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1. 发明授权

US06294094B1 Systems and methods for sensing red blood cell hematocrit 失效
标题翻译：用于感测红细胞血细胞比容的系统和方法
公开(公告)号：US06294094B1
公开(公告)日：2001-09-25
申请号：US09389506
申请日：1999-09-03
申请人： Matthew R. Muller , Michel L. F. Joie , Mark R. Vandlik
发明人： Matthew R. Muller , Michel L. F. Joie , Mark R. Vandlik
IPC分类号： B01D1712
CPC分类号： B01D21/302 , A61M1/0236 , A61M1/367 , A61M1/3696 , A61M1/38 , A61M2205/128 , A61M2205/3393 , A61M2230/207 , B01D17/0217 , B01D21/2444 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/34 , B01D2221/08 , B01D2221/10
摘要： Red blood cell sensing systems and methods rely upon straightforward measurement geometries. The systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.
摘要翻译：红细胞感测系统和方法依赖于简单的测量几何。系统和方法包括入射光源，光学传感器和采血管。系统和方法将采血管保持与入射光源预定的径向距离，其中在由光学传感器测量的感测反射光与红细胞血细胞比容之间存在线性关系，范围在至少10至90°。系统和方法可以在不使用特殊的光学比色杯，镜子或聚焦镜片的情况下进行准确的红血传感。系统和方法也可以使用标准的透明塑料管，而不依赖于特殊的光学比色皿。

2. 发明授权

US08114043B2 Electromagnetic induction access disconnect sensor 有权
标题翻译：电磁感应存取断路传感器
公开(公告)号：US08114043B2
公开(公告)日：2012-02-14
申请号：US12180318
申请日：2008-07-25
申请人： Matthew R. Muller
发明人： Matthew R. Muller
IPC分类号： A61M37/00
CPC分类号： A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3661 , A61M2205/13 , A61M2205/3561 , A61M2205/3569 , A61M2205/3592
摘要： A connection of a patient's vascular system to an extracorporeal blood treatment machine is monitored to ensure the patient's safety during a procedure. The procedure may be hemodialysis, apheresis, plasmapheresis, a coronary by-pass operation, or other procedure. To ensure safe electrical connection, a contact and a return are connected via a conductive connection into the extracorporeal blood circuit. A current is then generated between the contact and the return and is monitored by a non-contact sensor near an access site of the patient. If the current or other quantity related to the current changes significantly, a signal is sent to the machine or a controller to notify a caregiver or a medical professional. The signal may also be sent to immediately stop a blood pump or other component of the machine.
摘要翻译：监测患者血管系统与体外血液处理机的连接，以确保患者在手术过程中的安全。该程序可以是血液透析，单采血浆置换术，血浆置换术，冠状动脉旁路手术或其他手术。为了确保安全的电气连接，接触和返回通过导电连接连接到体外血液回路中。然后在接触和返回之间产生电流，并由患者接近位置附近的非接触传感器监测。如果与当前相关的当前或其他数量显着变化，则将信号发送到机器或控制器以通知护理人员或医疗专业人员。也可以发送信号以立即停止血液泵或机器的其他部件。

3. 发明授权

US07420660B2 Systems and methods for optically sensing characteristics of a blood flow 有权
标题翻译：用于光学感测血流特征的系统和方法
公开(公告)号：US07420660B2
公开(公告)日：2008-09-02
申请号：US11974652
申请日：2007-10-15
申请人： Matthew R. Muller
发明人： Matthew R. Muller
IPC分类号： G01N33/48
CPC分类号： G01N21/31 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3393 , B01D17/0217
摘要： Systems and methods for optically sensing characteristics of a blood flow provide a light source having a driver circuit that includes a source of constant current and a modulator that modulates the constant current at a selected carrier frequency for transmission to the light source. The systems and methods also include a light sensor for receiving light from the light source and producing a modulated output proportional to received light intensity. A receiver circuit including a bandpass filter is coupled to the light sensor to receive the modulated output and having a center frequency at or near the selected carrier frequency to eliminate frequency components above and below the selected carrier frequency.
摘要翻译：用于光学感测血流特性的系统和方法提供了具有包括恒定电流源的驱动器电路的光源和调制选定载波频率处的恒定电流以传输到光源的调制器。该系统和方法还包括用于接收来自光源的光的光传感器，并且产生与所接收的光强成正比的调制输出。包括带通滤波器的接收器电路被耦合到光传感器以接收调制输出并且具有处于或接近所选载波频率的中心频率，以消除所选载波频率之上和之下的频率分量。

4. 发明授权

US06419822B2 Systems and methods for sensing red blood cell hematocrit 有权
标题翻译：用于感测红细胞血细胞比容的系统和方法
公开(公告)号：US06419822B2
公开(公告)日：2002-07-16
申请号：US09901986
申请日：2001-07-10
申请人： Matthew R. Muller , Michel L. F. Joie , Mark R. Vandlik
发明人： Matthew R. Muller , Michel L. F. Joie , Mark R. Vandlik
IPC分类号： B01D1712
CPC分类号： B01D21/302 , A61M1/0236 , A61M1/367 , A61M1/3696 , A61M1/38 , A61M2205/128 , A61M2205/3393 , A61M2230/207 , B01D17/0217 , B01D21/2444 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/34 , B01D2221/08 , B01D2221/10
摘要： Red blood cell sensing systems and methods rely upon straightforward measurement geometries. The systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.
摘要翻译：红细胞感测系统和方法依赖于简单的测量几何。系统和方法包括入射光源，光学传感器和采血管。系统和方法将采血管保持与入射光源预定的径向距离，其中在由光学传感器测量的感测反射光与红细胞血细胞比容之间存在线性关系，范围在至少10至90°。系统和方法可以在不使用特殊的光学比色杯，镜子或聚焦镜片的情况下进行准确的红血传感。系统和方法也可以使用标准的透明塑料管，而不依赖于特殊的光学比色皿。

5. 发明申请

US20120296279A1 ACCESS DISCONNECTION METHOD USING OPTICAL AND OTHER SENSORS 审中-公开
标题翻译：使用光学和其他传感器的访问断开方法
公开(公告)号：US20120296279A1
公开(公告)日：2012-11-22
申请号：US13480787
申请日：2012-05-25
申请人： Matthew R. Muller , Luke Beehner , William W. Chan , James S. Slepicka , Atif Yardimci
发明人： Matthew R. Muller , Luke Beehner , William W. Chan , James S. Slepicka , Atif Yardimci
IPC分类号： A61M5/00
CPC分类号： A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M5/16831 , A61M5/16836 , A61M2205/15 , A61M2205/3306
摘要： A method for detecting movement or disconnection of a needle at an access site of a patient comprising: sensing for a presence of blood at the access site while a medical procedure is performed on the patient; separately sensing for a movement of (i) the needle or (ii) tubing connected to the needle; and sending a signal indicating movement or disconnection of the needle if one of (a) the presence of blood is sensed or (b) movement is sensed under (i) or (ii).
摘要翻译：一种用于检测针在患者进入位置处的移动或断开的方法，包括：在对患者执行医疗程序时，检测在所述进入部位处的血液的存在; 分别感测（i）针或（ii）连接到针的管的运动; 并且如果（a）感测到血液的存在或（b）在（i）或（ii）下感测到运动，则发送指示针的移动或断开的信号。

6. 发明授权

US08187184B2 Access disconnect system with optical and other sensors 有权
标题翻译：具有光学和其他传感器的接入断开系统
公开(公告)号：US08187184B2
公开(公告)日：2012-05-29
申请号：US11859556
申请日：2007-09-21
申请人： Matthew R. Muller , Luke Beehner , William W. Chan , James S. Slepicka , Atif Yardimci
发明人： Matthew R. Muller , Luke Beehner , William W. Chan , James S. Slepicka , Atif Yardimci
IPC分类号： A61B5/00
CPC分类号： A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M5/16831 , A61M5/16836 , A61M2205/15 , A61M2205/3306
摘要： An optical access disconnect system is useful for detecting the presence of blood. The optical access disconnect system includes one or more optical sensors placed near an access site of a patient, the optical sensors suitable for detecting the presence of blood, especially by detecting a difference in light reflected or absorbed by blood. The optical access disconnect system may also be used as an interlock to assure compliance. A detector may be placed adjacent the access site to detect the access needle, or an object or mark on the access needle or fluid line. A therapy machine, such as a dialysis machine, may be programmed not to start or continue operation unless the needle or fluid line is detected. The detector may be one of the optical sensors, calibrated or adjusted to detect a mark on the needle or access line, or may be another type of detector.
摘要翻译：光学接入断开系统可用于检测血液的存在。光学接入断开系统包括放置在患者进入位置附近的一个或多个光学传感器，适用于检测血液存在的光学传感器，特别是通过检测由血液反射或吸收的光的差异。光学接入断开系统也可以用作互锁以确保符合性。检测器可以放置在接近位置附近以检测进入针，或者进入针或流体线上的物体或标记。除非检测到针或流体管线，否则治疗机器（例如透析机）可被编程为不启动或继续操作。检测器可以是校准或调整以检测针或接入线上的标记的光学传感器之一，或者可以是另一种类型的检测器。

7. 发明授权

US08444587B2 Fluid and air handling in blood and dialysis circuits 有权
标题翻译：血液和透析电路中的流体和空气处理
公开(公告)号：US08444587B2
公开(公告)日：2013-05-21
申请号：US12237160
申请日：2008-09-24
申请人： Thomas D. Kelly , Marc S. Minkus , Angelito A. Bernardo , William P. Burns , Robert W. Childers , Shincy J. Maliekkal , Matthew R. Muller , Justin B. Rohde , Michael E. Hogard
发明人： Thomas D. Kelly , Marc S. Minkus , Angelito A. Bernardo , William P. Burns , Robert W. Childers , Shincy J. Maliekkal , Matthew R. Muller , Justin B. Rohde , Michael E. Hogard
IPC分类号： A61M37/00
CPC分类号： A61M1/3643 , A61M1/16 , A61M1/1601 , A61M1/282 , A61M1/288 , A61M1/3624 , A61M1/3627 , A61M1/3644 , A61M1/3649 , A61M2202/02 , A61M2202/0413 , A61M2205/10 , A61M2205/3382 , A61M2205/3386 , A61M2205/75 , Y10T137/0402
摘要： An air purging method includes: (a) detecting a low fluid level in a blood circuit indicating a high amount of air in the blood circuit; (b) stopping a blood pump; (c) closing a venous patient line; (d) opening a blood circuit air vent valve and a drain valve; and (e) running the blood pump to meter air through the air vent valve and the drain valve to a drain.
摘要翻译：空气净化方法包括：（a）检测表示血液回路中大量空气的血液循环中的低液位; （b）停止血液泵; （c）关闭静脉病人线; （d）打开血液循环通气阀和排水阀; 和（e）运行血液泵通过排气阀和排水阀将空气流通到排水管。

8. 发明授权

US07463343B2 Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing 有权
公开(公告)号：US07463343B2
公开(公告)日：2008-12-09
申请号：US11974650
申请日：2007-10-15
申请人： Matthew R. Muller
发明人： Matthew R. Muller
IPC分类号： G01N33/48
CPC分类号： G01N21/31 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3393 , B01D17/0217
摘要： Systems and related methods sense the presence of targeted cellular blood species during extracorporeal blood separation or processing. The systems and methods tailor the sensing parameters to the particular objectives of the blood processing procedure selected to be accomplished. Different cellular blood species are targeted for detection for different selected blood processing procedures. The systems and methods differentiate among different cellular blood species for detection, according to the blood processing procedure selected.

9. 发明授权

US06537445B2 Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing 有权
标题翻译：用于在体外血液分离或加工过程中区分不同细胞血液种类的感应系统和方法
公开(公告)号：US06537445B2
公开(公告)日：2003-03-25
申请号：US09931146
申请日：2001-08-16
申请人： Matthew R. Muller
发明人： Matthew R. Muller
IPC分类号： B01D1712
CPC分类号： G01N21/31 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3393 , B01D17/0217
摘要： A blood processing system comprises a blood separation chamber constructed and arranged for rotation about an axis separate blood into a plasma layer and an adjoining region comprising different first and second cellular blood species arranged in layers according to density. A collection line including a pump removes the plasma layer from the blood separation chamber. The pump operates to control flow through the collection line in response to pump control signals. A sensor assembly in the collection line detects concentration of first and second cellular blood species in the collection line. A controller coupled to the sensor assembly operates to generate the pump control signals according to a selected blood collection protocol. The controller operates, when a first blood collection protocol is selected, to generate a pump control signal when the sensor assembly detects changes in concentration of the first cellular blood species in the collection line. The controller also operates, when a second collection protocol is selected, to generate a pump control signal when the sensor assembly to detects changes in concentration of the second cellular blood species in the collection line.
摘要翻译：血液处理系统包括血液分离室，其构造和布置成围绕将血液分离成等离子体层的轴线以及包括根据密度分层排列的不同第一和第二细胞血液种类的邻接区域。包括泵的收集线从血液分离室去除等离子体层。泵响应于泵控制信号而操作以控制通过采集管线的流量。收集线中的传感器组件检测收集线中第一和第二细胞血液种类的浓度。耦合到传感器组件的控制器操作以根据所选择的血液采集方案产生泵控制信号。当选择第一采血协议时，控制器操作以在传感器组件检测到收集线中的第一细胞血液的浓度变化时产生泵控制信号。当选择第二收集协议时，控制器还操作以在传感器组件检测收集线中的第二细胞血液的浓度变化时产生泵控制信号。

10. 发明授权

US06348156B1 Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma 有权
标题翻译：具有传感器的血液处理系统和方法，用于检测由于存在细胞成分引起的污染或由于血浆的存在引起的稀释
公开(公告)号：US06348156B1
公开(公告)日：2002-02-19
申请号：US09390492
申请日：1999-09-03
申请人： Rohit Vishnoi , Tom Westberg , Matthew R. Muller , Kelly B Smith , Michel L. F. Joie , Mark R Vandlik
发明人： Rohit Vishnoi , Tom Westberg , Matthew R. Muller , Kelly B Smith , Michel L. F. Joie , Mark R Vandlik
IPC分类号： B01D2126
CPC分类号： B01D21/34 , A61M1/0236 , A61M1/3496 , A61M1/3646 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0429 , A61M2205/125 , A61M2205/128 , A61M2205/331 , A61M2205/3393 , B01D17/0217 , B01D21/2444 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/302 , B01D2221/08 , B01D2221/10
摘要： Blood processing systems and methods employ two sensors, one to detect a condition of plasma exiting a separation device and another sensor to detect a condition of a cellular component exiting the separation device. The first sensor detects, e.g., contamination of the plasma due to presence of unwanted cellular components. The second sensor detects, e.g., dilution of the cellular component due to presence of plasma. Blood processing parameters are carried out based, at least in part, by conditions detected by one or both of the sensors.
摘要翻译：血液处理系统和方法采用两个传感器，一个用于检测离开分离装置的等离子体的状态，另一个传感器用于检测离开分离装置的细胞组分的状况。第一传感器检测例如由于存在不想要的细胞组分而导致的等离子体的污染。第二传感器例如由于存在等离子体而检测细胞成分的稀释。至少部分地基于由一个或两个传感器检测到的条件进行血液处理参数。

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