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1. 发明授权

US6008348A Antipsychotic agents, compositions and method of use 有权
标题翻译：抗精神病药，组合物和使用方法
公开(公告)号：US6008348A
公开(公告)日：1999-12-28
申请号：US288388
申请日：1999-04-08
申请人： Mark G. Palermo , Lawrence L. Martin , Peter A. Nemoto
发明人： Mark G. Palermo , Lawrence L. Martin , Peter A. Nemoto
IPC分类号： C07D413/04 , C07D403/04 , C07D417/00 , C07D419/00
CPC分类号： C07D413/04
摘要： This invention relates to compounds of the formula wherein X, Y, Z, m, n and p are as defined within, pharmaceutical compositions containing these compounds and to their use as antipsychotic agents, particularly in the treatment of schizophrenia. Depot derivatives of the compounds are useful for providing long acting effects of the compounds.
摘要翻译：本发明涉及下式的化合物，其中X，Y，Z，m，n和p定义如下，含有这些化合物的药物组合物及其作为抗精神病药的用途，特别是治疗精神分裂症。化合物的储备衍生物可用于提供化合物的长效作用。

2. 发明授权

US5707409A Abrasive article having a diamond-like coating layer and method for making same 失效
公开(公告)号：US5707409A
公开(公告)日：1998-01-13
申请号：US698385
申请日：1996-08-15
申请人： Lawrence L. Martin , David G. O'Neill , Moses M. David
发明人： Lawrence L. Martin , David G. O'Neill , Moses M. David
IPC分类号： B24D3/00 , B24D3/20 , B24D3/28 , B24D11/00 , C23C14/06 , C23C16/02 , C23C16/26 , C23C16/27 , C30B29/04
CPC分类号： C23C16/0272 , B24D11/00 , B24D3/004 , B24D3/20 , B24D3/28 , C23C16/26
摘要： An abrasive article having a sheet-like substrate having at least one major surface; an abrasive coating adhered to the at least one major surface of the substrate, wherein the abrasive coating comprises a plurality of abrasive particles and an organic binder medium; and, a hard carbon coating layer comprising a diamond-like carbon film. The hard carbon coating layer in the coated abrasive article can be provided as a top coat or, alternatively, as located between the abrasive coating and a covering layer based on an organic binder layer. The invention also pertains to a method of making such an abrasive article.

3. 发明授权

US5646300A (1H-indol-1-yl)-2-(amino)acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use 失效
标题翻译：（1H-吲哚-1-基）-2-（氨基）乙酰胺和相关的（1H-吲哚-1-基） - （氨基烷基）酰胺，药物组合物和用途
公开(公告)号：US5646300A
公开(公告)日：1997-07-08
申请号：US457649
申请日：1995-06-01
申请人： Raymond W. Kosley, Jr. , Denise M. Flanagan , Lawrence L. Martin , Peter A. Nemoto
发明人： Raymond W. Kosley, Jr. , Denise M. Flanagan , Lawrence L. Martin , Peter A. Nemoto
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61P25/00 , C07D209/08 , C07D209/12 , C07D209/30 , C07D209/10 , C07D493/04
CPC分类号： C07D209/08 , A61K31/40 , C07D209/12 , C07D209/30
摘要： There are disclosed neuroprotective compounds having the formula ##STR1## wherein the moieties are defined in the specification, and processes for making them.
摘要翻译：公开了具有式“IMAGE”的神经保护性化合物，其中部分在说明书中定义，以及制备它们的方法。

4. 发明授权

US5424322A A personality disorder treatment method and composition 失效
标题翻译：人格障碍治疗方法及组成
公开(公告)号：US5424322A
公开(公告)日：1995-06-13
申请号：US38427
申请日：1993-03-25
申请人： Richard C. Effland , Joseph T. Klein , Lawrence L. Martin
发明人： Richard C. Effland , Joseph T. Klein , Lawrence L. Martin
IPC分类号： C07D401/12 , C07D409/12 , C07D417/12 , A61K31/44
CPC分类号： C07D401/12 , C07D409/12 , C07D417/12
摘要： This invention relates to compositions of substituted pyridinylamino-1H-indoles of the formula ##STR1## wherein Q is N or NR.sub.2 ;Y is CHR.sub.1 is hydrogen, loweralkyl, loweralkynyl, loweralkenyl, arylloweralkyl, loweralkoxycarbonylaminoloweralkylcarbonyl, arylloweralkoxycarbonylaminoloweralkylcarbonyl, aminoloweralkylcarbonyl, loweralkoxycarbonyl or acyl;R.sub.2 is hydrogen or loweralkyl;R.sub.3 is hydrogen or loweralkyl;X is hydrogen, loweralkyl, halogen; andn is 0 or 1 with utility in the treatment of personality disorders as obsessive compulsive disorders.
摘要翻译：本发明涉及式（I）的取代吡啶基氨基-1H-吲哚的组合物，其中Q是N或NR2; Y是CHR 1是氢，低级烷基，低级炔基，低级烯基，芳基低级烷基，低级烷氧基羰基氨基低级烷基羰基，芳基低级烷基羰基，低级烷氧基羰基或酰基。 R2是氢或低级烷基; R3是氢或低级烷基; X是氢，低级烷基，卤素; n为0或1，可用于治疗人格障碍作为强迫症。

5. 发明授权

US5350762A Tetrahydrocyclopent[B]indole methanamines and related compounds 失效
标题翻译：四氢环戊二烯[B]吲哚甲胺及相关化合物
公开(公告)号：US5350762A
公开(公告)日：1994-09-27
申请号：US28110
申请日：1993-03-08
申请人： Lawrence L. Martin , Larry Davis
发明人： Lawrence L. Martin , Larry Davis
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4427 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61P25/24 , A61P25/26 , A61P25/28 , C07D209/64 , C07D209/86 , C07D401/06 , C07D209/80 , C07D413/02
CPC分类号： C07D209/64
摘要： There are disclosed various compounds of the formula below, ##STR1## where the various parameters R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, m and n are as defined in the specification, which show activities as a monoamine oxidase inhibitor demonstrating a utility for the treatment of depression, and activities as a cholinesterase inhibitor demonstrating a utility for the treatment of various memory dysfunctions such as Alzheimer's disease.
摘要翻译：公开了下列公式的各种化合物，其中各种参数R1，R2，R3，R4，X，m和n如本说明书中所定义，其显示作为单胺氧化酶抑制剂的活性，其表现出用于抑郁症的治疗，以及作为胆碱酯酶抑制剂的活性，其表现出用于治疗各种记忆障碍如阿尔茨海默病的效用。

6. 发明授权

US5008285A (6,11-dihydro-11-oxodibenz[b,e]oxepin-yl)pentanoic acids and derivatives thereof 失效
标题翻译：（6,11-二氢-11-氧代二苯并[b，e]氧杂环庚烯基）戊酸及其衍生物
公开(公告)号：US5008285A
公开(公告)日：1991-04-16
申请号：US430045
申请日：1989-11-01
申请人： Lawrence L. Martin , Linda L. Setescak
发明人： Lawrence L. Martin , Linda L. Setescak
IPC分类号： C07C65/24 , C07D313/12
CPC分类号： C07D313/12 , C07C65/24
摘要： Novel (6,11-dihydro-11-oxodibenz[b,e]oxepinyl)pentanoic acids and derivatives thereof, intermediates and processes for the preparation thereof, and methods for suppressing arthritis-like inflammation utilizing compounds or compositions thereof are disclosed.
摘要翻译：公开了新型（6,11-二氢-11-氧代二苯并[b，e]氧自由基）戊酸及其衍生物，其中间体及其制备方法，以及利用化合物或其组合物抑制关节炎样炎症的方法。

7. 发明授权

US4908360A 1-aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetr ahydro-2H-1,3-benzodiazepine-2-ones 失效
标题翻译： 1-氨基烷基-3-氧代取代-4-芳基-1,3,4,5-四氢-2H-1,3-苯并二氮杂-
公开(公告)号：US4908360A
公开(公告)日：1990-03-13
申请号：US270335
申请日：1988-11-14
申请人： Lawrence L. Martin , Joseph F. Payack
发明人： Lawrence L. Martin , Joseph F. Payack
IPC分类号： A61K31/55 , A61P3/00 , A61P3/14 , A61P9/12 , A61P25/04 , C07D243/04
CPC分类号： C07D243/04
摘要： This invention relates to 1-aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetrahydro-2H-1,3-benzodiazepine-2-ones having the formula ##STR1## where R.sub.1 and R.sub.2 are each independently hydrogen, loweralkyl, aryl, arylloweralkyl, and acyl; R.sub.3 is hydrogen, loweralkyl, arylloweralkyl aryl and acyl; X is hydrogen, halogen, hydroxy loweralkyl, loweralkoxy, NO.sub.2, NH.sub.2 and CF.sub.3 ; m is an integer of 1 to 3, n is an integer of 1 to 3; the pharmaceutically acceptable acid addition salts thereof and where appropriate the geometric and optical isomers thereof. The compounds of this invention display utility as analgesics, calcium ion antagonists and antihypertensives.

8. 发明授权

US4751238A Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins 失效
标题翻译： 6,11-二氢-11-氧代二苯并[b，e]氧杂七环素的取代烷基胺衍生物
公开(公告)号：US4751238A
公开(公告)日：1988-06-14
申请号：US875844
申请日：1986-06-18
申请人： Lawrence L. Martin , Linda L. Setescak
发明人： Lawrence L. Martin , Linda L. Setescak
IPC分类号： C07C65/24 , C07D313/12 , C07D405/06 , C07D405/14 , C07D471/10 , A61K31/335
CPC分类号： C07D405/06 , C07C65/24 , C07D313/12 , C07D405/14 , C07D471/10
摘要： This invention relates to substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins of the formula: ##STR1## where X is hydrogen, halogen, lower alkoxy, lower alkyl, nitro, hydroxyl and CF.sub.3 ; R is H, and lower alkyl, R.sub.1 is CH.sub.3 SO.sub.3 and ##STR2## where R.sub.2 and R.sub.3 are the same of different and are hydrogen, lower alkyl, mesyl (CH.sub.3 SO.sub.2 --), and cycloalkyl loweralkyl; ##STR3## and the pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明涉及下式的6,11-二氢-11-氧代二苯并[b，e]氧杂环丁烷的取代的烷基胺衍生物，其中X是氢，卤素，低级烷氧基，低级烷基，硝基，羟基和CF 3; R是H，低级烷基，R 1是CH 3 SO 3和其中R 2和R 3是不同的并且是氢，低级烷基，甲磺酰基（CH 3 SO 2 - ）和环烷基低级烷基; + TR 及其药学上可接受的酸加成盐。

9. 发明授权

US4742061A Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents 失效
标题翻译： Benzoc [c] -1,5-萘啶和相关化合物作为记忆增强剂
公开(公告)号：US4742061A
公开(公告)日：1988-05-03
申请号：US870585
申请日：1986-06-04
申请人： Lawrence L. Martin , Linda L. Setescak , Susan J. Scott
发明人： Lawrence L. Martin , Linda L. Setescak , Susan J. Scott
IPC分类号： C07D207/28 , C07D471/04 , A61K31/495 , A61K31/435 , C07D401/14 , C07D487/04
CPC分类号： C07D471/04 , C07D207/28
摘要： There are disclosed novel compounds of the formula ##STR1## where m is 1 or 2; each X is independently H, halogen, loweralkyl, loweralkoxy, --CF.sub.3, or --OH; R is H, loweralkyl, chloroloweralkyl, bromoloweralkyl, iodoloweralkyl, aminoloweralkyl, loweralkylaminoloweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, thienylloweralkyl, furylloweralkyl, loweralkanoyl, chloroloweralkanoyl, bromoloweralkanoyl, iodoloweralkanoyl, aminoloweralkanoyl, loweralkylaminoloweralkanoyl, diloweralkylaminoloweralkanoyl, aroyl, arylloweralkanoyl or diarylloweralkanoyl, thienylloweralkanoyl, furylloweralkanoyl; and R.sub.1 is .dbd.O, ##STR2## or --NR.sub.2 R.sub.3, R.sub.2 and R.sub.3 being independently H or loweralkyl, or taken together with the nitrogen atom to which they are attached constituting ##STR3## R.sub.4 in turn being H, loweralkyl, hydroxyloweralkyl, aryl, arylloweralkyl or diarylloweralkyl, with the proviso that when R.sub.1 is --NR.sub.2 R.sub.3, R is nonexistent, that when R.sub.1 is .dbd.O, R is not an acyl group and that when R.sub.1 is ##STR4## R is not chloroloweralkyl, bromoloweralkyl or iodoloweralkyl; or pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.
摘要翻译：公开了新颖的式（Ⅰ）化合物，其中m为1或2; 每个X独立地为H，卤素，低级烷基，低级烷氧基，-CF 3或-OH; R为H，低级烷基，chloroloweralkyl，bromoloweralkyl，iodoloweralkyl，aminoloweralkyl，loweralkylaminoloweralkyl，diloweralkylaminoloweralkyl，芳基低级烷基，diarylloweralkyl，thienylloweralkyl，furylloweralkyl，loweralkanoyl，chloroloweralkanoyl，bromoloweralkanoyl，iodoloweralkanoyl，aminoloweralkanoyl，loweralkylaminoloweralkanoyl，diloweralkylaminoloweralkanoyl，芳酰基，arylloweralkanoyl或diarylloweralkanoyl，thienylloweralkanoyl，furylloweralkanoyl; R 1和R 2独立地是H或低级烷基，或者与它们所连接的氮原子一起构成R 4，其又是H，低级烷基，羟基低级烷基，芳基，芳基低级烷基或二芳基低级烷基，条件是当R 1是-NR 2 R 3时，R不存在，当R 1是= O时，R不是酰基，而当R 1是R 1时，R不是氯代低级烷基，溴代低级烷基或碘代低级烷基; 或其药学上可接受的酸加成盐，其可用于增强记忆。

10. 发明授权

US4560701A Oxothienobenzoxepins, medicinal use, and process for the preparation thereof 失效
标题翻译：噻吩并苯并氧辛昔松，药用及其制备方法
公开(公告)号：US4560701A
公开(公告)日：1985-12-24
申请号：US503456
申请日：1983-06-13
申请人： Lawrence L. Martin , Linda L. Setescak
发明人： Lawrence L. Martin , Linda L. Setescak
IPC分类号： C07D333/38 , C07D495/04 , A61K31/38 , C07D327/04 , C07D495/02
CPC分类号： C07D495/04 , C07D333/38
摘要： The invention relates to oxothienobenzoxepin compounds of the formula ##STR1## where X together with the carbon atoms to which it is attached is a thiophene ring;R.sub.1 is hydrogen, a straight or branched chain alkyl group having 1 to 5 carbon atoms or a halogen atom;R.sub.2 is hydrogen or a straight chain alkyl group having 1 to 5 carbon atoms; andR.sub.3 is hydroxyl or ##STR2## where R.sub.4 is a straight chain or branched chain alkyl group having 1 to 10 carbon atoms, a phenyl group or a trifluoromethyl group. Methods for preparing the compounds and their use as antiinflammatory and analgesic agents are provided.
摘要翻译：本发明涉及式（I）的噻吩并苯并氧杂环己酮化合物，其中X与连接的碳原子一起为噻吩环; R1是氢，具有1至5个碳原子的直链或支链烷基或卤素原子; R2是氢或碳原子数为1〜5的直链烷基; 并且R 3是羟基或者其中R 4是具有1-10个碳原子的直链或支链烷基，苯基或三氟甲基。提供了制备化合物的方法及其作为抗炎和止痛剂的用途。

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