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1. 发明申请

US20130165419A1 COMBINATION ANTI-INFLAMMATORY OPHTHALMIC COMPOSITIONS 审中-公开
公开(公告)号：US20130165419A1
公开(公告)日：2013-06-27
申请号：US13333534
申请日：2011-12-21
申请人： Richard L. Lindstrom , Kamran Hosseini , Lyle M. Bowman
发明人： Richard L. Lindstrom , Kamran Hosseini , Lyle M. Bowman
IPC分类号： A61K31/573 , A61P27/02 , A61P31/12 , A61P31/04 , A61P27/12 , A61P27/06 , A61P35/00 , A61P33/02 , A61P31/10 , A61P29/00 , A61P27/14
CPC分类号： A61K31/573 , A61K9/0048 , A61K9/08 , A61K31/196 , A61K31/57 , A61K45/06 , A61K2300/00
摘要： Compositions and systems for topical ophthalmic application, which include an aqueous mixture of steroidal and non-steroidal anti-inflammatory agents in a flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.

2. 发明授权

US07732415B2 Topical treatment or prevention of ocular infections 有权
标题翻译：局部治疗或预防眼部感染
公开(公告)号：US07732415B2
公开(公告)日：2010-06-08
申请号：US10898170
申请日：2004-07-26
申请人： Chandler R. Dawson , Lyle M. Bowman
发明人： Chandler R. Dawson , Lyle M. Bowman
IPC分类号： A61K31/70
CPC分类号： A61K45/06 , A61K9/0048 , A61K31/02 , A61K31/573 , A61K31/7048 , A61K31/7052 , A61K47/26 , A61K47/38 , Y02A50/411 , A61K2300/00
摘要： The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regimen can also be provided by the use of an appropriate depot. Furthermore, a composition containing a combination of medicaments is also provided.
摘要翻译：将azalide抗生素如阿奇霉素局部应用于眼睛可用于治疗或预防眼部感染。在一个实施方案中，将阿扎利德抗生素供应给贮存库中的眼睛用于持续释放。还可以通过使用适当的贮库来提供更方便的给药方案。此外，还提供了含有药物组合的组合物。

3. 发明授权

US5332582A Stabilization of aminosteroids for topical ophthalmic and other applications 失效
标题翻译：用于局部眼科和其他应用的氨基甾体的稳定化
公开(公告)号：US5332582A
公开(公告)日：1994-07-26
申请号：US984445
申请日：1992-12-02
申请人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekaran
发明人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekaran
IPC分类号： A61K9/107 , A61K9/00 , A61K9/127 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48 , A61P27/02 , C07J41/00 , A61K47/28 , A61K31/59 , A61K37/22 , A61K37/52
CPC分类号： B82Y5/00 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48969 , A61K9/0048 , Y10S514/801 , Y10S514/887 , Y10S514/912 , Y10S514/913 , Y10S514/944
摘要： The invention provides methods for stabilizing amino-substituted steroid therapeutic agents in topical ophthalmic and other pharmaceutical formulations using effective stabilizing amounts of lightly cross-linked carboxy-containing polymers; Stabilized and stabilized/solubilized pharmaceutical compositions adapted for various routes of administration are also described.
摘要翻译：本发明提供了使用有效稳定量的轻度交联的含羧基聚合物在局部眼用和其它药物制剂中稳定氨基取代的类固醇治疗剂的方法; 还描述了适用于各种给药途径的稳定和稳定/溶解的药物组合物。

4. 发明授权

US5124154A Aminosteroids for ophthalmic use 失效
标题翻译：用于眼科用途的氨基磷酸酯
公开(公告)号：US5124154A
公开(公告)日：1992-06-23
申请号：US537062
申请日：1990-06-12
申请人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekran
发明人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekran
IPC分类号： A61K9/107 , A61K9/00 , A61K9/127 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48 , A61P27/02 , C07J41/00
CPC分类号： B82Y5/00 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48969 , A61K9/0048 , Y10S514/801 , Y10S514/887 , Y10S514/912 , Y10S514/913 , Y10S514/944
摘要： Methods and compositions for preventing or treating ophthalmic diseases or disorders wherein an ophthalmically effective amount of the C.sub.20 through C.sub.26 aminosteroids of formula XI and their pharmaceutical, acceptable salts, hydrates or solvates is administered in an inert vehicle to arrest oxidation processes damaging to the eye.
摘要翻译：用于预防或治疗眼科疾病或病症的方法和组合物，其中将眼科有效量的式XI的C20至C26氨基甾体及其药物，可接受的盐，水合物或溶剂合物施用于惰性载体中以阻止对眼睛造成损害的氧化过程。

5. 发明授权

US07758553B2 Drop dispenser for the delivery of uniform droplets of viscous liquids 有权
标题翻译：用于输送粘性液体的均匀液滴的分液器
公开(公告)号：US07758553B2
公开(公告)日：2010-07-20
申请号：US11397047
申请日：2006-04-03
申请人： Patrick Poisson , Lyle M. Bowman
发明人： Patrick Poisson , Lyle M. Bowman
IPC分类号： A61M35/00 , B65D37/00
CPC分类号： A61M35/003 , A61F9/0008
摘要： A drop dispenser has a substantially conical sleeve member with a narrow upper end and a wide lower end. Centrally located at the apex of the upper end of the sleeve member is an aperture which has an inner diameter and is circumscribed by a raised ridge. The aperture and the ridge form a nozzle. The interior space of the substantially conical sleeve member forms a substantially conical chamber between the narrow upper end and wide lower end of the sleeve member. The nozzle is in liquid communication with the chamber through the aperture. The drop dispenser may have external threads at the lower end of the sleeve member for engaging a cap having a protuberance centrally located at its internal top end for hermetically engaging the aperture of the nozzle when the cap fully engages the sleeve member.
摘要翻译：液滴分配器具有基本上锥形的套筒构件，其具有窄的上端和宽的下端。位于套筒构件上端的顶点的中心位置是具有内径并由凸脊限定的孔。孔和脊形成喷嘴。基本上圆锥形的套筒构件的内部空间在套筒构件的窄的上端和宽的下端之间形成基本上圆锥形的室。喷嘴通过孔与腔室液体连通。液滴分配器可以在套筒构件的下端具有外螺纹，用于接合具有中心位于其内部顶端的突起的帽，用于当帽完全接合套筒构件时气密地接合喷嘴的孔。

6. 发明授权

US07749970B2 Topical treatment of prevention of ocular infections 有权
标题翻译：局部治疗预防眼部感染
公开(公告)号：US07749970B2
公开(公告)日：2010-07-06
申请号：US10407425
申请日：2003-04-07
申请人： Chandler R. Dawson , Lyle M. Bowman
发明人： Chandler R. Dawson , Lyle M. Bowman
IPC分类号： A61K31/70
CPC分类号： A61K45/06 , A61K9/0048 , A61K31/02 , A61K31/573 , A61K31/7048 , A61K31/7052 , A61K47/26 , A61K47/38 , Y02A50/411 , A61K2300/00
摘要： The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regimen can also be provided by the use of an appropriate depot. Furthermore, a composition containing a combination of medicaments is also provided.
摘要翻译：将azalide抗生素如阿奇霉素局部应用于眼睛可用于治疗或预防眼部感染。在一个实施方案中，将阿扎利德抗生素供应给贮存库中的眼睛用于持续释放。还可以通过使用适当的贮库来提供更方便的给药方案。此外，还提供了含有药物组合的组合物。

7. 发明授权

US07056893B2 Topical treatment for prevention of ocular infections 有权
标题翻译：用于预防眼部感染的局部治疗
公开(公告)号：US07056893B2
公开(公告)日：2006-06-06
申请号：US10160060
申请日：2002-06-04
申请人： Samir Roy , Lyle M. Bowman
发明人： Samir Roy , Lyle M. Bowman
IPC分类号： A61K31/70 , A61F2/00 , A61F13/00
CPC分类号： A61K31/02 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： Azalide antibiotics such as azithromycin are useful in the treatment and prevention of infections by bacteria and other parasites. Stabilized aqueous compositions containing azithromycin suitable for administration without reconstitution are provided for. Also provided for are aqueous formulations suitable for ocular administration in a employing a convenient dosing formulation suitable for administration in depot formats.
摘要翻译：阿胺类抗生素如阿奇霉素可用于治疗和预防细菌和其他寄生虫的感染。提供了含有阿奇霉素的稳定含水组合物，其适用于不重新配制。还提供了适用于眼部施用的水性制剂，其采用适于以贮库形式施用的方便的给药制剂。

8. 发明授权

US06699492B2 Quinolone carboxylic acid compositions and related methods of treatment 有权
公开(公告)号：US06699492B2
公开(公告)日：2004-03-02
申请号：US10126513
申请日：2002-04-22
申请人： Samir Roy , Santosh Kumar Chandrasekaran , Katsumi Imamori , Takemitsu Asaoka , Akihiro Shibata , Masami Takahashi , Lyle M. Bowman
发明人： Samir Roy , Santosh Kumar Chandrasekaran , Katsumi Imamori , Takemitsu Asaoka , Akihiro Shibata , Masami Takahashi , Lyle M. Bowman
IPC分类号： A61F1300
CPC分类号： A61K9/0048 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61K47/32 , A61K47/38 , A61K47/40 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/483 , Y10S514/912 , Y10S514/954 , Y10S514/964
摘要： The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release compositions comprising specific quinolone carboxylic acid compounds. The invention also relates to quinolone carboxylic acid compositions and methods of preparing the same.

9. 发明授权

US06397849B1 Methods of ophthalmic administration 有权
标题翻译：眼科给药方法
公开(公告)号：US06397849B1
公开(公告)日：2002-06-04
申请号：US09366072
申请日：1999-08-02
申请人： Lyle M. Bowman , James F. Pfeiffer , Leslie A. Clark , Karl I. Hecker
发明人： Lyle M. Bowman , James F. Pfeiffer , Leslie A. Clark , Karl I. Hecker
IPC分类号： A61B1900
CPC分类号： A61K31/00 , A61K9/0048 , A61K38/1866 , A61K48/00 , Y10S977/773 , Y10S977/904 , Y10S977/906 , Y10S977/908
摘要： Intrascleral injection of a therapeutic or diagnostic material at a location overlying the retina provides a minimally invasive technique for delivering the agent to the posterior segment of the eye. The procedure also allows for close proximity of the material to the targeted site and can be effectively used to treat conditions associated with the posterior segment of the eye, including macular degeneration, vein occlusion, and diabetic retinopathy. The sclera can be used to hold a depot of the material such as for sustained released or as a conduit for propelling material through whereby the material is delivered immediately to the underlying tissues but without physically penetrating the sclera with an instrument or otherwise unreasonably traumatizing the eye.
摘要翻译：在覆盖视网膜的位置进行治疗或诊断材料的静脉内注射提供了用于将药剂递送至眼后段的微创技术。该方法还允许材料与目标部位的紧密接近，并且可以有效地用于治疗与眼后段相关的病症，包括黄斑变性，静脉阻塞和糖尿病性视网膜病变。巩膜可以用于容纳材料的贮存库，例如用于持续释放的材料，或作为用于推进材料的导管，由此材料立即被递送到下面的组织，但是没有用仪器物理地穿透巩膜或以其他方式不合理地使眼睛创伤。

10. 发明授权

US06309374B1 Injection apparatus and method of using same 有权
公开(公告)号：US06309374B1
公开(公告)日：2001-10-30
申请号：US09127919
申请日：1998-08-03
申请人： Karl I. Hecker , Leslie A. Clark , James F. Pfeiffer , Lyle M. Bowman
发明人： Karl I. Hecker , Leslie A. Clark , James F. Pfeiffer , Lyle M. Bowman
IPC分类号： A61M500
CPC分类号： A61F9/007 , A61M5/32 , A61M5/46 , A61M25/04 , A61M2005/341
摘要： The present invention relates to an apparatus and method for using the apparatus for injecting an agent into a tissue, particularly into thin tissues such as the sclera of the eye. The invention provides an apparatus and method for effectively imbedding a needle into a tissue at a predetermined penetration approach angle and penetration distance thereby reducing the risk of penetrating the full thickness of the tissue. The invention includes a support element and a needle guide platform disposed on the support element with an external support surface and a channel extending therethrough and terminating in an aperture at the support surface. A needle disposed in the channel is axially movable along an axis of injection through the channel. The needle is movable from a first retracted position to an extended position corresponding to the penetration distance, along the axis of injection. The axis of injection forms a penetration approach angle of up to about 60° with a tangent of the support surface at a point of intersection of the axis of injection with the projection of the support surface across the aperture.

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