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1. 发明授权

US08921312B2 Combination of insulin and ascorbate to enhance wound healing 有权
标题翻译：结合胰岛素和抗坏血酸来增强伤口愈合
公开(公告)号：US08921312B2
公开(公告)日：2014-12-30
申请号：US12904489
申请日：2010-10-14
申请人： Kurt Musselmann , John R. Hassell , Brad Kane , Bridgette Alexandrou
发明人： Kurt Musselmann , John R. Hassell , Brad Kane , Bridgette Alexandrou
IPC分类号： A61K38/28 , C07K14/62 , A61K31/375 , C07K4/00 , A61K31/665 , A61K35/28
CPC分类号： A61K31/375 , A61K31/665 , A61K35/28
摘要： Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
摘要翻译：提供了一种刺激胶原合成和蛋白多糖（lumican和keratocan）积累的方法。用或不用具有或不含抗坏血酸盐的胰岛素培养胶原酶分离的角质形成细胞。胰岛素刺激胶原蛋白的合成，但不影响光合和角蛋白的积累。然而，胰岛素加抗坏血酸盐刺激胶原蛋白的合成并增加这些蛋白聚糖的积累。 PGDS（不与胶原蛋白相互作用的KSPG）的积累不受抗坏血酸的影响。只有在抗坏血酸盐存在下制成的胶原蛋白才能耐胃蛋白酶。 EDB克服了抗坏血酸对胃蛋白酶抗性和蛋白多糖累积的影响。

2. 发明申请

US20130112087A1 ROASTING PAN 审中-公开
标题翻译：烤盘
公开(公告)号：US20130112087A1
公开(公告)日：2013-05-09
申请号：US13292454
申请日：2011-11-09
申请人： JOHN R HASSELL
发明人： JOHN R HASSELL
IPC分类号： A47J37/04
CPC分类号： A47J37/108 , A47J43/18
摘要： A roasting pan is disclosed. The roasting pan may include a dual skewered system providing a stable mounting preventing pivoting and rotating of a mounted subject. The roasting pan may also include raised end walls providing a gap between the bottom surface of the subject and a base wall of the pan. The roasting pan may also include a lower profile side wall providing increased airflow to the sides, ends, and bottom of the subject.
摘要翻译：披露了一个烤盘。烤盘可以包括双串系统，其提供稳定的安装，防止安装的对象的枢转和旋转。焙烧盘还可以包括提供被检体的底表面和盘基底之间的间隙的隆起端壁。焙烧盘还可以包括下部轮廓侧壁，其向被检体的侧面，端部和底部提供增加的气流。

3. 发明申请

US20070281882A1 Combination of Insulin and Ascorbate to Enhance Wound Healing 有权
标题翻译：胰岛素和抗坏血酸组合加强伤口愈合
公开(公告)号：US20070281882A1
公开(公告)日：2007-12-06
申请号：US11758080
申请日：2007-06-05
申请人： Kurt Musselmann , John R. Hassell , Brad Kane , Bridgette Alexandrou
发明人： Kurt Musselmann , John R. Hassell , Brad Kane , Bridgette Alexandrou
IPC分类号： A61K38/28 , A61K31/665 , A61K31/375
CPC分类号： A61K31/375 , A61K31/665 , A61K35/28
摘要： Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
摘要翻译：提供了一种刺激胶原合成和蛋白多糖（lumican和keratocan）积累的方法。用或不用具有或不含抗坏血酸盐的胰岛素培养胶原酶分离的角质形成细胞。胰岛素刺激胶原蛋白的合成，但不影响光合和角蛋白的积累。然而，胰岛素加抗坏血酸盐刺激胶原蛋白的合成并增加这些蛋白聚糖的积累。 PGDS（不与胶原蛋白相互作用的KSPG）的积累不受抗坏血酸的影响。只有在抗坏血酸盐存在下制成的胶原蛋白才能耐胃蛋白酶。 EDB克服了抗坏血酸对胃蛋白酶抗性和蛋白多糖累积的影响。

4. 发明授权

US4034664A Juice extractor 失效
标题翻译：榨汁机
公开(公告)号：US4034664A
公开(公告)日：1977-07-12
申请号：US695581
申请日：1976-06-14
申请人： John R. Hassell
发明人： John R. Hassell
IPC分类号： A47J19/02 , A23N1/00 , B02C15/00 , B04B5/10 , B26D1/00
CPC分类号： A47J19/027
摘要： A centrifuge-type apparatus for extracting, by pulverization and filtering under centrifugal force, the juice component from plant materials such as fruits or vegetables. Plant material introduced into the open top of a stationary hopper is pulverized upon contact with a series of fast-moving non-bladed, blunt protrusions extending upwardly from the surface of a rapidly rotating plate member extending across the open bottom of the hopper. The resultant juice and pulp mixture is then thrown outwardly under centrifugal force through an annular space of predetermined height formed between the bottom of the stationary hopper and the upper surface of the rotating plate. A frusto-conical filter member attached to and surrounding the rotating plate member impedes the outward motion of the pulp component of the pulverized plant material whle permitting the passage of the juice component. The juice component thus separated is collected within a stationary enclosure surrounding the rotating filter and plate, and conducted to the exterior of the apparatus for dispensation as desired. The wall of the filter is slanted outwardly toward its base to encourage the plug component of the plant material impinging thereon to migrate downwardly under centrifugal force, thereby providing a self-cleaning type action impeding the detrimental accumulation of excess pulp material over the fiter surface. Means are provided for selectively releasing the accumulated pulp material from within the rotating fiter without significantly interrupting the operation of the apparatus, and for collecting the released pulp in removable pans at the bottom of the apparatus enclosure.
摘要翻译：离心机用于通过离心力粉碎和过滤从植物材料如水果或蔬菜中提取果汁成分。与固定料斗的开口顶部相接触的植物材料在与快速旋转的板构件的表面延伸穿过料斗的开口底部的一系列快速移动的非叶片钝的突起接触时被粉碎。然后将所得的果汁和纸浆混合物在离心力下通过形成在固定料斗的底部和旋转板的上表面之间的预定高度的环形空间向外抛出。附接到旋转板构件并围绕旋转板构件的截头圆锥形过滤构件妨碍了粉碎植物材料的纸浆组分向外运动，允许汁液组分通过。将如此分离的果汁组分收集在围绕旋转过滤器和板的固定外壳内，并根据需要传导至设备外部进行分配。过滤器的壁朝向其底部向外倾斜，以促使撞击在其上的植物材料的插塞部件在离心力下向下移动，由此提供自清洁型作用，阻止过量纸浆材料在叶轮表面上的有害积聚。提供了用于在不显着中断装置的操作的情况下选择性地释放积聚的纸浆材料的装置，并且用于将释放的纸浆收集在装置外壳的底部的可移动盘中。

5. 发明申请

US20110027884A1 COMBINATION OF INSULIN AND ASCORBATE TO ENHANCE WOUND HEALING 有权
标题翻译：胰岛素和抗坏血酸组合加强伤口愈合
公开(公告)号：US20110027884A1
公开(公告)日：2011-02-03
申请号：US12904489
申请日：2010-10-14
申请人： Kurt Musselmann , John R. Hassell , Brad Kane , Bridgette Alexandrou
发明人： Kurt Musselmann , John R. Hassell , Brad Kane , Bridgette Alexandrou
IPC分类号： C12N5/02
CPC分类号： A61K31/375 , A61K31/665 , A61K35/28
摘要： Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
摘要翻译：提供了一种刺激胶原合成和蛋白多糖（lumican和keratocan）积累的方法。用或不用具有或不含抗坏血酸盐的胰岛素培养胶原酶分离的角质形成细胞。胰岛素刺激胶原蛋白的合成，但不影响光合和角蛋白的积累。然而，胰岛素加抗坏血酸盐刺激胶原蛋白的合成并增加这些蛋白聚糖的积累。 PGDS（不与胶原蛋白相互作用的KSPG）的积累不受抗坏血酸的影响。只有在抗坏血酸盐存在下制成的胶原蛋白才能耐胃蛋白酶。 EDB克服了抗坏血酸对胃蛋白酶抗性和蛋白多糖累积的影响。

6. 发明授权

US07834153B2 Combination of insulin and ascorbate to enhance wound healing 有权
标题翻译：结合胰岛素和抗坏血酸来增强伤口愈合
公开(公告)号：US07834153B2
公开(公告)日：2010-11-16
申请号：US11758080
申请日：2007-06-05
申请人： Kurt Musselmann , John R. Hassell , Brad Kane , Bridgette Alexandrou
发明人： Kurt Musselmann , John R. Hassell , Brad Kane , Bridgette Alexandrou
IPC分类号： A61K36/39 , A61K8/65
CPC分类号： A61K31/375 , A61K31/665 , A61K35/28
摘要： Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.
摘要翻译：提供了一种刺激胶原合成和蛋白多糖（lumican和keratocan）积累的方法。用或不用具有或不含抗坏血酸盐的胰岛素培养胶原酶分离的角质形成细胞。胰岛素刺激胶原蛋白的合成，但不影响光合和角蛋白的积累。然而，胰岛素加抗坏血酸盐刺激胶原蛋白的合成并增加这些蛋白聚糖的积累。 PGDS（不与胶原蛋白相互作用的KSPG）的积累不受抗坏血酸的影响。只有在抗坏血酸盐存在下制成的胶原蛋白才能耐胃蛋白酶。 EDB克服了抗坏血酸对胃蛋白酶抗性和蛋白多糖累积的影响。

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