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1. 发明授权

US07943654B2 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors 有权
标题翻译：可用作激酶抑制剂的1H-噻吩并[2,3-c]吡唑化合物
公开(公告)号：US07943654B2
公开(公告)日：2011-05-17
申请号：US11988528
申请日：2006-07-10
申请人： Daniele Fancelli , Jurgen Moll , Maurizio Pulici , Francesca Quartieri , Tizizno Bandiera
发明人： Daniele Fancelli , Jurgen Moll , Maurizio Pulici , Francesca Quartieri , Tizizno Bandiera
IPC分类号： A01N43/56 , A01N43/06 , A61K31/415 , A61K31/38 , C07D487/02 , C07D231/54 , C07D333/00
CPC分类号： C07D495/04
摘要： There are provided thieno[2,3-c]pyrazole derivatives of formula (I), wherein A is an aryl or heteroaryl ring, on which the substituent-NHZR5 is at the ortho position to the CONH linker; R1 and R2 are the same or different and, independently from each other, represent a hydrogen atom or an organic group; R4 is a hydrogen or halogen atom or an organic group; Z is direct bond, >C═O, or —C(═O)NH—; R5 is hydrogen or an organic group; or isomers, tautomers, carriers, metabolites, prodrugs, and pharamaceutically acceptable salts thereof. A process for their preparation and pharamaceutical compositions comprising them are also disclosed; the compounds of the invention may be useful, in theraphy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译：提供式（I）的噻吩并[2,3-c]吡唑衍生物，其中A是芳基或杂芳基环，取代基-NHZR5在其上与CONH连接体的邻位; R1和R2相同或不同，彼此独立地表示氢原子或有机基团; R4是氢或卤素原子或有机基团; Z是直接键合，> C = O或-C（= O）NH-; R5是氢或有机基团; 或异构体，互变异构体，载体，代谢物，前药和药物上可接受的盐。还公开了其制备方法和包含它们的药用组合物; 本发明的化合物在治疗与失调的蛋白激酶活性相关的疾病（例如癌症）中可能是有用的。

2. 发明申请

US20100256160A1 METHOD OF ADMINISTERING AN ANTITUMOR COMPOUND 审中-公开
标题翻译：施用抗微生物化合物的方法
公开(公告)号：US20100256160A1
公开(公告)日：2010-10-07
申请号：US12513290
申请日：2007-10-25
申请人： Bernard Laffranchi , Jurgen Moll , Fabrina Bologna , Silvia Comis
发明人： Bernard Laffranchi , Jurgen Moll , Fabrina Bologna , Silvia Comis
IPC分类号： A61K31/496 , A61P35/00
CPC分类号： A61K31/4162
摘要： The present invention provides a method of treating a mammal, including humans, suffering from tumour, comprising administering Compound 1 of the formula A or a pharmaceutically acceptable salt thereof, to said mammal by intravenous infusion, characterised in that Compound 1 is conveniently administered employing particular schedules, infusion times and doses which allow a more efficacious treatment. Compound 1 of formula A is an aurora inhibitor, chemical name N-{5-[(2R)-2-methoxy-2-phenylethanoyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl}-4-(4-methylpiperazin-1-yl)benzamide, and the method is preferably for the treatment of patients having solid tumours or hematopoietic malignant tumours. The use of Compound 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient, in the manufacture of a medicament for the treatment of tumours employing particular schedules, infusion times and doses, as well as the use of Compound 1 for treatment of tumours in the same manner are also provided.
摘要翻译：本发明提供了一种治疗患有肿瘤的哺乳动物（包括人）的方法，其包括通过静脉内输注向所述哺乳动物施用式A化合物1或其药学上可接受的盐，其特征在于化合物1通过特别方法施用时间表，输液时间和剂量，可进行更有效的治疗。化学式A的化合物1是化学名称为N- {5 - [（2R）-2-甲氧基-2-苯基乙酰基] -1,4,5,6-四氢吡咯并[3,4-c]吡唑-3 - 基} -4-（4-甲基哌嗪-1-基）苯甲酰胺，该方法优选用于治疗患有实体瘤或造血恶性肿瘤的患者。化合物1或其药学上可接受的盐和药学上可接受的载体或赋形剂在制备用于治疗使用特定时间表，输注时间和剂量的肿瘤的药物中的用途以及化合物1用于也提供以相同方式治疗肿瘤。

3. 发明申请

US20090149457A1 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors 有权
标题翻译：可用作激酶抑制剂的1H-噻吩并[2,3-c]吡唑化合物
公开(公告)号：US20090149457A1
公开(公告)日：2009-06-11
申请号：US11988528
申请日：2006-07-10
申请人： Daniele Fancelli , Jurgen Moll , Maurizio Pulici , Francesca Quartieri , Tiziano Bandiera
发明人： Daniele Fancelli , Jurgen Moll , Maurizio Pulici , Francesca Quartieri , Tiziano Bandiera
IPC分类号： A61K31/5377 , C07D231/54 , A61K31/4162 , C12N9/99 , A61P35/00 , A61P37/00 , A61P25/00 , C07D409/14 , A61K31/496 , C07D413/14
CPC分类号： C07D495/04
摘要： There are provided thieno[2,3-c]pyrazole derivatives of formula (I), wherein A is an aryl or heteroaryl ring, on which the substituent-NHZR5 is at the ortho position to the CONH linker; R1 and R2 are the same or different and, independently from each other, represent a hydrogen atom or an organic group; R4 is a hydrogen or halogen atom or an organic group; Z is direct bond, >C═O, or —C(═O)NH—; R5 is hydrogen or an organic group; or isomers, tautomers, carriers, metabolites, prodrugs, and pharamaceutically acceptable salts thereof. A process for their preparation and pharamaceutical compositions comprising them are also disclosed; the compounds of the invention may be useful, in theraphy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译：提供式（I）的噻吩并[2,3-c]吡唑衍生物，其中A是芳基或杂芳基环，取代基-NHZR5在其上与CONH连接体的邻位; R1和R2相同或不同，彼此独立地表示氢原子或有机基团; R4是氢或卤素原子或有机基团; Z是直接键合，> C-O或-C（-O）NH-; R5是氢或有机基团; 或异构体，互变异构体，载体，代谢物，前药和药物上可接受的盐。还公开了其制备方法和包含它们的药用组合物; 本发明的化合物在治疗与失调的蛋白激酶活性相关的疾病（例如癌症）中可能是有用的。

4. 发明申请

US20050032839A1 Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them 有权
标题翻译：作为激酶抑制剂活性的吡咯并[3,4-c]吡唑衍生物，其制备方法和包含它们的药物组合物
公开(公告)号：US20050032839A1
公开(公告)日：2005-02-10
申请号：US10882493
申请日：2004-07-01
申请人： Daniele Fancelli , Barbara Forte , Jurgen Moll , Mario Varasi , Paola Vianello
发明人： Daniele Fancelli , Barbara Forte , Jurgen Moll , Mario Varasi , Paola Vianello
IPC分类号： A61K31/4162 , A61P35/00 , C07D487/04 , A61K31/454
CPC分类号： C07D487/04
摘要： Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译：公开了本说明书中定义的式（I）的吡咯并[3,4-c]吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。

5. 发明授权

US5981300A Test kit for analyzing body fluids and analysis method 失效
标题翻译：用于分析体液的试剂盒和分析方法
公开(公告)号：US5981300A
公开(公告)日：1999-11-09
申请号：US849659
申请日：1997-05-29
申请人： Claus-Jurgen Moll , Theodor Paessens , Jorg Althoff
发明人： Claus-Jurgen Moll , Theodor Paessens , Jorg Althoff
IPC分类号： G01N33/50 , A61B10/00 , C12Q1/04 , G01N33/487 , G01N33/48
CPC分类号： C12Q1/04 , A61B10/0051 , A61B2010/0003 , Y10S436/81 , Y10S436/811
摘要： A test kit is disclosed for analyzing a patient's saliva to determine the patient's risk of tooth decay, which contains: (a) a support; (b) an absorbent material in contact with said support and capable of removing saliva from the mouth and of absorbing the saliva; (c) a composition coated on said absorbent material, said composition soluble in saliva and capable of reaction inside the mouth of the patient with the saliva to reduce the pH of the saliva; and (d) a color scale for determining outside of the mouth of the patient the pH of the saliva absorbed by the absorbent material in which the composition is dissolved to measure the reaction of the composition with the saliva in the patient's mouth to determine the patient's risk of tooth decay.
摘要翻译： PCT No.PCT / EP95 / 04812 Sec。 371日期1997年5月29日 102（e）日期1997年5月29日PCT提交1995年12月7日PCT公布。 WO96 / 18902 PCT公开号日期1996年6月20日公开了一种用于分析患者唾液以测定患者蛀牙风险的测试包，其中包含：（a）支持; （b）与所述载体接触并能够从口中除去唾液并吸收唾液的吸收材料; （c）涂覆在所述吸收材料上的组合物，所述组合物可溶于唾液并且能够在患者口腔内与唾液反应以降低唾液的pH值; 和（d）用于确定患者口腔外部的颜色标尺，其中溶解有组合物的吸收材料吸收的唾液的pH值以测量组合物与患者口腔中的唾液的反应，以确定患者的蛀牙风险

6. 发明授权

US5763869A Data carrier having an electronic module 失效
标题翻译：具有电子模块的数据载体
公开(公告)号：US5763869A
公开(公告)日：1998-06-09
申请号：US687424
申请日：1996-08-08
申请人： Jurgen Moll , Franz Weikmann , Michael Lamla
发明人： Jurgen Moll , Franz Weikmann , Michael Lamla
IPC分类号： G06K19/07 , G06K19/073 , G07F7/10 , G06K19/00
CPC分类号： G07F7/1008 , G06K19/07 , G06K19/073 , G06K19/07703 , G06Q20/341 , G07F7/082
摘要： A data carrier having an electronic module includes an integrated circuit. The integrated circuit has not only has the usual components, but also an electronic check unit having a nonvolatile memory area and a separate interface. During normal operation of the data carrier, data are written additionally in the electronic check unit. If functional failure of the electronic module of the data carrier occurs, the data are still readable from the memory of the electronic check unit via the separate inter-face even if the integrated circuit is otherwise mechanically destroyed.
摘要翻译： PCT No.PCT / EP95 / 04822 Sec。 371日期：1996年8月8日 102（e）日期1996年8月8日PCT 1995年12月7日PCT PCT。公开号WO96 / 18172 日期1996年6月13日具有电子模块的数据载体包括集成电路。集成电路不仅具有通常的部件，而且具有具有非易失性存储区域和独立接口的电子检查单元。在数据载体的正常操作期间，在电子检查单元中另外写入数据。如果发生数据载体的电子模块的功能故障，则即使集成电路机械地被破坏，数据仍然可以经由单独的接口从电子检查单元的存储器读取。

7. 发明授权

US4756557A Security document having a security thread embedded therein and methods for producing and testing the authenticity of the security document 失效
标题翻译：具有嵌入其中的安全线程的安全文档和用于生成和测试安全文档的真实性的方法
公开(公告)号：US4756557A
公开(公告)日：1988-07-12
申请号：US812894
申请日：1985-12-23
申请人： Wittich Kaule , Gerhard Stenzel , Jurgen Moll , Gerhard Schwenk
发明人： Wittich Kaule , Gerhard Stenzel , Jurgen Moll , Gerhard Schwenk
IPC分类号： B43L13/00 , B41M3/14 , B42D15/00 , B42D25/355 , D21H21/48 , G06K19/10 , G06T1/00 , G07D7/12 , G07D7/121
CPC分类号： D21H21/48 , B42D25/355 , G06K19/10 , G07D7/12 , G07D7/121 , Y10S283/904 , Y10S428/915
摘要： In order to increase the protection of security documents such as ban notes, etc., against forgery, security threads are embedded in the document which have at least two areas extending in the longitudinal direction of the thread and differing in their physical properties. The thread is preferably a coextruded multicomponent synthetic thread whose individual components contain additives such as dyes or fluorescent substances and/or particles having electrical or magnetic properties. The testing of the authenticity of the security thread is directed toward the presence of these additives and their mutual geometrical distribution in certain areas of the security thread.
摘要翻译：为了增加对诸如禁令等安全文件的保护，防伪，安全线被嵌入到文件中，该文件具有沿着线的纵向方向延伸的至少两个区域并且其物理性质不同。螺纹优选是共挤出的多组分合成线，其单独的组分含有添加剂，例如染料或荧光物质和/或具有电或磁特性的颗粒。安全线程的真实性的测试针对这些添加剂的存在及其在安全线程的某些区域中的相互几何分布。

8. 发明申请

US20090239924A1 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权
标题翻译： 1H-FURO [3,2-C]吡唑化合物作为激酶抑制剂有用
公开(公告)号：US20090239924A1
公开(公告)日：2009-09-24
申请号：US12302569
申请日：2007-05-25
申请人： Daniele Fancelli , Maurizio Pulici , Jurgen Moll , Tiziano Bandiera
发明人： Daniele Fancelli , Maurizio Pulici , Jurgen Moll , Tiziano Bandiera
IPC分类号： A61K31/4162 , C07D491/048 , A61P35/00 , A61P35/04
CPC分类号： C07D491/048
摘要： Furo[3,2-c]pyrazole derivatives of formula (I) as defined in the description, and pharmaceutically acceptable salts thereof, wherein A is an aryl or heteroaryl ring, —NHZR5 is at the ortho position to the CONH linker; —R1 and R2 are the same or different and, independently from each other, represent a hydrogen atom, or an organic residue; R3 is a hydrogen or halogen atom or an organic group; R4 is a hydrogen or halogen atom or an organic group; Z is direct bond, >C═O, or —C(═O)NH—; —R5 is hydrogen or an optionally substituted organic group or isomers, tautomers, carriers, metabolites, prodrugs, and pharmaceutically acceptable salts thereof. A process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, in particular Aurora kinases activity or IGF-1R activity, like cancer.
摘要翻译：如描述中定义的式（I）的呋喃并[3,2-c]吡唑衍生物及其药学上可接受的盐，其中A是芳基或杂芳基环，-NHZR5位于与CONH接头的邻位; -R 1和R 2相同或不同，彼此独立地表示氢原子或有机残基; R3是氢或卤素原子或有机基团; R4是氢或卤素原子或有机基团; Z是直接键合，> C-O或-C（-O）NH-; -R5是氢或任选取代的有机基团或其异构体，互变异构体，载体，代谢物，前药及其药学上可接受的盐。公开了其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性，特别是Aurora激酶活性或IGF-1R活性相关的疾病，如癌症。

9. 发明申请

US20060276471A1 Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them 有权
公开(公告)号：US20060276471A1
公开(公告)日：2006-12-07
申请号：US11503256
申请日：2006-08-11
申请人： Daniele Fancelli , Barbara Forte , Jurgen Moll , Mario Varasi , Paola Vianello
发明人： Daniele Fancelli , Barbara Forte , Jurgen Moll , Mario Varasi , Paola Vianello
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , C07D487/02
CPC分类号： C07D487/04
摘要： Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

10. 发明授权

US4892336A Antifalsification document having a security thread embedded therein and a method for producing the same 失效
标题翻译：具有嵌入安全线的防伪文件及其制造方法
公开(公告)号：US4892336A
公开(公告)日：1990-01-09
申请号：US27552
申请日：1987-03-18
申请人： Wittich Kaule , Jurgen Moll , Gerhard Schwenk , Gerhard Stenzel
发明人： Wittich Kaule , Jurgen Moll , Gerhard Schwenk , Gerhard Stenzel
IPC分类号： B29C59/04 , B29D7/00 , B29D11/00 , B29D99/00 , B41F13/02 , B41F19/02 , B42D15/00 , B42D25/355 , B44B5/00 , B44F1/10 , B65H23/00 , B65H35/02 , D01D5/42 , D21H21/42 , D21H21/48 , G07D7/12
CPC分类号： B44B5/009 , B29C59/04 , B29D11/00 , B29D7/00 , B29D99/0078 , B41F13/025 , B42D25/355 , B44B5/00 , B44F1/10 , D21H21/48 , G07D7/12 , B29L2031/731
摘要： The present invention relates to an antifalsification document having an embedded secutiry thread, and to a method for producing the same. This security thread is transparent and has a printed pattern on one side and, on the opposite side, a lenticular structure coordinated with the printed pattern. Such threads change their appearance when the viewing angle changes. To produce the security threads, a transparent film impressed with the desired lenticular relief is directed to a printing apparatus in exact register via guide elements having a relief structure that is negative with respect to the film impression, and then divided in a cutting apparatus into individual threads.
摘要翻译：本发明涉及具有嵌入式螺旋线的防伪文件及其制造方法。该安全线是透明的，并且在一侧具有印刷图案，并且在相对侧上具有与印刷图案协调的透镜结构。当视角改变时，这种线会改变它们的外观。为了产生安全线，将所希望的双凸透镜压印的透明胶片通过具有相对于胶片印模为负的浮雕结构的引导元件精确对准印刷装置，然后在切割装置中分成单独的线程。

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