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1. 发明授权

US08783260B2 Apparatuses and methods for mandibular protrusion 有权
标题翻译：下颌突出的装置和方法
公开(公告)号：US08783260B2
公开(公告)日：2014-07-22
申请号：US12794555
申请日：2010-06-04
申请人： John E. Remmers , Hugo Tam , Terry Macartney , Peter Santosham
发明人： John E. Remmers , Hugo Tam , Terry Macartney , Peter Santosham
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： Embodiments of methods and mandibular protruders and positioning devices, comprising, for example: an upper mounting bracket having an upper dental appliance; a lower mounting bracket having a lower dental appliance; and a rail system configured to couple the upper mounting bracket to the lower mounting bracket. Some embodiments comprise a drive motor and/or an initial position adjustment mechanism.
摘要翻译：方法和下颌突出物和定位装置的实施例，包括例如：具有上牙科器具的上安装支架; 具有下牙科器具的下安装支架; 以及轨道系统，其被配置为将所述上安装支架联接到所述下安装支架。一些实施例包括驱动马达和/或初始位置调整机构。

2. 发明授权

US06752150B1 Ventilatory stabilization technology 失效
标题翻译：通气稳定技术
公开(公告)号：US06752150B1
公开(公告)日：2004-06-22
申请号：US09498504
申请日：2000-02-03
申请人： John E. Remmers , Eric A. Hajduk , Ronald S. Platt
发明人： John E. Remmers , Eric A. Hajduk , Ronald S. Platt
IPC分类号： A61M1600
CPC分类号： A61M16/085 , A61M16/0009 , A61M16/0045 , A61M16/0069 , A61M16/024 , A61M2016/0036 , A61M2016/0042 , A61M2016/103 , A61M2230/432
摘要： A system for reducing central sleep apnea (CSA) is described in which certain methods of increasing a patient's rebreathing during periods of the sleep cycle are used. By increasing rebreathing during periods of overbreathing, the over-oxygenation which typically results from the overbreathing period can be reduced, thus reducing the compensating underbreathing period and effectively reducing the loop gain associated with the central sleep apnea.
摘要翻译：描述了用于减少中枢性睡眠呼吸暂停（CSA）的系统，其中使用在睡眠周期期间增加患者的再呼吸的某些方法。通过在呼吸过度期间增加再呼吸，可以减少通气期间过度氧合，从而减少补充呼吸时间，有效降低与中枢性睡眠呼吸暂停相关的环路增益。

3. 发明授权

US5042478A Method of ventilation using nares seal 失效
标题翻译：使用鼻孔密封的通气方法
公开(公告)号：US5042478A
公开(公告)日：1991-08-27
申请号：US506557
申请日：1990-04-09
申请人： John A. Kopala , John E. Remmers
发明人： John A. Kopala , John E. Remmers
IPC分类号： A61M16/06
CPC分类号： A61M16/0666 , A61M16/0633 , Y10S128/912
摘要： A nasal adaptor device and seal for delivering gases under pressure to the nasal airway of an individual including an aerodynamically contoured manifold to receive gases from an inlet and to divide the gases for flow to a pair of flange members, preferably having a non-spherical curved "egg-shaped" surface, which members are, complementary to the nares of an individual without cannulating the nares to provide a seal to withstand positive pressure of gases to be distributed to the nasal airways. The devices and nares seals of this invention are especially useful in treatment of obstructive sleep apnea and in ventilation of individuals for whom positive pressure ventilation is indicated.
摘要翻译：一种用于在压力下将气体输送到包括空气动力学轮廓的歧管的鼻气道的鼻部适配器装置和密封件，用于接收来自入口的气体并将气体分成一对法兰构件，优选地具有非球形弯曲 “蛋形”表面，其成员与个体的鼻孔互补，而无需插入鼻孔以提供密封以承受气体被分配到鼻气道的正压。本发明的装置和鼻孔密封件特别可用于治疗阻塞性睡眠呼吸暂停和通气中指示正压通气的个体。

4. 发明申请

US20090133696A1 VENTILATION STABILIZATION SYSTEM 审中-公开
标题翻译：通风稳定系统
公开(公告)号：US20090133696A1
公开(公告)日：2009-05-28
申请号：US12258286
申请日：2008-10-24
申请人： John E. Remmers , John J. Laprairie
发明人： John E. Remmers , John J. Laprairie
IPC分类号： A61M16/00
CPC分类号： A61M16/06 , A61M16/0066 , A61M16/0488 , A61M16/0493 , A61M16/0497 , A61M16/0633 , A61M16/0683 , A61M16/0816 , A61M16/12 , A61M2016/0036 , A61M2210/0618 , A61M2210/0625 , A61M2230/432
摘要： There is an apparatus including a mandible positioner for positioning the mandible of a patient with respect to the maxilla of the patient and a breathing assistance apparatus. The breathing assistance apparatus has a sensor arranged to detect at least one element representative of a breathing state of the patient. A source of breathing gas includes a patient interface and has at least a first operable position and a second operable position. The source of breathing gas provides a different ratio of carbon dioxide and oxygen to the patient when in the first operable position than in the second operable position. The source of breathing gas may be moved between the first operable position and the second operable position in response to signals from the sensor. For example, the source of breathing gas may provide rebreathed air to the patient in the first position and atmospheric air in the second position. An apparatus for interfacing with a patient to allow breathing gas to be provided to the patient is also provided.
摘要翻译：存在包括用于将患者的下颌骨相对于患者的上颌骨定位的下颌定位器和呼吸辅助装置的装置。呼吸辅助装置具有传感器，其布置成检测表示患者的呼吸状态的至少一个元件。呼吸气体源包括患者接口并且具有至少第一可操作位置和第二可操作位置。当处于第一可操作位置时，与第二可操作位置相比，呼吸气体源提供与患者不同的二氧化碳和氧气比例。响应于来自传感器的信号，呼吸气体源可以在第一可操作位置和第二可操作位置之间移动。例如，呼吸气体源可以在第一位置向患者提供再呼吸的空气，并在第二位置提供大气。还提供了一种用于与患者接口以允许向患者提供呼吸气体的装置。

5. 发明授权

US5826579A Remote-controlled mandibular positioning device and method of using the device 失效
标题翻译：远程控制下颌定位装置及其使用方法
公开(公告)号：US5826579A
公开(公告)日：1998-10-27
申请号：US736900
申请日：1996-10-25
申请人： John E. Remmers , Eric A. Hajduk , Ronald S. Platt , Alan A. Lowe
发明人： John E. Remmers , Eric A. Hajduk , Ronald S. Platt , Alan A. Lowe
IPC分类号： A61F5/56 , A61M16/00
CPC分类号： A61M16/00 , A61F5/566 , A61M2230/60
摘要： A remote-controlled mandibular positioner for conveniently and precisely positioning the mandible during a sleep center or in-hospital study of patients who are candidates for mandibular positioner therapy. The remote-controlled mandibular positioner is used during sleep to perform a therapeutic titration study during full polysomnographic monitoring to determine the mandible position effective in treating obstructive sleep apnea. During the titration study, the mandible is advanced by a technician using the remote-controlled mandibular positioner until all apneas and hypopneas are eliminated. The titration study determines whether a mandibular positioner will be effective in treating a particular patient, and if so, the degree of mandibular ventral displacement required for effective treatment of obstructive sleep apnea.
摘要翻译：一种远程控制的下颌定位器，用于在睡眠中心或住院期间为下颌骨定位器治疗的候选者方便地和精确地定位下颌骨。远程控制的下颌定位器在睡眠期间用于在全多导睡眠监测期间进行治疗性滴定研究，以确定有效治疗阻塞性睡眠呼吸暂停的下颌骨位置。在滴定研究期间，下颌骨由技术人员使用远程控制的下颌骨定位器进行，直到所有呼吸暂停和呼吸不足消失。滴定研究确定下颌定位器是否有效治疗特定患者，如果是，则有效治疗阻塞性睡眠呼吸暂停所需的下颌腹侧位移程度。

6. 发明授权

US4919128A Nasal adaptor device and seal 失效
标题翻译：鼻适配器和密封
公开(公告)号：US4919128A
公开(公告)日：1990-04-24
申请号：US236941
申请日：1988-08-26
申请人： John A. Kopala , John E. Remmers
发明人： John A. Kopala , John E. Remmers
IPC分类号： A61M16/06
CPC分类号： A61M16/0666 , A61M16/0633
摘要： A nasal adaptor device and seal for delivering gases under pressure to the nasal airway of an individual including an aerodynamically contoured manifold to receive gases from an inlet and to divide the gases for flow to a pair of flange members, preferaly having a non-spherical curved "egg-shaped" surface, which members are, complementary to the nares of an individual without cannulating the nares to provide a seal to withstand positive pressure of gases to be distributed to the nasal airways. The devices and nares seals of this invention are especially useful in treatment of obstructive sleep apnea and in ventilation of individuals for whom positive pressure ventilation is indicated.
摘要翻译：一种用于在压力下将气体输送到包括空气动力学轮廓的歧管的鼻气道的鼻部适配器装置和密封件，用于接收来自入口的气体并将气体分成用于流动的一对凸缘构件，优选具有非球形弯曲 “蛋形”表面，其成员与个体的鼻孔互补，而无需插入鼻孔以提供密封以承受气体被分配到鼻气道的正压。本发明的装置和鼻孔密封件特别可用于治疗阻塞性睡眠呼吸暂停和通气中指示正压通气的个体。

7. 发明申请

US20100316973A1 Apparatuses and Methods for Mandibular Protrusion 有权
标题翻译：下颌骨突出的装置和方法
公开(公告)号：US20100316973A1
公开(公告)日：2010-12-16
申请号：US12794555
申请日：2010-06-04
申请人： John E. Remmers , Hugo Tam , Terry MaCartney , Peter Santosham
发明人： John E. Remmers , Hugo Tam , Terry MaCartney , Peter Santosham
IPC分类号： A61F5/56 , A61C9/00 , A61B5/107
CPC分类号： A61F5/566
摘要： Embodiments of methods and mandibular protruders and positioning devices, comprising, for example: an upper mounting bracket having an upper dental appliance; a lower mounting bracket having a lower dental appliance; and a rail system configured to couple the upper mounting bracket to the lower mounting bracket. Some embodiments comprise a drive motor and/or an initial position adjustment mechanism.
摘要翻译：方法和下颌突出物和定位装置的实施例，包括例如：具有上牙科器具的上安装支架; 具有下牙科器具的下安装支架; 以及轨道系统，其被配置为将所述上安装支架联接到所述下安装支架。一些实施例包括驱动马达和/或初始位置调整机构。

8. 发明申请

US20090025725A1 TRANSIENT INTERVENTION FOR MODIFYING THE BREATHING OF A PATIENT 审中-公开
标题翻译：用于修改患者呼吸的暂时性干预措施
公开(公告)号：US20090025725A1
公开(公告)日：2009-01-29
申请号：US12180465
申请日：2008-07-25
申请人： John E. Remmers
发明人： John E. Remmers
IPC分类号： A61M16/00
CPC分类号： A61M21/00 , A61M16/0045 , A61M16/026 , A61M16/06 , A61M2016/0027 , A61M2016/0036 , A61M2021/0022 , A61M2021/0027 , A61M2021/0072 , A61M2205/50 , A61N1/3601
摘要： A method for modifying the breathing of a patient while the patient is experiencing sleep apnea, for example Cheyne Stokes breathing. An instantaneous pulmonary ventilation of a patient is monitored. Limit cycle behavior of the instantaneous pulmonary ventilation is identified. A transient intervention is applied to the patient during a phase of a limit cycle of the instantaneous pulmonary ventilation. The transient intervention has an effect on a breathing state of the patient.
摘要翻译：一种在患者经历睡眠呼吸暂停时修改患者的呼吸的方法，例如Cheyne Stokes呼吸。监测患者的瞬时肺通气。确定瞬时肺通气的限制循环行为。在瞬时肺通气的极限循环期间，对患者施加暂时干预。暂时干预对患者的呼吸状态有影响。

9. 发明授权

US07073501B2 Ventilatory stabilization technology 失效
标题翻译：通气稳定技术
公开(公告)号：US07073501B2
公开(公告)日：2006-07-11
申请号：US10762979
申请日：2004-01-23
申请人： John E. Remmers , Eric A. Hajduk , Ronald S. Platt
发明人： John E. Remmers , Eric A. Hajduk , Ronald S. Platt
IPC分类号： A61M16/00
CPC分类号： A61M16/085 , A61M16/0045 , A61M16/0069 , A61M16/026 , A61M2016/0036 , A61M2016/0042 , A61M2016/103 , A61M2210/0618 , A61M2210/0625 , A61M2230/432 , A62B18/006
摘要： A system for reducing central sleep apnea (CSA) is described in which certain methods of increasing a patient's rebreathing during periods of the sleep cycle are used. By increasing rebreathing during periods of overbreathing, the over-oxygenation which typically results from the overbreathing period can be reduced, thus reducing the compensating underbreathing period and effectively reducing the loop gain associated with the central sleep apnea. Nasal occlusion and a leak resistant oral interface provide control for gas leaks from a patent interface.
摘要翻译：描述了用于减少中枢性睡眠呼吸暂停（CSA）的系统，其中使用在睡眠周期期间增加患者的再呼吸的某些方法。通过在呼吸过度期间增加再呼吸，可以减少通气期间过度氧合，从而减少补充呼吸时间，有效降低与中枢性睡眠呼吸暂停相关的环路增益。鼻闭塞和防渗漏口接口提供对专利界面气体泄漏的控制。

10. 发明授权

US06273859B1 Adaptively controlled mandibular positioning device and method of using the device 失效
标题翻译：自适应控制下颌定位装置及其使用方法
公开(公告)号：US06273859B1
公开(公告)日：2001-08-14
申请号：US09327497
申请日：1999-06-08
申请人： John E. Remmers , Eric A. Hajduk , Ronald S. Platt
发明人： John E. Remmers , Eric A. Hajduk , Ronald S. Platt
IPC分类号： A61B106
CPC分类号： A61F5/566 , A61M16/026 , A61M2230/60
摘要： The present invention relates to systems and methods for automatically and continuously regulating the amount of mandibular displacement to an optimal value during obstructive sleep apnea treatment. Obstructive sleep apnea therapy is implemented by a device which automatically reevaluates an applied mandibular displacement and continually searches for a minimum displacement required to adequately distend a patient's pharyngeal airway. The minimum optimal displacement varies with body position, stage of sleep throughout the night, the patient's body weight, and whether alcohol or sleeping medicine has been ingested.
摘要翻译：本发明涉及在阻塞性睡眠呼吸暂停治疗期间自动连续调节下颌位移量至最佳值的系统和方法。阻塞性睡眠呼吸暂停治疗由一种自动重新评估应用下颌骨移位的装置实现，并持续搜索充分扩张患者咽喉气道所需的最小位移。最小最佳位移随身体位置，整个睡眠阶段，患者体重以及酒精或睡眠药物是否被摄入而发生变化。

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