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1. 发明申请

US20140356299A1 ORAL CARE COMPOSITIONS 有权
标题翻译：口腔护理组合物
公开(公告)号：US20140356299A1
公开(公告)日：2014-12-04
申请号：US14362228
申请日：2011-12-02
申请人： Lin Fei , Stanislav Jaracz , Ying Yang , Guofeng Xu
发明人： Lin Fei , Stanislav Jaracz , Ying Yang , Guofeng Xu
IPC分类号： A61K8/34 , A61K8/81 , A61K8/25 , A61K8/21 , A61K8/46 , A61Q11/00 , A61K8/49
CPC分类号： A61K8/345 , A61K8/21 , A61K8/25 , A61K8/347 , A61K8/37 , A61K8/463 , A61K8/49 , A61K8/8111 , A61K2800/49 , A61Q11/00 , A61Q17/005
摘要： The invention provides oral care compositions comprising isobutyl magnolol and propylene glycol monolaurate, together with methods of making and using the same. Also described is a method of enhancing the solubility of isobutyl magnolol in an oral care composition comprising effective amount of propylene glycol monolaurate. The composition is for use in the treatment of caries, gingivitis, periodontitis, tooth yellowing and halitosis.
摘要翻译：本发明提供了包含异丁基木洛酚和丙二醇单月桂酸酯的口腔护理组合物及其制备和使用方法。还描述了提高异丁基硼酸在含有效量的丙二醇单月桂酸酯的口腔护理组合物中的溶解度的方法。该组合物用于治疗龋齿，牙龈炎，牙周炎，牙齿变黄和口臭。

2. 发明申请

US20130224271A1 Oral Compositions Containing Microaggregates 有权
标题翻译：含有微团的口服组合物
公开(公告)号：US20130224271A1
公开(公告)日：2013-08-29
申请号：US13884030
申请日：2010-11-08
申请人： Steven Miller , Guofeng Xu , Lin Fei , Ying Yang
发明人： Steven Miller , Guofeng Xu , Lin Fei , Ying Yang
IPC分类号： A61K8/11
CPC分类号： A61K8/11 , A61K8/0275 , A61K8/27 , A61K8/4993 , A61K8/731 , A61K8/86 , A61K2800/412 , A61Q11/00
摘要： The invention relates to a composite and oral care compositions for use in the mouth to retard the accumulation of dental plaque and/or calculus. The composite is a microaggregate comprising polymer coated, surfactant stabilized particles of a substantially insoluble metal, metal salt or metal oxide, for example zinc oxide. Also methods for retarding the accumulation of dental plaque and/or calculus are provided.
摘要翻译：本发明涉及一种用于口腔的复合和口腔护理组合物，以阻止牙菌斑和/或结石的积聚。该复合物是包含聚合物涂覆的表面活性剂稳定的基本上不溶的金属，金属盐或金属氧化物的颗粒，例如氧化锌的微团聚物。还提供了用于延缓牙斑和/或结石积聚的方法。

3. 发明授权

US10406082B2 Oral care compositions 有权
公开(公告)号：US10406082B2
公开(公告)日：2019-09-10
申请号：US14366975
申请日：2011-12-21
申请人： Suman Chopra , Lin Fei , Rahul Patel
发明人： Suman Chopra , Lin Fei , Rahul Patel
IPC分类号： A61Q11/00 , A61K8/21 , A61K8/25 , A61K8/81
摘要： Described herein are oral care compositions comprising (i) a magnesium alkali metal silicate complex clay, and (ii) an orally acceptable anionic polymer, in a dentifrice base, which compositions are useful for alleviating dental sensitivity. Also provided for, are methods of making and using the compositions described herein.

4. 发明授权

US09801940B2 Oral care compositions 有权
公开(公告)号：US09801940B2
公开(公告)日：2017-10-31
申请号：US13575671
申请日：2011-02-24
申请人： Lin Fei , Ravi Subramanyam , Guofeng Xu
发明人： Lin Fei , Ravi Subramanyam , Guofeng Xu
IPC分类号： A61K36/575 , A61G11/00 , A61K47/10 , A61K8/34 , A61K8/97 , A61K9/00 , A61Q11/00
CPC分类号： A61K47/10 , A61K8/347 , A61K8/97 , A61K9/006 , A61K36/575 , A61K2300/00 , A61Q11/00
摘要： Disclosed herein are methods of enhancing the solubility and delivery of one or more active ingredients found in magnolia extract, or a synthetic analog thereof, in an oral composition.

5. 发明授权

US09271906B2 Oral compositions containing microaggregates 有权
标题翻译：含有微团聚物的口服组合物
公开(公告)号：US09271906B2
公开(公告)日：2016-03-01
申请号：US13884030
申请日：2010-11-08
申请人： Steven Miller , Guofeng Xu , Lin Fei , Ying Yang
发明人： Steven Miller , Guofeng Xu , Lin Fei , Ying Yang
IPC分类号： A61K8/11 , A61K8/27 , A61K8/49 , A61K8/73 , A61K8/86 , A61Q11/00 , A61K8/02
CPC分类号： A61K8/11 , A61K8/0275 , A61K8/27 , A61K8/4993 , A61K8/731 , A61K8/86 , A61K2800/412 , A61Q11/00
摘要： The invention relates to a composite and oral care compositions for use in the mouth to retard the accumulation of dental plaque and/or calculus. The composite is a microaggregate comprising polymer coated, surfactant stabilized particles of a substantially insoluble metal, metal salt or metal oxide, for example zinc oxide. Also methods for retarding the accumulation of dental plaque and/or calculus are provided.
摘要翻译：本发明涉及一种用于口腔的复合和口腔护理组合物，以阻止牙菌斑和/或结石的积聚。该复合物是包含聚合物涂覆的表面活性剂稳定的基本上不溶的金属，金属盐或金属氧化物的颗粒，例如氧化锌的微团聚物。还提供了用于延缓牙斑和/或结石积聚的方法。

6. 发明申请

US20150004104A1 ORAL CARE COMPOSITIONS 有权
标题翻译：口腔护理组合物
公开(公告)号：US20150004104A1
公开(公告)日：2015-01-01
申请号：US14381024
申请日：2012-03-02
申请人： Lin Fei , Stanislav Jaracz , Ying Yang , Geofeng Xu
发明人： Lin Fei , Stanislav Jaracz , Ying Yang , Geofeng Xu
IPC分类号： A61K8/34 , A61Q11/00
CPC分类号： A61K8/345 , A01N31/08 , A61K8/347 , A61K8/375 , A61K36/575 , A61K2800/49 , A61Q11/00
摘要： Described herein are compositions comprising isopropyl magnolol; a surfactant system; and an orally acceptable carrier, together with methods of making and using the same.
摘要翻译：本文描述的是包含异丙基厚朴酚的组合物; 表面活性剂体系; 和口头可接受的载体，以及制备和使用它们的方法。

7. 发明申请

US20140234232A1 Oral and Skin Care Compositions Based on a 3,3-Dialkyl-1,1-Biphenyl-2,2-Diol or a 3,3-Dialkenyl-1,1-Biphenyl-2,2-Diol 有权
标题翻译：基于3,3-二烷基-1,1-联苯-2,2-二醇或3,3-二烯基-1,1-联苯-2,2-二醇的口服和护肤组合物
公开(公告)号：US20140234232A1
公开(公告)日：2014-08-21
申请号：US14343940
申请日：2011-09-08
申请人： Ravi Subramanyam , Neelima Utgikar , Guofeng Xu , Ying Yang , Lin Fei
发明人： Ravi Subramanyam , Neelima Utgikar , Guofeng Xu , Ying Yang , Lin Fei
IPC分类号： A61K31/05
CPC分类号： A61K31/05 , A61K8/347 , A61K2800/5922 , A61Q11/00 , A61Q15/00 , A61Q17/005 , A61Q19/10
摘要： Described herein are compositions comprising antibacterially effective amounts of a compound of Formula (I): or a salt thereof in which R1 and R2 are each independently (C1-C6) alkyl or (C2 C6) alkenyl, and a carrier. Suitable carriers include orally acceptable carriers and dermatologically acceptable carriers. The disclosed compositions include oral care and personal care compositions useful for treating or preventing oral and skin conditions, respectively.
摘要翻译：本文描述的是包含抗菌有效量的式（I）化合物或其盐，其中R 1和R 2各自独立地为（C 1 -C 6）烷基或（C 2 -C 6）烯基和载体的组合物。合适的载体包括口服可接受的载体和皮肤病学可接受的载体。所公开的组合物包括分别用于治疗或预防口腔和皮肤病症的口腔护理和个人护理组合物。

8. 发明申请

US20130315844A1 Oral Care Compositions 审中-公开
标题翻译：口腔护理组合
公开(公告)号：US20130315844A1
公开(公告)日：2013-11-28
申请号：US13982846
申请日：2011-01-31
申请人： Shyamala Pillai , Lin Fei , Guofeng Xu
发明人： Shyamala Pillai , Lin Fei , Guofeng Xu
IPC分类号： A61K47/02 , A61K31/05
CPC分类号： A61K47/02 , A61K8/19 , A61K8/347 , A61K8/35 , A61K8/99 , A61K31/05 , A61Q11/00 , A61Q19/08
摘要： Described herein are compositions comprising an active compound from an extract of magnolia, or a derivative thereof; and a non-surfactant electrolyte in an amount effective to stabilize the composition, and methods of making and using the same.
摘要翻译：本文描述的是包含来自木兰提取物的活性化合物或其衍生物的组合物; 和有效稳定组合物的量的非表面活性剂电解质及其制备和使用方法。

9. 发明授权

US06485716B1 High efficacy liquid gel product 失效
标题翻译：高效液体凝胶产品
公开(公告)号：US06485716B1
公开(公告)日：2002-11-26
申请号：US09971876
申请日：2001-10-05
申请人： Lin Fei , Suman Chopra , Eric Guenin , Peter Hilliard, Jr. , Jairajh Mattai , Neeta Patel
发明人： Lin Fei , Suman Chopra , Eric Guenin , Peter Hilliard, Jr. , Jairajh Mattai , Neeta Patel
IPC分类号： A61K732
CPC分类号： A61K8/894 , A61K8/042 , A61K8/046 , A61K8/26 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/375 , A61K8/891 , A61K2800/262 , A61Q15/00
摘要： The invention is a clear, elastomer-free, gel composition comprising: (a) 0.1-25 weight % of an antiperspirant active having a low metal to chloride ratio in the range of 0.9-1.3: 1; (b) 9-23.95 weight % of one or more volatile silicones having a flash point of 100 degrees C or less; (c) 0.05-0.5 weight % of a silicone surfactant having an HLB value≦8; (d) 30-70 weight % water; (e) 0-50 weight % selected water soluble organic solvents; and (f) 0-10 weight % of an emollient; wherein the composition is a liquid gel having a viscosity in the range of 5-50,000 centipoise and a ratio of oil phase to water phase in the range of 10:90 to 24:76.
摘要翻译：本发明是一种透明的，无弹性体的凝胶组合物，其包含：（a）0.1至25重量％的低金属与氯化物之比在0.9-1.3:1范围内的止汗活性剂; （b）9-23.95重量％的闪点为100℃以下的一种或多种挥发性有机硅; （c）0.05-0.5重量％的具有HLB值<= 8的硅氧烷表面活性剂; （d）30-70重量％的水; （e）0-50重量％选择的水溶性有机溶剂; 和（f）0-10重量％的润肤剂; 其中所述组合物是粘度在5-50,000厘泊范围内的液体凝胶，油相与水相的比例在10:90至24:76的范围内。

10. 发明授权

US06403069B1 High oil clear emulsion with elastomer 失效
标题翻译：高透明乳液与弹性体
公开(公告)号：US06403069B1
公开(公告)日：2002-06-11
申请号：US09693248
申请日：2000-10-20
申请人： Suman Chopra , Jairajh Mattai , Lin Fei , Eric Guenin , Xiaozhong Tang
发明人： Suman Chopra , Jairajh Mattai , Lin Fei , Eric Guenin , Xiaozhong Tang
IPC分类号： A61K732
CPC分类号： A61K8/895 , A61K8/064 , A61K8/585 , A61K8/894 , A61K2800/262 , A61Q15/00
摘要： A clear antiperspirant and/or deodorant composition is disclosed in the form of an emulsion having a refractive index less than 1.42 and comprising: (a) 25-70% of an external phase comprising: (i) 0.1-10%, on an actives basis, of at least one elastomer which is a dimethicone/vinyldimethicone crosspolymer composition made by reacting a polymethylhydrogensiloxane with an alpha, omega-divinylpolydimethyl siloxane for which the dimethicone/vinyl-dimethicone crosspolymer composition is used at a concentration of 4-10% in cyclomethicone, has a refractive index in the range of 1.392-1.402 at 25 degrees C and a viscosity in the range of 0.013-1×104 Pascal seconds; (ii) 0.1-5% of a silicone copolyol having an HLB value ≦8; (iii) 0.1-68% of a volatile silicone selected in an amount to complete the external phase; (iv) 0-10% of a cosurfactant or emulsifier having an HLB value in the range of 1-15; (v) 0-5% of a non-volatile silicone; and (b) 30-75% of an internal phase which is made with: (i) 7-25% (on an anhydrous actives basis (excluding the waters of hydration) of an antiperspirant active; (ii) 0-10% ethanol; (iii) additional water as required to adjust the refractive index; (iv) 0-5% of an antimicrobial agent; and (v) 0-5% of an ionizable salt; wherein the conductance of a water droplet applied to the surface of a thin film of the antiperspirant and/or deodorant composition is at least 250 micro Siemens/cm/ml as measured by a fixed geometry test at a loading of at least 7% by weight level of antiperspirant active.
摘要翻译：透明止汗剂和/或除臭剂组合物以折射率小于1.42的乳液的形式公开，并包含：（a）25-70％的外相，其包含：（i）0.1-10％的活性物质基于至少一种弹性体，其是通过使聚甲基氢硅氧烷与α，ω-二乙烯基聚二甲基硅氧烷反应制备的聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物组合物，其中在聚甲基硅氧烷中以4-10％的浓度使用聚二甲基硅氧烷/乙烯基聚二甲基硅氧烷交联聚合物组合物在25℃下的折射率在1.392-1.402的范围内，粘度在0.013-1×104帕斯卡秒的范围内; （ii）具有HLB值<= 8的0.1-5％的硅氧烷共聚多元醇; （iii）以完成外相的量选择0.1-68％的挥发性硅氧烷; （iv）0-10％HLB值在1-15范围内的辅助表面活性剂或乳化剂; （v）0-5％的非挥发性硅酮; 和（b）30-75％的内相，其由以下制备：（i）7-25％（基于无水活性物质（不包括水合水合））止汗活性物质;（ii）0-10％乙醇 ;（iii）调整折射率所需的额外的水;（iv）0-5％的抗微生物剂;和（v）0-5％的可电离盐;其中施加到表面的水滴的电导率的止汗剂和/或除臭剂组合物的薄膜是至少250微西门子/厘米/毫升，通过固定几何测试在至少7重量％的止汗活性剂的负载下测量。

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