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1. 外观设计

USD625639S1 Watch dial 有权
公开(公告)号：USD625639S1
公开(公告)日：2010-10-19
申请号：US29333264
申请日：2009-03-05
申请人： Junichi Kamata
设计人： Junichi Kamata

2. 发明申请

US20090247576A1 ANTI-TUMOR AGENT FOR MULTIPLE MYELOMA 审中-公开
标题翻译：多发性甲状腺肿的抗肿瘤药
公开(公告)号：US20090247576A1
公开(公告)日：2009-10-01
申请号：US12094492
申请日：2006-11-22
申请人： Junichi Kamata
发明人： Junichi Kamata
IPC分类号： A61K31/47 , C07D215/233 , C12N5/06 , A61P35/00 , G01N33/68 , C12Q1/02 , C12Q1/68
CPC分类号： C07D215/48 , A61K31/47 , C07D401/12
摘要： The object of the invention is to provide a pharmaceutical composition and a therapeutic method which can exert their effects with higher efficiency on a living organism having at least one cell selected from the group consisting of a cell overexpressing FGFR3, a cell that has a t(4;14) translocation and a cell expressing mutant FGFR3. The compound represented by General Formula (I), a pharmacologically acceptable salt thereof or a solvate thereof can exert their effects with higher efficiency on a living organism having at least one cell selected from the group consisting of a cell overexpressing FGFR3, a cell that has a t(4;14) translocation and a cell expressing mutant FGFR3.
摘要翻译：本发明的目的是提供一种药物组合物和治疗方法，该药物组合物和治疗方法能够对具有至少一种选自下组的细胞的生物体具有更高的效率：超细胞FGFR3，具有（4 ; 14）易位和表达突变型FGFR3的细胞。由通式（I）表示的化合物，其药理学上可接受的盐或其溶剂合物可以对具有至少一种选自以下的细胞的生物体具有更高的效率：细胞过量表达FGFR3，具有（4; 14）易位和表达突变型FGFR3的细胞。

3. 外观设计

USD597420S1 Watch case with a band 有权
标题翻译：带表带的表壳
公开(公告)号：USD597420S1
公开(公告)日：2009-08-04
申请号：US29333266
申请日：2009-03-05
申请人： Junichi Kamata
设计人： Junichi Kamata

4. 外观设计

USD531923S1 Watch dial 有权
公开(公告)号：USD531923S1
公开(公告)日：2006-11-14
申请号：US29234162
申请日：2005-07-14
申请人： Katsunori Kume , Junichi Kamata
设计人： Katsunori Kume , Junichi Kamata

5. 发明授权

US06784192B2 Piperidine compound and pharmaceutical composition thereof 失效
标题翻译：新型哌啶化合物及其药物组合物。
公开(公告)号：US06784192B2
公开(公告)日：2004-08-31
申请号：US10181560
申请日：2002-07-19
申请人： Fumihiro Ozaki , Toshihiko Kaneko , Mutsuko Tabata , Yoshinori Takahashi , Kazuki Miyazaki , Junichi Kamata , Ichiro Yoshida , Masayuki Matsukura , Hiroyuki Suzuki , Takashi Yoshinaga , Hiroki Ishihara , Hiroshi Katoh , Kohei Sawada , Tatsuhiro Onogi , Kiyoaki Kobayashi , Miyuki Ohkubo
发明人： Fumihiro Ozaki , Toshihiko Kaneko , Mutsuko Tabata , Yoshinori Takahashi , Kazuki Miyazaki , Junichi Kamata , Ichiro Yoshida , Masayuki Matsukura , Hiroyuki Suzuki , Takashi Yoshinaga , Hiroki Ishihara , Hiroshi Katoh , Kohei Sawada , Tatsuhiro Onogi , Kiyoaki Kobayashi , Miyuki Ohkubo
IPC分类号： A61K31445
CPC分类号： C07D401/14 , C07D401/06 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention provides a novel compound having a superior Na+ channel inhibitory activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, the ring A represents a ring represented by the formula: (wherein R1 represents a hydrogen atom etc.; and R2 represents indicates a hydrogen atom and the like) etc.; W represents an optionally substituted C1-6 alkylene group etc.; Z represents an optionally substituted C6-14 aromatic hydrocarbon cyclic group etc.; and l represents an integer from 0 to 6.
摘要翻译：本发明提供具有优异的Na +通道抑制活性的新型化合物。即，它提供由下式（I）表示的化合物，其盐或它们的水合物。在该式中，环A表示由下式表示的环：其中R 1表示氢原子等 R 2表示氢原子等）等; W表示任选取代的C 1-6亚烷基等; Z表示任选取代的C 6-14芳烃环基等。 l表示0〜6的整数。

6. 发明申请

US20150032247A1 NUMERICAL CONTROL DEVICE 有权
标题翻译：数控装置
公开(公告)号：US20150032247A1
公开(公告)日：2015-01-29
申请号：US14378533
申请日：2012-05-09
申请人： Yuki Hashizume , Masahiro Ozawa , Junichi Kamata
发明人： Yuki Hashizume , Masahiro Ozawa , Junichi Kamata
IPC分类号： G05B19/18
CPC分类号： G05B19/182 , G05B19/4063 , G05B2219/4708 , G05B2219/50063
摘要： A numerical control device inputs a machining program to control an operation of a machine tool and outputs feedback data obtained as a result of the operation of the machine tool. The numerical control device includes a machining-program analysis unit that analyzes the machining program having a machining shape command to which a mark or a specific program command is attached and that outputs a marking instruction; a delay unit that delays the marking instruction until the feedback data indicating a result of an operation of the machine tool based on the machining shape command is obtained; and a feedback-data output unit that, when having detected the feedback data and the delayed marking instruction, executes, onto the feedback data, marking corresponding to the mark or the specific program command attached to the machining shape command and outputs the feedback data.
摘要翻译：数控设备输入加工程序来控制机床的操作，并输出作为机床操作结果获得的反馈数据。数控装置包括：加工程序分析单元，其分析具有附加有标记或特定程序命令的加工形状命令的加工程序，并且输出标记指令; 延迟单元，其延迟所述标记指令，直到获得基于所述加工形状命令的指示所述机床的操作结果的反馈数据为止; 以及反馈数据输出单元，当检测到反馈数据和延迟标记指令时，在反馈数据上执行与加法形状命令相关的标记或特定程序命令相对应的标记，并输出反馈数据。

7. 发明授权

US07612092B2 Nitrogen-containing aromatic derivatives 有权
标题翻译：含氮芳香族衍生物
公开(公告)号：US07612092B2
公开(公告)日：2009-11-03
申请号：US11293785
申请日：2005-12-02
申请人： Yasuhiro Funahashi , Akihiko Tsuruoka , Masayuki Matsukura , Toru Haneda , Yoshio Fukuda , Junichi Kamata , Keiko Takahashi , Tomohiro Matsushima , Kazuki Miyazaki , Ken-ichi Nomoto , Tatsuo Watanabe , Hiroshi Obaishi , Atsumi Yamaguchi , Sachi Suzuki , Katsuji Nakamura , Fusayo Mimura , Yuji Yamamoto , Junji Matsui
发明人： Yasuhiro Funahashi , Akihiko Tsuruoka , Masayuki Matsukura , Toru Haneda , Yoshio Fukuda , Junichi Kamata , Keiko Takahashi , Tomohiro Matsushima , Kazuki Miyazaki , Ken-ichi Nomoto , Tatsuo Watanabe , Hiroshi Obaishi , Atsumi Yamaguchi , Sachi Suzuki , Katsuji Nakamura , Fusayo Mimura , Yuji Yamamoto , Junji Matsui
IPC分类号： A61K31/47
CPC分类号： C07D213/73 , A61K31/4706 , A61K31/4745 , A61K31/517 , A61K31/519 , C07D207/34 , C07D213/26 , C07D213/68 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/18 , C07D215/233 , C07D215/36 , C07D215/38 , C07D215/48 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/88 , C07D249/04 , C07D261/14 , C07D277/48 , C07D307/68 , C07D319/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—, Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.
摘要翻译：由以下通式表示的化合物：其中Ag是任选取代的5至14元杂环基等; Xg为-O-，-S-等; Yg是任选取代的C 6-14芳基，任选取代的5至14元杂环基等; Tg1为下列通式表示的基团：（其中Eg为单键或-N（Rg2） - ，Rg1和Rg2各自独立地表示氢原子，可以具有取代基的C1-6烷基等，Zg 表示C 1-8烷基，C 3-8脂环族烃基，C 6-14芳基等）]，其盐或前述的水合物。

8. 发明申请

US20050176712A1 Integrin expression inhibitor 失效
标题翻译：整合素表达抑制剂
公开(公告)号：US20050176712A1
公开(公告)日：2005-08-11
申请号：US11097218
申请日：2005-04-04
申请人： Toshiaki Wakabayashi , Yasuhiro Funahashi , Naoko Hata , Taro Semba , Yuji Yamamoto , Toru Haneda , Takashi Owa , Akihiko Tsuruoka , Junichi Kamata , Tadashi Okabe , Keiko Takahashi , Kazumasa Nara , Shinichi Hamaoka , Norihiro Ueda
发明人： Toshiaki Wakabayashi , Yasuhiro Funahashi , Naoko Hata , Taro Semba , Yuji Yamamoto , Toru Haneda , Takashi Owa , Akihiko Tsuruoka , Junichi Kamata , Tadashi Okabe , Keiko Takahashi , Kazumasa Nara , Shinichi Hamaoka , Norihiro Ueda
IPC分类号： A61K45/06 , A61K31/00 , A61K31/145 , A61K31/18 , A61K31/404 , A61K31/4045 , A61K31/438 , A61K31/4439 , A61K31/506 , A61P7/02 , A61P9/10 , A61P17/06 , A61P19/02 , A61P19/10 , A61P35/00 , A61P35/04 , C07D209/08 , C07D209/12 , C07D209/30 , C07D209/34 , C07D209/42 , C07D215/38 , C07D217/02 , C07D217/22 , C07D217/24 , C07D311/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D411/12 , C07D417/12 , C07D471/04 , A61K31/53 , A61K31/47 , A61K31/517 , A61K31/519
CPC分类号： C07D471/04 , A61K31/00 , A61K31/18 , A61K31/404 , A61K31/4045 , A61K31/4439 , A61K31/506 , C07D209/08 , C07D209/12 , C07D209/30 , C07D209/34 , C07D209/42 , C07D215/38 , C07D217/02 , C07D217/22 , C07D217/24 , C07D311/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D411/12 , C07D417/12
摘要： The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them, wherein in the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, —CH═CH— or —(CR4bR5b)mb— (wherein R4b and R5b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mb means an integer of 1 or 2); R1 means hydrogen atom or a C1-C6 alkyl group; Z means a single bond or —CO—NH—; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.
摘要翻译：本发明提供一种整联蛋白表达抑制剂，以及基于整联蛋白抑制作用的治疗动脉硬化，银屑病，癌症，视网膜血管生成，糖尿病性视网膜病变或炎性疾病，抗凝血剂或癌转移抑制剂的药剂。即，提供一种整联蛋白表达抑制剂，其包含作为活性成分的下式（I）表示的磺酰胺化合物，其药理学上可接受的盐或其水合物，其中，式中，B表示C6〜C10芳基环或6至10元杂芳基环，其可以具有取代基，并且其中一部分环可以饱和; K表示单键，-CH-CH-或 - （CR 4b）R b）（其中R 4b和R 5b彼此相同或不同，并且各自表示氢原子或C 1 -C 4烷基;且m b， / SUP>表示1或2的整数）; R 1表示氢原子或C 1 -C 6烷基; Z表示单键或-CO-NH-; 并且R表示可以分别具有取代基并且其中一部分环可以饱和的C 6 -C 10芳基环或6至10元杂芳基环。

9. 发明授权

US06787534B2 Sulfonamide-containing heterocyclic compounds 失效
标题翻译：含磺酰胺的杂环化合物
公开(公告)号：US06787534B2
公开(公告)日：2004-09-07
申请号：US10149253
申请日：2002-06-10
申请人： Toru Haneda , Akihiko Tsuruoka , Junichi Kamata , Tadashi Okabe , Keiko Takahashi , Kazumasa Nara , Shinichi Hamaoka , Norihiro Ueda , Toshiaki Wakabayashi , Yasuhiro Funahashi , Taro Semba , Naoko Hata , Yuji Yamamoto , Yoichi Ozawa , Naoko Tsukahara , Takashi Owa
发明人： Toru Haneda , Akihiko Tsuruoka , Junichi Kamata , Tadashi Okabe , Keiko Takahashi , Kazumasa Nara , Shinichi Hamaoka , Norihiro Ueda , Toshiaki Wakabayashi , Yasuhiro Funahashi , Taro Semba , Naoko Hata , Yuji Yamamoto , Yoichi Ozawa , Naoko Tsukahara , Takashi Owa
IPC分类号： A61K3133
CPC分类号： C07D215/38 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D311/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D417/12 , C07D471/04
摘要： The present invention provides a sulfonamide- or sulfonylurea-containing heterocyclic compounds. Specifically, it provides a heterocyclic compound represented by the formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, A is hydrogen atom, a halogen atom, a C1-C4 alkyl or alkoxy group which may be substituted with a halogen atom, or cyano group; B is an optionally substituted aryl group or monocyclic heteroaryl group, or: (wherein, the ring Q is an aromatic ring which may have nitrogen atom; and the ring M is a ring sharing a double bond with the ring Q, which ring may have a heteroatom; and the rings Q and M may share nitrogen atom); K is a single bond; T, W, X and Y are the same as or different from each other and each is ═C(D)— (wherein, D is hydrogen or a halogen atom) or nitrogen atom; U and V are the same as or different from each other and each is ═C(D)—, nitrogen atom, —CH2—, oxygen atom or —CO—; Z is a single bond or —CO—NH—; and R1 is hydrogen atom, etc.
摘要翻译：本发明提供了含磺酰胺或磺酰脲的杂环化合物。具体地说，它提供由式（I）表示的杂环化合物，其药理学上可接受的盐或它们的水合物。在该式中，A是氢原子，卤素原子，可以是C 1 -C 4烷基或烷氧基的被卤素原子或氰基取代; B是任选取代的芳基或单环杂芳基，或者：（其中，环Q是可以具有氮原子的芳环;环M是与环Q共享双键的环，该环可以具有杂原子;并且环Q和M可以共享氮原子）; K是单键; T，W，X和Y彼此相同或不同，并且各自为= C（D） - （其中，D为氢或卤素原子）或氮原子; U和V彼此相同或不同，并且各自为= C（D） - ，氮原子，-CH 2 - ，氧原子或-CO-; Z是单键或-CO-NH-; R1为氢原子等

10. 发明授权

US06469043B1 Sulfonamide-containing indole compounds 有权
标题翻译：含磺酰胺的吲哚化合物
公开(公告)号：US06469043B1
公开(公告)日：2002-10-22
申请号：US09647215
申请日：2000-09-28
申请人： Toru Haneda , Akihiko Tsuruoka , Junichi Kamata , Tadashi Okabe , Keiko Takahashi , Kazumasa Nara , Shinichi Hamaoka , Norihiro Ueda , Takashi Owa , Toshiaki Wakabayashi , Yasuhiro Funahashi , Taro Semba , Naoko Hata , Yuji Yamamoto , Yoichi Ozawa , Noako Tsukahara
发明人： Toru Haneda , Akihiko Tsuruoka , Junichi Kamata , Tadashi Okabe , Keiko Takahashi , Kazumasa Nara , Shinichi Hamaoka , Norihiro Ueda , Takashi Owa , Toshiaki Wakabayashi , Yasuhiro Funahashi , Taro Semba , Naoko Hata , Yuji Yamamoto , Yoichi Ozawa , Noako Tsukahara
IPC分类号： A61K31404
CPC分类号： C07D401/12 , C07D209/04 , C07D209/30 , C07D209/42 , C07D403/12 , C07D409/12
摘要： The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof. In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1˜C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1˜C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded. Further, when the ring A is cyanophenyl group, 2-amino-5-pyridyl group or a 2-halo-5-pyridyl group and R1 is cyano group or a halogen atom, at least one of R2 and R3 should not be a hydrogen atom.
摘要翻译：本发明创造出一种新型抗血管生成剂，并提供与常规抗肿瘤剂相比显示出高安全性的抗肿瘤剂，具有确定的作用并且能够长时间施用。也就是说，其提供由下式（I）表示的吲哚化合物，其药理学上可接受的盐或其水合物。在该式中，R1表示氢原子，卤素原子或氰基; R2和R3相同或不同，各自表示氢原子，C1〜C4低级烷基或卤原子; R4表示氢原子或C1〜C4低级烷基; 并且环A表示氰基苯基，氨基磺酰基苯基，氨基吡啶基，氨基嘧啶基，卤代吡啶基或氰基噻吩基，条件是所有的R 1，R 2和R 3均为氢原子，其中R 2和R 3均为氢原子或环A为氨基磺酰基，R1和R2均为卤素原子。此外，当环A为氰基苯基，2-氨基-5-吡啶基或2-卤代-5-吡啶基并且R 1为氰基或卤素原子时，R 2和R 3中的至少一个不应为氢原子。

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