专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07840357B2 Method of evaluating chromosome state and evaluation system 有权
标题翻译：评估染色体状态和评价体系的方法
公开(公告)号：US07840357B2
公开(公告)日：2010-11-23
申请号：US10565669
申请日：2004-07-29
申请人： Tomoharu Kiyuna , Kenji Okajima , Hiroaki Torii , Ken' ichi Kamijo , Masahiko Kuroda , Keiichi Yoshida , Kiyoshi Mukai
发明人： Tomoharu Kiyuna , Kenji Okajima , Hiroaki Torii , Ken' ichi Kamijo , Masahiko Kuroda , Keiichi Yoshida , Kiyoshi Mukai
IPC分类号： G06F19/00 , G06K9/00 , G06K9/20 , G06K9/36
CPC分类号： G06T7/0012 , G06K9/00127 , G06T7/41 , G06T2207/30024
摘要： A method of evaluating a cell state based on information of an image taken of a cell containing a chromosome territory is provided. This method includes extracting the chromosome territory from the image (S20), standardizing a positioning state of the chromosome territory and then quantifying the positioning state (S22), and evaluating the cell state based on the quantified positioning state of the chromosome territory (S26).
摘要翻译：提供了一种基于对包含染色体区域的细胞拍摄的图像的信息来评估细胞状态的方法。该方法包括从图像中提取染色体区域（S20），对染色体区域的定位状态进行标准化，然后定量定位状态（S22），并根据染色体区域的量化定位状态来评估细胞状态（S26）。

2. 发明申请

US20100120693A1 MEDICAMENT FOR IMPROVING PROGNOSTIC SURVIVAL IN THERAPY OF MALIGNANT TUMOR 审中-公开
标题翻译：改善恶性肿瘤治疗中预防性存活的药物
公开(公告)号：US20100120693A1
公开(公告)日：2010-05-13
申请号：US12691125
申请日：2010-01-21
申请人： Kenji OKAJIMA , Fujio Matsuo , Hiroyuki Sutoh , Yoichi Ogata , Tomohiro Nakagaki
发明人： Kenji OKAJIMA , Fujio Matsuo , Hiroyuki Sutoh , Yoichi Ogata , Tomohiro Nakagaki
IPC分类号： A61K38/16 , A61P35/00
CPC分类号： A61K38/4866
摘要： A medicament for improving prognostic survival in therapy of malignant tumor is provided that may improve prognostic survival in DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. The medicament according to the invention comprises as a main active ingredient Activated Protein C, which is obtained from plasma or prepared by using the genetic recombination technique, and efficiently prolongs life-span of DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. In particular, the medicament may reduce adverse side effects of chemotherapeutics in chemotherapy of malignant tumor to enhance efficacy of said therapy and improve prognostic survival of patients suffering from malignant tumor.
摘要翻译：提供了一种用于改善恶性肿瘤治疗预后生存的药物，可以改善基底疾病是恶性肿瘤，特别是造血器官恶性肿瘤的DIC患者的预后生存。根据本发明的药物包含作为主要活性成分的由血浆获得或通过使用遗传重组技术制备的活化蛋白C，并有效延长了基础疾病是恶性肿瘤，特别是恶性肿瘤的DIC患者的寿命在造血器官。特别地，药物可以减少化学治疗剂在恶性肿瘤化疗中的不良副作用，以增强所述治疗的疗效并改善恶性肿瘤患者的预后。

3. 发明申请

US20080182791A1 Medicament for Improving Prognostic Survival in Therapy of Malignant Tumor 审中-公开
标题翻译：改善恶性肿瘤治疗预后生存的药物
公开(公告)号：US20080182791A1
公开(公告)日：2008-07-31
申请号：US12035936
申请日：2008-02-22
申请人： Kenji Okajima , Fujio Matsuo , Hiroyuki Sutoh , Yoichi Ogata , Tomohiro Nakagaki
发明人： Kenji Okajima , Fujio Matsuo , Hiroyuki Sutoh , Yoichi Ogata , Tomohiro Nakagaki
IPC分类号： A61K38/16 , A61P35/00
CPC分类号： A61K38/4866
摘要： A medicament for improving prognostic survival in therapy of malignant tumor is provided that may improve prognostic survival in DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. The medicament according to the invention comprises as a main active ingredient Activated Protein C, which is obtained from plasma or prepared by using the genetic recombination technique, and efficiently prolongs life-span of DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. In particular, the medicament may reduce adverse side effects of chemotherapeutics in chemotherapy of malignant tumor to enhance efficacy of said therapy and improve prognostic survival of patients suffering from malignant tumor.
摘要翻译：提供了一种用于改善恶性肿瘤治疗预后生存的药物，可以改善基底疾病是恶性肿瘤，特别是造血器官恶性肿瘤的DIC患者的预后生存。根据本发明的药物包含作为主要活性成分的由血浆获得或通过使用遗传重组技术制备的活化蛋白C，并有效延长了基础疾病是恶性肿瘤，特别是恶性肿瘤的DIC患者的寿命在造血器官。特别地，药物可以减少化学治疗剂在恶性肿瘤化疗中的不良副作用，以增强所述治疗的疗效并改善恶性肿瘤患者的预后。

4. 发明授权

US08644582B2 Support system for histopathological diagnosis, support program for histopathological diagnosis and support method for histopathological diagnosis 有权
标题翻译：组织病理学诊断支持系统，组织病理学诊断支持方案和组织病理学诊断支持方法
公开(公告)号：US08644582B2
公开(公告)日：2014-02-04
申请号：US13119678
申请日：2009-10-06
申请人： Yoshiko Yoshihara , Kenji Okajima , Akira Saito
发明人： Yoshiko Yoshihara , Kenji Okajima , Akira Saito
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/0014 , G06T2207/10056 , G06T2207/30024
摘要： A support system for histopathological diagnosis includes a cell nucleus uniformity evaluation unit evaluating a uniformity of a plurality of cell nuclei included in a ductal region in an image. With this configuration, there is provided a support system, a support method and a support program for histopathological diagnosis, which enables realization of highly accurate cancer differentiation in a pathological diagnosis.
摘要翻译：用于组织病理学诊断的支撑系统包括评估包括在图像中的导管区域中的多个细胞核的均匀性的细胞核均匀性评估单元。通过该结构，提供了一种用于组织病理学诊断的支持系统，支持方法和支持程序，其能够实现病理诊断中高度准确的癌症分化。

5. 发明授权

US08594411B2 Pathologic tissue image analyzing apparatus, pathologic tissue image analyzing method, and pathologic tissue image analyzing program 有权
标题翻译：病理组织图像分析仪器，病理组织图像分析方法，病理组织图像分析程序
公开(公告)号：US08594411B2
公开(公告)日：2013-11-26
申请号：US13376073
申请日：2010-06-03
申请人： Yoshiko Yoshihara , Kenji Okajima , Akira Saito
发明人： Yoshiko Yoshihara , Kenji Okajima , Akira Saito
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/0014 , G06T2207/10056 , G06T2207/30024
摘要： This invention is directed to improvement of the accuracy of cancer differentiation in the pathologic diagnosis using a pathologic tissue image analysis. There are included a stroma area/duct area detecting module for detecting, from a biological tissue image, a duct area on the basis of duct characteristic information indicating the characteristic of ducts included in a tissue area in the biological tissue image; an intraduct cell-nucleus detecting module for extracting, based on a predetermined pigment reference, cell nucleuses included in the detected duct area; and a duct formation evaluating module for calculating a heterotypic degree of each duct on the basis of the distribution state of the cell nucleuses for a predetermined base areas in each duct.
摘要翻译：本发明旨在提高使用病理组织图像分析的病理诊断中癌症分化的准确性。包括基质区域/管道区域检测模块，用于根据生物组织图像中包含在组织区域中的管道的特征的管道特征信息从生物组织图像检测管道区域; 导管细胞核检测模块，用于基于预定的颜料参考提取包括在检测到的管道区域中的细胞核; 以及管道形成评估模块，用于基于每个管道中的预定基区的细胞核的分布状态来计算每个管道的异型度。

6. 发明授权

US08199998B2 Module for detecting poorly differentiated cancers and pathological image diagnosis support apparatus, program and recording medium including the same 有权
标题翻译：用于检测分化不良的癌症和病理图像诊断支持装置，程序和记录介质的模块
公开(公告)号：US08199998B2
公开(公告)日：2012-06-12
申请号：US12265292
申请日：2008-11-05
申请人： Kenji Okajima , Yoshiko Yamashita , Akira Saito
发明人： Kenji Okajima , Yoshiko Yamashita , Akira Saito
IPC分类号： G06K9/00
CPC分类号： G06K9/00127
摘要： The detection accuracy of poorly differentiated cancers in adenocarcinoma is improved by restricting false detection. Cell nucleus detection means 1 receives a digitized pathological image as an input and extracts the region of a cell nucleus therefrom. Gland duct detection means 2 detects a gland duct structure in the image. Poorly differentiated cancer detection means 4 detects poorly differentiated cancers only in the region other than the gland duct region. False detection rejection means 7 compares the detection density of poorly differentiated cancer in the vicinity of a detection point with a threshold that is predetermined depending on gland duct density in the vicinity of the detection point, at each detection point detected by poorly differentiated cancer detection means 4 and rejects the detection point as a false detection if the detection density of a poorly differentiated cancer is smaller than the threshold.
摘要翻译：通过限制假检测可以提高腺癌分化不良的癌症的检测准确性。细胞核检测装置1接收数字化的病理图像作为输入，并从中提取细胞核的区域。腺体管检测装置2检测图像中的腺体管结构。分化不良的癌症检测手段4仅在腺体管区域以外的区域检测分化不良的癌症。假检测抑制装置7将检测点附近的分化不良的癌症的检测密度与根据检测点附近的腺体密度预先确定的阈值，在低分辨率癌症检测手段检测的各检测点进行比较 4，如果分化不良的癌症的检测密度小于阈值，则将检测点拒绝为假检测。

7. 发明申请

US20120082365A1 PATHOLOGIC TISSUE IMAGE ANALYZING APPARATUS, PATHOLOGIC TISSUE IMAGE ANALYZING METHOD, AND PATHOLOGIC TISSUE IMAGE ANALYZING PROGRAM 有权
标题翻译：病理组织图像分析装置，病理组织图像分析方法和病理组织图像分析程序
公开(公告)号：US20120082365A1
公开(公告)日：2012-04-05
申请号：US13376073
申请日：2010-06-03
申请人： Yoshiko Yoshihara , Kenji Okajima , Akira Saito
发明人： Yoshiko Yoshihara , Kenji Okajima , Akira Saito
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/0014 , G06T2207/10056 , G06T2207/30024
摘要： This invention is directed to improvement of the accuracy of cancer differentiation in the pathologic diagnosis using a pathologic tissue image analysis. There are included a stroma area/duct area detecting module for detecting, from a biological tissue image, a duct area on the basis of duct characteristic information indicating the characteristic of ducts included in a tissue area in the biological tissue image; an intraduct cell-nucleus detecting module for extracting, based on a predetermined pigment reference, cell nucleuses included in the detected duct area; and a duct formation evaluating module for calculating a heterotypic degree of each duct on the basis of the distribution state of the cell nucleuses for a predetermined base areas in each duct.
摘要翻译：本发明旨在提高使用病理组织图像分析的病理诊断中癌症分化的准确性。包括基质区域/管道区域检测模块，用于根据生物组织图像中包含在组织区域中的管道的特征的管道特征信息从生物组织图像检测管道区域; 导管细胞核检测模块，用于基于预定的颜料参考提取包括在检测到的管道区域中的细胞核; 以及管道形成评估模块，用于基于每个管道中的预定基区的细胞核的分布状态来计算每个管道的异型度。

8. 发明授权

US07693334B2 Pathological diagnosis support device, program, method, and system 有权
标题翻译：病理诊断支持设备，程序，方法和系统
公开(公告)号：US07693334B2
公开(公告)日：2010-04-06
申请号：US11290294
申请日：2005-11-30
申请人： Maki Ogura , Akira Saitou , Kenichi Kamijo , Kenji Okajima , Tomoharu Kiyuna
发明人： Maki Ogura , Akira Saitou , Kenichi Kamijo , Kenji Okajima , Tomoharu Kiyuna
IPC分类号： G06K9/46 , G06K9/66 , G06K9/50 , G06K9/00
CPC分类号： G06K9/00127 , G06F19/00 , G06K9/6228 , G16H10/20
摘要： A pathological diagnosis support device, a pathological diagnosis support program, a pathological diagnosis support method, and a pathological diagnosis support system extract a pathological tissue for diagnosis from a pathological image and diagnose the pathological tissue. A tissue collected in a pathological inspection is stained using, for example, hematoxylin and eosin. In consideration of the state of the tissue in which a cell nucleus and its peripheral constituent items are stained in respective colors unique thereto, subimages such as a cell nucleus, a pore, cytoplasm, interstitium are extracted from the pathological image, and color information of the cell nucleus is also extracted. The subimages and the color information are stored as feature candidates so that presence or absence of a tumor and benignity or malignity of the tumor are determined.
摘要翻译：病理诊断支持装置，病理诊断支持方案，病理诊断支持方法和病理诊断支持系统，从病理图像提取病理组织进行诊断，诊断病理组织。使用例如苏木精和曙红对病理检查中收集的组织进行染色。考虑到细胞核及其周边成分物质以其独特的颜色被染色的组织的状态，从病理图像中提取诸如细胞核，孔，细胞质，间质的子图像，并且颜色信息也提取细胞核。子图像和颜色信息作为特征候选存储，从而确定肿瘤的存在或不存在以及肿瘤的良性或恶性。

9. 发明申请

US20060246458A1 Method of evaluating chromsome state and evaluation system 有权
标题翻译：评价染色体状态和评价体系的方法
公开(公告)号：US20060246458A1
公开(公告)日：2006-11-02
申请号：US10565669
申请日：2004-07-29
申请人： Tomoharu Kiyuna , Kenji Okajima , Hiroaki Torii , Ken'ichi Kamijo , Masahiko Kuroda , Keiichi Yoshida , Kiyoshi Mukai
发明人： Tomoharu Kiyuna , Kenji Okajima , Hiroaki Torii , Ken'ichi Kamijo , Masahiko Kuroda , Keiichi Yoshida , Kiyoshi Mukai
IPC分类号： C12Q1/68 , G06F19/00 , G06K9/00
CPC分类号： G06T7/0012 , G06K9/00127 , G06T7/41 , G06T2207/30024
摘要： A method of evaluating a cell state based on information of an image taken of a cell containing a chromosome territory is provided. This method includes extracting the chromosome territory from the image (S20), standardizing a positioning state of the chromosome territory and then quantifying the positioning state (S22), and evaluating the cell state based on the quantified positioning state of the chromosome territory (S26).
摘要翻译：提供了一种基于对包含染色体区域的细胞拍摄的图像的信息来评估细胞状态的方法。该方法包括从图像提取染色体区域（S 20），标准化染色体区域的定位状态，然后定量定位状态（S22），并根据染色体区域的量化定位状态来评估细胞状态（ S 26）。

10. 发明申请

US20050169516A1 Pattern feature selection method, classification method, judgment method, program, and device 有权
标题翻译：模式特征选择方法，分类方法，判断方法，程序和装置
公开(公告)号：US20050169516A1
公开(公告)日：2005-08-04
申请号：US10505903
申请日：2003-02-27
申请人： Kenji Okajima , Hitoshi Imaoka , Masanobu Miyasita
发明人： Kenji Okajima , Hitoshi Imaoka , Masanobu Miyasita
IPC分类号： G06F17/30 , G06K9/62 , G06N3/00 , G06T7/00
CPC分类号： G06K9/623
摘要： Feature decision means (303) decides a set of features appropriate for pattern identification from a plenty of feature candidates generated by feature candidate generation means (302) by using learning patterns stored in learning, pattern storage means (301). The feature decision means (303) successively decides features according to a reference of information maximization under the condition that the decided feature is known while adding an effective noise to the learning pattern and performs information amount calculation approximately and at a high speed while merging the learning patterns into a set of N elements when required. As a result, it is possible to automatically create a feature set appropriate for pattern identification of a high performance without requiring enormous learning. Moreover, by using a transition table (305) containing transitions between sets, it is possible to perform pattern judgment with a high efficiency.
摘要翻译：特征决定装置（303）通过使用存储在学习模式存储装置（301）中的学习模式，从特征候选生成装置（302）产生的大量特征候选中，确定适合于模式识别的特征的一组。特征决定装置（303）在所确定的特征已知的条件下，根据信息最大化的参考依次确定特征，同时向学习模式添加有效噪声，并且在合并学习期间大约和高速地执行信息量计算当需要时，模式成为一组N个元素。因此，可以自动创建适合于高性能的图案识别的特征集，而不需要巨大的学习。此外，通过使用包含组之间的转换的转换表（305），可以以高效率执行模式判断。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式