in height, forming tapered discs with rounded edges. A coating is sprayed onto one side to prevent release of the anesthetic on that side. The base sheets serve as packaging and a lid sheet may be adhered to the base sheet, such as by heat sealing with a hot platen pressing both sheets against an anvil. The platen or the anvil (or both) has recesses that prevent the discs from being pressed during sealing. The sealed package is then cut to size, such as by die cutting.
    • 用于治疗牙痛和口腔损伤的口腔补片,包括口服溃疡(溃疡疮/口疮性溃疡)与水溶性局部麻醉剂如盐酸地尼克宁。 在一个实施方案中,通过将包含麻醉剂,粘膜粘合剂水胶体例如胶原和粘合剂的湿混合物块沉积在平板上来制备贴片。 然后将片材上的斑块用空气对流干燥,使斑块高度收缩,形成具有圆形边缘的锥形盘。 将涂层喷涂到一侧以防止在该侧释放麻醉剂。 基片用作包装,并且盖片可以粘附到基片上,例如通过用热压板热压两个片材抵靠砧座。 压板或砧座(或两者)具有在密封期间防止盘被压制的凹部。 然后将密封包装切割成尺寸,例如通过模切。
    • 8. 发明申请
    • Method for manufacturing and packaging oral patches with rounded edges
    • 用于制造和包装具有圆形边缘的口腔贴剂的方法
    • US20050226915A1
    • 2005-10-13
    • US11157054
    • 2005-06-20
    • Jeffrey Haley
    • Jeffrey Haley
    • A61K9/00A61K9/70
    • A61K9/006A61K9/7007
    • A method of manufacturing and packaging discs made of hydrophilic gums, such as adherent, soluble oral patches for delivering topical medication in the mouth. The hydrophilic gums are mixed with water and deposited as blobs onto base sheet material such as thermoplastic. The blobs on the sheets are then dried with air convection, causing the blobs to shrink in height, forming tapered discs with rounded edges. Before being deposited, the mixture may be heated to above an activation temperature that is below boiling, and then, after being deposited, the mixture is allowed to cool to form a gel. The base sheets serve as packaging and a lid sheet may be adhered to the base sheet, such as by heat sealing with a hot platten pressing both sheets against an anvil. The platen or the anvil (or both) has recesses that prevent the discs from being pressed during sealing. The sealed package is then cut to size, such as by die cutting.
    • 制造和包装由亲水性树胶制成的圆盘的方法,例如用于在口中递送局部药物的粘附的可溶性口腔贴剂。 将亲水性树胶与水混合并且以斑点形式沉积到诸如热塑性塑料的基片材料上。 然后将片材上的斑块用空气对流干燥,使斑块高度收缩,形成具有圆形边缘的锥形盘。 在沉积之前,可将混合物加热至低于沸点的活化温度,然后沉积后,使混合物冷却以形成凝胶。 基片用作包装,并且盖片可以粘附到基片上,例如通过用热压板热压两个片材抵靠砧座。 压板或砧座(或两者)具有在密封期间防止盘被压制的凹部。 然后将密封包装切割成尺寸,例如通过模切。