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1. 发明申请

US20220056530A1 METHOD TO PREDICT THE PATTERN OF LOCOMOTION IN HORSES 有权
公开(公告)号：US20220056530A1
公开(公告)日：2022-02-24
申请号：US17523482
申请日：2021-11-10
申请人： Lisa S. Andersson , Leif Andersson , Gabriella Lindgren
发明人： Lisa S. Andersson , Leif Andersson , Gabriella Lindgren
IPC分类号： C12Q1/6883 , C12Q1/6876 , G01N33/68 , A01K29/00 , C12Q1/6881
摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.

2. 发明申请

US20130004520A1 METHODS AND MATERIALS RELATED TO HAIR PIGMENTATION AND CANCER 有权
标题翻译：与染发剂和癌症相关的方法和材料
公开(公告)号：US20130004520A1
公开(公告)日：2013-01-03
申请号：US13603109
申请日：2012-09-04
申请人： Leif Andersson , Gerli Rosengren Pielberg , Anna Olegovna Golovko , Kjell Robert Johan Lennartsson , Carl-Henrik Heldin
发明人： Leif Andersson , Gerli Rosengren Pielberg , Anna Olegovna Golovko , Kjell Robert Johan Lennartsson , Carl-Henrik Heldin
IPC分类号： A61K39/395 , A61P35/00 , A61K31/7088
CPC分类号： C12Q1/6881 , C12Q1/6886 , C12Q2600/124 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： This document relates to methods and materials for determining whether or not a horse contains a Grey allele. For example, diagnostic methods such as nucleic acid-based detection methods and materials such as nucleic acid probes and primer pairs that can be used to determine whether or not a horse contains a duplication in intron 6 of STX17 nucleic acid are provided. This document also relates to methods and materials for treating a mammal having or being likely to develop cancer (e.g., benign, malignant, or metastatic cancer). For example, methods and materials for treating cancer in a mammal by administering an agent having the ability to reduce expression of an STX17 polypeptide and/or an NR4A polypeptide (e.g., an NR4A1, NR4A2, or NR4A3 polypeptide) in the mammal are provided.
摘要翻译：本文件涉及用于确定马是否包含Gray等位基因的方法和材料。例如，提供诊断方法，例如基于核酸的检测方法和诸如核酸探针和引物对的材料，其可用于确定马是否含有STX17核酸的内含子6中的重复。本文件还涉及用于治疗具有或可能发展为癌症（例如良性，恶性或转移性癌症）的哺乳动物的方法和材料。例如，提供了通过在哺乳动物中施用具有降低STX17多肽和/或NR4A多肽（例如NR4A1，NR4A2或NR4A3多肽）的表达能力的药剂来治疗哺乳动物癌症的方法和材料。

3. 发明申请

US20100281547A1 Selecting animals for desired genotypic or potential phenotypic properties 审中-公开
标题翻译：选择动物以获得所需的基因型或潜在的表型性质
公开(公告)号：US20100281547A1
公开(公告)日：2010-11-04
申请号：US12658672
申请日：2010-02-12
申请人： Leif Andersson , Goran Andersson , Michel Georges , Nadine Buys
发明人： Leif Andersson , Goran Andersson , Michel Georges , Nadine Buys
IPC分类号： A61K49/00 , C12Q1/68 , C12N5/07 , C07H21/00 , A61K31/7052 , A61P3/04 , A61P21/00
CPC分类号： C12Q1/6876 , C12Q2600/124 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Described are methods to select animals, such as mammals, particularly domestic animals, breeding animals or animals destined for slaughter, for having desired genotypic or potential phenotypic properties, in particular, related to muscle mass and/or fat deposition lean meat, lean back fat, sow prolificacy and/or sow longevity. Provided is a method for selecting an animal having desired genotypic or potential phenotypic properties comprising testing the animal, a parent of the animal or its progeny for the presence of a nucleic acid modification affecting the activity of an evolutionary conserved CpG island, located in intron 3 of an IGF2 gene and/or for the presence of a nucleic acid modification affecting binding of a nuclear factor to an IGF2 gene.
摘要翻译：描述了选择动物的方法，例如哺乳动物，特别是家畜，用于屠宰的育种动物或动物，具有期望的基因型或潜在表型性质，特别是涉及肌肉质量和/或脂肪沉积瘦肉，瘦背脂肪，播种繁殖和/或播种长寿。提供了一种用于选择具有所需基因型或潜在表型性质的动物的方法，包括测试动物，动物的亲本或其后代，存在影响位于内含子3中的进化性保守CpG岛的活性的核酸修饰的IGF2基因和/或影响核因子与IGF2基因结合的核酸修饰的存在。

4. 发明申请

US20100275279A1 Selecting animals for parentally imprinted traits 审中-公开
标题翻译：选择动物的父母印记的性状
公开(公告)号：US20100275279A1
公开(公告)日：2010-10-28
申请号：US12658677
申请日：2010-02-12
申请人： Leif Andersson , Michel Georges , Geert Spincemaille , Carine D. A. Nezer
发明人： Leif Andersson , Michel Georges , Geert Spincemaille , Carine D. A. Nezer
IPC分类号： A01K67/027 , A61D19/04 , A61D19/02 , C12Q1/68 , C12N5/076 , C07H21/04 , C12N5/073
CPC分类号： C12Q1/6876 , A01K2227/108 , A01K2267/02 , C12Q2600/124 , C12Q2600/156 , C12Q2600/172
摘要： Described are methods for selecting a domestic animal having desired genotypic properties, the methods comprising testing the animal for the presence of a parentally imprinted quantitative trait locus (QTL). The invention further relates to the use of an isolated and/or recombinant nucleic acid comprising a QTL or functional fragment derived therefrom to select a breeding animal or animal destined for slaughter having desired genotypic or potential phenotypic properties. In particular, the properties are related to muscle mass, fat deposition, sow prolificacy, and/or sow longevity.
摘要翻译：描述了用于选择具有所需基因型性质的家畜的方法，所述方法包括测试动物以存在亲本印记的数量性状基因座（QTL）。本发明还涉及包含QTL或其衍生的功能片段的分离和/或重组核酸在选择具有所需基因型或潜在表型性质的注射屠宰的育种动物或动物中的用途。特别地，这些性质与肌肉质量，脂肪沉积，母猪繁殖和/或母猪寿命有关。

5. 发明申请

US20090197252A1 Detection of Mutations 审中-公开
标题翻译：检测突变
公开(公告)号：US20090197252A1
公开(公告)日：2009-08-06
申请号：US11852967
申请日：2007-09-10
申请人： Anne Lunden , Leif Andersson , Stefan Marklund
发明人： Anne Lunden , Leif Andersson , Stefan Marklund
IPC分类号： C12Q1/68
CPC分类号： C12N9/0073
摘要： The present invention relates to a polypeptide which is flavin-containing monooxygenase 3 (FMO3), wherein said FMO3 is a polypeptide comprising at least a sequence having at least 85% identity with the polypeptide sequence SEQ ID NO: 15, in particular to a polypeptide which is a functionally altered mutant of flavin-containing mono oxygenase 3 (FMO3) leading to a buildup of trimethylamine in an animal. Further, the invention relates to nucleic acid sequences encoding said polypeptide, and to the complements of such nucleic acid sequences. Such nucleic acid sequences and fragments thereof may be useful e.g. as primers. The invention further relates to various methods for determining the presence in e.g. a nucleic acid sample of a nucleic acid sequence encoding a mutated FMO3 polypeptide.
摘要翻译：本发明涉及含有黄素的单加氧酶3（FMO3）的多肽，其中所述FMO3是至少包含与多肽序列SEQ ID NO：15具有至少85％同一性的序列的多肽，特别是多肽其是功能性改变的含黄素的单加氧酶3的突变体（FMO3），导致动物中三甲胺的积聚。此外，本发明涉及编码所述多肽的核酸序列以及这些核酸序列的互补序列。这样的核酸序列及其片段可以是有用的。作为引物。本发明进一步涉及用于确定例如存在的各种方法。编码突变FMO3多肽的核酸序列的核酸样品。

6. 发明申请

US20060142134A1 Device and rotor means therefor 失效
标题翻译：装置和转子是指这样的装置
公开(公告)号：US20060142134A1
公开(公告)日：2006-06-29
申请号：US10535137
申请日：2003-11-18
申请人： Leif Andersson , Mats Malmqvist
发明人： Leif Andersson , Mats Malmqvist
IPC分类号： B04B5/02 , B04B15/02
CPC分类号： B01L7/54 , B01L2300/0829 , B01L2300/1844 , B01L2400/0409 , B04B5/0407 , B04B15/02 , G01N2035/00495 , G01N2035/00524
摘要： The invention relates to rotor means (5) for centrifuging reaction vessels containing reaction mixtures in a device for asymmetric heating and cooling of reaction mixtures during centrifugation. The rotor means (5) comprise/-s at least one fan blade (18), which force ambient gas to pass the reaction mixtures. The invention also relates to a device for asymmetric heating and cooling of reaction mixtures during centrifugation comprising said rotor means (5).
摘要翻译：本发明涉及用于离心含有反应混合物的反应容器的转子装置（5），用于在离心过程中不对称加热和冷却反应混合物的装置。转子装置（5）包括至少一个风扇叶片（18），其迫使环境气体通过反应混合物。本发明还涉及用于在包括所述转子装置（5）的离心期间对反应混合物进行不对称加热和冷却的装置。

7. 发明申请

US20050232307A1 Synchronous data transfer system for time-sensitive data in packet-switched networks 有权
标题翻译：用于分组交换网络中时间敏感数据的同步数据传输系统
公开(公告)号：US20050232307A1
公开(公告)日：2005-10-20
申请号：US10519596
申请日：2002-07-10
申请人： Leif Andersson , John Fullemann
发明人： Leif Andersson , John Fullemann
IPC分类号： H04J3/06 , H04L12/413 , H04L12/44 , H04L12/64
CPC分类号： H04L12/44 , H04J3/0658 , H04J3/0682
摘要： A transmission arrangement and method permits time-sensitive data to be transmitted through a packet-switched network and arrive synchronously at separate end points without synchronising all payload carrying nodes in the network. This is achieved by propagating a timing reference through the network from the sending node to the end nodes, each end node adjusting that phase of its local frequency generator to this timing reference. The sending node then sends data structure information to the end nodes, enabling the end nodes to regenerate the timing and structure of the synchronous data stream. Finally delay information is sent to each end node that allows the end nodes to adjust the start of synchronous data transmission by an amount such that all will commence transmission substantially simultaneously. With this information the end nodes independently recreate a signal in synchronisation. This solution has the advantage that the network infrastructure can remain substantially unchanged, although the timing sensitive application can treat the network as if it were a synchronised network.
摘要翻译：传输布置和方法允许通过分组交换网络传送时间敏感数据，并在不同的端点同步到达，而不使网络中的所有有效载荷承载节点同步。这是通过从发送节点向终端节点传播通过网络的定时参考来实现的，每个端节点将其本地频率发生器的相位调整到该定时参考。然后，发送节点向终端节点发送数据结构信息，使终端节点重新生成同步数据流的时序和结构。最后延迟信息被发送到每个终端节点，允许终端节点调整同步数据传输的开始量，使得所有的节点将基本上同时开始传输。使用该信息，终端节点独立地重新创建信号同步。该解决方案的优点在于，网络基础设施可以保持基本不变，尽管时序敏感的应用程序可以将网络视为同步网络。

8. 发明授权

US06545749B1 Electronic distance measuring device 有权
标题翻译：电子测距仪
公开(公告)号：US06545749B1
公开(公告)日：2003-04-08
申请号：US09787167
申请日：2001-03-14
申请人： Leif Andersson
发明人： Leif Andersson
IPC分类号： G01C308
CPC分类号： G01S7/497 , G01C3/08 , G01S7/4812 , G01S7/4818 , G01S17/10 , G01S17/105
摘要： The invention relates to an electronic distance measuring device which measures the propagation time to and from a target of a shor pulse of a trasmitted electromagnetic beam from a radiation source comprising a microchip laser, and comprising objective optical system (6; 16; 21); for the reflected beam from the target and a detecting unit (9; 13; 20) to which the received beam is transmitted. Means (4, 5; 15) is provided for making the transmitted and the receiving electromagnetic beam coaxial. Means (6, 10, 12; 14, 16; 21, 22) are also provided for focusing the received beam onto the detecting unit (9; 13; 20). A means (3) makes the transmitted electromagnetic beam simultaneously as narrow and as collimated as possible in order to get a well-defined radiation measuring spot on the target.
摘要翻译：电子距离测量装置本发明涉及一种电子距离测量装置，其测量来自包括微芯片激光器的辐射源的传输电磁波束的目标的传播时间，并包括物镜光学系统（6; 16; 21）; 对于来自目标的反射光束以及传输接收光束的检测单元（9; 13; 20）。提供装置（4,5; 15），用于使发射和接收电磁波束同轴。还提供了用于将接收的光束聚焦到检测单元（9; 13; 20）上的装置（6,10,12; 14,16,21,22）。一种装置（3）使得发射的电磁波束尽可能地同时窄并准直，以便在目标上获得明确的辐射测量点。

9. 发明授权

US06257552B1 Arrangement for handling a load 有权
标题翻译：处理负荷的安排
公开(公告)号：US06257552B1
公开(公告)日：2001-07-10
申请号：US09395582
申请日：1999-09-14
申请人： Perry A. Crow , Gregory C. Brucker , Leif Andersson
发明人： Perry A. Crow , Gregory C. Brucker , Leif Andersson
IPC分类号： B66F300
CPC分类号： B66F3/36 , B66F3/24 , B66F3/38 , B66F5/04 , B66F7/00
摘要： An arrangement for handling a load, such as an automotive component or the like, includes a jack assembly 12, a stand 16, and a platform assembly 14 that can be secured to the load and transferred between the jack assembly and stand. The jack assembly 12 includes a wheeled base supporting a piston-and-cylinder assembly. The stand 16 includes a beam 114 supported on a column 116 for relative height adjustment, and a docking tube 110 or the like supported at a free end of the beam. The platform assembly 14 presents a receiver block 48 sized for receipt on a receiver pin 46 of the jack assembly, and a docking pin 108 or the like sized for receipt in the docking tube 110 of the stand. As such, the load can be secured to the platform assembly and transferred between the jack assembly and the stand so that the load can be serviced and replaced.
摘要翻译：用于处理诸如汽车部件等的负载的装置包括千斤顶组件12，支架16和平台组件14，其可以固定到负载并在千斤顶组件和支架之间传送。千斤顶组件12包括支撑活塞和气缸组件的轮式底座。支架16包括支撑在用于相对高度调节的柱116上的梁114和支撑在梁的自由端处的对接管110等。平台组件14具有尺寸适于接收在插座组件的接收器针46上的接收器块48和尺寸适于接收在支架的对接管110中的对接销108或类似物。因此，负载可以被固定到平台组件并且在千斤顶组件和支架之间传送，使得可以维修和更换负载。

10. 发明申请

US20170356047A1 METHOD TO PREDICT THE PATTERN OF LOCOMOTION IN HORSES 审中-公开
公开(公告)号：US20170356047A1
公开(公告)日：2017-12-14
申请号：US15682124
申请日：2017-08-21
申请人： Lisa S. Andersson , Leif Andersson , Gabriella Lindgren
发明人： Lisa S. Andersson , Leif Andersson , Gabriella Lindgren
IPC分类号： C12Q1/68 , A01K29/00 , G01N33/68
CPC分类号： C12Q1/6883 , A01K29/00 , C12Q1/6876 , C12Q2600/124 , C12Q2600/156 , G01N33/6872 , G01N33/6875 , G01N2333/4703
摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.

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