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1. 发明授权

US07269313B2 Ultra-slow down and storage of light pulses, and altering of pulse spectrum 失效
标题翻译：光脉冲的超慢减速和脉冲光谱的改变
公开(公告)号：US07269313B2
公开(公告)日：2007-09-11
申请号：US11001492
申请日：2004-11-30
申请人： Mehmet Fatih Yanik , Shanhui Fan
发明人： Mehmet Fatih Yanik , Shanhui Fan
IPC分类号： G02B6/26 , G02F1/295
CPC分类号： B82Y20/00 , G02B6/1225
摘要： Light pulses can be stopped and stored coherently, with an all-optical process that involves an adiabatic and reversible pulse bandwidth compression occurring entirely in the optical domain. Such a process overcomes the fundamental bandwidth-delay constraint in optics, and can generate arbitrarily small group velocities for light pulses with a given bandwidth, without the use of any coherent or resonant light-matter interactions. This is accomplished only by small refractive index modulations performed at moderate speeds and has applications ranging from quantum communications and computing to coherent all-optical memory devices. A complete time reversal and/or temporal/spectral compression and expansion operation on any electromagnetic field is accomplished using only small refractive index modulations and linear optical elements. This process does not require any nonlinear multi-photon processes such as four-wave mixing and thus can be implemented using on-chip tunable microcavity complexes in photonic crystals. The tuning process requires only small refractive index modulations, and moderate modulation speeds without requiring any high-speed electronic sampling.
摘要翻译：光脉冲可以被停止并相干地存储，其全光学过程涉及完全在光学域中发生的绝热和可逆的脉冲带宽压缩。这种过程克服了光学中的基本带宽延迟约束，并且可以为具有给定带宽的光脉冲产生任意小的组速度，而不使用任何相干或共振的光物质相互作用。这仅通过在中等速度下执行的小折射率调制来实现，并且具有从量子通信和计算到相干全光存储器件的应用。在任何电磁场上的完全时间反转和/或时间/频谱压缩和扩展操作仅使用小的折射率调制和线性光学元件来实现。该过程不需要诸如四波混频的任何非线性多光子过程，因此可以使用光子晶体中的片上可调谐微腔复合体来实现。调谐过程只需要较小的折射率调制和适度的调制速度，而不需要任何高速电子采样。

2. 发明申请

US20100273220A1 INNATE IMMUNE SUPPRESSION ENABLES REPEATED DELIVERY OF LONG RNA MOLECULES 审中-公开
标题翻译： INNATE免疫抑制使用重复传递长RNA分子
公开(公告)号：US20100273220A1
公开(公告)日：2010-10-28
申请号：US12428378
申请日：2009-04-22
申请人： MEHMET FATIH YANIK , MATTHEW ANGEL
发明人： MEHMET FATIH YANIK , MATTHEW ANGEL
IPC分类号： C12P19/34 , C12N5/02 , C07H21/04
CPC分类号： C12N15/67 , C12N15/113 , C12N15/1136 , C12N2310/14
摘要： The present invention relates in part to methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid, to methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and to methods of changing the phenotype of a cell by differentiating, transdifferentiating or dedifferentiating cells by repeatedly delivering one or more nucleic acids that encode defined proteins. A method is provided for extended transient transfection by repeated delivery of an in vitro-transcribed RNA (“ivT-RNA”) to a cell to achieve a high and sustained level of expression of a protein encoded by an ivT-RNA transcripts.
摘要翻译：本发明部分涉及用外源核酸抑制细胞对转染的先天免疫应答的方法，通过将外源核酸重复递送至细胞来增加由外源核酸编码的蛋白质的表达的方法以及通过重复递送编码定义的蛋白质的一种或多种核酸来分化，转分化或去分化细胞来改变细胞表型的方法。提供了通过将体外转录的RNA（“ivT-RNA”）重复递送到细胞以实现由ivT-RNA转录物编码的蛋白质的高且持续水平的表达的延长的瞬时转染的方法。

3. 发明授权

US07412127B2 Photonic crystal reflectors/filters and displacement sensing applications 失效
标题翻译：光子晶体反射器/滤波器和位移传感应用
公开(公告)号：US07412127B2
公开(公告)日：2008-08-12
申请号：US11464781
申请日：2006-08-15
申请人： Wonjoo Suh , Mehmet Fatih Yanik , Olav Solgaard , Shanhui Fan
发明人： Wonjoo Suh , Mehmet Fatih Yanik , Olav Solgaard , Shanhui Fan
IPC分类号： G02B6/26 , G02B6/24
CPC分类号： B82Y20/00 , G02B6/1225
摘要： We introduce a mechanically tunable photonic crystal structure consisting of coupled photonic crystal slabs. Using both analytic theory, and first-principles finite-difference time-domain simulations, we demonstrate that the transmission and reflection coefficients for light normally incident upon such structures can be highly sensitive to nano-scale variations in the spacing between the slabs. Moreover, by specifically configuring the photonic crystal structures, the high sensitivity can be preserved in spite of significant fabrication-related disorders. We expect such a structure to play important roles in micro-mechanically tunable optical sensors and filters.
摘要翻译：我们引入了由耦合光子晶体板组成的机械可调光子晶体结构。使用分析理论和第一原理有限差分时域仿真，我们证明了通常在这种结构上入射的光的透射和反射系数可以对板之间的间距的纳米尺度变化高度敏感。此外，通过具体配置光子晶体结构，可以保持高灵敏度，尽管有显着的制造相关障碍。我们预计这种结构在微机械可调光学传感器和滤波器中起重要作用。

4. 发明申请

US20060115211A1 Stopping and time reversing light in a waveguide with an all-optical system 失效
公开(公告)号：US20060115211A1
公开(公告)日：2006-06-01
申请号：US11000679
申请日：2004-11-30
申请人： Mehmet Fatih Yanik , Wonjoo Suh , Zheng Wang , Shanhui Fan
发明人： Mehmet Fatih Yanik , Wonjoo Suh , Zheng Wang , Shanhui Fan
IPC分类号： G02B6/26
CPC分类号： G02B6/29343 , B82Y20/00 , G02B6/1225 , G02F1/365 , G02F2202/32
摘要： We introduce a new all-optical mechanism that can compress the bandwidth of light pulses to absolute zero, and bring them to a complete stop. The mechanism can be realized in a system consisting of a waveguide side-coupled to tunable resonators, which generates a photonic band structure that represents a classical analogue of the Electromagnetically Induced Transparency. The same system can also achieve a time-reversal operation. We demonstrate the operation of such a system by finite-difference time-domain simulations of an implementation in photonic crystals.

5. 发明授权

US07803712B2 Multilevel imprint lithography 失效
公开(公告)号：US07803712B2
公开(公告)日：2010-09-28
申请号：US11636264
申请日：2006-12-07
申请人： Pavel Kornilovich , Yong Chen , Duncan Stewart , R. Stanley Williams , Philip J. Kuekes , Mehmet Fatih Yanik
发明人： Pavel Kornilovich , Yong Chen , Duncan Stewart , R. Stanley Williams , Philip J. Kuekes , Mehmet Fatih Yanik
IPC分类号： H01L21/308
CPC分类号： H01L21/76838 , B81C99/009 , B81C2201/0153 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： A mold with a protruding pattern is provided that is pressed into a thin polymer film via an imprinting process. Controlled connections between nanowires and microwires and other lithographically-made elements of electronic circuitry are provided. An imprint stamp is configured to form arrays of approximately parallel nanowires which have (1) micro dimensions in the X direction, (2) nano dimensions and nano spacing in the Y direction, and three or more distinct heights in the Z direction. The stamp thus formed can be used to connect specific individual nanowires to specific microscopic regions of microscopic wires or pads. The protruding pattern in the mold creates recesses in the thin polymer film, so the polymer layer acquires the reverse of the pattern on the mold. After the mold is removed, the film is processed such that the polymer pattern can be transferred on a metal/semiconductor pattern on the substrate.

6. 发明申请

US20120208278A1 INNATE IMMUNE SUPPRESSION ENABLES REPEATED DELIVERY OF LONG RNA MOLECULES 审中-公开
标题翻译： INNATE免疫抑制使用重复传递长RNA分子
公开(公告)号：US20120208278A1
公开(公告)日：2012-08-16
申请号：US13455327
申请日：2012-04-25
申请人： Mehmet Fatih Yanik , Matthew Angel
发明人： Mehmet Fatih Yanik , Matthew Angel
IPC分类号： C12N15/85 , C12N13/00 , C12N5/10 , C12N5/071
CPC分类号： C12N15/67 , C12N15/113 , C12N15/1136 , C12N2310/14
摘要： The present invention relates in part to methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid, to methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and to methods of changing the phenotype of a cell by differentiating, transdifferentiating or dedifferentiating cells by repeatedly delivering one or more nucleic acids that encode defined proteins. A method is provided for extended transient transfection by repeated delivery of an in vitro-transcribed RNA (“ivT-RNA”) to a cell to achieve a high and sustained level of expression of a protein encoded by an ivT-RNA transcripts.
摘要翻译：本发明部分涉及用外源核酸抑制细胞对转染的先天免疫应答的方法，通过将外源核酸重复递送至细胞来增加由外源核酸编码的蛋白质的表达的方法以及通过重复递送编码定义的蛋白质的一种或多种核酸来分化，转分化或去分化细胞来改变细胞表型的方法。提供了通过将体外转录的RNA（“ivT-RNA”）重复递送到细胞以实现由ivT-RNA转录物编码的蛋白质的高且持续水平的表达的延长的瞬时转染的方法。

7. 发明申请

US20100112809A1 Multilevel imprint lithography 失效
标题翻译：多层压印光刻
公开(公告)号：US20100112809A1
公开(公告)日：2010-05-06
申请号：US11636264
申请日：2006-12-07
申请人： Pavel Kornilovich , Yong Chen , Duncan Stewart , R. Stanley Williams , Philip J. Kuekes , Mehmet Fatih Yanik
发明人： Pavel Kornilovich , Yong Chen , Duncan Stewart , R. Stanley Williams , Philip J. Kuekes , Mehmet Fatih Yanik
IPC分类号： H01L21/768
CPC分类号： H01L21/76838 , B81C99/009 , B81C2201/0153 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： A mold with a protruding pattern is provided that is pressed into a thin polymer film via an imprinting process. Controlled connections between nanowires and microwires and other lithographically-made elements of electronic circuitry are provided. An imprint stamp is configured to form arrays of approximately parallel nanowires which have (1) micro dimensions in the X direction, (2) nano dimensions and nano spacing in the Y direction, and three or more distinct heights in the Z direction. The stamp thus formed can be used to connect specific individual nanowires to specific microscopic regions of microscopic wires or pads. The protruding pattern in the mold creates recesses in the thin polymer film, so the polymer layer acquires the reverse of the pattern on the mold. After the mold is removed, the film is processed such that the polymer pattern can be transferred on a metal/semiconductor pattern on the substrate.
摘要翻译：提供具有突出图案的模具，其通过压印过程被压入薄聚合物膜。提供了纳米线和微丝之间的控制连接以及电子电路的其它光刻元件。打印印记被配置成形成大致平行的纳米线的阵列，其具有（1）X方向上的微尺寸，（2）在Y方向上的纳米尺寸和纳米间距，以及Z方向上的三个或更多个不同的高度。如此形成的印章可以用于将特定的单个纳米线连接到微细线或垫的特定微观区域。模具中的突出图案在薄聚合物膜中产生凹陷，因此聚合物层获得模具上图案的相反。在除去模具之后，处理膜，使得聚合物图案可以在基底上的金属/半导体图案上转印。

8. 发明授权

US07256435B1 Multilevel imprint lithography 有权
标题翻译：多层压印光刻
公开(公告)号：US07256435B1
公开(公告)日：2007-08-14
申请号：US10453329
申请日：2003-06-02
申请人： Pavel Kornilovich , Yong Chen , Duncan Stewart , R. Stanley Williams , Philip J. Kuekes , Mehmet Fatih Yanik
发明人： Pavel Kornilovich , Yong Chen , Duncan Stewart , R. Stanley Williams , Philip J. Kuekes , Mehmet Fatih Yanik
IPC分类号： H01L27/10
CPC分类号： H01L21/76838 , B81C99/009 , B81C2201/0153 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： A mold with a protruding pattern is provided that is pressed into a thin polymer film via an imprinting process. Controlled connections between nanowires and microwires and other lithographically-made elements of electronic circuitry are provided. An imprint stamp is configured to form arrays of approximately parallel nanowires which have (1) micro dimensions in the X direction, (2) nano dimensions and nano spacing in the Y direction, and three or more distinct heights in the Z direction. The stamp thus formed can be used to connect specific individual nanowires to specific microscopic regions of microscopic wires or pads. The protruding pattern in the mold creates recesses in the thin polymer film, so the polymer layer acquires the reverse of the pattern on the mold. After the mold is removed, the film is processed such that the polymer pattern can be transferred on a metal/semiconductor pattern on the substrate.
摘要翻译：提供具有突出图案的模具，其通过压印过程被压入薄聚合物膜。提供了纳米线和微丝之间的控制连接以及电子电路的其它光刻元件。打印印记被配置成形成大致平行的纳米线的阵列，其具有（1）X方向上的微尺寸，（2）在Y方向上的纳米尺寸和纳米间距，以及Z方向上的三个或更多个不同的高度。如此形成的印章可以用于将特定的单个纳米线连接到微细线或垫的特定微观区域。模具中的突出图案在薄聚合物膜中产生凹陷，因此聚合物层获得模具上图案的相反。在除去模具之后，处理膜，使得聚合物图案可以在基底上的金属/半导体图案上转印。

9. 发明授权

US07155087B2 Photonic crystal reflectors/filters and displacement sensing applications 失效
标题翻译：光子晶体反射器/滤波器和位移传感应用
公开(公告)号：US07155087B2
公开(公告)日：2006-12-26
申请号：US10682576
申请日：2003-10-08
申请人： Wonjoo Suh , Mehmet Fatih Yanik , Olav Solgaard , Shanhui Fan
发明人： Wonjoo Suh , Mehmet Fatih Yanik , Olav Solgaard , Shanhui Fan
IPC分类号： G02B6/26 , G02B6/24
CPC分类号： B82Y20/00 , G02B6/1225
摘要： We introduce a mechanically tunable photonic crystal structure consisting of coupled photonic crystal slabs. Using both analytic theory, and first-principles finite-difference time-domain simulations, we demonstrate that the transmission and reflection coefficients for light normally incident upon such structures can be highly sensitive to nano-scale variations in the spacing between the slabs. Moreover, by specifically configuring the photonic crystal structures, the high sensitivity can be preserved in spite of significant fabrication-related disorders. We expect such a structure to play important roles in micro-mechanically tunable optical sensors and filters.
摘要翻译：我们引入了由耦合光子晶体板组成的机械可调光子晶体结构。使用分析理论和第一原理有限差分时域仿真，我们证明了通常在这种结构上入射的光的透射和反射系数可以对板之间的间距的纳米尺度变化高度敏感。此外，通过具体配置光子晶体结构，可以保持高灵敏度，尽管有显着的制造相关障碍。我们预计这种结构在微机械可调光学传感器和滤波器中起重要作用。

10. 发明授权

US07116864B2 Stopping and time reversing light in a waveguide with an all-optical system 失效
标题翻译：在具有全光学系统的波导中停止和时间反转光
公开(公告)号：US07116864B2
公开(公告)日：2006-10-03
申请号：US11000679
申请日：2004-11-30
申请人： Mehmet Fatih Yanik , Wonjoo Suh , Zhang Wang , Shanhui Fan
发明人： Mehmet Fatih Yanik , Wonjoo Suh , Zhang Wang , Shanhui Fan
IPC分类号： G02B6/26 , G02F1/295
CPC分类号： G02B6/29343 , B82Y20/00 , G02B6/1225 , G02F1/365 , G02F2202/32
摘要： We introduce a new all-optical mechanism that can compress the bandwidth of light pulses to absolute zero, and bring them to a complete stop. The mechanism can be realized in a system consisting of a waveguide side-coupled to tunable resonators, which generates a photonic band structure that represents a classical analogue of the Electromagnetically Induced Transparency. The same system can also achieve a time-reversal operation. We demonstrate the operation of such a system by finite-difference time-domain simulations of an implementation in photonic crystals.
摘要翻译：我们引入了一种全光学机制，可以将光脉冲的带宽压缩到绝对零度，并使其完全停止。该机构可以在由耦合到可调谐谐振器的波导管组成的系统中实现，其产生代表电磁感应透明度的经典类似物的光子带结构。相同的系统也可以实现时间反转操作。我们通过光子晶体实现的有限差分时域仿真来证明这种系统的运行。

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