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    • 4. 发明授权
    • Method of making a protein polymer and uses of the polymer
    • 制备蛋白质聚合物的方法和聚合物的用途
    • US07459172B2
    • 2008-12-02
    • US09997807
    • 2001-11-30
    • Jay ShortEric J. MathurW. Michael LaffertyNelson BartonKevin Chow
    • Jay ShortEric J. MathurW. Michael LaffertyNelson BartonKevin Chow
    • A61K31/74A61K38/16
    • B82Y30/00A61K9/0092A61K9/1274C07K14/195
    • A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invention, the drug molecule may be delivered to a particular location of human body to effectively cure a disease or treat a symptom.Generally, the monomeric polypeptide unit of the present invention has a sequence found in Pyrodictium abyssi, a microorganism that produces an extracellular network having hollow protein tubes, or a sequence substantially identical thereto. The monomeric polypeptide may be mass produced using recombinant biotechnologies and be polymerized into the polymer of the present invention. One or more additional targeting vector may be attached to the monomeric polypeptide unit or the polymer to facilitate the targeting of the drug molecule that may be held there within. The sequence contained in the monomeric polypeptide unit may be further optimized using one or more technique selected from Gene Site Saturation Mutagenesis and GeneReasembly™.
    • 通过多个单体多肽单元的自组装制备聚合物。 聚合物倾向于形成纳米管并且能够封装特定的药物分子。 一旦包封在本发明的聚合物中,药物分子可以被递送到人体的特定位置以有效治愈疾病或治疗症状。 通常,本发明的单体多肽单元具有在黑腹果蝇(Pyrodictium abyssi)中发现的序列,该菌株产生具有中空蛋白管的细胞外网络或与其基本相同的序列。 单体多肽可以使用重组生物技术大规模生产并聚合成本发明的聚合物。 一个或多个另外的靶向载体可以连接到单体多肽单元或聚合物,以促进可能在其中保持的药物分子的靶向。 可以使用选自Gene Site Saturation Mutagenesis和GeneReasembly TM的一种或多种技术进一步优化单体多肽单元中所含的序列。
    • 10. 发明申请
    • CHIMERIC CANNULAE PROTEINS AND METHODS FOR MAKING AND USING THEM
    • CHIMERIC CANNULAE蛋白质及其制备和使用方法
    • US20100172968A1
    • 2010-07-08
    • US11929781
    • 2007-10-30
    • Jay ShortEric J. MathurW. Michael LaffertyNelson BartonKevin Chow
    • Jay ShortEric J. MathurW. Michael LaffertyNelson BartonKevin Chow
    • A61K9/48A61K9/10C12N15/63C07K14/00C07K16/00
    • B82Y30/00A61K9/0092A61K9/1274C07K14/195
    • A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invention, the drug molecule may be delivered to a particular location of human body to effectively cure a disease or treat a symptom.Generally, the monomeric polypeptide unit of the present invention has a sequence found in Pyrodictium abyssi, a microorganism that produces an extracellular network having hollow protein tubes, or a sequence substantially identical thereto. The monomeric polypeptide may be mass produced using recombinant biotechnologies and be polymerized into the polymer of the present invention. One or more additional targeting vector may be attached to the monomeric polypeptide unit or the polymer to facilitate the targeting of the drug molecule that may be held there within. The sequence contained in the monomeric polypeptide unit may be further optimized using one or more technique selected from Gene Site Saturation Mutagenesis and GeneReasembly.
    • 通过多个单体多肽单元的自组装制备聚合物。 聚合物倾向于形成纳米管并且能够封装特定的药物分子。 一旦包封在本发明的聚合物中,药物分子可以被递送到人体的特定位置以有效治愈疾病或治疗症状。 通常,本发明的单体多肽单元具有在黑腹果蝇(Pyrodictium abyssi)中发现的序列,该菌株产生具有中空蛋白管的细胞外网络或与其基本相同的序列。 单体多肽可以使用重组生物技术大规模生产并聚合成本发明的聚合物。 一个或多个另外的靶向载体可以连接到单体多肽单元或聚合物,以促进可能在其中保持的药物分子的靶向。 可以使用选自基因位点饱和诱变和基因重组的一种或多种技术进一步优化单体多肽单元中所含的序列。