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1. 发明授权

US08974529B2 Artificial disc 有权
标题翻译：人造盘
公开(公告)号：US08974529B2
公开(公告)日：2015-03-10
申请号：US13376108
申请日：2010-05-14
申请人： Cheng-kung Cheng , Peng Chai , Fuqiang Zhao , Jianxiang Liu
发明人： Cheng-kung Cheng , Peng Chai , Fuqiang Zhao , Jianxiang Liu
IPC分类号： A61F2/44 , A61F2/30
CPC分类号： A61F2/4425 , A61F2002/30062 , A61F2002/30079 , A61F2002/302 , A61F2002/305 , A61F2002/30502 , A61F2002/30504 , A61F2002/30505 , A61F2002/30566 , A61F2002/30604 , A61F2002/30607 , A61F2002/30647 , A61F2002/30649 , A61F2002/30662 , A61F2002/30841 , A61F2230/0065 , Y10T29/49826
摘要： An artificial disc includes an upper joint (3) and a lower joint (7) which fit each other in a corresponding upper and lower relationship, and a removable fixed connection structure for fixedly connecting the upper joint (3) and the lower joint (7).
摘要翻译：人造盘包括以相应的上下关系彼此配合的上接头（3）和下接头（7），以及用于固定地连接上接头（3）和下接头（7）的可拆卸固定连接结构）。

2. 发明申请

US20120095562A1 ARTIFICIAL DISC 有权
标题翻译：人造盘
公开(公告)号：US20120095562A1
公开(公告)日：2012-04-19
申请号：US13376108
申请日：2010-05-14
申请人： Cheng-kung Cheng , Peng Chai , Fuqiang Zhao , Jianxiang Liu
发明人： Cheng-kung Cheng , Peng Chai , Fuqiang Zhao , Jianxiang Liu
IPC分类号： A61F2/44 , B23P11/00
CPC分类号： A61F2/4425 , A61F2002/30062 , A61F2002/30079 , A61F2002/302 , A61F2002/305 , A61F2002/30502 , A61F2002/30504 , A61F2002/30505 , A61F2002/30566 , A61F2002/30604 , A61F2002/30607 , A61F2002/30647 , A61F2002/30649 , A61F2002/30662 , A61F2002/30841 , A61F2230/0065 , Y10T29/49826
摘要： An artificial intervertebral disc includes an upper joint (3) and a lower joint (7) configured according to the corresponding upper and lower positions, and which includes a removable fixing structure which makes a permanent connection between the upper joint (3) and the lower joint (7).
摘要翻译：人造椎间盘包括根据相应的上下位置构造的上接头（3）和下接头（7），并且其包括可移除的固定结构，其在上接头（3）和下接头关节（7）。

3. 发明授权

US07754683B2 Bioactive peptide of bone morphogenetic protein-2 失效
标题翻译：骨形态发生蛋白-2的生物活性肽
公开(公告)号：US07754683B2
公开(公告)日：2010-07-13
申请号：US12099869
申请日：2008-04-09
申请人： Xiaodong Guo , Qixin Zheng , Quan Yuan , Deyu Duan , Jianxiang Liu , Zhixia Duan
发明人： Xiaodong Guo , Qixin Zheng , Quan Yuan , Deyu Duan , Jianxiang Liu , Zhixia Duan
IPC分类号： A61K38/00 , A61K38/16 , A61K38/18
CPC分类号： C07K14/51 , A61K38/00 , A61K47/543
摘要： A bone morphogenetic protein-2 active peptide is characterized in that the structure is S[PO4]KIPKASSVPTELSAISTLYLDDD (SEQ ID NO: 1) or CCCCDDDS[PO4]KIPKASSVPTELSAISTLYL (SEQ ID NO: 2) or C16H31O—NH—CCCCGGGS[PO4]KIPKASSVPTELSAISTLYL (SEQ ID NO: 3). It overcomes the disadvantages of existing BMP-2, such as short half life, difficulty of sustained effect, complexity of equipments and preparation techniques, long production cycle, low yield, expensive price, and is accordingly difficult for large-scale production. In addition, the bone morphogenetic protein-2 active peptide exhibits the advantages, such as complete exposure of active sites, good ectopic osteogenesis ability, easy large-scale synthesis, lower cost, better stability and long duration. Meanwhile, the present invention also relates to the manufacturing method and application of such bone morphogenetic protein-2 active peptide.
摘要翻译：骨形态发生蛋白-2活性肽的特征在于结构为S [PO4] KIPKASSVPTELSAISTLYLDDD（SEQ ID NO：1）或CCCCDDDS [PO4] KIPKASSVPTELSAISTLYL（SEQ ID NO：2）或C16H31O-NH-CCCCGGGS [PO4] KIPKASSVPTELSAISTLYL （SEQ ID NO：3）。克服了现有BMP-2的缺点，如半衰期短，持续作用难度大，设备复杂度高，制备工艺复杂，生产周期长，产量低，价格昂贵，大规模生产难度大。此外，骨形态发生蛋白-2活性肽具有活性位点完全暴露，良好的异位成骨能力，易于大规模合成，成本低，稳定性好，持续时间长等优点。同时，本发明还涉及这种骨形态发生蛋白-2活性肽的制造方法和应用。

4. 发明申请

US20090082272A1 ACTIVE PEPTIDE OF BONE MORPHOGENETIC PROTEIN-2, METHOD FOR MANUFACTURING THE SAME AND THE APPLICATION 失效
标题翻译：骨形态蛋白-2的活性肽，其制备方法和应用
公开(公告)号：US20090082272A1
公开(公告)日：2009-03-26
申请号：US12099869
申请日：2008-04-09
申请人： Xiaodong GUO , Qixin ZHENG , Quan YUAN , Deyu DUAN , Jianxiang LIU , Zhixia DUAN
发明人： Xiaodong GUO , Qixin ZHENG , Quan YUAN , Deyu DUAN , Jianxiang LIU , Zhixia DUAN
IPC分类号： C07K14/435 , A61K38/17 , A61P19/00
CPC分类号： C07K14/51 , A61K38/00 , A61K47/543
摘要： A bone morphogenetic protein-2 active peptide is characterized in that the structure is S[PO4]KIPKASSVPTELSAISTLYLDDD or CCCCDDDS[PO4]KIPKASSVPTELSAISTLYL or C16H31O—NH—CCCCGGGS[PO4]-KIPKASSVPTELSAISTLYL. It overcomes the disadvantages of existing BMP-2, such as short half life, difficulty of sustained effect, complexity of equipments and preparation techniques, long production cycle, low yield, expensive price, and is accordingly difficult for large-scale production. In addition, the bone morphogenetic protein-2 active peptide exhibits the advantages, such as complete exposure of active sites, good ectopic osteogenesis ability, easy large-scale synthesis, lower cost, better stability and long duration. Meanwhile, the present invention also relates to the manufacturing method and application of such bone morphogenetic protein-2 active peptide
摘要翻译：骨形态发生蛋白-2活性肽的特征在于结构是S [PO4] KIPKASSVPTELSAISTLYLDDD或CCCCDDDS [PO4] KIPKASSVPTELSAISTLYL或C16H31O-NH-CCCCGGGS [PO4] -KIPKASSVPTELSAISTLYL。克服了现有BMP-2的缺点，如半衰期短，持续作用难度大，设备复杂度高，制备工艺复杂，生产周期长，产量低，价格昂贵，大规模生产难度大。此外，骨形态发生蛋白-2活性肽具有活性位点完全暴露，良好的异位成骨能力，易于大规模合成，成本低，稳定性好，持续时间长等优点。同时，本发明还涉及这种骨形态发生蛋白-2活性肽的制造方法和应用

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