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    • 3. 发明申请
    • Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery
    • 用于高剂量率气雾剂药物输送的气溶胶加工和吸入方法和系统
    • US20070144514A1
    • 2007-06-28
    • US11315951
    • 2005-12-22
    • Donovan YeatesJinghai YiGuanglin Li
    • Donovan YeatesJinghai YiGuanglin Li
    • A61M15/00B65D83/06
    • A61M15/0086A61M11/042A61M11/06A61M15/008A61M2016/0036A61M2205/362A61M2205/368B01D45/08
    • A method and system is disclosed which is capable of delivering at a high dose rate, respirable solid aerosols derived from aqueous- or nonaqueous-based solutions containing the desired therapeutic agent(s). The method and system comprises the integration of an aerosol generator, an aerosol evaporator, an aerosol concentrator, and an aerosol flow regulator. The aerosol generator generates 10-30 μm droplets, with a narrow size distribution. The aerosol jet is arrested by a coaxial counter-flow heated air jet, and evaporated rapidly by annular swirling heated air. Most of the air, together with the unwanted solvent vapor, is removed from the aerosol stream during the process of aerosol concentration. The output aerosol carries the dry particles to be inhaled by the patient. The respiratory-governed control of aerosol fluid generation system delivers fluid containing the test agent of interest (drug or toxin) to the aerosol generator throughout inhalation.
    • 公开了能够以高剂量率递送来自含有所需治疗剂的含水或非水性溶液的可呼吸固体气溶胶的方法和系统。 该方法和系统包括气溶胶发生器,气溶胶蒸发器,气溶胶浓缩器和气溶胶流量调节器的集成。 气溶胶发生器产生10-30个液滴,尺寸分布窄。 气溶胶射流被同轴逆流加热的空气射流阻止,并通过环形旋转的加热空气迅速蒸发。 在气溶胶浓缩过程中,大部分空气与不需要的溶剂蒸气一起从气溶胶流中除去。 输出的气溶胶携带干燥的颗粒被患者吸入。 呼吸控制的气溶胶液体发生系统在吸入过程中将含有感兴趣的测试剂(药物或毒素)的流体输送到气溶胶发生器。
    • 4. 发明授权
    • Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery
    • 用于高剂量率气雾剂药物输送的气溶胶加工和吸入方法和系统
    • US07802569B2
    • 2010-09-28
    • US11315951
    • 2005-12-22
    • Donovan B. YeatesJinghai YiGuanglin Li
    • Donovan B. YeatesJinghai YiGuanglin Li
    • A61M16/00
    • A61M15/0086A61M11/042A61M11/06A61M15/008A61M2016/0036A61M2205/362A61M2205/368B01D45/08
    • A method and system is disclosed which is capable of delivering at a high dose rate, respirable solid aerosols derived from aqueous- or nonaqueous-based solutions containing the desired therapeutic agent(s). The method and system comprises the integration of an aerosol generator, an aerosol evaporator, an aerosol concentrator, and an aerosol flow regulator. The aerosol generator generates 10-30 μm droplets, with a narrow size distribution. The aerosol jet is arrested by a coaxial counter-flow heated air jet, and evaporated rapidly by annular swirling heated air. Most of the air, together with the unwanted solvent vapor, is removed from the aerosol stream during the process of aerosol concentration. The output aerosol carries the dry particles to be inhaled by the patient. The respiratory-governed control of aerosol fluid generation system delivers fluid containing the test agent of interest (drug or toxin) to the aerosol generator throughout inhalation.
    • 公开了能够以高剂量率递送来自含有所需治疗剂的含水或非水性溶液的可呼吸固体气溶胶的方法和系统。 该方法和系统包括气溶胶发生器,气溶胶蒸发器,气溶胶浓缩器和气溶胶流量调节器的集成。 气溶胶发生器产生10-30微米的液滴,分布狭窄。 气溶胶射流被同轴逆流加热的空气射流阻止,并通过环形旋转的加热空气迅速蒸发。 在气溶胶浓缩过程中,大部分空气与不需要的溶剂蒸气一起从气溶胶流中除去。 输出的气溶胶携带干燥的颗粒被患者吸入。 呼吸控制的气溶胶液体发生系统在吸入过程中将含有感兴趣的测试剂(药物或毒素)的流体输送到气溶胶发生器。