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1. 发明申请

US20120289561A1 COMBINATIONS OF FESOTERODINE AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
公开(公告)号：US20120289561A1
公开(公告)日：2012-11-15
申请号：US13467230
申请日：2012-05-09
申请人： Mehdi PABORJI , Kenneth L. DUCHIN , Roger S. FLUGEL
发明人： Mehdi PABORJI , Kenneth L. DUCHIN , Roger S. FLUGEL
IPC分类号： A61K31/4178 , A61P13/10
CPC分类号： A61K31/222 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.

2. 发明申请

US20120289547A1 COMBINATIONS OF PROPIVERINE AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：丙肝和唾液乳液联合用于治疗过敏性叶片
公开(公告)号：US20120289547A1
公开(公告)日：2012-11-15
申请号：US13468002
申请日：2012-05-09
申请人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
发明人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
IPC分类号： A61K31/445 , A61P13/10
CPC分类号： A61K31/445 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release propiverine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release propiverine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release propiverine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放丙哌嗪或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放促丙素或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放素或药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

3. 发明申请

US20120289539A1 COMBINATIONS OF TROSPIUM AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
公开(公告)号：US20120289539A1
公开(公告)日：2012-11-15
申请号：US13476912
申请日：2012-05-21
申请人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
发明人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
IPC分类号： A61K31/439 , A61P13/10
CPC分类号： A61K31/46 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.

4. 发明申请

US20120289529A1 COMBINATIONS OF TROSPIUM AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：用于治疗过敏性叶片的铁和唾液的组合
公开(公告)号：US20120289529A1
公开(公告)日：2012-11-15
申请号：US13467244
申请日：2012-05-09
申请人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
发明人： Mehdi PABORJI , Kenneth L. DUCHIN , Wendy Jade Limayo HERNANDEZ , Roger S. FLUGEL
IPC分类号： A61K31/46 , A61P13/10
CPC分类号： A61K31/46 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放蚤或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放蚤或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放蚤或其药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

5. 发明申请

US20090275629A1 THERAPY FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：治疗疾病的治疗方法
公开(公告)号：US20090275629A1
公开(公告)日：2009-11-05
申请号：US12503432
申请日：2009-07-15
申请人： Mehdi Paborji
发明人： Mehdi Paborji
IPC分类号： A61K31/4178 , A61P25/00
CPC分类号： A61K31/4178 , A61K31/00 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/4172 , A61K31/439 , A61K31/46 , A61K31/717 , A61K33/06 , A61K36/482 , A61K36/68 , A61K36/72 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising various combinations of an antimuscarinic or an anticholinergic agent, a compound that causes stimulation of salivary glands, and a compound that relieves constipation. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient the above pharmaceutical composition.
摘要翻译：本文公开了包含抗毒蕈碱或抗胆碱能药物的各种组合，引起唾液腺刺激的化合物和缓解便秘的化合物的药物组合物。还公开了治疗患有膀胱过度活动症的患者的方法，包括向患者施用上述药物组合物。

6. 发明申请

US20120289566A1 COMBINATIONS OF FESOTERODINE AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：用于治疗过敏性叶片的菲司托品和唾液酸凝胶的组合
公开(公告)号：US20120289566A1
公开(公告)日：2012-11-15
申请号：US13476874
申请日：2012-05-21
申请人： Mehdi PABORJI , Kenneth L. DUCHIN , Roger S. FLUGEL
发明人： Mehdi PABORJI , Kenneth L. DUCHIN , Roger S. FLUGEL
IPC分类号： A61K31/4178 , A61P13/00
CPC分类号： A61K31/222 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放非索罗定或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放非索罗定或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放的非索罗定或其药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

7. 发明申请

US20120289544A1 COMBINATIONS OF SOLIFENACIN AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 有权
标题翻译：用于治疗过敏性叶片的溶胶素和唾液酸凝胶的组合
公开(公告)号：US20120289544A1
公开(公告)日：2012-11-15
申请号：US13476883
申请日：2012-05-21
申请人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
发明人： Mehdi PABORJI , Wendy Jade Limayo HERNANDEZ , Kenneth L. DUCHIN , Roger S. FLUGEL
IPC分类号： A61K31/439 , A61P13/00
CPC分类号： A61K31/4178 , A61K31/4725 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放索非那新或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放索非那新或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放索非那新或其药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

8. 发明申请

US20110244051A1 PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT OF OVERACTIVE BLADDER 有权
标题翻译：用于治疗过敏性叶片的药物制剂
公开(公告)号：US20110244051A1
公开(公告)日：2011-10-06
申请号：US13078881
申请日：2011-04-01
申请人： Mehdi PABORJI , Roger S. FLUGEL
发明人： Mehdi PABORJI , Roger S. FLUGEL
IPC分类号： A61K9/16 , A61K31/4178 , A61K31/439 , A61K31/137 , A61K31/222 , A61K31/216 , A61K31/4725 , A61K31/4025 , A61K31/403 , A61K31/4174 , A61K31/445 , A61K31/215 , A61P13/10
CPC分类号： A61K9/1652 , A61K9/1617 , A61K9/1676 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/222 , A61K31/4178
摘要： Disclosed herein are pharmaceutical compositions comprising a plurality of first beads each comprising: a core; a first layer comprising pilocarpine or a pharmaceutically acceptable salt thereof; and a second layer comprising a first polymer. Also disclosed are pharmaceutical compositions comprising a plurality of second beads each comprising: a core; and a first layer comprising tolterodine or a pharmaceutically acceptable salt thereof. Further disclosed are pharmaceutical formulations comprising: a) a plurality of the first beads; b) a plurality of the second beads; or c) a plurality of the first beads and a plurality of the second beads.
摘要翻译：本文公开了包含多个第一珠粒的药物组合物，每个第一珠粒各自包含：核心; 包含毛果芸香碱或其药学上可接受的盐的第一层; 和包含第一聚合物的第二层。还公开了包含多个第二珠粒的药物组合物，每个第二珠粒各自包含：核心; 以及包含托特罗定或其药学上可接受的盐的第一层。进一步公开的是药物制剂，其包含：a）多个第一珠粒; b）多个第二珠粒; 或c）多个第一珠和多个第二珠。

9. 发明授权

US07781472B2 Therapy for the treatment of disease 有权
公开(公告)号：US07781472B2
公开(公告)日：2010-08-24
申请号：US12710310
申请日：2010-02-22
申请人： Mehdi Paborji
发明人： Mehdi Paborji
IPC分类号： A61K31/4178 , A61K31/216
CPC分类号： A61K31/4178 , A61K31/00 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/4172 , A61K31/439 , A61K31/46 , A61K31/717 , A61K33/06 , A61K36/482 , A61K36/68 , A61K36/72 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising oxybutynin, or a free base thereof or a pharmaceutically acceptable salt thereof, and pilocarpine, or a free base thereof or a pharmaceutically acceptable salt thereof. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient the above pharmaceutical composition.

10. 发明申请

US20100137392A1 THERAPY FOR THE TREATMENT OF DISEASE 有权
标题翻译：治疗疾病的治疗方法
公开(公告)号：US20100137392A1
公开(公告)日：2010-06-03
申请号：US12710310
申请日：2010-02-22
申请人： Mehdi PABORJI
发明人： Mehdi PABORJI
IPC分类号： A61K31/4178 , A61P13/06 , A61P13/10
CPC分类号： A61K31/4178 , A61K31/00 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/4172 , A61K31/439 , A61K31/46 , A61K31/717 , A61K33/06 , A61K36/482 , A61K36/68 , A61K36/72 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising oxybutynin, or a free base thereof or a pharmaceutically acceptable salt thereof, and pilocarpine, or a free base thereof or a pharmaceutically acceptable salt thereof. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient the above pharmaceutical composition.
摘要翻译：本文公开了包含奥昔布宁或其游离碱或其药学上可接受的盐，毛果芸香碱或其游离碱或其药学上可接受的盐的药物组合物。还公开了治疗患有膀胱过度活动症的患者的方法，包括向患者施用上述药物组合物。

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