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1. 发明授权

US08109953B1 Catheter device, hub assembly and method for traversing total occlusions 有权
标题翻译：导管装置，轮毂组件和穿过全部闭塞的方法
公开(公告)号：US08109953B1
公开(公告)日：2012-02-07
申请号：US11838313
申请日：2007-08-14
申请人： Spencer B. King, III , Matt D. Pursley
发明人： Spencer B. King, III , Matt D. Pursley
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/22 , A61B2017/22044 , A61B2017/22049 , A61B2017/22069 , A61B2017/22094 , A61B2090/034 , A61M25/0097 , A61M25/0152 , A61M2025/0681 , A61M2025/09125
摘要： A medical device for traversing an occlusion in a vessel includes a straightening sleeve positioned at a distal aspect of a catheter, a steering sleeve having an arcuate distal end, and a guidewire disposed through the steering sleeve. The steering sleeve has a first position in which the arcuate distal end is straightened within the straightening sleeve, and a second position in which the steering sleeve extends distally past the straightening sleeve to expose the arcuate distal end. The tip of the arcuate distal end of the steering sleeve or the guidewire can be used to pierce the occlusion. An arrangement of hub assemblies with locking mechanisms and motion limiting structures facilitates adjusting and locking the relative positions of the straightening sleeve, the steering sleeve, and the guidewire. Detent mechanisms are associated with the motion limiting structures for providing controlled incremental movement of the sleeves and the guidewire.
摘要翻译：用于穿过容器中的闭塞的医疗装置包括定位在导管的远侧方面的矫直套筒，具有弓形远端的转向套管和穿过转向套筒的导丝。转向套筒具有第一位置，其中弓形远端在矫直套筒内矫直，以及第二位置，转向套筒向远侧延伸穿过矫直套筒以暴露弓形远端。转向套筒或导丝的弓形远端的尖端可用于刺穿闭塞。具有锁定机构和运动限制结构的轮毂组件的布置有助于调节和锁定矫直套筒，转向套筒和导丝的相对位置。止动机构与运动限制结构相关联，用于提供套筒和导丝的受控的增量运动。

2. 发明授权

US06402736B1 Apparatus and method for filtering intravascular fluids and for delivering diagnostic and therapeutic agents 失效
标题翻译：用于过滤血管内液体和递送诊断和治疗剂的装置和方法
公开(公告)号：US06402736B1
公开(公告)日：2002-06-11
申请号：US09558078
申请日：2000-04-25
申请人： Joe E. Brown , Matt D. Pursley
发明人： Joe E. Brown , Matt D. Pursley
IPC分类号： A61M2500
CPC分类号： A61M25/0017 , A61F2/88 , A61F2250/0067 , A61F2250/0098 , A61M25/0021 , A61M25/0041 , A61M25/0108 , A61M25/0662 , A61M2025/0057 , A61N2005/1021
摘要： An apparatus and method for filtering intravascular fluids and for delivering diagnostic and therapeutic agents intravascularly is disclosed in which the apparatus has a shape defined by a preset shape of a resilient fiber core. The resilient fiber core is covered by a soft polymer tubing or other polymer material to form a delivery apparatus that takes the shape of the resilient fiber core. Various shapes and structures are disclosed that infuse diagnostic and therapeutic agents through a lumen of the polymer tubing, that deliver the agents in the form of a soluble coating, that circulate or contain a preloaded charge of radioactive material for intravascular radiotherapy, and that deploy filtration devices intravascularly for removing particulate matter from body fluid. The resilient fiber core and soft polymer material permit the construction of a very small apparatus that can be removed easily following treatment. Various deployment systems are disclosed for deploying the filtering and delivery apparatuses into a vessel and for protecting against radiation exposure.
摘要翻译：公开了一种用于过滤血管内液体和用于输送血管内的诊断和治疗剂的装置和方法，其中该装置具有由弹性纤维芯的预设形状限定的形状。弹性纤维芯被软聚合物管或其它聚合物材料覆盖以形成呈弹性纤维芯形状的输送装置。公开了各种形状和结构，其通过聚合物管的内腔注入诊断和治疗剂，该内腔以可溶性涂层的形式递送试剂，其循环或容纳用于血管内放射治疗的放射性物质的预加载电荷，并且部署过滤用于从体液中去除颗粒物的血管内装置。弹性纤维芯和软质聚合物材料允许构造非常小的装置，其可以在处理后容易地除去。公开了用于将过滤和递送装置部署到容器中并用于防止辐射暴露的各种部署系统。

3. 发明授权

US6053900A Apparatus and method for delivering diagnostic and therapeutic agents intravascularly 有权
标题翻译：血管内递送诊断和治疗药物的装置和方法
公开(公告)号：US6053900A
公开(公告)日：2000-04-25
申请号：US168133
申请日：1998-10-07
申请人： Joe E. Brown , Matt D. Pursley
发明人： Joe E. Brown , Matt D. Pursley
IPC分类号： A61F2/00 , A61F2/06 , A61F2/88 , A61M25/00 , A61M25/01 , A61M25/06 , A61N5/10 , A61K9/22
CPC分类号： A61M25/0041 , A61M25/0017 , A61M25/0021 , A61F2/88 , A61F2250/0067 , A61F2250/0098 , A61M2025/0057 , A61M25/0108 , A61M25/0662 , A61N2005/1021
摘要： An apparatus and method for delivering diagnostic and therapeutic agents intravascularly in which the apparatus has a shape defined by a preset shape of a resilient fiber core. The resilient fiber core is covered by a soft polymer tubing or other polymer material to form a delivery apparatus that takes the shape of the resilient fiber core. Various shapes and structures are disclosed that infuse diagnostic and therapeutic agents through a lumen of the polymer tubing, that deliver the agents in the form of a soluble coating, and that circulate or contain a preloaded charge of radioactive material for intravascular radiotherapy. The resilient fiber core and soft polymer material permit the construction of a very small apparatus that can be removed easily following treatment. Various deployment systems are disclosed for deploying the delivery apparatuses into a vessel and for protecting against radiation exposure.
摘要翻译：用于递送血管内的诊断和治疗剂的装置和方法，其中该装置具有由弹性纤维芯的预设形状限定的形状。弹性纤维芯被软聚合物管或其它聚合物材料覆盖以形成呈弹性纤维芯形状的输送装置。公开了各种形状和结构，其通过聚合物管的管腔输注诊断和治疗剂，其以可溶性涂层的形式递送药剂，并且循环或容纳用于血管内放射治疗的放射性物质的预加载电荷。弹性纤维芯和软质聚合物材料允许构造非常小的装置，其可以在处理后容易地除去。公开了用于将输送装置部署到容器中并用于防止辐射暴露的各种部署系统。

4. 发明授权

US10092386B1 Multi lumen IVC filter retrieval device 有权
公开(公告)号：US10092386B1
公开(公告)日：2018-10-09
申请号：US15091411
申请日：2016-04-05
申请人： Matt D. Pursley
发明人： Matt D. Pursley
IPC分类号： A61F2/01
摘要： A device for retrieving items endovascularly includes a sheath having a first lumen containing a snare that can be deployed out a distal end of the sheath and retracted back into the sheath for pulling an IVC filter into the sheath. The sheath has a second lumen that opens through a sidewall of the sheath proximal of the distal end. The second lumen contains a removal assist device that can be deployed through the sidewall and used to dislodge and/or cut an item to be retrieved from a vein wall. The removal assist device includes a catheter, a cutting head, and a pull wire. The pull wire has a proximal portion protruding from a proximal end of the catheter and a distal end connected to the cutting head. The pull wire is movable within the catheter to selectively extend and retract the cutting head from the distal end of the catheter.

5. 发明授权

US09592079B1 Device and method for assisting removal of items endovascularly 有权
标题翻译：帮助血管内清除物品的装置和方法
公开(公告)号：US09592079B1
公开(公告)日：2017-03-14
申请号：US14214273
申请日：2014-03-14
申请人： Matt D. Pursley
发明人： Matt D. Pursley
IPC分类号： A61B17/50 , A61B17/00 , A61B18/20 , A61F2/01
CPC分类号： A61B17/50 , A61B17/00234 , A61B18/20 , A61B18/22 , A61F2/01 , A61F2002/011
摘要： A device for assisting in the removal of items endovascularly includes a catheter, a cutting head, and a pull wire. The pull wire has a proximal portion protruding from a proximal end of the catheter and a distal end connected to the cutting head. The pull wire is movable within the catheter to selectively extend and retract the cutting head from the distal end of the catheter. The cutting head is arranged to hold and/or cut an item to be removed.
摘要翻译：用于辅助血管内移除物品的装置包括导管，切割头和拉丝。拉线具有从导管的近端突出的近端部分和连接到切割头的远端。拉线可在导管内移动以选择性地从导管的远端延伸和缩回切割头。切割头被设置成保持和/或切割待移除的物品。

6. 发明授权

US08703229B2 Method of making catheters with porous structure for carrying agents 失效
标题翻译：制造带有多孔结构导管的导管的方法
公开(公告)号：US08703229B2
公开(公告)日：2014-04-22
申请号：US12759249
申请日：2010-04-13
申请人： Matt D. Pursley
发明人： Matt D. Pursley
IPC分类号： A61L33/00 , B05D3/02 , A61M25/00 , B05D1/12 , B05D5/00
CPC分类号： A61M25/0012 , B05D1/04 , B05D1/34 , B05D1/36 , B05D3/067 , B05D3/107 , B05D5/00
摘要： A method of making catheters is disclosed in which the wall of the catheter has a porous structure for carrying additional agents, such as therapeutic agents, diagnostic agents and/or device enhancements. The method includes applying a base polymer material and an inert material over the outer surface of a core, and curing or consolidating the base polymer material to form a catheter having a porous polymer layer with the inert material contained within the pores thereof. The inert material can be applied with the base polymer material or in a separate step after the base polymer material has been partially cured or consolidated to form the porous polymer layer. Additional agents can be mixed with the inert material before it is applied to the catheter, or can be applied to the porous polymer layer of the catheter in a separate step after the inert material is removed therefrom.
摘要翻译：公开了制造导管的方法，其中导管的壁具有用于承载附加试剂（例如治疗剂，诊断剂和/或装置增强）的多孔结构。该方法包括在芯的外表面上施加基础聚合物材料和惰性材料，以及固化或固结基础聚合物材料以形成具有多孔聚合物层的导管，惰性材料包含在其孔内。惰性材料可以与基础聚合物材料一起施用，或者在基础聚合物材料已经被部分固化或固化以形成多孔聚合物层之后的单独步骤中。在将惰性材料施用于导管之前，可以将其它试剂与惰性材料混合，或者在惰性材料从其中除去之后，可以在单独的步骤中将其施加到导管的多孔聚合物层。

7. 发明授权

US08377084B1 Method of using a catheter for traversing total occlusions 有权
标题翻译：使用导管穿过全部闭塞的方法
公开(公告)号：US08377084B1
公开(公告)日：2013-02-19
申请号：US13249952
申请日：2011-09-30
申请人： Spencer B. King, III , Matt D. Pursley
发明人： Spencer B. King, III , Matt D. Pursley
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/22 , A61B2017/22044 , A61B2017/22049 , A61B2017/22069 , A61B2017/22094 , A61B2090/034 , A61M25/0097 , A61M25/0152 , A61M2025/0681 , A61M2025/09125
摘要： A medical device and method for traversing an occlusion in a vessel includes a straightening sleeve positioned at a distal aspect of a catheter, a steering sleeve having an arcuate distal end, and a guidewire disposed through the steering sleeve. The steering sleeve has a first position in which the arcuate distal end is straightened within the straightening sleeve, and a second position in which the steering sleeve extends distally past the straightening sleeve to expose the arcuate distal end. The tip of the arcuate distal end of the steering sleeve or the guidewire can be used to pierce the occlusion. An arrangement of hub assemblies with locking mechanisms and motion limiting structures facilitates adjusting and locking the relative positions of the straightening sleeve, the steering sleeve, and the guidewire. Detent mechanisms are associated with the motion limiting structures for providing controlled incremental movement of the sleeves and the guidewire.
摘要翻译：用于横穿容器中的闭塞的医疗装置和方法包括定位在导管的远侧方面的矫直套筒，具有弓形远端的转向套管和穿过转向套筒的导丝。转向套筒具有第一位置，其中弓形远端在矫直套筒内矫直，以及第二位置，转向套筒向远侧延伸穿过矫直套筒以暴露弓形远端。转向套筒或导丝的弓形远端的尖端可用于刺穿闭塞。具有锁定机构和运动限制结构的轮毂组件的布置有助于调节和锁定矫直套筒，转向套筒和导丝的相对位置。止动机构与运动限制结构相关联，用于提供套筒和导丝的受控的增量运动。

8. 发明授权

US08241267B2 Method and apparatus for curving a catheter 有权
标题翻译：用于弯曲导管的方法和装置
公开(公告)号：US08241267B2
公开(公告)日：2012-08-14
申请号：US13019962
申请日：2011-02-02
申请人： Matt D. Pursley
发明人： Matt D. Pursley
IPC分类号： A61M25/00
CPC分类号： A61M25/0152
摘要： An apparatus and method for curving a catheter after deployment include a catheter having a primary lumen, a secondary lumen, and a resilient fiber contained within the secondary lumen. The resilient fiber and the secondary lumen have corresponding, preformed curve shapes when the catheter is in a straight, unstressed condition. The resilient fiber is slidable within the secondary lumen to create a desired curve shape in the catheter as the curved portion of the resilient fiber slides into an originally straight portion of the secondary lumen. In another embodiment, the preformed curve shape of the resilient fiber is held in a straight condition within a stiff, marker ring segment of the catheter until after the catheter is deployed. Once deployed, the resilient fiber is slid out of the marker ring segment, and the preformed curve shape of the resilient fiber creates a corresponding curve shape in the catheter.
摘要翻译：用于在展开后弯曲导管的装置和方法包括具有主腔，辅管腔和包含在次腔内的弹性纤维的导管。当导管处于直的不受应力状态时，弹性纤维和次内腔具有相应的预成型曲线形状。当弹性纤维的弯曲部分滑入第二内腔的原始直线部分时，弹性纤维可以在次内腔内滑动以在导管中产生期望的曲线形状。在另一个实施例中，将弹性纤维的预成形曲线形状保持在导管的刚性标记环段内的直线状态，直到导管部署之后。一旦部署，弹性纤维从标记环段滑出，并且弹性纤维的预成型曲线形状在导管中产生相应的曲线形状。

9. 发明授权

US07909813B2 Method and apparatus for curving a catheter 有权
公开(公告)号：US07909813B2
公开(公告)日：2011-03-22
申请号：US12237248
申请日：2008-09-24
申请人： Matt D. Pursley
发明人： Matt D. Pursley
IPC分类号： A61M25/00
CPC分类号： A61M25/0152
摘要： An apparatus and method for curving a catheter after deployment include a catheter having a primary lumen, a secondary lumen, and a resilient fiber contained within the secondary lumen. The resilient fiber and the secondary lumen have corresponding, preformed curve shapes when the catheter is in a straight, unstressed condition. The resilient fiber is slidable within the secondary lumen to create a desired curve shape in the catheter as the curved portion of the resilient fiber slides into an originally straight portion of the secondary lumen. In another embodiment, the preformed curve shape of the resilient fiber is held in a straight condition within a stiff, marker ring segment of the catheter until after the catheter is deployed. Once deployed, the resilient fiber is slid out of the marker ring segment, and the preformed curve shape of the resilient fiber creates a corresponding curve shape in the catheter.

10. 发明授权

US07776380B2 Method of making catheters with additives consolidated into polymer wall 有权
标题翻译：使用固定在聚合物壁上的添加剂制成导管的方法
公开(公告)号：US07776380B2
公开(公告)日：2010-08-17
申请号：US11234514
申请日：2005-09-22
申请人： Matt D. Pursley
发明人： Matt D. Pursley
IPC分类号： A61M25/00 , B05D3/02 , B05D1/02 , B05D1/36
CPC分类号： A61M25/0012 , A61M25/0009
摘要： A method of making catheters is disclosed in which various additives are consolidated into polymer walls of the catheters. The method includes providing a core, spraying a base polymer material over the outer surface of the core, spraying an additive material over or together with the base polymer material, and consolidating the additive material and the base polymer material together to form the catheter wall. The base polymer material and additive material are each applied as a fine particulate powder or solution of fine particulate, which can be sprayed over an outer surface of the core and the catheter wall as the catheter is formed. The additive material can be selected from several therapeutic agents, diagnostic agents, and/or polymers for modifying the base polymer materials. The additive material can be consolidated with the base polymer material throughout the polymer wall or primarily on the outer surface of the polymer wall.
摘要翻译：公开了制造导管的方法，其中各种添加剂被固结到导管的聚合物壁中。该方法包括提供芯部，在基体聚合物材料的外表面上喷涂基础聚合物材料，在基体聚合物材料上或与基体聚合物材料一起喷涂添加剂材料，以及将添加剂材料和基础聚合物材料固结在一起以形成导管壁。基础聚合物材料和添加剂材料各自作为细颗粒粉末或细颗粒溶液施用，其可以在形成导管时喷射在芯部和导管壁的外表面上。添加剂材料可以选自用于改性基础聚合物材料的几种治疗剂，诊断剂和/或聚合物。添加剂材料可以在整个聚合物壁上或主要在聚合物壁的外表面上与基础聚合物材料固结。

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