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1. 发明申请

US20120264792A1 FURAZANOBENZIMIDAZOLES AS PRODRUGS TO TREAT NEOPLASTIC OR AUTOIMMUNE DISEASES 有权
标题翻译：作为PROPRUGS治疗神经性或自身免疫性疾病的FURAZANOBENZIMIDAZOLES
公开(公告)号：US20120264792A1
公开(公告)日：2012-10-18
申请号：US13384467
申请日：2010-07-26
申请人： Jens Pohlmann , Felix Bachmann
发明人： Jens Pohlmann , Felix Bachmann
IPC分类号： A61K31/4245 , A61P37/06 , A61P37/00 , C07D413/04 , A61P35/00
CPC分类号： C07D413/04
摘要： A compound of formula (II) wherein represents a divalent benzene residue which is unsubstituted or substituted by one or two additional substituents independently selected from lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, mono(lower alkyl)amino, di(lower alkyl)amino, mono(lower alkenyl)amino, di(lower alkenyl)amino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, cyano, halogen, and nitro; or wherein two adjacent substituents can be methylenedioxy; or a divalent pyridine residue (Z=N) which is unsubstituted or substituted additionally by lower alkyl, lower alkoxy, lower alkoxy-lower alkoxy, amino, optionally substituted by one or two substituents selected from lower alkyl, lower alkenyl and alkylcarbonyl, halo-lower alkyl, lower alkoxy-lower alkyl, or halogen; R1 represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkyl; and R2 represents a group selected from: or pharmaceutically acceptable salts thereof.
摘要翻译：式（II）的化合物，其表示未取代的或被一个或两个独立地选自低级烷基，卤代低级烷基，羟基 - 低级烷基，低级烷氧基 - 低级烷基，酰氧基 - 低级烷基苯基，羟基，低级烷氧基，羟基 - 低级烷氧基，低级烷氧基 - 低级烷氧基，苯基 - 低级烷氧基，低级烷基羰基氧基，氨基，单（低级烷基）氨基，二（低级烷基）氨基，单（低级烯基）氨基，二（低级烯基）氨基，低级烷氧基羰基氨基，低级烷基羰基氨基，取代氨基，其中氮上的两个取代基与氮杂环基，低级烷基羰基，羧基，低级烷氧基羰基，氰基，卤素和硝基形成。或其中两个相邻的取代基可以是亚甲二氧基; 或未经取代或被低级烷基，低级烷氧基，低级烷氧基 - 低级烷氧基取代的二价吡啶残基（Z = N），任选被一个或两个选自低级烷基，低级烯基和烷基羰基，卤代烷基，低级烷基，低级烷氧基 - 低级烷基或卤素; R 1表示氢，低级烷基羰基，羟基 - 低级烷基或氰基 - 低级烷基; 并且R 2表示选自下列的基团：或其药学上可接受的盐。

2. 发明授权

US07767702B2 Substituted oxazolidinones for combinational therapy 有权
标题翻译：用于组合治疗的取代恶唑烷酮
公开(公告)号：US07767702B2
公开(公告)日：2010-08-03
申请号：US10481297
申请日：2002-06-07
申请人： Alexander Straub , Thomas Lampe , Josef Pernerstorfer , Elisabeth Perzborn , Jens Pohlmann , Susanne Röhrig , Karl-Heinz Schlemmer
发明人： Alexander Straub , Thomas Lampe , Josef Pernerstorfer , Elisabeth Perzborn , Jens Pohlmann , Susanne Röhrig , Karl-Heinz Schlemmer
IPC分类号： A61K31/421
CPC分类号： A61K31/422 , A61K31/421 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The invention relates to combinations of A) oxazolidinones of formula (I) and B) other active ingredients, to a method for producing said combinations and to the use thereof as medicaments, in particular for the treatment and/or prophylaxis of thrombo-embolic diseases.
摘要翻译：本发明涉及式（I）的A）恶唑烷酮和B）其它活性成分的组合，用于制备所述组合的方法及其作为药物的用途，特别是用于治疗和/或预防血栓栓塞性疾病。

3. 发明申请

US20100041646A1 Phenylene-Bis-Oxazolidine Derivatives and Their Use as Anticoagulants 审中-公开
标题翻译：苯二酚 - 双恶唑烷衍生物及其作为抗凝剂的用途
公开(公告)号：US20100041646A1
公开(公告)日：2010-02-18
申请号：US12084267
申请日：2006-10-20
申请人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
发明人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
IPC分类号： A61K31/422 , C07D413/14 , A61K31/5355 , A61P7/02 , C12N5/00
CPC分类号： C07D413/14
摘要： The present application relates to novel 1,4-phenylene-bis-oxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译：本申请涉及新的1,4-亚苯基 - 双恶唑烷衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防的药物的用途的疾病，特别是血栓栓塞性疾病。

4. 发明申请

US20080214533A1 Cyclic Iminocarbamates And Their Use 审中-公开
标题翻译：循环下列腺素和其使用
公开(公告)号：US20080214533A1
公开(公告)日：2008-09-04
申请号：US11792108
申请日：2005-11-22
申请人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
发明人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
IPC分类号： A61K31/5355 , C07D401/14 , C07D413/14 , A61K31/4439 , C07D417/14 , A61K31/497 , A61P7/00
CPC分类号： C07D413/14
摘要： The invention relates to novel cyclic iminocarbamates of formula (I), wherein R1, R2, R3, A, Z, and n have the meanings recited in the description, to a method for the production thereof, to pharmaceutical compositions containing such materials, and to methods for the treatment and/or prophylaxis of thromboembolic diseases using them.
摘要翻译：本发明涉及式（I）的新型环状亚氨基化物，其中R 1，R 2，R 3，A，Z和n 具有本说明书中所述的含义，其制备方法，含有这些材料的药物组合物，以及使用它们治疗和/或预防血栓栓塞性疾病的方法。

5. 发明申请

US20080200674A1 SUBSTITUTED OXAZOLIDINONES AND THEIR USE IN THE FIELD OF BLOOD COAGULATION 有权
标题翻译：替代奥昔洛芬及其在血液凝固领域的应用
公开(公告)号：US20080200674A1
公开(公告)日：2008-08-21
申请号：US12027553
申请日：2008-02-07
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： C07D413/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译：本发明涉及血液凝固领域。描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。

6. 发明申请

US20060287315A1 Pyrazinedicarboxamides and their use 审中-公开
标题翻译：吡嗪二甲酰胺及其用途
公开(公告)号：US20060287315A1
公开(公告)日：2006-12-21
申请号：US11299342
申请日：2005-12-08
申请人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
发明人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
IPC分类号： A61K31/5377 , A61K31/497 , C07D413/02 , C07D403/02
CPC分类号： C07D491/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel pyridinedicarboxamides, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译：本发明涉及新的吡啶二酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

7. 发明申请

US20060258724A1 Substituted Oxazolidinones and Their Use in the Field of Blood Coagulation 有权
标题翻译：取代的恶唑烷酮及其在血液凝固领域的应用
公开(公告)号：US20060258724A1
公开(公告)日：2006-11-16
申请号：US11460529
申请日：2006-07-27
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Rohrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/422 , C07D413/02
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
摘要翻译：本发明涉及血液凝固领域。描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。

8. 发明授权

US06933295B2 Substituted isoindoles and the use thereof 失效
标题翻译：取代的异吲哚及其用途
公开(公告)号：US06933295B2
公开(公告)日：2005-08-23
申请号：US10484369
申请日：2002-07-03
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Stephan Jordan , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Stephan Jordan , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： C07D473/00 , A61K31/4025 , A61K31/4035 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/52 , A61K31/5377 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P19/02 , A61P25/28 , A61P35/00 , C07D209/46 , C07D209/48 , C07D213/81 , C07D409/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/14 , C07D521/00 , C07D487/04
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D409/12 , C07D409/14 , C07D471/14
摘要： The invention relates to the field of blood clotting, to novel compounds of formula (I), to a method for their production and to the use of these compounds as active ingredients in medicaments for preventing and/or treating diseases. The compounds are factor Xa inhibitors.
摘要翻译：本发明涉及血液凝固领域，关于式（I）的新化合物，其制备方法和这些化合物作为用于预防和/或治疗疾病的药物中的活性成分的用途。化合物是因子Xa抑制剂。

9. 发明授权

US09224528B2 Electromagnetically actuatable valve 有权
标题翻译：电磁致动阀
公开(公告)号：US09224528B2
公开(公告)日：2015-12-29
申请号：US13512513
申请日：2010-10-07
申请人： Jens Pohlmann , Juergen Graner
发明人： Jens Pohlmann , Juergen Graner
IPC分类号： F16K31/02 , H01F7/08 , F16K31/06 , B22F3/22 , F02M51/06 , F02M63/00 , H01F41/02 , H01F7/16
CPC分类号： H01F7/081 , B22F3/225 , F02M51/0664 , F02M63/007 , F02M2200/08 , F02M2200/8046 , F16K31/0655 , H01F41/0246 , H01F2007/086 , H01F2007/1676 , Y10T29/4902
摘要： An electrically actuatable valve for injecting fuel includes a magnetic actuator having multiple components, at least one component of the magnetic actuator having multiple sectors made of soft magnetic material and multiple insulating separating webs. A separating web is situated between each two neighboring sectors and entirely separates the neighboring sectors from one another electrically.
摘要翻译：用于喷射燃料的电致动阀包括具有多个部件的磁致动器，所述磁致动器的至少一个部件具有由软磁材料制成的多个扇区和多个绝缘隔离带。分离纸幅位于每个两个相邻扇区之间，并且将相邻扇区彼此电气地完全分离。

10. 发明申请

US20100267685A1 Methods For The Prophylaxis And/or Treatment Of Thromboembolic Disorders By Combination Therapy With Substituted Oxazolidinones 审中-公开
标题翻译：通过与取代的恶唑烷酮组合治疗预防和/或治疗血栓栓塞障碍的方法
公开(公告)号：US20100267685A1
公开(公告)日：2010-10-21
申请号：US12766365
申请日：2010-04-23
申请人： Alexander Straub , Thomas Lampe , Josef Pernerstorfer , Elisabeth Perzborn , Jens Pohlmann , Susanne Röhrig , Karl-Heinz Schlemmer
发明人： Alexander Straub , Thomas Lampe , Josef Pernerstorfer , Elisabeth Perzborn , Jens Pohlmann , Susanne Röhrig , Karl-Heinz Schlemmer
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/541 , A61K31/4365 , A61K31/428 , A61K31/496 , A61K31/444 , A61K31/454 , A61K31/422 , A61K31/423 , A61K31/538 , A61K31/4439 , A61K31/5355 , A61K31/427 , A61P9/08 , A61P7/02 , A61P9/10 , A61P3/06 , A61P9/00 , A61P9/04 , A61K31/5365
CPC分类号： A61K31/422 , A61K31/421 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The invention relates to combinations of A) oxazolidinones of formula (I) and B) other active ingredients, to a method for producing said combinations and to the use thereof as medicaments, in particular for the treatment and/or prophylaxis of thrombo-embolic diseases.
摘要翻译：本发明涉及式（I）的A）恶唑烷酮和B）其它活性成分的组合，用于制备所述组合的方法及其作为药物的用途，特别是用于治疗和/或预防血栓栓塞性疾病。

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