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1. 发明申请

US20160145309A1 DISULFIDE CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE 有权
标题翻译：用于治疗心力衰竭的解决循环多糖
公开(公告)号：US20160145309A1
公开(公告)日：2016-05-26
申请号：US14905338
申请日：2014-07-21
申请人： Frédéric ZECRI , Philipp GROSCHE , Kayo YASOSHIMA , Hongjuan ZHAO , Jun YUAN
发明人： Frederic ZECRI , Philipp GROSCHE , Kayo YASOSHIMA , Hongjuan ZHAO , Jun YUAN
IPC分类号： C07K7/08 , A61K45/06 , A61K38/10 , C07K7/06 , A61K38/08
CPC分类号： C07K7/08 , A61K38/08 , A61K38/10 , A61K45/06 , C07K7/06 , C07K14/47
摘要： The invention provides a synthetic polypeptide of Formula I′: X1-R-P-R-X5-X6-X7-K-X9-P-X11-X12-X13 or an amide, an ester, a salt or a bioconjugate thereof, wherein X1, X5, X6, X7, X9 and X11 to X13 are defined herein. The polypeptides and bioconjugates are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides or bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I'的合成多肽：X1-RPR-X5-X6-X7-K-X9-P-X11-X12-X13或其酰胺，酯，盐或生物缀合物，其中X1，X5 ，X6，X7，X9，X11〜X13。多肽和生物缀合物是APJ受体的激动剂。本发明还涉及制备本发明的多肽或生物缀合物的方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，Brugada综合征，室性心动过速，动脉粥样硬化，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，保水，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤受伤（包括晒伤）和先兆子痫。本发明还提供药理活性剂和药物组合物的组合。

2. 发明申请

US20160108091A1 CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE 审中-公开
公开(公告)号：US20160108091A1
公开(公告)日：2016-04-21
申请号：US14963391
申请日：2015-12-09
申请人： Frederic ZECRI , Philipp GROSCHE , Kayo YASOSHIMA , Hongjuan ZHAO , Jun YUAN , Aimee Richardson USERA , Changgang LOU , Aaron KANTER , Alexandra Marshall BRUCE , Carla GUIMARAES
发明人： Frederic ZECRI , Philipp GROSCHE , Kayo YASOSHIMA , Hongjuan ZHAO , Jun YUAN , Aimee Richardson USERA , Changgang LOU , Aaron KANTER , Alexandra Marshall BRUCE , Carla GUIMARAES
IPC分类号： C07K7/64 , C07K14/765
CPC分类号： C07K14/47 , A61K38/12 , A61K38/1709 , A61K45/06 , A61K47/542 , A61K47/60 , A61K47/643 , A61K47/6811 , C07K7/64 , C07K14/765 , C07K16/461 , C07K2319/30 , C07K2319/31
摘要： The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13 I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

3. 发明授权

US09288024B2 Systems and methods for uplink signaling using time-frequency resources 有权
标题翻译：使用时间频率资源的上行链路信令的系统和方法
公开(公告)号：US09288024B2
公开(公告)日：2016-03-15
申请号：US13617224
申请日：2012-09-14
申请人： Robert Novak , Mo-Han Fong , Sophie Vrzic , Jun Yuan , Dong-Sheng Yu , Jianglei Ma
发明人： Robert Novak , Mo-Han Fong , Sophie Vrzic , Jun Yuan , Dong-Sheng Yu , Jianglei Ma
IPC分类号： H04W4/00 , H04L5/00
CPC分类号： H04W72/0413 , H04B7/12 , H04L5/0007 , H04L5/0037 , H04L5/0044 , H04L5/0053 , H04W72/1268 , H04W74/0866
摘要： Methods, base stations and access terminals for uplink signalling are provided. Resource request channel characteristics such as location in time-frequency, sequence, time slot, are assigned to each access terminal to distinguish their resource requests from the resource requests of other access terminals. Access terminals make requests using a resource request on a resource request channel having the assigned characteristics. The base station can then determine which access terminal transmitted 0 the resource request based on the resource request channel characteristics of the resource request channel upon which the resource>request was received. The base station then transmits a response to the request which may for example be a new resource allocation, a default allocation or a renewal of a previous allocation.
摘要翻译：提供了用于上行链路信令的方法，基站和接入终端。向每个接入终端分配资源请求信道特性，例如时频，序列，时隙中的位置，以将其资源请求与其他接入终端的资源请求区分开。接入终端在具有分配特性的资源请求信道上使用资源请求进行请求。然后，基站可以基于接收到资源>请求的资源请求信道的资源请求信道特性来确定哪个接入终端发送了资源请求。然后，基站发送对该请求的响应，该请求例如可以是新的资源分配，默认分配或先前分配的更新。

4. 发明授权

US09266925B2 Cyclic polypeptides for the treatment of heart failure 有权
标题翻译：循环多肽用于治疗心力衰竭
公开(公告)号：US09266925B2
公开(公告)日：2016-02-23
申请号：US14336262
申请日：2014-07-21
申请人： Frederic Zecri , Philipp Grosche , Kayo Yasoshima , Hongjuan Zhao , Jun Yuan , Aimee Richardson Usera , Changgang Lou , Aaron Kanter , Alexandra Marshall Bruce , Carla Giumaraes
发明人： Frederic Zecri , Philipp Grosche , Kayo Yasoshima , Hongjuan Zhao , Jun Yuan , Aimee Richardson Usera , Changgang Lou , Aaron Kanter , Alexandra Marshall Bruce , Carla Giumaraes
IPC分类号： C07K7/64 , C07K16/46 , A61K38/12 , A61K45/06 , C07K14/47
CPC分类号： C07K14/47 , A61K38/12 , A61K38/1709 , A61K45/06 , A61K47/542 , A61K47/60 , A61K47/643 , A61K47/6811 , C07K7/64 , C07K14/765 , C07K16/461 , C07K2319/30 , C07K2319/31
摘要： The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13 I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I（SEQ ID NO：1）的环状多肽：X1-R-X3-X4-LS-X7-X8-X9-X10-X11-X12-X13I或酰胺，酯或盐或其生物缀合物，其中X1，X3，X4，X7，X8，X9，X10，X11，X12和X13在本文中定义。多肽是APJ受体的激动剂。本发明还涉及制备本发明多肽或其生物缀合物的方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，Brugada综合征，心室心动过速，动脉粥样硬化，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，潴留，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤（包括晒伤）和先兆子痫。本发明还提供药理活性剂和药物组合物的组合。

5. 发明授权

US09143296B2 Systems and methods for uplink signaling using time-frequency resources 有权
公开(公告)号：US09143296B2
公开(公告)日：2015-09-22
申请号：US13617224
申请日：2012-09-14
申请人： Robert Novak , Mo-Han Fong , Sophie Vrzic , Jun Yuan , Dong-Sheng Yu , Jianglei Ma
发明人： Robert Novak , Mo-Han Fong , Sophie Vrzic , Jun Yuan , Dong-Sheng Yu , Jianglei Ma
IPC分类号： H04W4/00 , H04L5/00
摘要： Methods, base stations and access terminals for uplink signalling are provided. Resource request channel characteristics such as location in time-frequency, sequence, time slot, are assigned to each access terminal to distinguish their resource requests from the resource requests of other access terminals. Access terminals make requests using a resource request on a resource request channel having the assigned characteristics. The base station can then determine which access terminal transmitted 0 the resource request based on the resource request channel characteristics of the resource request channel upon which the resource>request was received. The base station then transmits a response to the request which may for example be a new resource allocation, a default allocation or a renewal of a previous allocation.

6. 发明授权

US08969969B2 High threshold voltage NMOS transistors for low power IC technology 有权
公开(公告)号：US08969969B2
公开(公告)日：2015-03-03
申请号：US12727312
申请日：2010-03-19
申请人： Victor W. C. Chan , Narasimhulu Kanike , Huiling Shang , Varadarajan Vidya , Jun Yuan , Roger Allen Booth, Jr.
发明人： Victor W. C. Chan , Narasimhulu Kanike , Huiling Shang , Varadarajan Vidya , Jun Yuan , Roger Allen Booth, Jr.
IPC分类号： H01L27/092 , H01L21/8234 , H01L21/8238
CPC分类号： H01L21/823807 , H01L21/823412
摘要： Transistors exhibiting different electrical characteristics such as different switching threshold voltage or different leakage characteristics are formed on the same chip or wafer by selectively removing a film or layer which can serve as an out-diffusion sink for an impurity region such as a halo implant and out-diffusing an impurity such as boron into the out-diffusion sink, leaving the impurity region substantially intact where the out-diffusion sink has been removed. In forming CMOS integrated circuits, such a process allows substantially optimal design for both low-leakage and low threshold transistors and allows a mask and additional associated processes to be eliminated, particularly where a tensile film is employed to increase electron mobility since the tensile film can be removed from selected NMOS transistors concurrently with removal of the tensile film from PMOS transistors.

7. 发明授权

US08934426B2 Method and apparatus for determining channel quality index in multiple user-MIMO communication networks 有权
标题翻译：用于在多个用户MIMO通信网络中确定信道质量指数的方法和装置
公开(公告)号：US08934426B2
公开(公告)日：2015-01-13
申请号：US13265639
申请日：2010-04-21
申请人： Jun Yuan , Sophie Vrzic , Mo-Han Fong , Robert Novak , Dong-Sheng Yu , Jianglei Ma
发明人： Jun Yuan , Sophie Vrzic , Mo-Han Fong , Robert Novak , Dong-Sheng Yu , Jianglei Ma
IPC分类号： H04W4/00 , H04W72/08 , H04B7/04 , H04W36/38
CPC分类号： H04W72/085 , H04B7/0452 , H04B7/0456 , H04B7/0623 , H04B7/0632 , H04B7/0634 , H04B7/0686 , H04B17/373 , H04L1/0005 , H04L1/0016 , H04L1/0026 , H04L1/0031 , H04L1/0656 , H04W36/385 , H04W88/08
摘要： In order to minimize the control signaling overhead associated with transmitting CQI data from mobile stations to base stations in wireless communication networks supporting MU-MIMO, the CQI during MU-MIMO operation is estimated based on SU-MIMO CQI data, mobile station geometry data, and mobile station PMI (Precoding Matrix Index) data. More particularly, the base station maintains and updates a knowledge pool that correlates geometry data and learned impact of interfering precoder data to degradation of CQI values responsive to switching from SU-MIMO operation to MU-MIMO operations. Then, when the base station switches from SU-MIMO operation to MU-MIMO operation, it consults the knowledge pool to predict the degradation in CQI and subtracts them from the known, pre-switching SU-MIMO CQI feedback data for each relevant mobile station to predict the post-switching MU-MIMO CQIs for that mobile station.
摘要翻译：为了最小化支持MU-MIMO的无线通信网络中的将CQI数据从移动站发送到基站的控制信令开销，基于SU-MIMO CQI数据，移动站几何数据，和移动台PMI（预编码矩阵索引）数据。更具体地，基站维护和更新将几何数据与学习的干扰预编码器数据的影响相关联的知识库与响应于从SU-MIMO操作切换到MU-MIMO操作的CQI值劣化。然后，当基站从SU-MIMO操作切换到MU-MIMO操作时，它咨询知识库以预测CQI中的劣化，并从每个相关移动站的已知的预切换SU-MIMO CQI反馈数据中减去它们以预测该移动台的后切换MU-MIMO CQI。

8. 发明授权

US08847315B2 Complementary metal-oxide-semiconductor (CMOS) device and method 有权
标题翻译：互补金属氧化物半导体（CMOS）器件及方法
公开(公告)号：US08847315B2
公开(公告)日：2014-09-30
申请号：US13465064
申请日：2012-05-07
申请人： Bin Yang , Xia Li , Jun Yuan
发明人： Bin Yang , Xia Li , Jun Yuan
IPC分类号： H01L27/12 , H01L29/47 , H01L29/10 , H01L29/66 , H01L21/8238 , H01L21/84
CPC分类号： H01L21/823814 , H01L21/28026 , H01L21/823828 , H01L21/84 , H01L27/1203 , H01L27/1211 , H01L29/1054 , H01L29/165 , H01L29/42376 , H01L29/47 , H01L29/66545 , H01L29/66621 , H01L29/66628 , H01L29/66636 , H01L29/7834
摘要： A complementary metal-oxide-semiconductor (CMOS) device and methods of formation thereof are disclosed. In a particular embodiment, a CMOS device includes a silicon substrate, a dielectric insulator material on the silicon substrate, and an extension layer on the dielectric insulator material. The CMOS device further includes a gate in contact with a channel and in contact with an extension region. The CMOS device also includes a source in contact with the extension region and a drain in contact with the extension region. The extension region includes a first region in contact with the source and the gate and includes a second region in contact with the drain and the gate.
摘要翻译：公开了一种互补金属氧化物半导体（CMOS）器件及其形成方法。在特定实施例中，CMOS器件包括硅衬底，硅衬底上的介电绝缘体材料以及介电绝缘体材料上的延伸层。 CMOS器件还包括与沟道接触并与延伸区域接触的栅极。 CMOS器件还包括与延伸区域接触的源极和与延伸区域接触的漏极。延伸区域包括与源极和栅极接触的第一区域，并且包括与漏极和栅极接触的第二区域。

9. 发明授权

US08761115B2 Method and system for providing an uplink structure and minimizing pilot signal overhead in a wireless communication network 有权
标题翻译：用于在无线通信网络中提供上行链路结构并最小化导频信号开销的方法和系统
公开(公告)号：US08761115B2
公开(公告)日：2014-06-24
申请号：US12989044
申请日：2009-04-21
申请人： Sophie Vrzic , Jun Yuan , Mo-Han Fong , Robert Novak , Dong-Sheng Yu , Jianglei Ma
发明人： Sophie Vrzic , Jun Yuan , Mo-Han Fong , Robert Novak , Dong-Sheng Yu , Jianglei Ma
IPC分类号： H04W72/00
CPC分类号： H04W72/0446 , H04J11/00 , H04L5/005 , H04L5/0053 , H04L5/0055 , H04L27/2602 , H04W72/0413 , H04W72/042 , H04W74/004 , H04W74/0833 , H04W74/0866 , H04W84/12 , H04W88/085 , H04W88/12
摘要： Methods and systems for providing uplink control in a wireless communication network are described herein. The wireless communication network includes at least one base station that is communicatively coupled to at least one mobile terminal. A method includes providing a dedicated random access channel to communicatively couple the base station and the mobile terminal; initiating the mobile terminal to select a random access signaling identification; generating a resource request at the at least one base station to receive uplink resource information from the mobile terminal; and receiving an initial access information request from the at least one mobile terminal to configure the base station connection.
摘要翻译：本文描述了用于在无线通信网络中提供上行链路控制的方法和系统。无线通信网络包括至少一个通信地耦合到至少一个移动终端的基站。一种方法包括提供专用随机接入信道，以通信地耦合所述基站和所述移动终端; 发起移动终端选择随机接入信令标识; 在所述至少一个基站处生成资源请求以从所述移动终端接收上行链路资源信息; 以及从所述至少一个移动终端接收初始接入信息请求以配置所述基站连接。

10. 发明授权

US08702860B2 Stabilized kaolin slurry and methods for improving kaolin slurry stability 有权
标题翻译：稳定化高岭土浆料和改善高岭土浆料稳定性的方法
公开(公告)号：US08702860B2
公开(公告)日：2014-04-22
申请号：US12910295
申请日：2010-10-22
申请人： Jun Yuan , Michael J. Garska , Robert J. Pruett
发明人： Jun Yuan , Michael J. Garska , Robert J. Pruett
IPC分类号： C09C1/42
CPC分类号： C04B33/04 , C01P2004/20 , C01P2004/51 , C01P2004/54 , C01P2004/61 , C01P2006/22 , C01P2006/40 , C01P2006/80 , C04B35/624 , C04B35/6263 , C04B35/6264 , C04B35/63 , C04B35/632 , C04B2235/5436 , C09C1/42
摘要： Disclosed herein are stabilized kaolin slurries comprising a kaolin comprising no more than about 80% by weight of particles having an equivalent spherical diameter of less than 2 microns and at least one stabilizer, wherein the stabilized kaolin slurry has a 28-day pour test result of at least about 80% poured. Also disclosed are methods of making such stabilized kaolin slurries.
摘要翻译：本文公开了包含高岭土的稳定化高岭土浆料，其包含不超过约80重量％的当量球形直径小于2微米的颗粒和至少一种稳定剂，其中稳定化的高岭土浆料具有28天的倾倒试验结果至少约80％倾倒。还公开了制备这种稳定的高岭土浆料的方法。

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