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    • 5. 发明申请
    • IR SPECTROGRAPHIC APPARATUS AND METHOD FOR DIAGNOSIS OF DISEASE
    • 红外光谱仪和疾病诊断方法
    • US20090118601A1
    • 2009-05-07
    • US11576229
    • 2005-09-29
    • John F. RaboltMei-Wei Tsao
    • John F. RaboltMei-Wei Tsao
    • A61B5/1455
    • A61B3/10A61B5/0059A61B5/14546G01J3/02G01J3/0208G01J3/021G01J3/0218G01J3/0294G01J3/04G01J3/108G01J3/14G01J3/2803G01J2003/2813G01N21/35G01N21/3504
    • A method for detecting disease in a patient includes providing infrared (IR) light and coupling the IR light through direct lens coupling or through a first group of one or more optical fibers. IR light is reflected from a portion of the patient and collected by a lens arrangement or a second group of one or more optical fibers. The reflected IR light is dispersed into its spectrum which is detected and analyzed. An apparatus suitable for diagnosing a disease in a patient includes an IR light source and optical fiber or direct lens coupling of IR light onto a body part or fluid of the patient. Reflected light from the patient is optically dispersed using a prism or grating. An IR focal plane array receives the optically dispersed light. The spectrum of the reflected IR light is used to provide a diagnosis of disease in the patient by identifying various disease markers or chemical fingerprints. The method and apparatus are capable of non-invasively detecting disease markers in a patient.
    • 用于检测患者疾病的方法包括提供红外(IR)光并通过直接透镜耦合或通过第一组一根或多根光纤耦合IR光。 IR光从患者的一部分反射并由透镜装置或第二组一根或多根光纤收集。 反射的红外光被分散到其光谱中,该光谱被检测和分析。 适用于诊断患者疾病的装置包括IR光源和光纤或将IR光直接连接到患者的身体部位或液体上的直接透镜。 来自患者的反射光使用棱镜或光栅进行光学分散。 IR焦平面阵列接收光学分散的光。 反射红外光的光谱用于通过识别各种疾病标志物或化学指纹来提供患者疾病的诊断。 该方法和装置能够非侵入性地检测患者中的疾病标志物。
    • 8. 发明授权
    • Simultaneous multi-beam planar array IR (pair) spectroscopy
    • 同时多光束平面阵列IR(对)光谱
    • US06943353B2
    • 2005-09-13
    • US10708927
    • 2004-04-01
    • Douglas L. ElmoreJohn F. RaboltMei-Wei Tsao
    • Douglas L. ElmoreJohn F. RaboltMei-Wei Tsao
    • G01J3/02G01J3/14G01J3/28G01J3/42G01N21/35
    • G01J3/02G01J3/0216G01J3/0218G01J3/0224G01J3/0294G01J3/14G01J3/28G01J3/2803G01J3/42G01N21/3563G01N21/3577
    • An apparatus and method capable of providing spatially multiplexed IR spectral information simultaneously in real-time for multiple samples or multiple spatial areas of one sample using IR absorption phenomena requires no moving parts or Fourier Transform during operation, and self-compensates for background spectra and degradation of component performance over time. IR spectral information and chemical analysis of the samples is determined by using one or more IR sources, sampling accessories for positioning the samples, optically dispersive elements, a focal plane array (FPA) arranged to detect the dispersed light beams, and a processor and display to control the FPA, and display an IR spectrograph. Fiber-optic coupling can be used to allow remote sensing. Portability, reliability, and ruggedness is enhanced due to the no-moving part construction. Applications include determining time-resolved orientation and characteristics of materials, including polymer monolayers. Orthogonal polarizers may be used to determine certain material characteristics.
    • 能够使用IR吸收现象实时地对一个样本的多个样本或多个空间区域实时地提供空间多路复用的IR光谱信息的装置和方法在运行期间不需要运动部分或傅立叶变换,并且自我补偿背景光谱和降解 的组件性能。 通过使用一个或多个IR源,用于定位样品的采样附件,光学色散元件,布置成检测分散光束的焦平面阵列(FPA)以及处理器和显示器来确定样品的IR光谱信息和化学分析 控制FPA,并显示红外光谱仪。 可以使用光纤耦合来进行遥感。 由于无移动部件结构,便携性,可靠性和耐用性得到了提高。 应用包括确定材料的时间分辨取向和特性,包括聚合物单层。 可以使用正交偏振器来确定某些材料特性。
    • 9. 发明授权
    • Apparatus and method for real time IR spectroscopy
    • 用于实时红外光谱的装置和方法
    • US06784428B2
    • 2004-08-31
    • US09984137
    • 2001-10-29
    • John F. RaboltMei-Wei Tsao
    • John F. RaboltMei-Wei Tsao
    • G01N2135
    • G01J3/28G01J3/02G01J3/0216G01J3/0218G01J3/0224G01J3/0294G01J3/14G01J3/2803G01J3/42G01N21/35G01N21/3563G01N21/3577
    • An apparatus and method capable of providing IR spectral information using IR absorption phenomena requires no moving parts or Fourier Transform during operation. IR spectral information and chemical analysis of a sample in a sample containing functional groups is determined by using an IR source, a sampling accessory for positioning the sample volume, an optically dispersive element, a focal plane array (FPA) arranged to detect the dispersed light beam, and a processor and display to control the FPA, and display an IR spectrograph. Fiber-optic coupling allows remote sensing, and portability, reliability, and ruggedness is enhanced due to the no-moving part construction. Use of the apparatus and method has broad industrial and environmental application, including measurement of thickness and chemical composition of various films, coatings, and liquids, and may also be used in real-time sensing of hazardous materials, including chemical and biological warfare agents.
    • 能够使用红外吸收现象提供红外光谱信息的装置和方法在运行期间不需要移动部件或傅立叶变换。 通过使用IR源,用于定位样品体积的取样附件,光学色散元件,布置成检测分散光的焦平面阵列(FPA)来确定含有官能团的样品中的样品的IR光谱信息和化学分析 光束,以及处理器和显示器来控制FPA,并显示IR光谱仪。 由于无移动部件结构,光纤耦合允许遥感,便携性,可靠性和耐用性得到提高。 该设备和方法的使用具有广泛的工业和环境应用,包括测量各种膜,涂料和液体的厚度和化学成分,还可用于实时检测危险物质,包括化学和生物战剂。