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1. 发明授权

US09547060B2 Magnetic resonance using quazi-continuous RF irradiation 有权
标题翻译：使用quazi连续RF辐射的磁共振
公开(公告)号：US09547060B2
公开(公告)日：2017-01-17
申请号：US14002549
申请日：2012-02-28
申请人： Jochen Keupp , Johan Samuel Van Den Brink , Paul Royston Harvey
发明人： Jochen Keupp , Johan Samuel Van Den Brink , Paul Royston Harvey
IPC分类号： G01R33/56 , G01R33/54 , G01R33/36 , G01R33/561 , G01R33/565 , G01R33/32 , G01R33/34
CPC分类号： G01R33/54 , G01R33/32 , G01R33/34076 , G01R33/3614 , G01R33/5605 , G01R33/5612 , G01R33/5659
摘要： The invention relates to a method of MR imaging of at least a portion of a body (110) of a patient placed in an examination volume of a MR device, the method comprising the steps of:—subjecting the portion of the body (110) to an imaging sequence comprising at least one RF pulse, the RF pulse being transmitted toward the portion of the body (110) via a RF coil arrangement (109) to which RF signals are supplied by two or more RF power amplifiers the RF power amplifiers being activated alternately during the imaging sequence in a time-multiplexed fashion, wherein the imaging sequence requires a RF duty cycle and/or a RF pulse duration exceeding the specification of at least one of the RF power amplifiers;—acquiring MR signals from the portion of the body (110); and—reconstructing a MR image from the acquired MR signals. Moreover, the invention relates to a method of MR spectroscopy involving the alternating use of RF power amplifiers in a time-multiplexed fashion.
摘要翻译：本发明涉及放置在MR装置的检查体积中的患者的身体（110）的至少一部分的MR成像方法，该方法包括以下步骤： - 将身体部分（110）涉及包括至少一个RF脉冲的成像序列，所述RF脉冲经由RF线圈装置（109）朝向身体（110）的部分传输，RF信号由两个或更多个RF功率放大器提供给RF功率放大器在成像序列期间以时间复用的方式交替激活，其中所述成像序列需要超过RF功率放大器中的至少一个的规定的RF占空比和/或RF脉冲持续时间; - 从所述部分获取MR信号的身体（110）; 并从所获取的MR信号重构MR图像。此外，本发明涉及涉及以时分复用方式交替使用RF功率放大器的MR光谱的方法。

2. 发明申请

US20130342207A1 MAGNETIC RESONANCE USING QUAZI-CONTINUOUS RF IRRADIATION 有权
标题翻译：使用QUAZI连续射频辐射的磁共振
公开(公告)号：US20130342207A1
公开(公告)日：2013-12-26
申请号：US14002549
申请日：2012-02-28
申请人： Jochen Keupp , Johan Samuel Van Den Brink , Paul Royston Harvey
发明人： Jochen Keupp , Johan Samuel Van Den Brink , Paul Royston Harvey
IPC分类号： G01R33/54 , G01R33/32
CPC分类号： G01R33/54 , G01R33/32 , G01R33/34076 , G01R33/3614 , G01R33/5605 , G01R33/5612 , G01R33/5659
摘要： The invention relates to a method of MR imaging of at least a portion of a body (110) of a patient placed in an examination volume of a MR device, the method comprising the steps of:—subjecting the portion of the body (110) to an imaging sequence comprising at least one RF pulse, the RF pulse being transmitted toward the portion of the body (110) via a RF coil arrangement (109) to which RF signals are supplied by two or more RF power amplifiers the RF power amplifiers being activated alternately during the imaging sequence in a time-multiplexed fashion, wherein the imaging sequence requires a RF duty cycle and/or a RF pulse duration exceeding the specification of at least one of the RF power amplifiers;—acquiring MR signals from the portion of the body (110); and—reconstructing a MR image from the acquired MR signals. Moreover, the invention relates to a method of MR spectroscopy involving the alternating use of RF power amplifiers in a time-multiplexed fashion.
摘要翻译：本发明涉及放置在MR装置的检查体积中的患者的身体（110）的至少一部分的MR成像方法，该方法包括以下步骤： - 将身体部分（110）涉及包括至少一个RF脉冲的成像序列，所述RF脉冲经由RF线圈装置（109）朝向身体（110）的部分传输，RF信号由两个或更多个RF功率放大器提供给RF功率放大器在成像序列期间以时间复用的方式交替激活，其中所述成像序列需要超过RF功率放大器中的至少一个的规定的RF占空比和/或RF脉冲持续时间; - 从所述部分获取MR信号的身体（110）; 并从所获取的MR信号重构MR图像。此外，本发明涉及涉及以时分复用方式交替使用RF功率放大器的MR光谱的方法。

3. 发明申请

US20110288402A1 MR IMAGING WITH CEST CONTRAST ENHANCEMENT 审中-公开
标题翻译：成像与CEST对比增强
公开(公告)号：US20110288402A1
公开(公告)日：2011-11-24
申请号：US13139518
申请日：2009-12-15
申请人： Jeroen Alphons Pikkemaat , Sander Langereis , Holger Gruell , Dirk Burdinski , Rudolf Mathias Johannes Nicolaas Lamerichs , Jochen Keupp
发明人： Jeroen Alphons Pikkemaat , Sander Langereis , Holger Gruell , Dirk Burdinski , Rudolf Mathias Johannes Nicolaas Lamerichs , Jochen Keupp
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , G01R33/5616
摘要： The invention relates to a method of MR imaging of at least a portion of a body of a patient placed in an examination volume of an MR device. The object of the invention is to improve CEST contrast enhanced imaging. The method of the invention comprises the following steps: a) saturation of nuclear magnetization of exchangeable protons of a CEST contrast agent administered to the patient by subjecting the portion of the body to at least one frequency-selective saturation RF pulse matched to the MR frequency of exchangeable protons of the CEST contrast agent, wherein the saturation period, i.e. the duration of the frequency-selective saturation RF pulse, is shorter than the time required for saturation to build up a full CEST contrast enhancement effect when starting from zero saturation; b) generating at least one MR signal of water protons of the body by subjecting the portion of the body to an MR imaging sequence comprising at least one RF pulse and switched magnetic field gradients; c) acquiring sampling the at least one MR signal from the body; d) repeating steps a) to c) a number of times under variation of parameters of the MR imaging sequence, wherein MR signals are acquired and sampled during a saturation build-up period, i.e. before a steady state of the CEST effect is achieved; e) reconstructing a proton-density weighted, CEST contrast-enhanced MR image from the acquired and sampled MR signals.
摘要翻译：本发明涉及放置在MR装置检查体积中的患者身体的至少一部分的MR成像方法。本发明的目的是改善CEST对比度增强成像。本发明的方法包括以下步骤：a）通过使身体的一部分经受与MR频率匹配的至少一个频率选择性饱和RF脉冲，使给予患者的CEST造影剂的可交换质子的核磁化饱和的CEST造影剂的可交换质子，其中饱和周期，即频率选择性饱和RF脉冲的持续时间比从零饱和开始时建立饱和CEST对比度增强效果所需的时间短; b）通过使身体的一部分经受包括至少一个RF脉冲和切换的磁场梯度的MR成像序列来产生身体的水质子的至少一个MR信号; c）从身体采集至少一个MR信号; d）在MR成像序列的参数变化下重复步骤a）至c）多次，其中在饱和建立期间，即在实现CEST效应的稳定状态之前获取和采样MR信号; e）从获取和采样的MR信号重构质子密度加权的CEST对比度增强的MR图像。

4. 发明授权

US09733328B2 Compressed sensing MR image reconstruction using constraint from prior acquisition 有权
公开(公告)号：US09733328B2
公开(公告)日：2017-08-15
申请号：US14006244
申请日：2012-02-28
申请人： Mariya Ivanova Doneva , Stefanie Remmele , Peter Börnert , Peter Mazurkewitz , Julien Senegas , Jochen Keupp , Kay Nehrke
发明人： Mariya Ivanova Doneva , Stefanie Remmele , Peter Börnert , Peter Mazurkewitz , Julien Senegas , Jochen Keupp , Kay Nehrke
IPC分类号： G01R33/56 , G01R33/561 , G01R33/48 , G01R33/565
CPC分类号： G01R33/56 , G01R33/4824 , G01R33/5608 , G01R33/5611 , G01R33/56509
摘要： The invention relates to a method of MR imaging of at least a portion of a body (10) of a patient placed in an examination volume of a MR device (1), the method comprising the steps of: —subjecting the portion of the body (10) to a first imaging sequence for acquiring a first signal data set (21); —subjecting the portion of the body (10) to a second imaging sequence for acquiring a second signal data set (23), wherein the imaging parameters of the second imaging sequence differ from the imaging parameters of the first imaging sequence; —reconstructing a MR image from the second signal data set (23) by means of regularization using the first signal data set (21) as prior information. Moreover, the invention relates to a MR device (1) and to a computer program for a MR device (1).

5. 发明申请

US20090177076A1 MRI OF A CONTINUOUSLY MOVING OBJECT INVOLVING MOTION COMPENSATION 审中-公开
标题翻译：涉及运动补偿的连续移动对象的MRI
公开(公告)号：US20090177076A1
公开(公告)日：2009-07-09
申请号：US12296936
申请日：2007-04-05
申请人： Bernd Aldefeld , Peter Boernert , Jochen Keupp , Johan Samuel Van Den Brink
发明人： Bernd Aldefeld , Peter Boernert , Jochen Keupp , Johan Samuel Van Den Brink
IPC分类号： A61B5/05
CPC分类号： G01R33/56375 , G01R33/56383 , G01R33/56509 , G01R33/5673 , G01R33/5676
摘要： A magnetic resonance examination system has an object carrier (14) to move an object to be examined relative to the field of view. A monitoring system (33) monitors examination circumstances under which magnetic resonance signals are acquired from the object within the field of view. In particular the monitoring system monitors the degree of physiological motion in the patient to be examined. A velocity control system (32) to control the velocity of the movement of the object relative to the field of view and to control the velocity on the basis of the monitored examination circumstances, i.e. the degree of physiological motion.
摘要翻译：磁共振检查系统具有用于相对于视场移动待检查物体的物体载体（14）。监视系统（33）监视从视野内的物体获取磁共振信号的检查情况。特别地，监测系统监测待检查患者的生理运动程度。一种速度控制系统（32），用于控制物体相对于视场的移动速度，并且基于所监视的检查情况即生理运动的程度来控制速度。

6. 发明授权

US09795693B2 Drug carrier providing MRI contrast enhancement 有权
公开(公告)号：US09795693B2
公开(公告)日：2017-10-24
申请号：US13062550
申请日：2009-09-03
申请人： Sander Langereis , Jochen Keupp , Holger Gruell , Dirk Burdinski , Danielle Beelen
发明人： Sander Langereis , Jochen Keupp , Holger Gruell , Dirk Burdinski , Danielle Beelen
IPC分类号： A61K49/00 , A61K49/08 , A61K41/00 , A61K49/10 , A61K49/12 , A61K49/18 , A61K9/127
CPC分类号： A61K49/08 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K41/0028 , A61K49/10 , A61K49/12 , A61K49/1812
摘要： Described are drug carriers useful in magnetic resonance imaging (MRI)-guided drug release comprising a shell capable of releasing an enclosed biologically active agent as a result of a local stimulus, e.g. energy input, such as heat, wherein the shell encloses a 19F MR contrast agent. Preferably, the carrier also acts as a contrast enhancement agent for MRI based on the principle of Chemical Exchange-dependent Saturation Transfer (CEST). To this end the shell encloses a cavity that comprises a paramagnetic chemical shift reagent, a pool of proton analytes, and the 19F contrast agent, and wherein the shell allows diffusion of the proton analytes.

7. 发明申请

US20120089010A1 HYPERPOLARIZED CONTRAST AGENT DISPENSER FOR MAGNETIC RESONANCE IMAING 审中-公开
标题翻译：用于磁共振成像的超高对比度对比剂分配器
公开(公告)号：US20120089010A1
公开(公告)日：2012-04-12
申请号：US13377831
申请日：2010-06-23
申请人： Christoph Leussler , Peter Boernert , Daniel Wirtz , Bernd David , Holger Eggers , Jochen Keupp , Johannes Adrianus Overweg , Rainer Eckart
发明人： Christoph Leussler , Peter Boernert , Daniel Wirtz , Bernd David , Holger Eggers , Jochen Keupp , Johannes Adrianus Overweg , Rainer Eckart
IPC分类号： A61B5/055
CPC分类号： A61M16/10 , A61B5/055 , A61M16/14 , A61M2016/0015 , A61M2202/066
摘要： A dispenser (132), a magnetic resonance imaging system (100), and a method for using hyperpolarized contrast agent (304) during a magnetic resonance imaging examination. The dispenser comprises an attachment component (136) for a face piece (138). The face piece is adapted for receiving the surface of a subject (114) such that when the subject inhales hyperpolarized contrast agent enters the respiratory system of the subject. The dispenser further comprises a reservoir (300) adapted for receiving the hyperpolarized contrast agent. The dispenser further comprises a gas flow (406) tube connected to the attachment component and a vaporizer (406, 408, 412, 510, 602, 606) for vaporizing the hyperpolarized contrast agent in the gas flow tube into a hyperpolarized vapor. The dispenser further comprises a controller (402) for controlling when the vaporizer vaporizes the hyperpolarized contrast agent.
摘要翻译：分配器（132），磁共振成像系统（100）以及在磁共振成像检查期间使用超极化造影剂（304）的方法。分配器包括用于面件（138）的附接部件（136）。面部件适于接纳被检体（114）的表面，使得当受试者吸入超极化造影剂进入受试者的呼吸系统时。分配器还包括适于接收超极化造影剂的贮存器（300）。分配器还包括连接到附接部件的气流（406）管和用于将气体流管中的超极化造影剂蒸发成超极化蒸气的蒸发器（406,408,412,510,602,606）。分配器还包括控制器（402），用于控制何时蒸发器蒸发超极化造影剂。

8. 发明申请

US20110177009A1 DRUG CARRIER PROVIDING MRI CONTRAST ENHANCEMENT 有权
标题翻译：药物载体提供MRI对比增强
公开(公告)号：US20110177009A1
公开(公告)日：2011-07-21
申请号：US13062550
申请日：2009-09-03
申请人： Sander Langereis , Jochen Keupp , Holger Gruell , Dirk Burdinski , Danielle Beelen
发明人： Sander Langereis , Jochen Keupp , Holger Gruell , Dirk Burdinski , Danielle Beelen
IPC分类号： A61K49/18 , A61P35/00 , A61P9/00 , A61P43/00 , B82Y5/00
CPC分类号： A61K49/08 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K41/0028 , A61K49/10 , A61K49/12 , A61K49/1812
摘要： Described are drug carriers useful in magnetic resonance imaging (MRI)-guided drug release comprising a shell capable of releasing an enclosed biologically active agent as a result of a local stimulus, e.g. energy input, such as heat, wherein the shell encloses a 19F MR contrast agent. Preferably, the carrier also acts as a contrast enhancement agent for MRI based on the principle of Chemical Exchange-dependent Saturation Transfer (CEST). To this end the shell encloses a cavity that comprises a paramagnetic chemical shift reagent, a pool of proton analytes, and the 19F contrast agent, and wherein the shell allows diffusion of the proton analytes.
摘要翻译：描述了可用于磁共振成像（MRI）指导的药物释放的药物载体，其包含能够释放作为局部刺激的结果的封闭的生物活性剂的壳，例如，能量输入，例如热量，其中壳体包围19F MR造影剂。优选地，基于化学交换依赖性饱和转移（CEST）的原理，载体也用作MRI的对比度增强剂。为此，壳体包围包含顺磁化学位移试剂，质子分析物池和19F造影剂的空腔，并且其中壳允许质子分析物的扩散。

9. 发明申请

US20090033327A1 Magnetic Resonance Imaging of a Continuously Moving Object 审中-公开
标题翻译：连续移动物体的磁共振成像
公开(公告)号：US20090033327A1
公开(公告)日：2009-02-05
申请号：US11911723
申请日：2006-04-07
申请人： Bernd Aldefeld , Peter Boernert , Jochen Keupp
发明人： Bernd Aldefeld , Peter Boernert , Jochen Keupp
IPC分类号： G01R33/563
CPC分类号： G01R33/56375
摘要： A continuous moving table magnetic resonance imaging method is proposed where a ‘lateral’ read out is performed that is transverse to the direction of motion. This magnetic resonance imaging method for imaging a moving object includes spatially selective RF excitations are applied for respective phase-encodings. The sub-volume is excited by the spatially selective RF excitation moves with the motion of the object for respective subsets of primary phase-encodings. Acquisition of magnetic resonance signals is performed from a three-dimensional sub-volume of the object. The magnetic resonance signals are read encoded in a direction transverse to the direction of motion of the object and phase-encoded in at least the direction of motion of the object.
摘要翻译：提出了一种连续移动台磁共振成像方法，其中执行横向于运动方向的“横向”读出。用于对运动物体成像的这种磁共振成像方法包括空间选择性的RF激励用于各自的相位编码。子体积被空间选择性RF激发移动与物体的运动激励，以相应的主相位编码子集。从对象的三维子体积执行磁共振信号的获取。磁共振信号在横向于物体的运动方向的方向上被读取，并且至少在物体的运动方向上进行相位编码。

10. 发明申请

US20090003674A1 Sense Mr Parallel Imaging With Continuously Moving Bed 审中-公开
标题翻译：感觉并行成像与不断移动的床
公开(公告)号：US20090003674A1
公开(公告)日：2009-01-01
申请号：US11909167
申请日：2006-03-27
申请人： Jochen Keupp , Peter Boernert , Bernd Aldefeld
发明人： Jochen Keupp , Peter Boernert , Bernd Aldefeld
IPC分类号： G06K9/54
CPC分类号： G01R33/56375 , G01R33/5611
摘要： During continuous moving of an imaging subject (12) through a scanner field of view (20), k-space data are acquired using a plurality of radio frequency coils (24, 26). The acquiring includes undersampling of k-space in at least one undersampled direction. A weighted transform (62) from k-space to real space is defined for at least one undersampled direction. The weighted transform incorporates patient position-dependent coil sensitivity weighting factors and a Fourier transform. The acquired k-space data are hybrid transformed along the direction of continuous moving to define hybrid space data having a real space dimension in the transformed direction of continuous moving and a k-space dimension in a transverse direction that is transverse to the direction of continuous moving. The hybrid space data are transformed along the transverse direction to generate a reconstructed image. The hybrid transforming and the transforming employ the defined weighted transform (62) conditional upon the corresponding direction being undersampled.
摘要翻译：在成像对象（12）通过扫描仪视野（20）的连续移动期间，使用多个射频线圈（24,26）获取k空间数据。获取包括至少一个欠采样方向的k空间欠采样。对于至少一个欠采样方向，定义从k空间到实际空间的加权变换（62）。加权变换包括患者位置相关的线圈灵敏度加权因子和傅里叶变换。所获取的k空间数据沿着连续移动的方向被混合变换以限定在连续移动的变换方向上具有实际空间尺寸的混合空间数据和横向于连续方向的横向方向上的k空间尺寸移动。混合空间数据沿着横向变换以产生重构图像。混合变换和变换采用定义的加权变换（62），条件是相应方向被欠采样。

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