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1. 发明授权

US11589767B2 Low power apparatus and method to measure complex electrical admittance or impedance 有权
公开(公告)号：US11589767B2
公开(公告)日：2023-02-28
申请号：US16536146
申请日：2019-08-08
申请人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
发明人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
IPC分类号： A61B5/0538 , A61N1/05 , A61N1/36 , A61N1/365 , A61N1/37 , A61B5/0215 , A61B5/029
摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.

2. 发明授权

US10420952B2 Method and apparatus for treating a patient's heart using hemodynamics 有权
公开(公告)号：US10420952B2
公开(公告)日：2019-09-24
申请号：US13648725
申请日：2012-10-10
申请人： Marc D. Feldman , Erik R. Larson , John A. Pearce , Jonathan W. Valvano , John Porterfield
发明人： Marc D. Feldman , Erik R. Larson , John A. Pearce , Jonathan W. Valvano , John Porterfield
IPC分类号： A61N1/39 , A61B5/02 , A61B5/00
摘要： An apparatus for treating a patient's heart includes a sensor for measuring hemodynamics of the heart. The apparatus includes a processing unit which receives the hemodynamics from the sensor and uses the hemodynamics to determine whether to shock the heart. A method for treating a patient's heart. The method includes the steps of measuring hemodynamics of the heart with a sensor. There is the step of receiving the hemodynamics from the sensor at a processing unit which uses the hemodynamics to determine whether to shock the heart.

3. 发明授权

US09820673B2 Method and apparatus for monitoring an organ of a patient 有权
公开(公告)号：US09820673B2
公开(公告)日：2017-11-21
申请号：US14213473
申请日：2014-03-14
申请人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61N1/05 , A61B5/053 , A61B5/107 , A61B5/20 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/08 , A61B5/029 , A61B5/0295 , A61B5/00 , A61B5/0215 , A61N1/365 , A61N1/368 , A61N1/39
CPC分类号： A61B5/0537 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/0535 , A61B5/0538 , A61B5/0809 , A61B5/1076 , A61B5/204 , A61B5/441 , A61B5/4519 , A61B5/4878 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： An implanted device for an organ of a patient including a housing. The device includes a detector having electrodes that have a varying distance over time between them which produces a detector signal based on electrical signals derived from the organ. The device includes a signal processor disposed in the housing in communication with the detector which determines admittance from the detector signal based on the varying distance over time between the electrodes. The device includes a drive circuit disposed in the housing to cause the electrodes to generate emitted electrical signals. A method for monitoring a patient's organ.

4. 发明申请

US20160302691A1 Method and Apparatus for Determining Cardiac Performance in a Patient With a Conductance Catheter 审中-公开
标题翻译：用电导导管确定患者心脏性能的方法和装置
公开(公告)号：US20160302691A1
公开(公告)日：2016-10-20
申请号：US15193931
申请日：2016-06-27
申请人： Marc D. Feldman , Jonathan W. Valvano , John A. Pearce , Chia-Ling Wei
发明人： Marc D. Feldman , Jonathan W. Valvano , John A. Pearce , Chia-Ling Wei
IPC分类号： A61B5/053 , A61B5/0215 , A61B5/029
CPC分类号： A61B5/0538 , A61B5/02007 , A61B5/0215 , A61B5/029 , A61B5/053
摘要： An apparatus for determining cardiac performance in the patient includes a plurality of electrodes adapted to be placed in the patient and in communication with a heart chamber of the patient for measuring conductance and blood volume in the heart chamber of the patient; and a processor for determining instantaneous volume of the ventricle based on measurement of complex admittance at a plurality of frequencies to identify mechanical strength of the chamber, the processor in communication with the electrodes. A method for determining cardiac performance in a patient.
摘要翻译：用于确定患者心脏性能的装置包括多个电极，其适于放置在患者体内并与患者的心室连通，用于测量患者心室中的电导和血容量; 以及处理器，用于基于多个频率处的复合导纳的测量来确定心室的瞬时体积，以识别腔室的机械强度，处理器与电极连通。一种用于确定患者心脏性能的方法。

5. 发明授权

US09295404B2 Low power apparatus and method to measure complex electrical admittance or impedance 有权
标题翻译：低功率设备和测量复杂导电或阻抗的方法
公开(公告)号：US09295404B2
公开(公告)日：2016-03-29
申请号：US13425119
申请日：2012-03-20
申请人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
发明人： Jonathan W. Valvano , Marc D. Feldman , John Porterfield , John A. Pearce , Erik Larson , Lev Shuhatovich , Kathryn Loeffler , Raffaele Cetrulo
IPC分类号： A61N1/36 , A61B5/053 , A61N1/05 , A61N1/365 , A61N1/37
CPC分类号： A61B5/0538 , A61B5/0215 , A61B5/029 , A61N1/056 , A61N1/36125 , A61N1/36521 , A61N1/3706
摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.
摘要翻译：用于测量动物或人类患者中的复电导纳和/或复电阻抗的装置包括第一电极和适于设置在患者体内的至少第二电极。该装置包括适于设置在患者体内的壳体。壳体设置有与至少第一电极电连通的刺激器，以用电流或电压来刺激第一电极，传感器至少与第二电极电连通，以基于第二电极感测来自第二电极的响应对第一电极的刺激以及与传感器电通信的信号处理器，以确定患者的复杂电导纳或阻抗。

6. 发明申请

US20140257121A1 Method and Apparatus for Monitoring an Organ of a Patient 审中-公开
标题翻译：用于监测患者器官的方法和装置
公开(公告)号：US20140257121A1
公开(公告)日：2014-09-11
申请号：US14213473
申请日：2014-03-14
申请人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , John Porterfield , Karthik Raghavan , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61B5/053 , A61N1/39 , A61B5/0488 , A61B5/0476 , A61B5/0452 , A61B5/08
CPC分类号： A61B5/0537 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0452 , A61B5/0476 , A61B5/0488 , A61B5/0535 , A61B5/0538 , A61B5/0809 , A61B5/1076 , A61B5/204 , A61B5/441 , A61B5/4519 , A61B5/4878 , A61N1/36521 , A61N1/3684 , A61N1/3962
摘要： An apparatus for determining tissue versus fluid components of an organ include a detector that generates a detector signal based on electrical signals derived from tissue and fluid. The apparatus includes a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal. A method for monitoring a patient's fluid volume of a patient's organ. An apparatus for monitoring a patient's organ. A method for monitoring a patient's organ. A method to piggyback an admittance system onto a AICD/Bi-ventricular Pacemaker for a heart of a patient, in particular a weakened heart having features consistent with congestive heart failure. An apparatus for monitoring an organ, such as a heart, lungs, brain, skeletal muscle, and bladder of a patient which includes a detector which detects the admittance of the organ. The apparatus includes a transmitter in communication with the detector which transmits a wireless signal indicative of the admittance of the organ. A method for monitoring an organ of a patient includes the steps of detecting with a detector the admittance of the organ. There is the step of transmitting with a transmitter in communication with the detector a wireless signal indicative of admittance of the organ.
摘要翻译：用于确定器官的组织与流体成分的装置包括基于从组织和流体得到的电信号产生检测器信号的检测器。该装置包括与检测器通信的信号处理器，其实时地从检测器信号中减去组织成分并产生流体体积信号。一种用于监测患者器官的患者体液量的方法。用于监测患者器官的装置。一种监测患者器官的方法。将导纳系统搭载到患者心脏的AICD /双心室起搏器的方法，特别是具有与充血性心力衰竭一致的特征的弱化心脏。一种用于监测患者的器官（例如心脏，肺，脑，骨骼肌和膀胱）的装置，其包括检测器官的入射的检测器。该装置包括与检测器通信的发射器，其发射指示器官的导纳的无线信号。用于监测患者器官的方法包括以下步骤：用检测器检测器官的导纳。存在与发射机通信的步骤，该发射机与检测器通信，指示器官进入的无线信号。

7. 发明授权

US07983737B2 Optical coherence tomographic detection of cells and compositions 有权
标题翻译：光学相干断层扫描检测细胞和组成
公开(公告)号：US07983737B2
公开(公告)日：2011-07-19
申请号：US11441824
申请日：2006-05-26
申请人： Marc D. Feldman , Thomas E. Milner , Jung-Hwan Oh , Mehmet Cilingiroglu
发明人： Marc D. Feldman , Thomas E. Milner , Jung-Hwan Oh , Mehmet Cilingiroglu
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0261 , A61B5/0275 , A61B5/0515 , A61B5/416 , A61B8/06 , A61B8/13 , G01N21/1717 , G01N21/4795
摘要： Provided herein are systems and methods for the detection of cells and/or compositions using optical coherence tomography. The systems and methods comprise a plurality of magnets for applying a plurality of distinct magnetic field strengths to the cells and/or compositions and a phase sensitive optical coherence tomographic imaging modality for detecting the cells and/or compositions while same are disposed in the presence of at least one of the plurality of distinct magnetic field strengths.
摘要翻译：本文提供了使用光学相干断层扫描检测细胞和/或组合物的系统和方法。所述系统和方法包括用于向细胞和/或组合物施加多个不同的磁场强度的多个磁体和用于检测细胞和/或组合物的相敏光学相干断层摄影成像模式，同时在所述多个不同的磁场强度中的至少一个。

8. 发明授权

US07747315B2 Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures 有权
标题翻译：在治疗和诊断成像过程中减少光散射的方法和组合物
公开(公告)号：US07747315B2
公开(公告)日：2010-06-29
申请号：US10500577
申请日：2003-01-15
申请人： Joseph W. Villard , Marc D. Feldman , Thomas E. Milner , JeeHyun Kim , Gregory L. Freeman
发明人： Joseph W. Villard , Marc D. Feldman , Thomas E. Milner , JeeHyun Kim , Gregory L. Freeman
IPC分类号： A61B6/00 , A61B5/05
CPC分类号： A61B5/14551 , A61B5/0066 , A61B5/0073 , A61B5/14535 , A61B5/14553 , A61B5/416
摘要： Disclosed are improved methods and compositions for use in light-based in vivo imaging and treatment. The techniques described involve the use of low-scattering, oxygen-carrying blood substitutes in imaging and treatment methods, including OCT imaging. The invention has particular advantages in imaging within the cardiovascular system and highly vascularized or oxygen-dependent tissues.
摘要翻译：公开了用于基于光的体内成像和治疗的改进的方法和组合物。所描述的技术涉及在成像和治疗方法中使用低散射，含氧载体的血液代用品，包括OCT成像。本发明在心血管系统和高度血管化或氧依赖性组织中的成像中具有特别的优点。

9. 发明申请

US20090210020A1 Method and Apparatus for Determining Cardiac Performance in a Patient 审中-公开
标题翻译：用于确定患者心脏性能的方法和装置
公开(公告)号：US20090210020A1
公开(公告)日：2009-08-20
申请号：US12086040
申请日：2006-12-14
申请人： Marc D. Feldman , Jonathan W. Valvano , John A. Pearce
发明人： Marc D. Feldman , Jonathan W. Valvano , John A. Pearce
IPC分类号： A61N1/368 , A61B5/02 , A61B5/0215 , A61N1/39
CPC分类号： A61N1/36514 , A61B5/0215 , A61B5/053 , A61B5/413 , A61N1/3627 , A61N1/36585 , A61N1/368 , A61N1/3684 , A61N1/3702 , A61N1/3962 , A61N1/3968
摘要： An apparatus for determining heart transplant rejection of a heart in a patient includes at least two electrodes adapted to be sewn into the heart that span the left ventricle. The apparatus includes a voltage generator adapted to be inserted in the patient which generates a voltage to the two electrodes and senses the resulting voltage from the two electrodes. A method for determining heart transplant rejection of a heart in a patient. A pacemaker for a patient (including bi-ventricular pacing and AICDs). The pacemaker includes an RV lead having four electrodes adapted to be inserted into the RV apex. The pacemaker includes a voltage generator which generates a voltage signal to the electrodes and senses the instantaneous voltage along the length of the RV and determines the real and imaginary components to remove the myocardial components of the septum and RV free wall to determine absolute RV blood volume. The pacemaker includes a battery connected to the voltage generator. The pacemaker includes a defibrillator connected to the battery. The pacemaker can also be a bi-ventricular pacemaker to restore RV and LV synchrony during contraction. A method for assisting a heart of a patient.
摘要翻译：用于确定患者心脏移植排斥反应的装置包括至少两个适于被缝合到穿过左心室的心脏中的电极。该装置包括适于插入到患者体内的电压发生器，该电压产生对两个电极的电压并感测来自两个电极的所得到的电压。用于确定患者心脏心脏移植排斥反应的方法。患者的起搏器（包括双心室起搏和AICD）。起搏器包括RV引线，其具有适于插入RV顶点的四个电极。起搏器包括电压发生器，其向电极产生电压信号并且感测沿着RV长度的瞬时电压，并且确定实部和虚部分量以去除隔膜和RV游离壁的心肌分量以确定绝对RV血容量。起搏器包括连接到电压发生器的电池。起搏器包括连接到电池的除颤器。起搏器也可以是一个双心室起搏器，用于在收缩期间恢复RV和LV同步。一种辅助患者心脏的方法。

10. 发明授权

US06197013B1 Method and apparatus for drug and gene delivery 失效
公开(公告)号：US06197013B1
公开(公告)日：2001-03-06
申请号：US08743902
申请日：1996-11-06
申请人： Michael L. Reed , Lee E. Weiss , Clarence C. Wu , Marc D. Feldman
发明人： Michael L. Reed , Lee E. Weiss , Clarence C. Wu , Marc D. Feldman
IPC分类号： A61M3100
CPC分类号： A61F2/86 , A61F2/848 , A61F2220/005 , A61F2220/0058 , A61F2250/0067 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2037/0023 , A61M2037/0046
摘要： An apparatus for treating a patient. The apparatus includes a deployment mechanism having a surface. The apparatus also includes at least one probe disposed on the deployment mechanism surface. The probe extends between 25 microns and 1000 microns from the surface of the deployment mechanism. The apparatus also includes material coated on the probe. A method for treating a patient. The method includes the steps of placing a material with a probe which extends less than 1000 microns from a surface of a deployment mechanism. Next, there is the step of inserting the probe into preferably a blood vessel of a patient. Then, there is the step of penetrating the interior wall of the vessel from the interior of the vessel with the probe by activating the deployment mechanism so the material can contact the vessel.

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