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1. 发明授权

US09682054B2 Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis 有权
公开(公告)号：US09682054B2
公开(公告)日：2017-06-20
申请号：US10544350
申请日：2004-02-06
申请人： Christopher Penney , Lyne Gagnon , Pierre Laurin , Boulos Zacharie
发明人： Christopher Penney , Lyne Gagnon , Pierre Laurin , Boulos Zacharie
IPC分类号： A61K31/20 , A61K31/23 , A61K47/14 , A61K45/06
CPC分类号： A61K31/20 , A61K31/23 , A61K45/06 , A61K47/14 , A61K2300/00
摘要： Use of a composition comprising a compound of any of formulae I, II, Ila, III and Illa; or a combination thereof wherein each R1 is independently C7-11 alkyl; A and B are independently H or CO—R1; R2 is H or C1-4 alkyl; M is a metal monocation (k=1) or dication (k=2); Y is 0 or NH; and Z is 0, NH, CH2O or a bond; for the manufacture of a medicament for stimulating erythropoiesis. Preferably, the composition further comprises human erythroporietin.

2. 发明授权

US08071580B2 Medium-chain length fatty alcohols as stimulators of hematopoiesis 有权
标题翻译：中链长脂肪醇作为造血刺激物
公开(公告)号：US08071580B2
公开(公告)日：2011-12-06
申请号：US11663888
申请日：2005-09-29
申请人： Christopher Penney , Lyne Gagnon , Jean Barabé
发明人： Christopher Penney , Lyne Gagnon , Jean Barabé
IPC分类号： A61K31/33 , A61K31/045
CPC分类号： A61K31/045
摘要： Medium-chain length fatty alcohols such as octanol, decanol, dodecanol, or analogues thereof can be used as a stimulator of hematopoiesis, hematopoietic stem cell proliferation, and/or proliferation of one or more of the progenitors of red or white blood cells (e.g., erythrocyte, leukocyte, neutrophil, granulocyte, megakaryocyte, or any combination thereof). It also relates to the treatment of myelosuppression; in particular, this includes the treatment of anemia and/or neutropenia associated with chemotherapy and/or radiotherapy. Moreover, anemia arising from chronic renal failure or treatment of HIV-infected patients with AZT (zidovudine), or other inhibitors of reverse transcriptase, can be treated. Furthermore, neutropenia arising from infections, hematologic diseases, or nutritional deficiencies can be treated. It also relates to reducing drug toxicity and enhancing drug efficiency.
摘要翻译：中链长度脂肪醇如辛醇，癸醇，十二烷醇或其类似物可用作红细胞或白细胞的一种或多种祖细胞造血干细胞增殖和/或增殖的刺激物（例如，，红细胞，白细胞，嗜中性粒细胞，粒细胞，巨核细胞或其任何组合）。它还涉及骨髓抑制的治疗; 特别地，这包括治疗与化学疗法和/或放射疗法相关的贫血和/或中性白细胞减少症。此外，可以治疗由慢性肾衰竭引起的贫血或治疗感染AZT（齐多夫定）的HIV感染患者或其他逆转录酶抑制剂的贫血。此外，可以治疗由感染，血液病或营养缺乏引起的中性粒细胞减少症。它还涉及降低药物毒性和提高药物效率。

3. 发明授权

US07745488B2 Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors 有权
标题翻译：中链长度脂肪酸，甘油酯和类似物作为嗜中性粒细胞存活和激活因子
公开(公告)号：US07745488B2
公开(公告)日：2010-06-29
申请号：US10475266
申请日：2002-04-18
申请人： Lyne Gagnon , Jean Barabe , Pierre Laurin , Christopher Penney , Boulos Zacharie
发明人： Lyne Gagnon , Jean Barabe , Pierre Laurin , Christopher Penney , Boulos Zacharie
IPC分类号： A61K31/255 , A61K31/225
CPC分类号： C07C237/22 , A61K31/18 , A61K31/194 , A61K31/20 , A61K31/23 , A61K31/255 , A61K31/7024 , A61K38/193 , A61K38/2013 , A61K38/2086 , A61K45/06 , C07B2200/11 , C07C233/18 , C07C233/47 , C07C235/06 , C07C235/08 , C11C3/003 , C11C3/02 , C40B40/00 , Y02A50/387 , Y02A50/483 , A61K2300/00
摘要： A composition and method for promoting neutrophil survival and activation such as the treatment of neutropenia arising as an undesirable side effect of chemotherapy and radiation therapy. A composition containing medium-chain fatty acids, such as Capri acid or caprylic acid, or salts or triglycerides thereof, or mono- or diglycerides or other analogues thereof or medium-chain triglycerides (MCT) is administered to a human or animal needing treatment in an amount sufficient to reduce or eliminate neutropenia. The composition is administered in an amount effective to treat the disorder. The methods are also useful in the management of bone narrow transplantation and in the treatment of various neutropenic diseases.
摘要翻译：用于促进嗜中性粒细胞存活和激活的组合物和方法，例如治疗作为化疗和放射治疗的不良副作用引起的中性粒细胞减少。将含有中链脂肪酸的组合物，例如Capri酸或辛酸，或其盐或甘油三酯，或甘油单酯或甘油二酯或其它类似物或中链甘油三酸酯（MCT）给予需要治疗的人或动物足以减少或消除中性粒细胞减少的量。组合物以有效治疗病症的量给药。该方法也可用于骨狭窄移植的治疗和各种嗜中性粒细胞减少症的治疗。

4. 发明申请

US20100129350A1 Triazine Derivatives, Compositions Containing Such Derivatives, and Methods of Treatment of Cancer and Autoimmune Diseases Using Such Derivatives 有权
标题翻译：三嗪衍生物，含有此类衍生物的组合物，以及使用此类衍生物治疗癌症和自身免疫性疾病的方法
公开(公告)号：US20100129350A1
公开(公告)日：2010-05-27
申请号：US12598273
申请日：2008-04-25
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Shaun D. Abbott
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Shaun D. Abbott
IPC分类号： A61K31/53 , C07D251/54 , A61K31/704 , A61K31/675 , A61K38/00 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K39/395 , A61P35/00 , A61P37/00
CPC分类号： C07D251/18 , C07D251/70
摘要： We describe compounds of the following general formula (I): wherein X is fluorine or chlorine; Y is oxygen, sulfur, or an amino group; R is an amino, hydroxyl, sulfonamide, or carboxamide group or an N-monomethyl or N-dimethyl analog thereof; m is an integer from 2 to 6, and n is an integer from 0 to 2. The compounds may be used for treating certain cancers and autoimmune diseases.
摘要翻译：我们描述以下通式（I）的化合物：其中X是氟或氯; Y是氧，硫或氨基; R是氨基，羟基，磺酰胺或羧酰胺基团或其N-甲基或N-二甲基类似物; m为2〜6的整数，n为0〜2的整数。化合物可用于治疗某些癌症和自身免疫性疾病。

5. 发明申请

US20080090848A1 Substituted Purinyl Derivatives With Immunomodulator And Chemoprotective Activity And Use Alone Or With Medium-Chain Length Fatty Acids Or Glycerides 审中-公开
标题翻译：具有免疫调节剂和化学保护活性和单独使用的中链链脂肪酸或甘油酯的取代的紫杉基衍生物
公开(公告)号：US20080090848A1
公开(公告)日：2008-04-17
申请号：US11661108
申请日：2005-09-02
申请人： Christopher Penney , Boulos Zacharie , Jean Barabe , Pierre Laurin , Lyne Gagnon
发明人： Christopher Penney , Boulos Zacharie , Jean Barabe , Pierre Laurin , Lyne Gagnon
IPC分类号： A61K31/52 , A61P35/00 , A61P39/00
CPC分类号： A61K31/20 , A61K31/23 , A61K31/417 , A61K31/52 , A61K2300/00
摘要： The present invention describes new biological activities of immunomodulating 6-substituted purinyl compounds which make them particularly useful during the treatment of cancer. Collectively, these new biological activities make these purinyl compounds useful chemoprotective agents for the treatment of myelosuppression which is associated with cancer chemotherapy and/or radiotherapy. This chemoprotective activity is in addition to the immunomodulating and subsequent anticancer activity displayed by these compounds. The chemoprotective usefulness of these compounds is further enhanced by the use of medium-chain fatty acids or salts or triglycerides or mono- or diglycerides in combination with the 6-substituted purinyl compounds of this invention.
摘要翻译：本发明描述了使其在癌症治疗期间特别有用的免疫调节6-取代嘌呤基化合物的新生物活性。总的来说，这些新的生物活性使得这些嘌呤基化合物可用于治疗与癌症化学疗法和/或放射疗法相关的骨髓抑制的化学保护剂。这种化学保护活性是由这些化合物显示的免疫调节和随后的抗癌活性的补充。通过使用中链脂肪酸或甘油三酯或甘油单酯或甘油二酯与本发明的6-取代的嘌呤基化合物的组合，这些化合物的化学保护作用进一步增强。

6. 发明申请

US20050101632A1 Method for the treatment of inflammation 审中-公开
标题翻译：治疗炎症的方法
公开(公告)号：US20050101632A1
公开(公告)日：2005-05-12
申请号：US10415793
申请日：2001-11-08
申请人： Lyne Gagnon , Pierre Laurin
发明人： Lyne Gagnon , Pierre Laurin
IPC分类号： A61K45/00 , A61K31/47 , A61K31/573 , A61K31/695 , A61K31/728 , A61K31/80 , A61K45/06 , A61P1/02 , A61P1/04 , A61P13/00 , A61P13/10 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/08 , A61P17/10 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P37/08 , A61P43/00
CPC分类号： A61K45/06 , A61K31/47 , A61K31/573 , A61K31/695 , A61K31/80 , A61K2300/00
摘要： A method for treating, eliminating and preventing an inflammation of the skin or mucous membrane of a mammal, including a human, by administering to the skin or mucous membrane a composition containing dimethicone and a pharmaceutically acceptable carrier. The dimethicone composition is applied to the skin or mucous membrane in an amount effective to treat, eliminate or prevent the inflammation.
摘要翻译：通过向皮肤或粘膜施用含有二甲聚硅氧烷和药学上可接受的载体的组合物来治疗，消除和预防哺乳动物（包括人）的皮肤或粘膜的炎症的方法。将聚二甲基硅氧烷组合物以有效治疗，消除或预防炎症的量施用于皮肤或粘膜。

7. 发明授权

US09475750B2 Phenylketone carboxylate compounds and pharmaceutical uses thereof 有权
标题翻译：苯甲酮羧酸酯化合物及其药物用途
公开(公告)号：US09475750B2
公开(公告)日：2016-10-25
申请号：US13882363
申请日：2011-10-26
申请人： Boulos Zacharie , Christopher Penney , Shaun Abbott , Lyne Gagnon , Brigitte Grouix , Pierre Laurin , Jean-François Bienvenu
发明人： Boulos Zacharie , Christopher Penney , Shaun Abbott , Lyne Gagnon , Brigitte Grouix , Pierre Laurin , Jean-François Bienvenu
IPC分类号： C07C59/90 , C07C62/38 , C07C65/32 , C07C69/92 , C07C217/84 , C07C225/22 , C07C229/18 , C07C323/20 , C07C323/52 , C07C323/62 , A61K31/192 , A61K31/196 , A61K31/222 , A61K31/235 , C07C59/68 , C07C59/84
CPC分类号： C07C59/90 , A61K31/192 , A61K31/196 , A61K31/222 , A61K31/235 , C07C59/68 , C07C59/84 , C07C62/38 , C07C65/32 , C07C69/92 , C07C217/84 , C07C225/22 , C07C229/18 , C07C323/20 , C07C323/52 , C07C323/62 , C07C2602/08
摘要： Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R═C(0); —OC(O)— or —CH(OH)—; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=1-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.

8. 发明授权

US08946190B2 Medium-chain length fatty acids, salts and triglycerides in combination with gemcitabine for treatment of pancreatic cancer 有权
标题翻译：中链长度脂肪酸，盐和甘油三酯与吉西他滨联合治疗胰腺癌
公开(公告)号：US08946190B2
公开(公告)日：2015-02-03
申请号：US12809380
申请日：2008-12-18
申请人： Lyne Gagnon , Lilianne Geerts , Christopher Penney
发明人： Lyne Gagnon , Lilianne Geerts , Christopher Penney
IPC分类号： A61K31/7068 , A61K31/517 , A61K31/23 , A61K31/20 , A61P35/00
CPC分类号： A61K31/23 , A61K31/20 , A61K31/517 , A61K31/7068 , A61K2300/00
摘要： The present invention relates to the use of medium-chain length fatty acids of formula I, triglycerides of formula 2 (wherein n=6-10), salts thereof, or mixtures thereof, in combination with gemcitabine and optionally erlotinib in the treatment of pancreatic cancer in human patients. Exemplary medium-chain length fatty acid/triglyceride compounds include capric acid, sodium caprate, tricaprin, lauric acid, sodium laurate, and trilaurin.
摘要翻译：本发明涉及式I的中链长度脂肪酸，式2的甘油三酯（其中n = 6-10），其盐或其混合物与吉西他滨和任选的厄洛替尼联合用于胰腺治疗的用途人类癌症。示例性的中链长度脂肪酸/甘油三酸酯化合物包括癸酸，癸酸钠，三萜素，月桂酸，月桂酸钠和三月桂酸。

9. 发明授权

US08927765B2 Substituted aromatic compounds and pharmaceutical uses thereof 有权
标题翻译：取代的芳香族化合物及其药物用途
公开(公告)号：US08927765B2
公开(公告)日：2015-01-06
申请号：US13289592
申请日：2011-11-04
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
IPC分类号： C07C53/134 , C07C57/30 , C07C61/39 , C07D257/04 , C07C59/48 , C07D213/55 , C07C57/58 , C07C59/52
CPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C57/42 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
摘要： The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
摘要翻译：本发明涉及取代的式I的芳族化合物及其药物用途。本发明的特定方面涉及这些化合物在预防和/或治疗受试者的各种疾病和病症中的用途，包括预防或治疗（i）血液病症，（ii）肾病，肾病或肾脏疾病并发症; （iii）炎性相关疾病; 和/或（iv）氧化应激相关疾病。

10. 发明申请

US20130225683A1 Compounds and Pharmaceutical Compositions for Uses in Diabetes 审中-公开
标题翻译：用于糖尿病的化合物和药物组合物
公开(公告)号：US20130225683A1
公开(公告)日：2013-08-29
申请号：US13882373
申请日：2011-10-26
申请人： Lyne Gagnon , Brigette Grouix , Pierre Laurin
发明人： Lyne Gagnon , Brigette Grouix , Pierre Laurin
IPC分类号： A61K31/192 , A61K31/155 , A61K31/426 , A61K31/20
CPC分类号： A61K31/192 , A61K31/155 , A61K31/20 , A61K31/426
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I, IA, IB and IC, and their pharmaceutical acceptable salts are described for prevention or treatment of diabetes or a diabetes-related disorder in a subject in need thereof. Diabetes and diabetes-related disorder include Type I diabetes, Type II diabetes, maturity-onset diabetes of the young, latent autoimmune diabetes of adults (LADA), gestational diabetes, diabetic nephropathy, proteinuria, ketonuria, obesity, hyperglycemia, glucose intolerance, insulin resistance, hyperinsulinemia, hypercholesterolemia, hypertension, hyperlipoproteinemia, hyperlipidemia, hypertriglyceridemia, dyslipidemia, metabolic syndrome, syndrome X, diabetic neuropathy, diabetic retinopathy, hypoglycemia, cardiovascular disease, atherosclerosis, diabetic kidney disease, ketoacidosis, thrombotic disorders, sexual dysfunction, dermatopathy, edema, metabolic syndrome and renal disorders. The related pharmaceutical compositions and methods are also described. These compounds can be used in combination with comprising a therapeutic agent for lowering or controlling blood glucose level such as metformin or a thiazolidinedione.
摘要翻译：描述了用于预防或治疗有需要的受试者中的糖尿病或糖尿病相关疾病的式I，式I，IA，IB和IC的苯甲酮羧酸酯化合物和取代的芳族化合物及其药学上可接受的盐的新用途。糖尿病和糖尿病相关疾病包括I型糖尿病，II型糖尿病，年轻成熟期糖尿病，成人潜伏性自身免疫性糖尿病（LADA），妊娠糖尿病，糖尿病肾病，蛋白尿，酮尿症，肥胖症，高血糖症，葡萄糖不耐症，胰岛素高血脂，高脂血症，高脂血症，高甘油三酯血症，血脂异常，代谢综合征，综合征X，糖尿病性神经病，糖尿病性视网膜病变，低血糖症，心血管病，代谢综合征和肾脏疾病。还描述了相关的药物组合物和方法。这些化合物可以与降低或控制血糖水平的治疗剂如二甲双胍或噻唑烷二酮组合使用。

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