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1. 发明申请

US20110212457A1 Methods and compositions for determining the pathogenic status of infectious agents 有权
标题翻译：用于确定感染因子的致病状态的方法和组合物
公开(公告)号：US20110212457A1
公开(公告)日：2011-09-01
申请号：US13011754
申请日：2011-01-21
申请人： Matthew C. Mulvey , Leo Einck , Katherine Sacksteder
发明人： Matthew C. Mulvey , Leo Einck , Katherine Sacksteder
IPC分类号： C12Q1/68 , C12N15/63
CPC分类号： C12Q1/689 , C12Q1/06 , C12Q1/18
摘要： The present invention relates to methods and compositions for improved detection of infectious agents and microbes. In particular, the present invention provides novel methods for detecting infectious agents, providing information about the viability status of such infectious agents and for determining drug susceptibility. In certain embodiments, the present invention employs techniques involving nucleic acid amplification-based microbial identification together with phage-based biological detection of drug resistance. The methods of the invention are suitable for all microbes and infectious agents, including bacterial agents such as Mycobacteria.
摘要翻译：本发明涉及用于改善感染因子和微生物检测的方法和组合物。特别地，本发明提供了用于检测感染因子的新方法，提供关于这种感染剂的生存状态的信息和用于确定药物敏感性。在某些实施方案中，本发明使用涉及基于核酸扩增的微生物鉴定以及基于噬菌体的药物抗性生物检测的技术。本发明的方法适用于所有微生物和感染因子，包括细菌剂如分枝杆菌。

2. 发明申请

US20100106665A1 INFECTIOUS DISEASE HEALTHCARE DELIVERY SYSTEMS AND METHODS 审中-公开
标题翻译：感染性疾病传播系统和方法
公开(公告)号：US20100106665A1
公开(公告)日：2010-04-29
申请号：US11991684
申请日：2006-09-08
申请人： Leo Einck
发明人： Leo Einck
IPC分类号： G06Q90/00
CPC分类号： G06Q99/00 , G16H40/20 , Y02A90/22
摘要： The invention relates to infectious disease healthcare systems and methods. One embodiment of systems and processes according to various embodiments of the invention focuses on a method for providing a healthcare delivery franchise system. The method includes creating a not-for-profit franchisor entity. In addition, the method includes assessing a plurality of locations for a corresponding plurality of healthcare delivery clinics, wherein the demand for healthcare services from each healthcare delivery clinic and the revenue from each healthcare delivery clinic are estimated. Furthermore, the method includes based at least in part on the demand and revenue estimates, constructing at least a portion of the plurality of healthcare delivery clinics in corresponding locations, wherein the portion of the plurality of healthcare delivery clinics is associated with the not-for-profit franchisor entity.
摘要翻译：本发明涉及传染病保健系统和方法。根据本发明的各种实施例的系统和过程的一个实施例着重于提供医疗保健递送专营系统的方法。该方法包括创建非营利特许经营实体。此外，该方法包括评估相应的多个医疗保健递送诊所的多个位置，其中估计来自每个医疗保健递送诊所的医疗保健服务的需求以及来自每个保健递送诊所的收入。此外，该方法至少部分地基于需求和收入估计，在相应的位置构建多个医疗保健递送诊所的至少一部分，其中多个医疗保健递送诊所的部分与不适用于 - 特许经营实体。

3. 发明申请

US20090192173A1 ANTI-TUBERCULAR DRUGS: COMPOSITIONS AND METHODS 有权
标题翻译：抗结核药物：组合物和方法
公开(公告)号：US20090192173A1
公开(公告)日：2009-07-30
申请号：US12255976
申请日：2008-10-22
申请人： Marina Nikolaevna PROTOPOPOVA , Leo Einck , Boris Nikonenko , Ping Chen
发明人： Marina Nikolaevna PROTOPOPOVA , Leo Einck , Boris Nikonenko , Ping Chen
IPC分类号： A61K31/4965 , A61K31/437 , A61K31/4409 , A61K31/137 , A61K31/132 , A61K31/403 , A61K31/496 , A61P31/00
CPC分类号： A61K31/132 , A61K31/13 , A61K31/137 , C07C211/01 , C07C215/06 , Y02A50/401 , Y02A50/402
摘要： Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis. In certain embodiments, the present invention comprises compositions comprising novel substituted ethylene diamine compounds further comprising antitubercular agents such as rifampicin, isoniazid, pyrazinamide and ethambutol.
摘要翻译：用于治疗由感染因子，特别是结核病引起的疾病的方法和组合物。特别地，提供了包含用于治疗感染性疾病的取代的乙二胺的方法和组合物。在一个实施方案中，这些方法和组合物用于治疗分枝杆菌感染，包括但不限于结核病。在某些实施方案中，本发明包含还包含抗结核剂如利福平，异烟肼，吡嗪酰胺和乙胺丁醇的新型取代的乙二胺化合物的组合物。

4. 发明申请

US20090047658A1 Methods and compositions for determining the pathogenic status of infectious agents 有权
标题翻译：用于确定感染性病原体状态的方法和组合物
公开(公告)号：US20090047658A1
公开(公告)日：2009-02-19
申请号：US12080929
申请日：2008-04-07
申请人： Matthew C. Mulvey , Leo Einck , Katherine Sacksteder
发明人： Matthew C. Mulvey , Leo Einck , Katherine Sacksteder
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/689
摘要： Methods and compositions for the detection of disease caused by infectious agents and microbes are provided. In particular, methods and compositions comprising novel combinations of nucleic acid amplification and drug susceptibility technologies are provided. In certain embodiments, the present invention enables the detection of infectious agents and microbes as well as providing information concerning the viability status of the agent or microbe. In one embodiment, the present invention is used for the detection of mycobacterial infections, including, but not limited to, tuberculosis.
摘要翻译：提供了用于检测感染性和微生物引起的疾病的方法和组合物。特别地，提供了包含核酸扩增和药物敏感性技术的新组合的方法和组合物。在某些实施方案中，本发明能够检测感染因子和微生物以及提供关于试剂或微生物的活力状态的信息。在一个实施方案中，本发明用于检测分枝杆菌感染，包括但不限于结核病。

5. 发明授权

US07842729B2 Anti tubercular drug: compositions and methods 有权
标题翻译：抗结核药物：组合物和方法
公开(公告)号：US07842729B2
公开(公告)日：2010-11-30
申请号：US11145499
申请日：2005-06-03
申请人： Marina Nikolaevna Protopopova , Richard Edward Lee , Richard Allan Slayden , Clifton E. Barry, III , Elena Bogatcheva , Leo Einck
发明人： Marina Nikolaevna Protopopova , Richard Edward Lee , Richard Allan Slayden , Clifton E. Barry, III , Elena Bogatcheva , Leo Einck
IPC分类号： A61K31/132 , A61K31/135 , A61K31/44 , A61K31/445
CPC分类号： C07C323/25 , A61K31/132 , A61K31/133 , A61K31/137 , A61K31/40 , A61K31/445 , C07C211/27 , C07C211/29 , C07C211/34 , C07C211/35 , C07C211/42 , C07C215/14 , C07C215/30 , C07C215/60 , C07C217/08 , C07C217/10 , C07C217/58 , C07C217/60 , C07C217/62 , C07C323/47 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D211/46 , Y02A50/401 , Y02A50/402 , Y02A50/478 , Y02A50/479
摘要： Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
摘要翻译：用于治疗由感染因子，特别是结核病引起的疾病的方法和组合物。特别地，提供了包含用于治疗感染性疾病的取代的乙二胺的方法和组合物。在一个实施方案中，这些方法和组合物用于治疗分枝杆菌感染，包括但不限于结核病。

6. 发明申请

US20060020041A1 Anti tubercular drug: compositions and methods 有权
公开(公告)号：US20060020041A1
公开(公告)日：2006-01-26
申请号：US11145499
申请日：2005-06-03
申请人： Marina Protopopova , Richard Lee , Richard Slayden , Clifton Barry , Elena Bogatcheva , Leo Einck
发明人： Marina Protopopova , Richard Lee , Richard Slayden , Clifton Barry , Elena Bogatcheva , Leo Einck
IPC分类号： A61K31/137
CPC分类号： C07C323/25 , A61K31/132 , A61K31/133 , A61K31/137 , A61K31/40 , A61K31/445 , C07C211/27 , C07C211/29 , C07C211/34 , C07C211/35 , C07C211/42 , C07C215/14 , C07C215/30 , C07C215/60 , C07C217/08 , C07C217/10 , C07C217/58 , C07C217/60 , C07C217/62 , C07C323/47 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D211/46 , Y02A50/401 , Y02A50/402 , Y02A50/478 , Y02A50/479
摘要： Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.

7. 发明授权

US08268894B2 Compositions and methods for the treatment of infectious diseases 有权
标题翻译：用于治疗感染性疾病的组合物和方法
公开(公告)号：US08268894B2
公开(公告)日：2012-09-18
申请号：US12944231
申请日：2010-11-11
申请人： Marina Nikolaevna Protopopova , Elena Bogatcheva , Leo Einck , Richard Edward Lee , Richard Allan Slayden , Clifton E. Barry, III
发明人： Marina Nikolaevna Protopopova , Elena Bogatcheva , Leo Einck , Richard Edward Lee , Richard Allan Slayden , Clifton E. Barry, III
IPC分类号： A61K31/132 , A61K31/135 , A61K31/44 , A61K31/445
CPC分类号： C07C323/25 , A61K31/132 , A61K31/133 , A61K31/137 , A61K31/40 , A61K31/445 , C07C211/27 , C07C211/29 , C07C211/34 , C07C211/35 , C07C211/42 , C07C215/14 , C07C215/30 , C07C215/60 , C07C217/08 , C07C217/10 , C07C217/58 , C07C217/60 , C07C217/62 , C07C323/47 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D211/46 , Y02A50/401 , Y02A50/402 , Y02A50/478 , Y02A50/479
摘要： Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
摘要翻译：用于治疗由感染因子，特别是结核病引起的疾病的方法和组合物。特别地，提供了包含用于治疗感染性疾病的取代的乙二胺的方法和组合物。在一个实施方案中，这些方法和组合物用于治疗分枝杆菌感染，包括但不限于结核病。

8. 发明授权

US07919234B2 Methods and compositions for determining the pathogenic status of infectious agents 有权
标题翻译：用于确定感染因子的致病状态的方法和组合物
公开(公告)号：US07919234B2
公开(公告)日：2011-04-05
申请号：US12080929
申请日：2008-04-07
申请人： Matthew C. Mulvey , Leo Einck , Katherine Sacksteder
发明人： Matthew C. Mulvey , Leo Einck , Katherine Sacksteder
IPC分类号： C12Q1/02 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/689
摘要： Methods and compositions for the detection of disease caused by infectious agents and microbes are provided. In particular, methods and compositions comprising novel combinations of nucleic acid amplification and drug susceptibility technologies are provided. In certain embodiments, the present invention enables the detection of infectious agents and microbes as well as providing information concerning the viability status of the agent or microbe. In one embodiment, the present invention is used for the detection of mycobacterial infections, including, but not limited to, tuberculosis.
摘要翻译：提供了用于检测感染性和微生物引起的疾病的方法和组合物。特别地，提供了包含核酸扩增和药物敏感性技术的新组合的方法和组合物。在某些实施方案中，本发明能够检测感染因子和微生物以及提供关于试剂或微生物的活力状态的信息。在一个实施方案中，本发明用于检测分枝杆菌感染，包括但不限于结核病。

9. 发明授权

US07456222B2 Anti tubercular drug: compositions and methods 有权
标题翻译：抗结核药物：组合物和方法
公开(公告)号：US07456222B2
公开(公告)日：2008-11-25
申请号：US11173192
申请日：2005-07-01
申请人： Marina Nikolaevna Protopopova , Richard Edward Lee , Richard Allan Slayden , Clifton E. Barry, III , Elena Bogatcheva , Leo Einck
发明人： Marina Nikolaevna Protopopova , Richard Edward Lee , Richard Allan Slayden , Clifton E. Barry, III , Elena Bogatcheva , Leo Einck
IPC分类号： A61K31/132 , A61K31/135 , A61K31/44 , A61K31/445
CPC分类号： A61K31/132 , A61K31/13 , A61K31/137 , C07C211/01 , C07C215/06 , Y02A50/401 , Y02A50/402
摘要： Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
摘要翻译：用于治疗由感染因子，特别是结核病引起的疾病的方法和组合物。特别地，提供了包含用于治疗感染性疾病的取代的乙二胺的方法和组合物。在一个实施方案中，这些方法和组合物用于治疗分枝杆菌感染，包括但不限于结核病。

10. 发明授权

US08501400B2 Methods and compositions for determining the pathogenic status of infectious agents 有权
标题翻译：用于确定感染因子的致病状态的方法和组合物
公开(公告)号：US08501400B2
公开(公告)日：2013-08-06
申请号：US13011754
申请日：2011-01-21
申请人： Matthew C. Mulvey , Leo Einck , Katherine Sacksteder
发明人： Matthew C. Mulvey , Leo Einck , Katherine Sacksteder
IPC分类号： C12Q1/02 , C12Q1/68 , C12Q1/70 , C07H21/02 , C12N15/00
CPC分类号： C12Q1/689 , C12Q1/06 , C12Q1/18
摘要： The present invention relates to methods and compositions for improved detection of infectious agents and microbes. In particular, the present invention provides novel methods for detecting infectious agents, providing information about the viability status of such infectious agents and for determining drug susceptibility. In certain embodiments, the present invention employs techniques involving nucleic acid amplification-based microbial identification together with phage-based biological detection of drug resistance. The methods of the invention are suitable for all microbes and infectious agents, including bacterial agents such as Mycobacteria.
摘要翻译：本发明涉及用于改善感染因子和微生物检测的方法和组合物。特别地，本发明提供了用于检测感染因子的新方法，提供关于这种感染剂的生存状态的信息和用于确定药物敏感性。在某些实施方案中，本发明使用涉及基于核酸扩增的微生物鉴定以及基于噬菌体的药物抗性生物检测的技术。本发明的方法适用于所有微生物和感染因子，包括细菌剂如分枝杆菌。

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