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1. 发明申请

US20170342117A1 GHRELIN SPLICE VARIANT FOR TREATING NEURONAL DAMAGE,NEURODEGENERATIVE DISEASE, PARKINSONS DISEASE, ALZHEIMERS DISEASE, AND/OR DEPRESSION 审中-公开
公开(公告)号：US20170342117A1
公开(公告)日：2017-11-30
申请号：US15663039
申请日：2017-07-28
申请人： Liat Mintz
发明人： Liat Mintz
IPC分类号： C07K14/47 , A61K38/25
CPC分类号： C07K14/47 , A61K38/25
摘要： The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereat: or a ghrelin splice variant-like compound for the preparation of a medicament for one or more of: treatment and/or prevention of neuronal damage and/or neurodegeneration and, prophylaxis or treatment of neuronal damage and/or neurodegenerative disease, Parkinson's disease, Alzheimer's disease, depression stimulation of neuronal activity. A further aspect relates to a number of new ghrelin splice variant like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin splice variant-like compounds.

2. 发明授权

US08653022B2 Use of ghrelin splice variant for treating hypercholesterolemia and/or high cholesterol and/or high cholesterol complication and/or lipemia and/or lipemia complication and/or coronary heart disease and/or weight management and/or diabetes and/or hyperglycemia 有权
标题翻译：使用生长素释放肽剪接变体用于治疗高胆固醇血症和/或高胆固醇和/或高胆固醇并发症和/或脂血症和/或血脂并发症和/或冠心病和/或体重管理和/或糖尿病和/或高血糖
公开(公告)号：US08653022B2
公开(公告)日：2014-02-18
申请号：US12294823
申请日：2007-03-27
申请人： Liat Mintz
发明人： Liat Mintz
IPC分类号： A61K38/00 , A61P3/06
CPC分类号： C07K14/575 , A61K38/00
摘要： The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof for the preparation of a medicament for one or more of: treatment and/or prevention of hypercholesterolemia and/or high cholesterol and/or high cholesterol complication and/or lipemia and/or lipemia complication and/or CHD and/or weight management and/or diabetes and/or hyperglycemia.
摘要翻译：本公开一方面涉及使用生长素释放肽剪接变体或其类似物来制备用于以下一种或多种的药物：治疗和/或预防高胆固醇血症和/或高胆固醇和/或高胆固醇并发症，和 /或脂血症和/或血脂并发症和/或CHD和/或体重管理和/或糖尿病和/或高血糖症。

3. 发明申请

US20120035240A1 CONSERVED HBV AND HCV SEQUENCES USEFUL FOR GENE SILENCING 有权
标题翻译：保留用于基因沉默的HBV和HCV序列
公开(公告)号：US20120035240A1
公开(公告)日：2012-02-09
申请号：US13065601
申请日：2005-12-12
申请人： CATHERINE J. PACHUK , CHANDRASEKHAR SATISHCHANDRAN , VINCENT R. ZURAWSKI, JR. , LIAT MINTZ
发明人： CATHERINE J. PACHUK , CHANDRASEKHAR SATISHCHANDRAN , VINCENT R. ZURAWSKI, JR. , LIAT MINTZ
IPC分类号： A61K31/713 , C12N15/85 , C07H21/02 , C07H21/04 , C12N15/63 , C12N5/10 , A61P31/14 , A61P31/20 , C12N5/071 , C12N15/113
CPC分类号： C12N15/1131 , A61K31/713 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12N2730/10122 , C12N2770/24222
摘要： Conserved consensus sequences from known hepatitis B virus strains and known hepatitis C virus strains, which are useful in inhibiting the expression of the viruses in mammalian cells, are provided. These sequences are useful to silence the genes of HBV and HCV, thereby providing therapeutic utility against HBV and HCV viral infection in humans.
摘要翻译：提供了可用于抑制哺乳动物细胞中病毒表达的已知乙型肝炎病毒株和已知丙型肝炎病毒株的保守共有序列。这些序列对于使HBV和HCV的基因沉默是有用的，从而提供对人类HBV和HCV病毒感染的治疗效用。

4. 发明授权

US07981860B2 Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation 有权
标题翻译：使用生长素释放肽剪接变体治疗恶病质和/或厌食症和/或厌食 - 恶病质和/或营养不良和/或脂肪营养不良和/或肌肉消瘦和/或食欲刺激
公开(公告)号：US07981860B2
公开(公告)日：2011-07-19
申请号：US11716137
申请日：2007-03-09
申请人： Liat Mintz
发明人： Liat Mintz
IPC分类号： A61K38/22 , A61K38/25 , A61K38/10
CPC分类号： C07K14/60 , A61K38/00 , A61K38/1754 , A61K38/27 , A61K38/30 , A61K38/465 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof for the preparation of a medicament for one or more of: treatment and/or prevention of loss of body weight and body fat, prophylaxis or treatment of cachexia, stimulation of appetite, stimulation of food intake, stimulation of weight gain, or increasing body fat mass, or increasing body lean mass. Another aspect relates to the use of a ghrelin splice variant-like compound for the preparation of a medicament for the prophylaxis or treatment of cancer cachexia in an individual in need of such treatment. Another aspect relates to the use of a ghrelin splice variant-like compound for the preparation of a medicament for prophylaxis or treatment of cachexia in an individual by administering a subcutaneous dosage of said medicament to the individual. A further aspect relates to the use of a ghrelin splice variant-like compound or a pharmaceutically acceptable salt thereof for the preparation of a medicament for stimulation of appetite in an individual by administering a subcutaneous dosage of said medicament to the individual. A further aspect relates to a number of new ghrelin splice variant-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin splice variant-like compounds.
摘要翻译：本公开一方面涉及使用生长素释放肽剪接变体或其类似物来制备用于以下一种或多种的药物：治疗和/或预防体重和体脂肪的丧失，预防或治疗恶病质刺激食欲，刺激食物摄入量，刺激体重增加，或增加身体脂肪量，或增加瘦体重。另一方面涉及使用生长素释放肽剪接变体样化合物来制备用于在需要这种治疗的个体中预防或治疗癌症恶病质的药物。另一方面涉及通过向个体施用皮下剂量的所述药物来制备用于预防或治疗个体恶病质的药物的生长素释放肽剪接变体样化合物的用途。另一方面涉及生长素释放肽剪接变体样化合物或其药学上可接受的盐在制备通过向个体施用皮下剂量的所述药物的个体中刺激个体食欲的药物中的用途。另一方面涉及许多新的生长素释放肽剪接变体样化合物及其用途，以及包含新的生长素释放肽剪接变体样化合物的药物组合物和医药包装。

5. 发明申请

US20070099275A1 Compositions, reagents and kits for and methods of diagnosing, monitoring and treating hormonal imbalance 有权
标题翻译：组合物，试剂和试剂盒以及诊断，监测和治疗荷尔蒙失衡的方法
公开(公告)号：US20070099275A1
公开(公告)日：2007-05-03
申请号：US11591649
申请日：2006-11-01
申请人： Liat Mintz
发明人： Liat Mintz
IPC分类号： A61K38/22 , A61K48/00 , C07H21/04 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/566 , G01N33/68 , G01N33/6845 , G01N2333/575
摘要： The present invention concerns ten novel variants of alternative splicing of the hormonal imbalance related genes.
摘要翻译：本发明涉及激素失调相关基因的选择性剪接的十个新变体。

6. 发明申请

US20160122403A1 GHRELIN SPLICE VARIANT FOR TREATING NEURONAL DAMAGE,NEURODEGENERATIVE DISEASE, PARKINSONS DISEASE, ALZHEIMERS DISEASE, AND/OR DEPRESSION 审中-公开
标题翻译： GHRELIN SPLICE变体治疗神经损伤，神经病变疾病，帕金森病，阿尔茨海默病和/或恶化
公开(公告)号：US20160122403A1
公开(公告)日：2016-05-05
申请号：US14896449
申请日：2014-07-15
申请人： Liat MINTZ
发明人： Liat Mintz
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/25
摘要： The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof, or a ghrelin splice variant-like compound for the preparation of a medicament for one or more of: treatment and/or prevention of neuronal damage and/or neurodegeneration and, prophylaxis or treatment of neuronal damage and/or neurodegenerative disease, Parkinson's disease, Alzheimer's disease, depression stimulation of neuronal activity. A further aspect relates to a number of new ghrelin splice variant-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin splice variant-like compounds.
摘要翻译：本公开一方面涉及使用生长素释放肽剪接变体或其类似物或生长素释放肽剪接变体样化合物来制备用于以下一种或多种的药物：治疗和/或预防神经元损伤和/ 或神经变性，以及预防或治疗神经元损伤和/或神经退行性疾病，帕金森病，阿尔茨海默病，抑制神经元活性刺激。另一方面涉及许多新的生长素释放肽剪接变体样化合物及其用途，以及包含新的生长素释放肽剪接变体样化合物的药物组合物和医药包装。

7. 发明授权

US07858744B2 Compositions, reagents and kits for and methods of diagnosing, monitoring and treating hormonal imbalance 有权
标题翻译：组合物，试剂和试剂盒以及诊断，监测和治疗荷尔蒙失衡的方法
公开(公告)号：US07858744B2
公开(公告)日：2010-12-28
申请号：US11591649
申请日：2006-11-01
申请人： Liat Mintz
发明人： Liat Mintz
IPC分类号： C07K14/435 , C07K14/605
CPC分类号： C07K14/575 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/566 , G01N33/68 , G01N33/6845 , G01N2333/575
摘要： The present invention concerns ten novel variants of alternative splicing of the hormonal imbalance related genes.
摘要翻译：本发明涉及激素失调相关基因的选择性剪接的十个新变体。

8. 发明申请

US20090043074A1 Use of Ghrelin Splice Variant for Treating Cachexia and/or Anorexia and/or Anorexia-Cachexia and/or Malnutrition and/or Lipodystrophy and/or Muscle Wasting and/or Appetite-Stimulation 有权
标题翻译：使用生长激素释放肽剪接变体来治疗恶病质和/或厌食症和/或厌食症 - 恶病质和/或营养不良和/或脂肪营养不良和/或肌肉挥发和/或食欲刺激
公开(公告)号：US20090043074A1
公开(公告)日：2009-02-12
申请号：US12239229
申请日：2008-09-26
申请人： Liat Mintz
发明人： Liat Mintz
IPC分类号： C07K14/575 , C07K7/08
CPC分类号： A61K38/25
摘要： The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof for the preparation of a medicament for one or more of: treatment and/or prevention of loss of body weight and body fat, prophylaxis or treatment of cachexia, stimulation of appetite, stimulation of food intake, stimulation of weight gain, or increasing body fat mass, or increasing body lean mass. Another aspect relates to the use of a ghrelin splice variant-like compound for the preparation of a medicament for the prophylaxis or treatment of cancer cachexia in an individual in need of such treatment. Another aspect relates to the use of a ghrelin splice variant-like compound for the preparation of a medicament for prophylaxis or treatment of cachexia in an individual by administering a subcutaneous dosage of said medicament to the individual. A further aspect relates to the use of a ghrelin splice variant-like compound or a pharmaceutically acceptable salt thereof for the preparation of a medicament for stimulation of appetite in an individual by administering a subcutaneous dosage of said medicament to the individual. A further aspect relates to a number of new ghrelin splice variant-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin splice variant-like compounds.
摘要翻译：本公开一方面涉及使用生长素释放肽剪接变体或其类似物来制备用于以下一种或多种的药物：治疗和/或预防体重和体脂肪的丧失，预防或治疗恶病质刺激食欲，刺激食物摄入量，刺激体重增加，或增加身体脂肪量，或增加瘦体重。另一方面涉及使用生长素释放肽剪接变体样化合物来制备用于在需要这种治疗的个体中预防或治疗癌症恶病质的药物。另一方面涉及通过向个体施用皮下剂量的所述药物来制备用于预防或治疗个体恶病质的药物的生长素释放肽剪接变体样化合物的用途。另一方面涉及生长素释放肽剪接变体样化合物或其药学上可接受的盐在制备通过向个体施用皮下剂量的所述药物的个体中刺激个体食欲的药物中的用途。另一方面涉及许多新的生长素释放肽剪接变体样化合物及其用途，以及包含新的生长素释放肽剪接变体样化合物的药物组合物和医药包装。

9. 发明授权

US07176292B2 Ghrelin variant protein 有权
标题翻译：生长素释放肽变异蛋白
公开(公告)号：US07176292B2
公开(公告)日：2007-02-13
申请号：US10659782
申请日：2003-09-11
申请人： Liat Mintz
发明人： Liat Mintz
IPC分类号： A61K38/22 , C07K14/00 , C07H21/04
CPC分类号： C12Q1/6883 , C07K14/47 , C12N9/0006 , C12Y101/01146 , Y10S930/12
摘要： The present invention concerns a protein produced from an alternative splice form of the human Ghrelin gene, an obesity and/or diabetes related gene.
摘要翻译：本发明涉及由人类Ghrelin基因的替代剪接形式产生的蛋白质，肥胖症和/或糖尿病相关基因。

10. 发明申请

US20060068405A1 Methods and systems for annotating biomolecular sequences 审中-公开
标题翻译：注释生物分子序列的方法和系统
公开(公告)号：US20060068405A1
公开(公告)日：2006-03-30
申请号：US11043860
申请日：2005-01-27
申请人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
摘要翻译：提供多肽序列和多核苷酸序列。还提供了关于这些序列的这些序列和用途的注释信息。

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